1. Highly modified nor-clerodane diterpenoids from Croton yanhuii.
- Author
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Zou MF, Pan YH, Hu R, Yuan FY, Huang D, Tang GH, Li W, and Yin S
- Subjects
- 3T3-L1 Cells, A549 Cells, Animals, China, Diterpenes, Clerodane isolation & purification, Humans, Mice, Molecular Structure, Nitric Oxide, Phytochemicals chemistry, Phytochemicals isolation & purification, Plant Leaves chemistry, RAW 264.7 Cells, Croton chemistry, Diterpenes, Clerodane chemistry
- Abstract
Phytochemical investigation of the leaves and twigs of Croton yanhuii led to the isolation of seven highly modified nor-clerodane diterpenoids (1-7), including three new ones, croyanoids A-C (1-3), along with four known analogues (4-7). Compound 1 incorporates a 5,12-epoxy ring, forming a unique cage-like, 6/6/6/5-fused tetracyclic ring system. Their structures were established by extensive spectroscopic analysis, and the absolute configurations of 1-4 were determined by a combination of circular dichroism (CD) analysis and single-crystal X-ray diffraction. All compounds were tested in an array of bioassays, but were inactive. Crotoeurin A (7), a nor-clerodane dimer with a high yield of 0.2‰ isolated in current study, was considered as a chemotaxonomic marker for this species., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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