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2 results on '"Ottery F"'

1. Sarcopenia etymology: Sarcos (flesh) penia (poverty) i.e. absence, lack or deficiency of a body constituent.

Author

Kubrak C, Martin L, Grossberg AJ, Olson B, Ottery F, Findlay M, Bauer JD, Jha N, Scrimger R, Debenham B, Chua N, Walker J, and Baracos V

Subjects
Humans, Terminology as Topic, Sarcopenia
Abstract

Competing Interests: Conflict of interest Dr. Kubrak reported no conflicts of interest or financial disclosure. Dr. Martin reported no conflicts of interest or financial disclosure. Dr. Olson reported no conflicts of interest or financial disclosure. Dr. Grossberg reported serving as a consultant for Endevica Bio. No other disclosures were reported. Dr. Findlay reported receiving a Sydney Research PhD Scholarship (2018–2021) and Maridulu Budyari Gumal (SPHERE) Cancer Clinical Academic Group Senior Research Fellowship supported by a Cancer Institute NSW Research Capacity Building Grant (2021/CBG003). Dr. Bauer reported an honorarium from Nutricia. No other conflicts of interest or financial disclosure. Dr. Ottery reported affiliation with a consulting group Ottery and Associates LLC. No other disclosures were reported. Dr. Jha reported no conflicts of interest or financial disclosure. Dr. Scrimger reported no conflicts of interest or financial disclosure. Dr. Debenham reported no conflicts of interest or financial disclosure. Dr. Chua reported an honorarium from Merck and EMD Serono. No other conflicts of interest or financial disclosure. Dr. Walker reported serving as a consultant for Merck. No other conflicts of interest or financial disclosure. Dr. Baracos reported serving as a consultant for Pfizer Inc., Nestle Health Science and Baxter Health Sciences. No other disclosures were reported.

Published
2024
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2. Quantifying the severity of sarcopenia in patients with cancer of the head and neck.

Author

Kubrak C, Martin L, Grossberg AJ, Olson B, Ottery F, Findlay M, Bauer JD, Jha N, Scrimger R, Debenham B, Chua N, Walker J, and Baracos V

Subjects
Young Adult, Humans, Male, Female, Tomography, X-Ray Computed methods, Muscle, Skeletal diagnostic imaging, Muscle, Skeletal pathology, Retrospective Studies, Prognosis, Sarcopenia etiology, Head and Neck Neoplasms complications, Head and Neck Neoplasms pathology
Abstract

Background & Aims: Existing skeletal muscle index (SMI) thresholds for sarcopenia are inconsistent, and do not reflect severity of depletion. In this study we aimed to define criterion values for moderate and severe skeletal muscle depletion based on the risk of mortality in a population of patients with head and neck cancer (HNC). Additionally, we aimed to identify clinical and demographic predictors of skeletal muscle depletion, evaluate the survival impact of skeletal muscle depletion in patients with minimal nutritional risk or good performance status, and finally, benchmarking SMI values of patients with HNC against healthy young adults., Methods: Population cohort of 1231 consecutive patients and external validation cohorts with HNC had lumbar SMI measured by cross-sectional imaging. Optimal stratification determined sex-specific thresholds for 2-levels of SMI depletion (Class I and II) based on overall survival (OS). Adjusted multivariable regression analyses (tumor site, stage, performance status, age, sex, dietary intake, weight loss) determined relationships between 2-levels of SMI depletion and OS., Results: Mean SMI (cm 2 /m 2 ) was 51.7 ± 9.9 (males) and 39.8 ± 7.1 (females). The overall and sex-specific population demonstrated an increased risk of mortality associated with decreasing SMI. Sex-specific SMI (cm 2 /m 2 ) depletion thresholds for 2-levels of muscle depletion determined by optimal stratification for males and females, respectively (male: 45.2-37.5, and <37.5; female: 40.9-34.2, and <34.2). In the overall population, Normal SMI, Class I and II SMI depletion occurred in 65.0%, 24.0%, and 11.0%, respectively. Median OS was: Normal SMI (114 months, 95% CI, 97.1-130.8); Class I SMI Depletion (42 months, 95% CI, 28.5-55.4), and Class II SMI Depletion (15 months, 95% CI, 9.8-20.1). Adjusted multivariable analysis compared with Normal SMI (reference), Class I SMI Depletion (HR, 1.49; 95% CI, 1.18-1.88; P < .001), Class II SMI Depletion (HR, 1.91; 95% CI, 1.42-2.58; P < .001)., Conclusions: Moderate and severe SMI depletion demonstrate discrimination in OS in patients with HNC. Moderate and severe SMI depletion is prevalent in patients with minimal nutrition risk and good performance status. Benchmarking SMI values against healthy young adults exemplifies the magnitude of SMI depletion in patients with HNC and may be a useful method in standardizing SMI assessment., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Published
2024
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