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1. Gattuso's Differential Diagnosis in Surgical Pathology

Author

Vijaya B. Reddy, Odile David, Daniel J. Spitz, Meryl H. Haber, Vijaya B. Reddy, Odile David, Daniel J. Spitz, and Meryl H. Haber

Abstract

Widely used by residents, fellows, and practicing pathologists around the world, Gattusso's Differential Diagnosis in Surgical Pathology provides a user-friendly road map to the main criteria to consider in order to differentiate between a variety of potential diagnoses that all have a very similar appearance. This comprehensive guide helps you make informed decisions for even your most complex and challenging cases, presenting a comprehensive differential diagnosis list and comparisons for every entity discussed. The 4th Edition brings you fully up to date with updated diagnostic techniques, new classifications, and new content throughout—perfect for quick reference at every microscope in the sign-out room. - Provides brief descriptions of both common and uncommon disorders, with an emphasis on differential diagnosis, along with excellent illustrative examples of the pathology and carefully selected references. - Streamlines the differential diagnosis process by offering a series of bullet point checklists that detail the respective features of the entities being considered. - Discusses a complete range of tumors and tumor-like conditions in all organ systems. - Contains updated information on personalized/precision medicine especially as it pertains to the immunotherapies; for example, PDL-1 targeted therapies in many cancers. - Includes new classification of neuroendocrine tumors, new classification and updates of follicular variant of papillary thyroid carcinoma, and a new section on the most common metastatic tumors and utilization of ancillary techniques for diagnosis and molecular studies. - Uses a reader friendly, outline format for each diagnosis that details clinical information, epidemiology, gross and microscopic findings, ancillary stains and tests, differential diagnoses, and pearls of wisdom. - Features 1,400 full-color macro- and micrographs that provide a realistic basis for comparison of what you see under the microscope. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Published
2021

2. Differential Diagnosis in Surgical Pathology

Author

Meryl H. Haber, Daniel J. Spitz, Odile David, Vijaya B. Reddy, and Paolo Gattuso

Subjects
Pathology, medicine.medical_specialty, Urinary bladder, business.industry, Genitourinary system, Mediastinum, Soft tissue, Surgical pathology, Ureter, medicine.anatomical_structure, medicine, Pericardium, Differential diagnosis, business
Abstract

1. Special Diagnostic Techniques in Surgical Pathology 2. Skin and Adnexal Structures 3. Head and Neck 4. Lung and Pleura 5. Thymus and Mediastinum 6. Gastrointestinal System 7. Hepatobiliary System 8. Pancreas 9. Adrenal Gland 10. Ureter, Urinary Bladder and Kidney 11. Male Genitourinary System 12. Female Reproductive System 13. Breast 14. Lymph Nodes 15. Spleen 16. Bones and Joints 17. Soft Tissue 18. Heart, Pericardium and Blood Vessels 19. Central Nervous System 20. Eye and Orbit

Published
2010

3. PTEN and Cancer

Author

Odile David

Subjects
Kinase, Tumor progression, medicine, Cancer research, biology.protein, Tensin, Microsatellite instability, Cancer, PTEN, Biology, medicine.disease, Protein kinase B, Metastasis
Abstract

The clinical significance of phosphatase and tensin homolog (PTEN), an increasingly important and seemingly ubiquitous tumor suppressor, is most apparent in endometrial adenocarcinomas. Mutations are frequent in both preneoplastic and neoplastic endometrial lesions. Many different mutations have been identified. Promoter methylation and microsatellite instability have also been implicated as mechanisms of PTEN inactivation, which seems to be an early event in endometrial carcinogenesis. More significantly, loss of the PTEN protein product may be identified by routine immunohistochemical techniques and is considered an unfavorable prognostic indicator. The role of PTEN in other tumor systems with respect to tumor progression and metastasis appears to be varied and cell-type dependent. The role of the PTEN protein product, a dual-specificity phosphatase, is a negative regulation of the phosphoinositide (PI)3-kinase/Akt cell survival pathway. PTEN phosphorylates PI3 at the 3' position, thereby preventing the activation of numerous downstream pathways, which would otherwise promote cell survival. Concerning immunohistochemical techniques related to the identification of PTEN protein products, it is important to distinguish between antibodies that detect total PTEN, unphosphorylated PTEN (the active form) and phosphorylated PTEN (the inactive form).

Published
2005

4. Authors and Coauthors of Volume 3

Author

Geunghwan Ahn, Taku Aoki, Frank Bergmann, Alexander Berndt, Dionissis S. Bonikos, Habib Boukerche, Markus W. Büchler, George G. Chen, Mi Sun Choi, Marcia M. Clayton, Steven W. Cole, William B. Coleman, Regine Dahse, Odile David, Ming Dong, Hiroshi Egami, Hiroshi Egusa, Irene Esposito, Manel Esteller, Mark A. Feitelson, Paul B. Fisher, Helmut Friess, Toshio Fukusato, Toru Furukawa, Charalambos Gogos, Weida Gong, Xin-Yuan Guan, Kejian Guo, Yoshihiko Hamamoto, M.A. Hayat, George Hemstreet, Akira Horii, Suyun Huang, Norio Iizuka, Hiroshi Imamura, Satoshi Inoue, Cristine Kalogeropoulou, Dong-chul Kang, Chrisoula Karatza, Dionissios Karavias, Dimitrios Kardamakis, Noriko Kimura, Gunter Kloppel, Stefanie Knob, Paul Komminoth, Hartwig Kosmehl, Fumiki Kushihata, Paul B.S. Lai, Sze-Hang Lau, Zhaorui Lian, Fan Lin, Wilma L. Lingle, Jie Liu, Thomas Makatsoris, Masatoshi Makuuchi, Marie-Pierre A. Mathoulin-Portier, Juanita L. Merchant, Ute M. Moll, Genevieve M. Monges, Toshio Morohoshi, Hans Konrad Müller-Hermelink, Tetsuhiro Nakano, Marco Niedergethmann, Ichiro Nishimura, Yilmaz Niyaz, Young Lyun Oh, Nobuyuki Ohike, Susumu Ohwada, Masaaki Oka, Makoto Osanai, Jingbo Pan, Aurel Perren, Theodore Petsas, Monika Pilichowska, Stefan Post, Jian Yu Rao, Enrique Rengifo-Calzado, Santiago Ropero, Thomas Rüdiger, Mika Sakaki, Jeffrey L. Salisbury, Toshiaki Sano, Norio Sawabu, Karin Schütze, David Seligson, Neda Slade, Dong Eun Song, Gregg Staerkel, Zao-zhong Su, Ming-Hong Tai, Xiaodong Tan, Andrea Tannapfel, Takayoshi Toyota, Henry Tsai, Athanassios C. Tsamandas, N. Lale Tufan, Alicia Viloria-Petit, Yi Wang, Hiroyuki Watanabe, Jota Watanabe, Akira Watanuki, Aileen Wee, David T.W. Wong, Keping Xie, Hisafumi Yamada-Okabe, Kazuto Yamazaki, Yun Yen, Eunsil Yu, Zuo-Feng Zhang, Jianming Zhao, Xiaofeng Zhou, and Vassiliki Zolota

Subjects
Mathematical analysis, Mathematics, Volume (compression)
Published
2005

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