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8 results on '"Ocak, Sebahat"'

1. Prognostic Significance of IgA+ B Cells in Non-Small Cell Lung Cancer [P72.10]

Author

Vanderputten, Marie, Aboubakar Nana, Frank, Bouzin, Caroline, Hoton, Delphine, Stanciu Pop, Claudia Maria, Lecocq, Marylène, Ambroise, Jérôme, Pilette, Charles, Ocak, Sebahat, 2020 World Conference on Lung Cancer, UCL - SSS/IREC/CTMA - Centre de technologies moléculaires appliquées (plate-forme technologique), UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de pneumologie, UCL - (SLuc) Service d'anatomie pathologique, UCL - (MGD) Service d'anatomie pathologique, and UCL - (MGD) Service de pneumologie

Subjects
Pulmonary and Respiratory Medicine, Oncology, respiratory tract diseases
Abstract

Introduction : Lung cancer is the most frequent and the deadliest cancer in the world. In non-small cell lung cancer (NSCLC), which represents 85% of all lung cancers, up to 55% patients relapse following surgery alone or in combination with chemotherapy or radiotherapy. Tumor-infiltrating lymphocytes play a key role in the control of the malignancy and display different phenotypes whilst interacting with cancer cells. Hence, immunoglobulin-A (IgA)-producing cells have been described to have an immunosuppressive function, promoting tumor development and growth in hepatocarcinoma and prostate cancer. Due to the important role of IgA in the lung, we aimed to study the prognostic significance of IgA+ cell infiltration in the epithelial and stromal compartments of resected NSCLCs. [...]

Published
2021

2. Prognostic Significance of IgA+ B Cells in Non-Small Cell Lung Cancer [P72.10]

Author

UCL - SSS/IREC/CTMA - Centre de technologies moléculaires appliquées (plate-forme technologique), UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de pneumologie, UCL - (SLuc) Service d'anatomie pathologique, UCL - (MGD) Service d'anatomie pathologique, UCL - (MGD) Service de pneumologie, Vanderputten, Marie, Aboubakar Nana, Frank, Bouzin, Caroline, Hoton, Delphine, Stanciu Pop, Claudia Maria, Lecocq, Marylène, Ambroise, Jérôme, Pilette, Charles, Ocak, Sebahat, 2020 World Conference on Lung Cancer, UCL - SSS/IREC/CTMA - Centre de technologies moléculaires appliquées (plate-forme technologique), UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de pneumologie, UCL - (SLuc) Service d'anatomie pathologique, UCL - (MGD) Service d'anatomie pathologique, UCL - (MGD) Service de pneumologie, Vanderputten, Marie, Aboubakar Nana, Frank, Bouzin, Caroline, Hoton, Delphine, Stanciu Pop, Claudia Maria, Lecocq, Marylène, Ambroise, Jérôme, Pilette, Charles, Ocak, Sebahat, and 2020 World Conference on Lung Cancer

Abstract

Introduction : Lung cancer is the most frequent and the deadliest cancer in the world. In non-small cell lung cancer (NSCLC), which represents 85% of all lung cancers, up to 55% patients relapse following surgery alone or in combination with chemotherapy or radiotherapy. Tumor-infiltrating lymphocytes play a key role in the control of the malignancy and display different phenotypes whilst interacting with cancer cells. Hence, immunoglobulin-A (IgA)-producing cells have been described to have an immunosuppressive function, promoting tumor development and growth in hepatocarcinoma and prostate cancer. Due to the important role of IgA in the lung, we aimed to study the prognostic significance of IgA+ cell infiltration in the epithelial and stromal compartments of resected NSCLCs. [...]

Published
2021

3. Dual Role of the Focal Adhesion Kinase in Small-Cell Lung Cancer [P1.07-028]

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, UCL - (SLuc) Service de pneumologie, Aboubakar Nana, Frank, Lecocq, Marylène, Ladjemi, Maha, Detry, Bruno, Dupasquier, Sébastien, Massion, Pierre, Sibille, Yves, Pilette, Charles, Ocak, Sebahat, IASLC 17th World Conference on Lung Cancer, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, UCL - (SLuc) Service de pneumologie, Aboubakar Nana, Frank, Lecocq, Marylène, Ladjemi, Maha, Detry, Bruno, Dupasquier, Sébastien, Massion, Pierre, Sibille, Yves, Pilette, Charles, Ocak, Sebahat, and IASLC 17th World Conference on Lung Cancer

Abstract

BACKGROUND : Small cell-lung cancer (SCLC) is a devastating illness with five-year overall survival as low as 5%. The molecular steps leading to SCLC development and progression are still poorly understood and this has translated into the absence of targeted therapies. Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase which regulates integrin and growth factor signaling pathways involved in cell proliferation, survival, migration, and invasion. FAK is overexpressed and/or activated in many cancers, including SCLC. We hypothesized that FAK overexpression/activation in SCLC contributes to its aggressive behavior and that FAK may represent a therapeutic target in SCLC. [...]

Published
2017

4. Distinct Role of FAK Kinase and C-Terminal Domains on Small-Cell Lung Cancer Proliferation [P3.15-004]

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, UCL - (SLuc) Service de pneumologie, Aboubakar Nana, Frank, Lecocq, Marylène, Ladjemi, Maha, Detry, Bruno, Dupasquier, Sébastien, Massion, Pierre, Sibille, Yves, Pilette, Charles, Ocak, Sebahat, IASLC 18th World Conference on Lung Cancer, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, UCL - (SLuc) Service de pneumologie, Aboubakar Nana, Frank, Lecocq, Marylène, Ladjemi, Maha, Detry, Bruno, Dupasquier, Sébastien, Massion, Pierre, Sibille, Yves, Pilette, Charles, Ocak, Sebahat, and IASLC 18th World Conference on Lung Cancer

Abstract

Small-cell lung cancer (SCLC) is a devastating illness with a median five-year overall survival of 5%. Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase which regulates integrin and growth factor signaling pathways involved in cell proliferation, survival, migration, and invasion. FAK is overexpressed/activated in many cancers, including SCLC. We hypothesized that FAK overexpression/activation in SCLC contributes to its aggressive behavior and that FAK may represent a novel therapeutic target in SCLC.

Published
2017

5. Inhibition of the Focal Adhesion Kinase Has Anti-Tumoral Effect in Small-Cell Lung Cancer Cell Lines

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, UCL - (SLuc) Service de pneumologie, Aboubakar Nana, Frank, Lecocq, Marylène, Detry, Bruno, Ladjemi, Maha, Massion, Pierre P., Sibille, Yves, Pilette, Charles, Ocak, Sebahat, European Lung Cancer Conference (ELCC), UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, UCL - (SLuc) Service de pneumologie, Aboubakar Nana, Frank, Lecocq, Marylène, Detry, Bruno, Ladjemi, Maha, Massion, Pierre P., Sibille, Yves, Pilette, Charles, Ocak, Sebahat, and European Lung Cancer Conference (ELCC)

Abstract

AIM: Lung cancer is the most common cancer and also the leading cause of cancer-related death worldwide among both men and women. Small cell lung cancer (SCLC) accounts for 15% of all cases. It is the most aggressive one in its clinical behavior with a 5-year overall survival as low as 5%. Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase which regulates integrin and growth factor signaling pathways involved in cell proliferation, survival, migration, and invasion. FAK is overexpressed and/or activated in many cancers including SCLC. We hypothesized that FAK may represent a good target for therapeutic interventions in SCLC and tested the changes of cell phenotype induced by a FAK inhibitor (PF-228). [...]

Published
2015

6. Lung Cancer in Belgium.

Author

Ocak S, Tournoy K, Berghmans T, Demedts I, Durieux R, Janssens A, Moretti L, Nackaerts K, Pieters T, Surmont V, Van Eycken L, Vrijens F, Weynand B, and van Meerbeeck JP

Subjects
Belgium epidemiology, Humans, Lung Neoplasms epidemiology
Published
2021
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7. Discovery of new membrane-associated proteins overexpressed in small-cell lung cancer.

Author

Ocak S, Friedman DB, Chen H, Ausborn JA, Hassanein M, Detry B, Weynand B, Aboubakar F, Pilette C, Sibille Y, and Massion PP

Subjects
Adenocarcinoma metabolism, Adenocarcinoma mortality, Adenocarcinoma pathology, Aged, Blotting, Western, Bronchi cytology, Carcinoma, Non-Small-Cell Lung mortality, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Squamous Cell metabolism, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Cells, Cultured, Electrophoresis, Gel, Two-Dimensional, Female, Humans, Immunoenzyme Techniques, Lung Neoplasms mortality, Lung Neoplasms pathology, Male, Middle Aged, Neoplasm Staging, Prognosis, Small Cell Lung Carcinoma mortality, Small Cell Lung Carcinoma pathology, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Survival Rate, Biomarkers, Tumor metabolism, Bronchi metabolism, Carcinoma, Non-Small-Cell Lung metabolism, Lung Neoplasms metabolism, Membrane Proteins metabolism, Small Cell Lung Carcinoma metabolism
Abstract

Introduction: Small-cell lung cancer (SCLC) is the most aggressive subtype of lung cancer, with no early detection strategy or targeted therapy currently available. We hypothesized that difference gel electrophoresis (DIGE) may identify membrane-associated proteins (MAPs) specific to SCLC, advance our understanding of SCLC biology, and discover new biomarkers of SCLC., Methods: MAP lysates were prepared from three SCLCs, three non-small-cell lung cancers, and three immortalized normal bronchial epithelial cell lines and coanalyzed by DIGE. Subsequent protein identification was performed by mass spectrometry. Proteins were submitted to Ingenuity Pathway Analysis. Candidate biomarkers were validated by Western blotting (WB) and immunohistochemistry (IHC)., Results: Principal component analysis on the global DIGE data set demonstrated that the four replicates derived from each of the nine cell lines clustered closely, as did samples within the same histological group. One hundred thirty-seven proteins were differentially expressed in SCLC compared with non-small-cell lung cancer and immortalized normal bronchial epithelial cells. These proteins were overrepresented in cellular/tissue morphology networks. Dihydropyrimidinase-related protein 2, guanine nucleotide-binding protein alpha-q, laminin receptor 1, pontin, and stathmin 1 were selected as candidate biomarkers among MAPs overexpressed in SCLC. Overexpression of all candidates but RSSA in SCLC was verified by WB and/or IHC on tissue microarrays. These proteins were significantly associated with SCLC histology and survival in univariables analyses., Conclusion: DIGE analysis of a membrane-associated subproteome discovered overexpression of dihydropyrimidinase-related protein 2, guanine nucleotide-binding protein alpha-q, RUVB1, and stathmin 1 in SCLC. Results were verified by WB and/or IHC in primary tumors, suggesting that investigating their functional relevance in SCLC progression is warranted. Association with survival requires further validation in larger clinical data sets.

Published
2014
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