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Objective: This study evaluated the reliability of a face scanner in measuring the vertical dimension of occlusion (VDO)., Methods: Fully dentate volunteers (n = 20; mean-age = 30.0 ± 10.7 years) were recruited. Clinical facial measurements were obtained using a digital caliper and a face scanner (Obiscanner, Fifthingenium, Italy). The scans were imported into a mesh-processing software, and the distances were measured digitally. Measurements were obtained for each participant with the jaws positioned in maximal intercuspation (MI) and with increased vertical distances of 2, 4, and 6 mm. Vertical and horizontal measures were obtained using facial anatomical landmarks: Glabella (GL), Pronasale (PrN), Subnasale (SbN), inferior border of the right and left Alare, Labiale superius (Ls), right and left Cheilion (Ch), Soft Pogonion (SPg), right and left Tragus of the ear (Tr), for all selected vertical positions. Data analysis included intra-class correlation coefficient (ICC), pairwise comparison tests, Bland-Altman plots, and Passing-Bablok regression., Results: 120 VDO measurements (clinical=60, digital=60) were recorded by two independent evaluators. Mean differences between digital and clinical measurements ranged from 0.054 ± 0.14 mm to 0.203 ± 0.13 mm. All parameters were strongly correlated (r > 0.93; p < 0.001). ICC estimates revealed excellent reliability, and the measuring procedure yielded the same results on repeated trials irrespective of the raters and measurement methods. Bland-Altman plots revealed a difference, between digital and clinical measurements, of 1.7 % for the vertical measurements. Regression analysis revealed no significant proportional difference between the two methods, so both can be used interchangeably., Conclusions: The findings of this study demonstrate that VDO can be measured accurately from face scans using 3D mesh-processing software and that even small changes in the VDO could be detected using the digital methods., Clinical Significance: Findings provide evidence about the reliability of a digital method for jaw relation registrations and may be applied towards incorporating this method into clinical workflows for computer-aided-design/ computer-assisted-manufacturing (CAD-CAM) dentures., Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interests., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Forensic facial reconstruction is the last recourse to establish the identity of an unknown skull. The facial soft-tissue thickness (FSTT) is required to reconstruct various facial features on a skull. Unlike other facial features, the nose is made of cartilaginous tissue except for a small nasal bone. A large cavity (pyriform aperture) exists on the skull in place of the nose, which makes it a challenging job for reconstruction. The nose is a vital feature for the recognition of a face. Any change in the shape or size of the nose can alter the original aesthetic of the face. The present study proposes angles and regression functions on the bony structure to predict the various parts of the soft nose. A sample of computed tomography (CT) images of 100 males and 100 females aged between 18 and 45 years were included in the study. Apart from measuring fourteen linear parameters with three angles, simple linear regression models were derived for five pairs of parameters. Pearson's correlation coefficients for most of the parameters ranging between 0.221 and 0.872 were found to be significant at p ≤ 0.05 level. FSTT at three anatomical landmarks of the nose was also measured. A morphological observation study was undertaken to find the most frequent direction of the bony anterior nasal spine (ans) and its relation with the position of the pronasale (prn) on the soft nose. The devised parameters proposed in the study may also prove useful for reconstructing the nose in other populations., Competing Interests: Declaration of competing interest None., (Copyright © 2024 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.)

Background: To quantify the accuracy of Dolphin Imaging software in predicting soft tissue changes of Class II Division 1 incisor relationship treated by all first premolar extraction compared with actual changes., Methods: Pretreatment and post-treatment lateral cephalograms of 30 young adult subjects (25 females and 5 males; age range of 16 to 21 years) were imported and traced in Dolphin Imaging software (version 11.95). Tracings of actual treatment results and the Dolphin predicted treatment outcome were superimposed to calculate the prediction errors. The mean difference for the Holdaway soft tissue analysis and at each landmark was measured in both the X and Y axes. Paired t test was used to compare the statistical differences in Holdaway soft tissue analysis parameters., Results: There were significant differences between the predicted and actual values in three parameters of the Holdaway soft tissue analysis (P < 0.05). The overall accuracy of estimation was better in vertical direction than horizontal. Prediction of upper and lower lip landmarks was overestimated horizontally and underestimated vertically, whereas that belonging to chin was underestimated horizontally and overestimated vertically. Soft tissue nasion and soft tissue A-point were most accurately predicted, whereas the least accuracy was found in soft tissue chin region., Conclusions: Dolphin Imaging Software (version 11.95) can be accurate enough for use in patient communication and education but should be used with caution. It is most accurate in predicting soft tissue changes in the nasion and A-point regions, but least accurate in chin region., (Copyright © 2024 World Federation of Orthodontists. Published by Elsevier Inc. All rights reserved.)

Background: There is a lack of standardized surgery for cleft rhinoplasty. We felt that the technique described by Dr Louise Caouette Laberge is an ideal way to approach this problem, thus we tried to quantify the outcome of surgery by volumetric assessment., Material and Method: We recorded 3D images using an Artec scanner and performed volume calculations of the cleft side and noncleft side of the nose. These readings were taken once in the preoperative and then 2 weeks postoperative. Another scan of the face was performed 2 years after the surgery to compare the volumes of the cleft and noncleft side nostril., Results: Of the 31 patients with unilateral cleft lip operated on (mean age 3-8 months), we found a significant increase in the cleft side volume at 3 weeks postoperative from 3.95 mm 3 to 5.65 mm 3 (p < 0.001 on paired t-test). A repeat scan done on the study population at 2 years postoperative found that the mean volume of the cleft side was 30.43 mm 3 (standard deviation [SD], 2.49) and that of the normal side was 30.82 mm 3 (SD, 2.51). An independent t-test found that there was no significant difference between the two volumes (p > 0.05) CONCLUSION: The use of volumetric data in the evaluation of postoperative outcomes provides an objective criterion for assessing the aesthetics as well as the growth. Our study concludes that the Laberge technique provides a good aesthetic outcome with minimal scarring for the management of cleft nose and lip with the anterior palate., Competing Interests: Declaration of Competing Interest The authors do not have any conflict of interest., (Copyright © 2023 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.)

Backgrounds: 3D simulation is increasingly used in rhinoplasty. However, during the operation, there is no tool to directly link the 3D simulation results with the intraoperative operation. Doctors rely on 3D simulation results only according to their intuition. Recently, the authors have discovered a simple, low-cost, and practical method for intraoperative assessment: a film model can be made according to the contour of the nose shape in its midsagittal view. The authors aimed to evaluate the effectiveness of the innovative method for intraoperative assessment of nasal shape in rhinoplasty., Methods: Thirty-nine patients who underwent rhinoplasty for the first time between January 2019 and January 2021 were included in this study. All the patients confirmed ideal nasal shape based on preoperative three-dimensional photography (INOVA 3D-EX). In the guide group, procedures were based on guide of the film model and a picture of 3D simulation, and in the control group, procedures were performed based on the surgeon's intuition and a picture of 3D simulation., Results: There were no statistical differences in basic data between the two groups before operation. Both groups showed a satisfactory correlation. Except for the columellar lobular angle, the ICC of nasal length, nasal depth, dorsum height, columella length, nasofrontal angle, nasorostral angle, and nasolabial angle were all stronger in the guide group than in the control group., Conclusion: This study demonstrates the usefulness of the nasal-shaped film model, which is made according to the contour of the nose shape in its midsagittal view. This approach is simple, low-cost, and practical., (Copyright © 2022. Published by Elsevier Ltd.)

Background: Morphometric changes achieved in rhinoplasty are mostly analyzed on two-dimensional (2D) images. However, most of these alterations are amenable to three-dimensional (3D) analysis., Objectives: Objective measurements for rhinoplasty are currently done on 2D photographic analyses. We believe that newer techniques will develop. This is a study to help define new parameters., Methods: Landmarks that are widely used in the literature were used to define the boundaries of these measurements. They comprised certain parts of the nose (tip, dorsum, radix, etc.). Measurements were done on a generic face (GF) 3D model. The model's nose was then morphed using the free, open-source 3D modeling software (Blender) to generate seven different deformed noses and to perform the area and volume measurements., Results: Each nose with a different type of deformity demonstrated significant area and volume differences. For example, comparing area measurements to GF-Pleasant nose, GF-Snub nose showed a significant difference at the tip (43.3% reduction). Volume measurements were found to be mostly parallel to the area measurements; however, some incongruences were noted., Conclusions: We show that new area and volume measurements can be reliably developed for 3D-scanned images. These measurements can be utilized and will enrich the facial analysis and evaluation of the outcomes of rhinoplasty., Competing Interests: Declaration of Competing Interest All authors declare that they do not have any financial or personal relationships with other people or organizations that could inappropriately influence (bias) their work., (Copyright © 2023 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.)

Objectives: This study aimed to investigate the 3-dimensional (3D) facial morphology of children with skeletal Class II structure with different breathing patterns., Methods: The 3dMDFace system (3dMD Inc.) was used to obtain 3D facial images. A total of 65 patients aged 10 to 12 years with skeletal Class II malocclusion (A point-Nasion-B point angle >5°) were grouped by sex into nasal-breathing (NB) and mouth-breathing (MB) participants. A total of 19 measurements, including linear distances, angles, and ratios, were measured. The measurements were compared using independent sample t test and Mann-Whitney U test. Factor analysis and logistic regression were used to test the correlation between facial morphology and different breathing patterns., Results: For male children, the lower lip was longer in the MB group than in the NB group (P < .05). For female children, compared to NB, MB patients had a narrower mandibular width (P < .05), a smaller ratio of mandibular width to face height (MB: 0.99 ± 0.08 vs NB: 1.04 ± 0.09; P < .05), and a larger ratio of lower lip height to lip width (MB: 1.24 ± 0.10 vs NB: 1.19 ± 0.16; P < .05). In both male and female children, MB participants had a more convex nasolabial angle (P < .05) and an increased ratio of the lower part of the face to the upper facial height (male MB: 1.61 ± 0.17 vs male NB: 1.50 ± 0.12; female MB: 1.52 ± 0.10 vs female NB: 1.50 ± 0.20; P < .05). The logistic regression test showed no significant correlation between facial morphology and breathing patterns., Conclusions: In participants with skeletal Class II pattern, MB children compared with NB children showed different facial morphology in the same sex group. The children with MB showed a more protruded upper lip and increased lower facial height, accounting for a larger proportion of the facial height. However, no significant correlation was found between facial morphology and breathing pattern. Only correlative trends were found., (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)

The aim of this retrospective long-term study was to assess the influence of primary columella lengthening and presurgical nasoalveolar molding (NAM) on the skeletal development at the completion of growth in patients with bilateral cleft lip and palate (BCLP). Lateral cephalometric radiographs at the completion of growth of consecutively treated patients BCLP patients, operated by the same surgeon, who had undergone NAM were compared with a second group of BCLP patients who were not treated with NAM. The groups were matched for sex and age. Independent samples t tests were carried out. 23 Lateral cephalometric radiographs of BCLP patients (mean age 18.2 ± 1.3 years) who had undergone NAM were compared with a second group of 23 BCLP patients (mean age 18.4 ± 1.3 years) who were not treated with NAM. The only two significant differences were observed in Ans-Me/N-Me (control group = 0.6 ± 0.02; sample group = 0.57 ± 0.05; p = 0.019) and ILs^AnsPns (control group = 105.5 ± 7.9; sample group = 112.4 ± 8.6; p = 0.007). No other significant differences were observed in terms of facial skeletal development between the two groups. Presurgical NAM performed during infancy in BCLP patients does not seem to have negative effects on the skeletal development at the completion of craniofacial growth compared to the group of patients treated without NAM., Competing Interests: Declaration of competing interest The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (Copyright © 2022 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

Introduction: A standardized procedure was proposed to control involuntary motion and other factors during the capture of structural light scanning that could influence the morphology of 3-dimensional facial models; interoperator reproducibility was evaluated., Methods: Twenty subjects volunteered for facial scanning. Three researchers scanned each volunteer 3 times on the same day using the FaceScan structural light scanning system (Isravision, Darmstadt, Germany) and after the proposed procedure. Captures were done at 5-minute intervals. The 3 facial scans acquired by the same researcher were compared by reverse engineering software (Geomagic; 3D Systems, Rock Hill, SC). Six facial regions, including forehead, nose, paranasal, upper lip, lower lip and chin, and cheek, were divided. With the first scan as a reference, the other 2 scans were registered, and surface-to-surface distance maps were acquired to calculate the mean, standard deviation, and root mean squares (RMS) between 2 surfaces. The reproducibility between 3 researchers was then evaluated by a 1-way analysis of variance., Results: The mean of 6 facial regions was close to 0. The RMS of lip regions were largest (0.48-0.53 mm), the forehead was smallest (0.21 mm), and the others ranged 0.37 mm to 0.42 mm. The standard deviation was slightly smaller than RMS and had the same trend of change. There was no significant difference in RMS among the 3 researchers (P >0.05)., Conclusions: With the constraint of the standardized procedure, the morphologic reproducibility of facial models in 6 regions was satisfying., (Copyright © 2021 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.)

Background: Current descriptions of the unilateral cleft lip and nasal deformity (uCLND) are based upon limited sample sets and subjective observations. While those descriptions are inconsistent and contradictory, theoretical models, including Hogan's "tilted tripod" and Fisher's "nasal arch forms", have never been tested. Given that favorable outcomes of treatment remain elusive, detailed study of the deformity is critical in devising better treatments. The purpose of this study was to develop a data-driven three-dimensional (3D) model of uCLND that spans the spectrum of presentation and involves a pervasive underlying mechanism., Methods: We studied 3D images of 100 infants with unrepaired cleft lip at 6 months of age. Objective assessment included the landmark positions, anthropometric dimensions, and shape-based measures. Cleft severity was stratified by the lateral displacement of subnasale, so that a model could be developed using linear regression., Results: With progressive deviation of subnasale, the non-cleft alar base moved lateral, the cleft alar base was left posterior, and the nasal dorsum followed the caudal septum (deviating towards the non-cleft side). The "twist" resulted in opposing cleft alar dome collapse, non-cleft alar ring constriction (the non-cleft nasal sill narrowed, lateral genu rose, and alar-cheek junction became more acute), and displacement of the philtrum from midline., Conclusions: Our study not only supports theoretical models of uCLND but also clarifies vectors of change and reveals significant non-cleft side alterations. On the basis of our findings, the objectives of treatment should involve centralization of the columella and philtrum and rebalancing the nose by untwisting the orthogonal displacement of the alar bases., Competing Interests: Declaration of Competing Interest None., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Introduction: The purpose of this study was to evaluate the correlation between cephalometric measurements and patients' perception of nasal changes in those with Class III malocclusion who had undergone orthognathic surgery., Methods: Eighty-five patients (36 men and 49 women) who received maxillary advancement with (group 1) or without (group 2) maxillary impaction were included in this study. Lateral cephalometric radiographs taken before and at the end of the treatment were analyzed. The patients were given an esthetic evaluation form and asked to evaluate their own noses on the Likert scale (subjective perception), while at the same time, they were asked to evaluate profile silhouettes without knowing that it was their own profile (objective perception). The changes and correlations between the cephalometric measurements and the scores obtained from the esthetic perception questionnaire were evaluated statistically., Results: Postoperative nasal tip inclination and rotation, nasofacial angle, and sagittal position of pronasale had increased significantly (P <0.05), whereas nasal tip protrusion, nasofrontal angle, and vertical position of pronasale had decreased (P <0.05). The change in the nasolabial angle and vertical position of pronasale was statistically different between the 2 surgical groups (P <0.05). In the end, a significant increase was observed in the patients' objective nasal esthetic scores (P <0.05)., Conclusions: Soft tissues are affected by the vertical and sagittal surgical movements of the maxilla. There was a moderate correlation between patients' perception of nasal changes and cephalometric measurements. The subjective evaluation of the nose was similar among patients after surgery, but in the objective assessment, patients found their noses more esthetic., (Copyright © 2021 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.)

Background: Surgical mobilization of the maxillary segment affects nasal morphology. This study assessed the impact of the type of maxillary mobilization on the three-dimensional (3D) nasal morphometry., Methods: Pre- and postsurgery cone beam computed tomography-derived facial image datasets of consecutive patients who underwent two-jaw orthognathic surgery were reviewed. Using preoperative 3D facial models as the positional reference of the skeletal framework, 12-month postoperative 3D facial models were classified into four types of maxillary mobilizations (advancement [n = 83], setback [n = 24], intrusion [n = 55], and extrusion [n = 52]) and four types of final maxillary positions (anterosuperior [n = 44], anteroinferior [n = 39], posterosuperior [n = 11], and posteroinferior [n = 13]). Six 3D soft tissue nasal morphometric parameters were measured, with excellent intra- and interexaminer reliability scores (ICC>0.897) for all the measurements. The 3D nasal change for each nasal parameter was computed as the difference between postoperative and preoperative measurement values., Results: The intrusion maxillary mobilization resulted in a significantly (all p<0.05) larger 3D nasal change in terms of alar width, alar base width, and nostril angle parameters, and a smaller change in terms of the nasal tip height parameter than the extrusion maxillary mobilization; however, no significant (all p>0.05) difference was observed between advancement and setback maxillary mobilizations. The anterosuperior and posterosuperior maxillary positions had a significantly (all p<0.05) larger 3D nasal change in terms of the alar base width and nostril angle than the anteroinferior and posteroinferior maxillary positions., Conclusion: The type of maxillary mobilization affects the 3D nasal morphometry., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Objectives: Cinch sutures attempt to counteract alar base widening but may lead to unintended increases in the nasolabial angle and nasal tip elevation. The aim of this investigation was to assess nasolabial angle changes after maxillary osteotomies with and without alar base cinch sutures in the short and long terms., Study Design: Seventy-eight patients were assessed, with 51 in the cinch group (38 females, 13 males; age range 16-39 years) and 27 in the no-cinch group (12 females, 15 males; age range 17-27 years). The upper component (nasal tip elevation), lower component (lower lip inclination), and the overall nasolabial angle were measured on preoperative, postoperative, and long-term follow-up lateral cephalometric radiographs., Results: The overall nasolabial angle (P = .006) and its upper component (P < .001) increased significantly in the cinch group immediately postoperatively but resolved by 6 to 12 months for the overall nasolabial angle and by 12+ months (up to 5.7 years) for the upper component. There were no significant changes in the no-cinch group., Conclusions: In the short term, the alar base cinch suture increases nasal tip elevation and the overall nasolabial angle. In the long term, there was no significant difference, suggesting that the initial nasal tip elevation resolves over time and that the cinch suture may have a limited effect on nasal tip elevation in the longer term., (Copyright © 2020 Elsevier Inc. All rights reserved.)

Introduction: Children with unilateral cleft lip and palate (UCLP) exhibit snoring and mouth breathing. They are also reported to show obstructive sleep apnea syndrome. However, their upper airway ventilation condition is not clearly understood. Therefore, this study was performed to evaluate upper airway ventilation condition in children with UCLP with the use of computational fluid dynamics., Methods: Twenty-one children (12 boys, 9 girls; mean age 9.1 years) with UCLP and 25 children (13 boys, 12 girls; mean age 9.2 years) without UCLP who required orthodontic treatment underwent cone-beam computed tomography (CBCT). Nasal resistance and upper airway ventilation condition were evaluated with the use of computational fluid dynamics from CBCT data. The groups were compared with the use of Mann-Whitney U tests and Student t tests., Results: Nasal resistance of the UCLP group (0.97 Pa/cm 3 /s) was significantly higher than that of the control group (0.26 Pa/cm 3 /s; P < 0.001). Maximal pressure of the upper airway (335.02 Pa) was significantly higher in the UCLP group than in the control group (67.57 Pa; P < 0.001). Pharyngeal airway (from choanae to base of epiglottis) pressure in the UCLP group (140.46 Pa) was significantly higher than in the control group (15.92 Pa; P < 0.02)., Conclusions: Upper airway obstruction in children with UCLP resulted from both nasal and pharyngeal airway effects., (Copyright © 2019 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.)

Purpose: To analyze three-dimensional (3D) nasolabial forms and upper lip surface symmetry after primary lip repair in children with unilateral cleft lip and palate (UCLP)., Methods: Subjects were 22 Japanese children with complete UCLP who underwent primary lip repair and were followed-up for 4-6 years. The 3D coordinates of facial landmarks and the angle and radius of the approximate nasal alar circle were calculated. Upper lip surface symmetry was analyzed using histogram intersection., Results: The nasal tip and columella base were slightly dislocated to the cleft side, and the midpoint of Cupid's bow shifted to the non-cleft side. The nasal alar and the top of Cupid's bow were reconstructed at the same height, while the approximate nasal alar circle was smaller on the cleft side. The mean value of similarity for upper lip surface symmetry was 0.82; a subject with a higher value had more symmetrical contour lines in the visualized surface image., Conclusions: Postoperative nasolabial forms were almost restored to symmetrical levels, while retaining a small nasal alar. Histogram intersection is applicable as a method for the quantitative evaluation of upper lip surface symmetry in UCLP., (Copyright © 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

Background: Three-dimensional (3D) photogrammetry has reached high standards and accuracy but is mainly conducted with stationary and expensive systems. The purpose of this study was to evaluate the accuracy of a low-budget portable system with special regard to the gracile and challenging nasal region., Material and Methods: 3D models of the perinasal area were acquired by impression-taking and the scanning of the generated plaster models (3Shape D500) or with a portable low-budget 3D stereophotogrammetry (FUEL3D ® SCANIFY ® ) system. Four examiners analysed defined landmarks of the generated Standard Tessellation Language files with regard to accuracy and interobserver reliability by using 3dMDvultus™ software. A semi-automatic 3D best-fit analysis of both models was performed by using Geomagic ® and the Root Mean Squared (RMS) errors were calculated., Results: 41 volunteers were included, with 22 perinasal and perioral landmarks, 15 3D distances and eight 3D angles being analysed per data set. In a point-based analysis the mean spreads were partially smaller in the plaster model scans. Most measurements showed very high (>0.8) to excellent (>0.9) intraclass correlation coefficients, the lowest being found for columella length (0.686) and left nostril width (0.636). Overall, the mean RMS error between the superimposed surfaces was 0.89 ± 0.22 mm in the best-fit analysis., Conclusions: The corresponding software program was operator-friendly. The findings indicate that the analysed, affordable and portable system is a feasible solution for 3D image acquisition with comparable accuracy reported in the literature. Further studies will analyse the feasibility in neonates., (Copyright © 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

Introduction: The aim of this retrospective study was to assess the influence of presurgical nasoalveolar molding (NAM) on skeletal development in patients with operated unilateral cleft lip and palate at 5 years of age., Materials: Lateral cephalometric radiographs of 26 unilateral cleft lip and palate patients who had undergone presurgical NAM (NAM group) and 20 unilateral cleft lip and palate patients who did not have any presurgical NAM (non-NAM group) were analyzed. The radiographs were digitally traced using Quick Ceph Studio software (version 3.5.1.r (1151); Quick Ceph Systems, San Diego, Calif). Independent samples t tests were performed for statistical analysis., Results: No significant differences were observed in sagittal and vertical skeletal measurements between the NAM and non-NAM groups., Conclusions: NAM resulted in no significant difference in skeletal development in unilateral cleft lip and palate patients compared with those without NAM in early childhood., (Copyright © 2018. Published by Elsevier Inc.)

Nasoalveolar Molding (NAM) is associated with ambivalent acceptance regarding effectiveness and unknown long-term results. Our purpose was to analyze the stress distribution patterns within the viscero- and neurocranium of neonates during the first phase of NAM therapy. A finite element (FE) model of a healthy four-week-old neonate was generated, derived from a computed tomography scan allowing the implementation of a bone-density-dependent material model. The influence of dental germs with variable material properties, the cleft width and area of expected force application were analyzed in a worst-case scenario. The resulting stress distribution patterns for each situation were analyzed using the software Ansys APDL. The established FE model was verified with a convergence analysis. Overall, stress patterns at the age of four weeks showed von Mises stress values below 60.000 Pa in the viscero- and neurocranium. The influences of the allocation of material properties for the dental germs, the area of force application, and the cleft width were negligible. A workflow to simulate the stress distribution and deformation in neonates attributable to various areas of force application has been established. Further analyses of the skulls of younger and older neonates are needed to describe the stress distribution patterns during NAM therapy., (Copyright © 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

Background: Optimization of treatment of the unilateral cleft lip nasal deformity (uCLND) is hampered by lack of objective means to assess initial severity and changes produced by treatment and growth. The purpose of this study was to develop automated 3D image analysis specific to the uCLND; assess the correlation of these measures to esthetic appraisal; measure changes that occur with treatment and differences amongst cleft types., Methods: Dorsum Deviation, Tip-Alar Volume Ratio, Alar-Cheek Definition, and Columellar Angle were assessed using computer-vision techniques. Subjects included infants before and after primary cleft lip repair (N = 50) and children aged 8-10 years with previous cleft lip (N = 50). Two expert surgeons ranked subjects according to esthetic nose appearance., Results: Computer-based measurements strongly correlated with rankings of infants pre-repair (r = 0.8, 0.75, 0.41 and 0.54 for Dorsum Deviation, Tip-Alar Volume Ratio, Alar-Cheek Definition, and Columellar Angle, p < 0.01) while all measurements except Alar-Cheek Definition correlated moderately with rankings of older children post-repair (r ∼ 0.35, p < 0.01). Measurements were worse with greater severity of cleft type but improved following initial repair. Abnormal Dorsum Deviation and Columellar Angle persisted after surgery and were more severe with greater cleft type., Conclusions: Four fully-automated measures were developed that are clinically relevant, agree with expert evaluations and can be followed through initial surgery and in older children. Computer vision analysis techniques can quantify the nasal deformity at different stages, offering efficient and standardized tools for large studies and data-driven conclusions., (Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

Cranium bifidum occultum is a disorder of skull ossification presenting as an enlarged posterior fontanelle in the upper posterior angle of the parietal bone near the intersection of the sagittal and lambdoid sutures. The standard treatment for cranium bifidum occultum is observation. We present a case of a 5-year-old boy who presented with a 15 × 4.5 cm midline posterior cranial vault defect consistent with diagnosis of cranium bifidum occultum associated with orbital hypertelorism and a widened nose. The patient underwent posterior vault reconstruction for correction of cranium bifidum occultum defect followed by bifrontal craniotomy and orbital box osteotomies for correction of orbital hypertelorism and nasal deformity. To our knowledge, this is the first reported case describing surgical treatment for cranium bifidum occultum associated with orbital hypertelorism., (Copyright © 2017. Published by Elsevier Inc.)

In the evolution of cleft lip repair, there have been continuous attempts to minimize local trauma and to improve lip and nasal appearances. In order to obtain an aesthetically balanced development of midface, the primary surgical correction of the nasolabial area is of paramount importance. In this study, the importance of a back-cut extending cephalically above the inferior turbinate at the mucocutaneous junction which elevates the nostril floor on the cleft side for the purpose of achieving symmetry of the alar bases are analyzed by pre and postoperative photographic anthropometry. This study comprised of fifty cases of the unilateral complete cleft lip. At the time of surgery, the patient age ranged from 3-9 months. The surgeries, performed by a single surgeon, employed the standard Millard technique, incorporating Mohler modifications of lip repair. Anthropometric analysis revealed that the preoperative mean difference between the normal side and the cleft side was 0.2056 with a standard deviation of 0.133. In the postoperative analysis, the mean difference was reduced to 0.0174 with a standard deviation of 0.141. The paired t-test showed that the p-value is <0.001, indicating high statistical significance. To conclude, in complete unilateral cleft lip and palate, the geometrically placed nasal back-cut incision has a definite role in the correction of the alar base symmetry during primary surgery., (Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.)

Objective: For the assessment of the nasolabial appearance in cleft patients, a widely accepted, reliable scoring system is not available. In this study four different methods of assessment are compared, including 2D and 3D asymmetry and aesthetic assessments., Methods: The data and ratings from an earlier study using the Asher-McDade aesthetic index on 3D photographs and the outcomes of 3D facial distance mapping were compared to a 2D aesthetic assessment, the Cleft Aesthetic Rating Scale, and to SymNose, a computerized 2D asymmetry assessment technique. The reliability and correlation between the four assessment techniques were tested using a sample of 79 patients., Results: The 3D asymmetry assessment had the highest reliability and could be performed by just one observer (Intraclass correlation coefficient (ICC): 0.99). The 2D asymmetry assessment of the nose was highly reliable when performed by just one observer (ICC: 0.89). However, for the 2D asymmetry assessment of the lip more observers were needed. For the 2D aesthetic assessments 3 observers were needed. The 3D aesthetic assessment had the lowest single-observer reliability (ICC: 0.38-0.56) of all four techniques. The agreement between the different assessment methods is poor to very poor. The highest correlation (R: 0.48) was found between 2D and 3D aesthetic assessments. Remarkably, the lowest correlations were found between 2D and 3D asymmetry assessments (0.08-0.17)., Conclusion: Different assessment methods are not in agreement and seem to measure different nasolabial aspects. More research is needed to establish exactly what each assessment technique measures and which measurements or outcomes are relevant for the patients., (Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

Background: Studies have suggested that contact between opposing mucosal surfaces in the nasal wall and cavity can be a target of the surgical treatment of migraines. Unfortunately, not enough is known about the role of nasal pathology in the pathogenesis of this condition. The co-existence of further rhinological disorders can be an impediment to defining the cause and effect of anatomical variants. The authors compared the MRI scans of migraine- and non-migraine patients (MPs and NMPs, respectively) to determine the prevalence of such mucosal contact points in order to extrapolate whether there is a significant association with migraines., Methods: Coronal and axial MRI brain scans of 522 patients (412 migraineurs and 110 non-migraineurs) were analysed for the prevalence of anatomical variations of the nasal cavity, e.g. concha bullosa, septal deviations, mucosal swelling and contact points., Results: The results showed no significant difference between MPs and NMPs patients for any of the parameters examined. Moreover, 87% MPs and 79% NMPs had at least one contact point. The most frequent contact point was between the middle turbinate and the septum, observed in 54% of MPs and 45% of NMPs., Conclusions: Contact points with the nasal mucosa are highly prevalent in both MPs and NMPs. Although a contact point does not cause a migraine in the absence of the disease, the concomitant presence of migraine and contact points can trigger an attack, and therefore, it is necessary to differentiate or exclude a rhinological disorder in these patients., (Copyright © 2017 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.)

We report a child with misdiagnosed nasal dermal sinus and frontonasal dermoid cyst, that was complicated by brain abscess. Familiarizing physicians with this peculiar clinical picture may allow prompt recognition of this malformation, with subsequent imaging study, and surgical treatment, aimed to preventing fatal infectious complications., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Purpose: The aim of this study was to use a novel system, 'Analyse It Doc' (A.I.D.) for a complex anthropometric analysis of the nasolabial region in patients with repaired unilateral complete cleft lip and palate and in healthy individuals., Materials and Methods: A set of standardized facial photographs in frontal, lateral and submental view have been taken in 50 non-cleft controls (mean age 20.6 years) and 42 patients with repaired unilateral complete cleft and palate (mean age 19.57 years). Then, based on linear, angular and area measurements taken from the digital photographs with the aid of the A.I.D. system, a photogrammetric analysis of intergroup differences in nasolabial morphology and symmetry was conducted., Results: Patients with cleft lip and palate differed from the controls in terms of more than half of analysed angular measurements and proportion indices derived from linear and area measurements of the nasolabial region., Conclusions: The findings presented herein imply that despite primary surgical repair, patients with unilateral complete cleft lip and palate still show some degree of nasolabial dysmorphology. Furthermore, the study demonstrated that the novel computer system is suitable for a reliable, simple and time-efficient anthropometric analysis in a clinical setting., (Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

Purpose: The need for a widely accepted method suitable for a multicentre quantitative evaluation of facial aesthetics after surgical treatment of cleft lip and palate (CLP) has been emphasized for years. The aim of this study was to validate a novel computer system 'Analyse It Doc' (A.I.D.) as a tool for objective anthropometric analysis of the nasolabial region., Materials and Methods: An indirect anthropometric analysis of facial photographs was conducted with the A.I.D. system and Adobe Photoshop/ImageJ software. Intra-rater and inter-rater reliability and the time required for the analysis were estimated separately for each method and compared., Results: Analysis with A.I.D. system was nearly 10-fold faster than that with the reference evaluation method. The A.I.D. system provided strong inter-rater and intra-rater correlations for linear, angular and area measurements of the nasolabial region, as well as a significantly higher accuracy and reproducibility of angular measurements in submental view. No statistically significant inter-method differences were found for other measurements., Conclusions: The hereby presented novel computer system is suitable for simple, time-efficient and reliable multicenter photogrammetric analyses of the nasolabial region in CLP patients and healthy subjects., (Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

Aim of Study: Five cases of the same congenital malformation of the nose, affecting the nasal dorsum and the supra-tip, were supported in our university plastic surgery center. This malformation has not been described in the literature known to the authors. The aim of this study is to analyze this nasal deformity., Patients and Methods: Five children presented this congenital deformity between 1994 and 2014. The patients were examined and the malformation precisely described. Genetic and histological examinations were carried on. The diagnosis and treatment of this pathology were discussed., Results: This malformation associated 4 anomalies: hypertrophy of soft tissue of the dorsum located in the middle third of the nasal bridge, deformed alar cartilages turned back downward and outside, advanced support default and median skin brand similar to a scar. These patients showed no other abnormalities of the midline or respiratory disorders. No genetic disorder was found for these five patients, and no histological arguments were found. Three patients were operated, one until adulthood with a satisfying cosmetic result., Conclusion: Bibliographic research has not allowed us to make an accurate diagnosis of this malformation that appears to be non-syndromic and to have a genetic origin. Our therapeutic approach became more clear and it now seems legitimate to propose early excision of fat mass to prevent alar deformations, associated with a cortico-cancellous graft, which in our experience grows with age, to support the tip., (Copyright © 2016 Elsevier Masson SAS. All rights reserved.)

Introduction: The aim of this study was to examine the effects of orthodontic treatment with and without extractions on the anatomic characteristics of the upper airway in adults., Methods: For this retrospective study, the pretreatment and posttreatment cone-beam computed tomography scans of 74 adult patients meeting defined eligibility criteria were analyzed. Imaging software was used to segment and measure upper airway regions including the nasopharynx, the retropalatal, and retroglossal areas of the oropharynx, as well as the total airway. The Wilcoxon signed rank test was used to compare volumetric and minimal cross-sectional area changes from pretreatment to posttreatment., Results: The reliability values were high for all measurements, with intraclass correlation coefficients of 0.82 or greater. The volumetric treatment changes for the extraction and nonextraction groups were as follows: total airway, 1039.6 ± 3674.3 mm 3 vs 1719.2 ± 4979.2 mm 3 ; nasopharynx, 136.1 ± 1379.3 mm 3 vs -36.5 ± 1139.8 mm 3 ; retropalatal, 412.7 ± 3042.5 mm 3 vs 399.3 ± 3294.6 mm 3 ; and retroglossal, 412.5 ± 1503.2 mm 3 vs 1109.3 ± 2328.6 mm 3 . The treatment changes in volume or minimal cross-sectional area for all airway regions examined were not significantly (P >0.05) different between the extraction and nonextraction groups., Conclusions: Orthodontic treatment in adults does not cause clinically significant changes to the volume or the minimally constricted area of the upper airway. These results suggest that dental extractions in conjunction with orthodontic treatment have a negligible effect on the upper airway in adults., (Copyright © 2016 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.)

Introduction: The purposes of this study were to evaluate and compare the dentoskeletal changes concurrent with 4-point bone-borne and tooth-borne rapid maxillary expanders in growing children., Methods: The study was conducted with 20 growing girls (ages, 12 ± 0.6 years) with posterior crossbite. They were divided into 2 equal groups; patients in one group were treated with a tooth-borne maxillary hyrax expander (TBME), and those in the other group received a bone-borne maxillary hyrax expander (BBME) anchored directly to the palatal bone. Changes were assessed using cone-beam computed tomography. Images were taken before and immediately after expansion., Results: Superimpositions of the 3-dimensional palatal images showed significant increases in skeletal widths at the canine, first premolar, and first molar areas in both groups. The TBME group had greater nasal width expansion. Regarding the transverse dentolinear measurements, significant increases were seen in both groups, whereas the TBME group showed a greater increase than the BBME group. Significant increases in the dentoangular measurements were seen in the TBME group only and were significantly greater than in the BBME group at the first premolars., Conclusions: There were significant increases in facial and maxillary widths for the BBME group and in nasal width for the TBME group. Both expanders produced basal bone expansion at the level of the hard palate. The TBMEs produced more dental expansion, buccal rolling, and a greater increase in nasal width than did the BBMEs., (Copyright © 2015 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.)

Objectives: To determine the superimposition accuracy of full-face stereophotographic images with 22 cm and 13 cm cone beam computed tomography (CBCT) scans., Material and Methods: 22 cm CBCT scans and corresponding stereophotographic images (3 dMD) for 30 subjects requiring orthognathic surgery were randomly selected. A 13 cm CBCT scan was generated from the 22 cm scan for each subject. All scans and images were converted into STL format. For each subject, the 22 cm and 13 cm CBCT scans were imported into CAD/CAM software and each superimposed with the corresponding 3 dMD image. A one-sample t-test was used to test the null hypothesis that the difference in the 90th percentile of the mean absolute distance between the two 3dMD images when aligned on the 22 cm and the 13 cm CBCT scans was not clinically significant (<0.5 mm)., Results: The 90th percentile of the mean absolute distance between the two 3 dMD surfaces using the 22 cm and 13 cm CBCT scans was significantly less than 0.5 mm (p < 0.001; 0.2 ± 0.2 mm; 95% CI, 0.16-0.30 mm)., Conclusions: There is no difference in the accuracy of superimposition of a stereophotogrammetry image with a 22 cm CBCT scan or a 13 cm CBCT scan. It should now be possible to use a 13 cm CBCT scan and a full-face stereophotogrammetry image during 3D orthognathic planning to reduce radiation exposure., (Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

As there is no single ideal material for dorsal augmentation in rhinoplasty, there has been a continuing need for the development of improved materials. Therefore, we aimed to evaluate the outcome of using a novel tissue-engineered construct composed of autologous chondrocytes cultured with a porcine cartilage-derived substance (PCS) scaffold as an augmentation material in rhinoplasty. A scaffold derived from decellularized and powdered porcine articular cartilage was prepared. The rabbit articular cartilage was used as the source of homologous chondrocytes, which were expanded and cultured with the PCS scaffold for 7 weeks. The chondrocyte-PCS constructs were then surgically implanted on the nasal dorsum of six rabbits. Four and eight weeks after implantation, the gross morphology, radiologic images, and histologic features of the site of implant were analyzed. The rabbits showed no signs of postoperative inflammation and infection. The degree of dorsal augmentation was maintained during the 8-week postoperative observation period. Postoperative histologic examinations showed chondrocyte proliferation without an inflammatory response. However, neo-cartilage formation from the constructs was not confirmed. The biocompatibility and structural features of tissue-engineered chondrocyte-PCS constructs indicate their potential as candidate dorsal augmentation material for use in rhinoplasty., (Copyright © 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.)

Despite fifty years of statistics, congresses, publications, the cleft nose remains an enigma to the great majority of cleft specialists. Most of the published papers give recipes to camouflage the cleft deformity, very few are concerned by the functional anatomy and its relation with facial growth. The complexity of the matter, the results frequently disappointing, the lack of awareness of the necessity of early nasal breathing, and the academic condemnation of any imperfect attempt to correct the nose at the time of the first operation have led to resignation. For the last forty years, we have been involved in a careful and obstinate research about the early correction of the cleft nose deformity. We wish to present our conclusions in this chapter with at least 17 years of follow-up. They are as following: in cleft patients the nasal cartilages are only deformed. We can achieve sub periosteal and sub perichondrial dissections by 6 months of age without being harmful for facial and nasal growth. Repositioning accurately the nasal structures is enough if we are able to control the healing process and prevent endonasal wound contraction. We have not to do any compromise and favor one function with regard to the others, nasal ventilation being the most important for a good facial growth. In a word, nasal pediatric surgery is necessary at the time of the first operation from 6 months of age and should be carried on with a double demand, aesthetic and functional. To achieve this goal, we must have a sound knowledge of the cleft nose deformity, of the adequate surgical techniques and of the logic chronology to reach the best result. The nose repair cannot be limited to the nasal cartilages. The whole nasal structure is concerned especially its bony framework, the width of which at the level of the piriform orifice and the nasal floor depends on the outcomes of any surgical step that it would relate to the lip, palate or alveolar closure. Interaction of all these factors calls for an appropriate answer in adequation with the diagnosis of the deformity and a coherent answer as we know that any local action may induce an unfavorable chain reaction and should integrate a global and logic project. After the primary surgery, additional correction for aesthetic or functional purpose as well, may be useful during the period of growth. For cleft teenagers or adults, the rhinoplasty can simply be indicated for harmonization after a good primary nasal correction and optimal facial growth. On the contrary, the rhinoplasty may be more or less a complex operation for the usual and severe deformities. In the last case, the diagnosis must take into account all the residual deformities, even the labial and alveolar ones, and the treatment plan integrate all the principles and techniques of the primary surgery. What has not been done at the time of the primary surgery, should be done secondarily: all the structures are present, only deformed and embedded in scarred tissues. Primary or secondary cleft rhinoplasty must be undertaken by surgeons accustomed to cleft patients, but also trained in the other fields of nasal surgery, aesthetic and reconstructive., (Copyright © 2014. Published by Elsevier Masson SAS.)

Introduction: Two-dimensional maxillary superimposition techniques have been routinely used in clinical practice, but a 3-dimensional plane has yet to be introduced and validated. The purposes of this study were to propose a new plane for regional superimposition of the maxillary complex and then to validate it through clinical data., Methods: Pretreatment and posttreatment palatal expansion records were used. The magnitudes of the transverse expansion at the levels of the first premolars and the first molars were assessed using the proposed superimposition plane and then were compared with the gold standard plaster model measurements. Descriptive statistics and agreement testing were performed to compare the methods., Results: When comparing the superimposition and plaster measurement methods, the mean errors for intermolar and interpremolar distances were 0.57 and 0.59 mm, respectively. Both the intraclass correlation coefficient and the Bland-Altman plot demonstrated high agreement between the 2 methods (intraclass correlation coefficient greater than 0.9)., Conclusions: The proposed maxillary superimposition plane yields clinically suitable results when compared with the gold standard technique, with a mean error of less than 0.6 mm for typical intra-arch measurements. This new landmark-derived maxillary plane for superimposition is a promising tool for evaluating maxillary dentoalveolar changes after treatment., (Copyright © 2014 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.)

Background: The nasal septum plays an important role in nasal growth, but there have been few reports on the relationship between the septum and nasal growth. The authors investigated the relationship between septa and external noses using computed tomography during the growth period., Methods: One hundred and ninety-eight patients under the age of 21 were enrolled in this study between 2008 and 2012. The authors evaluated a total of 9 measurement items (five for nasal bones and septa, and four for external noses)., Results: In the final age group, most measurement items were significantly larger in males than in females. However, there was no remarkable difference between male and female growth processes. Nasal bridge length and nasal height were significantly correlated with the nasal bone or septum in almost all age groups. The relative proportion of the cartilaginous septum decreased significantly with age, and was negatively correlated with the perpendicular plate in all age groups., Conclusions: Nasal septa and external noses were both larger in males than in females at the beginning of the study period, although not significantly. The differences became significant throughout the study due to differential increases between the sexes during the monitored growth spurts., (Copyright © 2014 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

Purpose: To evaluate the current beliefs about the ways to reduce target registration error (TRE) values in image guided Sinus surgery by rearranging the fiducial configuration, and investigating the best configurations for various surgical fields in a phantom study., Methods: A new CT-compatible skull phantom consisting of implanted targets was designed to enable direct measurement of TRE in four fields of sinus surgery, Frontal, Ethmoid, Sphenoid and Maxillary. The effects of different landmark configurations on TRE values, measured by the Parsiss-IV navigation system were investigated to find the best landmark arrangement for each region, and compared to the TRE prediction formula to assess the clinically accepted landmark selection approaches based on this formula., Results: It was shown that smaller values of TRE could be attained by arranging the center of the fiducials to be more focused on the surgery target. The addition of more fiducials and keeping non-linear arrangement of landmark would not necessarily decrease the TRE value., Conclusion: Optimizing the landmark configuration is important for increasing the localization accuracy in image guided sinus surgery. The common beliefs accepted in the clinical community about the ways to reduce the TRE are very general and should be adapted to specific field of image guided surgery., (Copyright © 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

Background: Recombinant human bone morphogenetic protein (rhBMP)-2 has been used in some craniofacial centers worldwide. However, its influence on nasal morphology is unknown. Thus, the objective of this investigation was to assess the effect of maxillary alveolar reconstruction on nasal position and symmetry in unilateral complete cleft lip patients who underwent traditional iliac crest bone grafting transferring versus reconstruction using rhBMP-2., Methods: Nineteen unilateral complete cleft lip patients were randomly divided into two groups. In group 1, patients underwent traditional iliac crest bone grafting transferring (n = 11) and in group 2, patients underwent alveolar reconstruction using collagen matrix with lyophilized rhBMP-2 (n = 8). Computerized tomography (CT) imaging was performed preoperatively and at 6 months postoperatively using a previously standardized protocol. Linear distances using anatomic landmarks were performed using tridimensional CT data reformatted by the OsiriX(®) software. Quantitative and qualitative measurements to assess intra- and inter-group nasal position modifications were performed., Results: Intra-group pre- and postoperative comparisons showed significant differences (p < 0.05) in two linear measurements of group 1, while group 2 did not present a difference (p > 0.05). Group 2 presented significant postoperative enhancement (p < 0.05) in the quantitative nasal symmetry in one measurement. Qualitative analysis showed postoperative nasal symmetry enhancement in 75% of the measurements of group 2 and 36% of group 1. There was no statistically significant difference in the inter-group comparisons., Conclusions: Our study demonstrated that both groups showed similar effect on nasal symmetry., (Copyright © 2014 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.)

Introduction: The purpose of this study was to evaluate the concept that the affected and contralateral sides do not grow at the same rate in patients with hemifacial microsomia. Changes in the cranial base, maxilla, mandible, and occlusal plane were evaluated on 3-dimensional images from cone-beam computed tomography data in untreated patients., Methods: Six patients were classified as having mandibular Pruzansky/Kaban type I, IIA, or IIB hemifacial microsomia. Cone-beam computed tomography (MercuRay; Hitachi, Tokyo, Japan) scans were taken before orthodontic treatment during both growth and postpuberty periods., Results: The cranial base as defined by the position of the mastoid process was in a different position between the affected and contralateral control sides. The nasomaxillary length or height was shorter on the affected side for all 6 patients with hemifacial microsomia regardless of its severity, and it grew less than on the contralateral control side in 5 of the 6 patients. The occlusal plane angle became more inclined in 4 of the 6 patients. The mandibular ramus was shorter on the affected side in all patients and grew less on the affected side in 5 of the 6 patients. The mandibular body grew slower, the same, or faster than on the control side., Conclusions: The cranial base, position of the condyle, lengths of the condyle and ramus, and positions of the gonial angle and condyle can vary between the affected and contralateral control sides of patients with hemifacial microsomia, with the ramus and nasomaxillary length usually growing slower than they grow on the control side. These results suggest that many factors affect the growth rate of the craniofacial region and, specifically, the mandible in patients with hemifacial microsomia., (Copyright © 2014 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.)

Introduction: To correct dentofacial deformities, a combination of orthodontic treatment and orthognathic surgery is needed. Prediction software packages are beneficial in treatment planning and achieving improved outcomes, but before using any software, its reliability and reproducibility must be assessed. The aim of this study was to evaluate the accuracy of 2-dimensional Dolphin (version 10; Dolphin Imaging & Management Solutions, Chatsworth, Calif) and 3-dimensional Maxilim (Medicim, Sint-Niklaas, Belgium) softwares in predicting the soft-tissue profiles of patients who had Le Fort I osteotomies., Methods: The presurgical and postsurgical cone-beam computed tomography synthesized lateral cephalograms of 13 patients were collected. Using the Dolphin and Maxilim softwares, the postsurgical profiles were predicted. The positions of the soft-tissue landmarks in profile views were compared with landmarks in the postsurgical photographs. The data were analyzed with the coefficient of reliability and paired-sample t tests., Results: The alpha values of the interclass correlations for each landmark in the x and y planes were between 0.96 and 0.99, except for stomion superior in Maxilim (0.83). The 95% confidence interval and the absolute mean of the error showed that errors in the Dolphin software were greater than those in the Maxilim software, but the differences were not significant (P >0.05), except for soft-tissue A-point. The greatest errors were seen in the chin region. The prediction errors of the nasolabial and mentolabial angles were greater; the prediction error in the Dolphin software was 9°, which has clinical significance., Conclusions: The Dolphin and Maxilim softwares are both appropriate for clinical use. Their inaccuracies in the prediction of the chin region should be considered in complicated surgical planning., (Copyright © 2013 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.)

Introduction: Orthodontists rely heavily on soft-tissue analysis to determine facial esthetics and treatment stability. The aim of this retrospective study was to determine the equivalence of soft-tissue measurements between the 3dMD imaging system (3dMD, Atlanta, Ga) and the segmented skin surface images derived from cone-beam computed tomography., Methods: Seventy preexisting 3dMD facial photographs and cone-beam computed tomography scans taken within minutes of each other for the same subjects were registered in 3 dimensions and superimposed using Vultus (3dMD) software. After reliability studies, 28 soft-tissue measurements were recorded with both imaging modalities and compared to analyze their equivalence. Intraclass correlation coefficients and Bland-Altman plots were used to assess interexaminer and intraexaminer repeatability and agreement. Summary statistics were calculated for all measurements. To demonstrate equivalence of the 2 methods, the difference needed a 95% confidence interval contained entirely within the equivalence limits defined by the repeatability results., Results: Statistically significant differences were reported for the vermilion height, mouth width, total facial width, mouth symmetry, soft-tissue lip thickness, and eye symmetry., Conclusions: There are areas of nonequivalence between the 2 imaging methods; however, the differences are clinically acceptable from the orthodontic point of view., (Copyright © 2013 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.)

Introduction: The aim of this prospective, longitudinal study was to evaluate changes to the external shape and form of the nose after surgically assisted rapid maxillary expansion and orthodontic treatment. The changes were registered using a 3-dimensional computer tomography technique, based on superimposition on the anterior base of the skull., Methods: The subjects comprised 35 patients (mean age, 19.7 years; range, 16.1-43.9 years). Low-dose, helical computerized tomography images were taken at treatment start and after orthodontic treatment, about 18 months postsurgery. The 3-dimensional models were registered and superimposed on the anterior cranial base., Results: There were in general significant widening and overall anterior and inferior displacement of the nasal soft tissues. The changes varied in size and direction. No correlation was found between the initial and final widths of the nose, or between the initial and final widths of the nostrils., Conclusions: After surgically assisted rapid maxillary expansion, the most obvious changes to the external features of the nose were at the most lateral alar bases. The difference in lateral displacement profoundly influenced the perception of a more rounded nose. Patients with narrow and constrained nostrils can benefit from these changes. The 3-dimensional superimposition applied in this study is a reliable method, circumventing projection and measurement errors., (Copyright © 2013 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.)

The aim of this article is to compare the soft-tissue changes in the midfacial areas of patients who had undergone mandibular setback sagittal split ramus osteotomy (SSRO) with that of mandibular setback SSRO with paranasal augmentation. The subjects included 15 patients (group I), SSRO with paranasal augmentation and 20 patients (group II), SSRO alone. To evaluate the difference of the midfacial soft-tissue changes between groups, cone-beam computed tomography superimposition was utilized and the soft-tissue changes were measured both preoperatively and postoperatively by a 10 × 27 grid. In group I, the soft tissues were changed at the areas bounded superiorly by the infraorbital foramen, zygomatic eminence, posteriorly by the masseteric muscle and medially by the lateral aspect of the nose and following the nasolabial fold. In group II, the midfacial soft-tissue measurements were unchanged. This study may help clinicians to predict improvement in the midfacial region from mandibular setback SSRO with or without a paranasal augmentation procedure in class III deformities., (Copyright © 2012 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

Background: The purpose of this study was to evaluate nasal morphologic and maxillary skeletal changes occurring after bimaxillary surgery in skeletal class III patients, using a new method entailing superimposition of cone-beam computed tomography (CBCT) volumes., Materials & Methods: The subjects consisted of 30 adults (15 males and 15 females) who had presented with skeletal class III deformities. The subjects underwent Le Fort I advancement and impaction osteotomy and mandibular setback surgery. For closure of the maxillary vestibular incision, alar cinch suture and V-Y closure were performed. The pre- and post-operative CBCT data were superimposed and evaluated by voxel-by-voxel registration., Results: After surgery, the nasolabial angle, nasal tip angle, nasal tip inclination and columellar angle showed significant increases (P < 0.01). The nasal tip protrusion and nasal height, meanwhile, had significantly decreased (P < 0.01), and the alar base width had increased (P < 0.01). The columellar length and nostril axis angle also had decreased, but the nostril area did not show any significant change., Conclusions: After surgery, as the maxilla had been moved upward and forward, the nasal tip was shifted antero-superiorly and the alar base width and nostrils were widened. CBCT superimposition, enabling 3D assessment of nasal morphologic changes, can be an effective tool for simultaneous measurement of skeletal and soft-tissue changes., (Copyright © 2011 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

Objective: The aim of this study was to explore the bone-soft tissue relationships around the nasolabial area in uncorrected secondary unilateral cleft nose deformities., Study Design: Measurements taken from photographs and cone-beam computerized tomography (CBCT) results were derived and paired up to represent the deformity features of bone and soft tissue, respectively., Results: All soft tissue measurements were significantly smaller than the corresponding bone measurements. Various bone-soft tissue correlation patterns were observed in different measurement pairs., Conclusions: The adopted photography-CBCT combined measurement method appeared to be reliable in evaluating the hard-soft tissue relationships in the nasolabial area. In unoperated unilateral cleft nose deformities, bony deformities would decide the soft tissue contours, and soft tissue in turn could camouflage the underlying bone deformities in various patterns and scale, making the external configuration less deformed than its bone basis., (Copyright © 2012 Elsevier Inc. All rights reserved.)

Background: Nasal tip features of cleft lip nose cannot be defined well using conventional measurement methods. Therefore, we developed a new method in which vertical nasal tip (the pronasale) position is evaluated based on the Frankfurt-Horizontal plane. This measurement was applied to bilateral cleft lip patients in early childhood., Methods: Cone beam computed tomography (CT) records of bilateral cleft lip patients after primary rhinoplasty aged from 5 to 8 years (n = 13) were investigated retrospectively. As age-matched controls, data from a normal group (n = 17) and complete unilateral cleft lip group after primary rhinoplasty (n = 19) were included. In each group, nasolabial angle (β), nasal tip angle (α), nasal width (al-al), columellar length (sn-c' ), nasal tip protrusion (sn-prn), and vertical nasal tip position (sn'-prn'/sn'-n') were investigated., Results: With the exception of vertical nasal tip position and nasal width, the measurement data of the bilateral cleft lip patients were acceptable. In the bilateral cleft lip group, however, vertical nasal tip position was significantly higher and nasal width was significantly larger than those in the normal and unilateral groups (P < 0.0001 and P = 0.0298; P = 0.0001 and P = 0.0002, respectively)., Conclusions: In cleft lip nose, the lower lateral cartilage that normally composes the nasal tip domes is splayed out, causing cephalic positioning of the pronasale. Nasal tip collapse was more severe in bilateral cleft lip than in the unilateral group. These results were compatible with the fact that many bilateral cleft lip patients require augmentation rhinoplasty after adolescence even after primary rhinoplasty., (Copyright © 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.)

Introduction: In this study, using a cone-beam computed tomography system, we evaluated the airways of 30 adults., Methods: The shapes of the 3-dimensional volume of the airway were analyzed and compared among the subjects by using surface superimposition software techniques., Results: The airway had the greatest variability in the hypopharynx, in the region below the epiglottis, and above the vocal folds. Moderate variation was apparent at the nares, behind the soft palate, and at the base of the tongue. Conservation of form was seen at the central portion of the nasal airway surrounding the inferior turbinate., Conclusions: The potential for comparing the shape of the airway among subjects is possible., (Copyright © 2011 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.)

Objective: The objectives of this study were (1) to develop a 3D cephalometric analysis scheme applicable to assessing dentofacial deformities; and (2) to create a normative database of 3D cephalometric measurements for adult Chinese in Hong Kong., Study Design: A cross-sectional study was conducted on 50 male and 50 female adults with normal balanced facial profile and occlusion. Cone-beam computed tomography and stereo photogrammetry imaging were performed on all subjects. Three-dimensional virtual models were generated from imaging data, and cephalometric analysis was performed using specialized software. A new 3D cephalometric analysis scheme appropriate for orthognathic surgery as well as a new reference plane (supraorbital margin plane) for midfacial assessment was used in this study., Results: The cephalometric norms generated in this study were comparable with those reported in the literature for conventional 2D cephalometric analysis and the unique features of Chinese faces. The results also showed significant differences between males and females in most of the facial height measurements (P < .01)., Conclusions: This is the first database of 3D cephalometric norms based on CBCT and 3D photogrammetry of the Chinese population in Hong Kong. This can be a useful reference for characterizing facial deformities in 3 dimensions. Moreover, 3D cephalometric analysis has the potential of incorporating new measurement methods that are difficult if not impossible in 2D cephalometric analysis., (Copyright © 2011 Mosby, Inc. All rights reserved.)

Introduction: The purposes of this study were to detect, locate, and examine the changes in transverse nasal width, area, and volume from bone-borne, surgically assisted rapid maxillary expansion (SARME) with the Dresden distractor by using computer tomography (CT)., Methods: Sixteen patients (average age, 28.7 years) underwent axial CT scanning before and 6 months after SARME. They also underwent CT fusion on specific bony structures. The nasal bone width was examined in the coronal plane. The cross-sectional images of the nasal cavity were taken of the area surrounding the apertura piriformis, the choanae, and in between. We calculated cross-sectional areas and nasal volume according to these data., Results: All but 2 patients had an increase in nasal volume of at least 5.1% (SD, 4.6%). The largest value of 35.3% (SD, 45.8%) was measured anteriorly on the nasal floor, decreasing cranially and posteriorly. This correlated with the V-shaped opening of the sutura palatina. There was no significant correlation between increase in nasal volume and transversal expansion., Conclusions: Because most of the air we breathe passes over the lower nasal floor, SARME is likely to improve nasal breathing., (2010 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.)