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1. Contributors

Author

Akçakaya, Mehmet, primary, Alpendurada, Francisco, additional, Appelbaum, Evan, additional, Arai, Andrew, additional, Auger, Dominique, additional, Balaban, Robert S., additional, Bax, Jeroen J., additional, Bellenger, Nicholas G., additional, Bluemke, David A., additional, Botnar, René M., additional, Butler, Craig Ronald, additional, Caravan, Peter, additional, Celeng, Csilla, additional, Chuang, Michael L., additional, de Roos, Albert, additional, Delgado, Victoria, additional, Dharmakumar, Rohan, additional, Dweck, Marc R., additional, Farzaneh-Far, Afshin, additional, Fayad, Zahi A., additional, Firmin, David, additional, Fogel, Mark A., additional, Frank, Herbert, additional, Friedrich, Matthias G., additional, Gale, Eric M., additional, Geva, Tal, additional, Grizzard, John D., additional, Halliday, Brian P., additional, Hansen, Michael, additional, Hauser, Thomas H., additional, Hong, Susie N., additional, Huelnhagen, Till, additional, Hundley, W. Gregory, additional, Ibrahim, El-Sayed H., additional, Ipek, Esra Gucuk, additional, Jerosch-Herold, Michael, additional, Judd, Robert M., additional, Keegan, Jennifer, additional, Kellman, Peter, additional, Khan, Muhammad Shahzeb, additional, Khosa, Faisal, additional, Khurshid, Kiran, additional, Kilner, Philip J., additional, Kim, Daniel H., additional, Kim, Raymond J., additional, Kim, W. Yong, additional, Kramer, Christopher M., additional, Krieger, Eric V., additional, Kwong, Raymond Y., additional, Leb, Jay S., additional, Lederman, Robert, additional, Leiner, Tim, additional, Li, Debiao, additional, Lopez, David, additional, Maceira, Alicia M., additional, Mahrholdt, Heiko, additional, Makowski, Marcus R., additional, Manning, Warren J., additional, Marcu, Constantin B., additional, Maron, Martin S., additional, Mohiaddin, Raad H., additional, Moon, James C., additional, Motwani, Manish, additional, Nakamori, Shiro, additional, Nazarian, Saman, additional, Nensa, Felix, additional, Neubauer, Stefan, additional, Nezafat, Reza, additional, Nienaber, Christoph A., additional, Niendorf, Thoralf, additional, Partington, Sara L., additional, Paterson, Ian, additional, Paul, Katharina, additional, Pennell, Dudley J., additional, Peshock, Ronald M., additional, Peters, Dana C., additional, Planken, R. Nils, additional, Plein, Sven, additional, Powell, Andrew J., additional, Prasad, Sanjay, additional, Prieto, Claudia, additional, Pushparajah, Kuberan, additional, Rashid, Imran, additional, Razavi, Reza S., additional, Rehwald, Wolfgang G., additional, Robson, Philip M., additional, Rodgers, Christopher T., additional, Rogers, Toby, additional, Rowin, Ethan J., additional, Rudd, James H.F., additional, Sakuma, Hajime, additional, Salerno, Michael, additional, Schlosser, Thomas, additional, Schwitter, Juerg, additional, Sechtem, Udo P., additional, Stacey, R. Brandon, additional, Stuber, Matthias, additional, Sykora, Teresa, additional, Tayal, Upasana, additional, te Riele, Anneline S.J.M., additional, Treibel, Thomas A., additional, Tsaftaris, Sotirios A., additional, Valente, Anne Marie, additional, van den Bosch, Harrie, additional, van der Bijl, Pieter, additional, van Rossum, Albert C., additional, Wendell, David C., additional, Westenberg, Jos J.M., additional, Westwood, Mark A., additional, Wilke, Norbert, additional, Winter, Lukas, additional, and Yang, Hsin-Jung, additional

Published
2019
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3. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

Author

Johnson, Katherine, Leary, Peter J., Govaere, Olivier, Barter, Matthew J., Charlton, Sarah H., Cockell, Simon J., Tiniakos, Dina, Zatorska, Michalina, Bedossa, Pierre, Brosnan, M. Julia, Cobbold, Jeremy F., Ekstedt, Mattias, Aithal, Guruprasad P., Boursier, Jerome, Ratziu, Vlad, Bugianesi, Elisabetta, Anstee, Quentin M., Daly, Ann K., Clark, James, Cockell, Simon, Cordell, Heather J., Darlay, Rebecca, Day, Christopher P., Hardy, Tim, Liu, Yang-Lin, Oakley, Fiona, Palmer, Jeremy, Queen, Rachel, Wonders, Kristy, Bossuyt, Patrick M., Holleboom, Adriaan G., Zafarmand, Hadi, Vali, Yasaman, Lee, Jenny, Clement, Karine, Pais, Raluca, Schuppan, Detlef, Allison, Michael, Cuenca, Sergio Rodriguez, Pellegrinelli, Vanessa, Vacca, Michele, Vidal-Puig, Antonio, McGlinchey, Aidan, Sen, Partho, Mato, Jose, Dufour, Jean-Francois, Harrison, Stephen, Neubauer, Stefan, Pavlides, Michael, Mozes, Ferenc, Akhtar, Salma, Banerjee, Rajarshi, Kelly, Matt, Shumbayawonda, Elizabeth, Dennis, Andrea, Erpicum, Charlotte, Romero-Gomez, Manuel, Karsdal, Morten, Leeming, Diana, Fisker, Mette Juul, Erhardtsen, Elisabeth, Rasmussen, Daniel, Qvist, Per, Sinisi, Antonia, Sandt, Estelle, Tonini, Maria Manuela, Parola, Maurizio, Rosso, Chiara, Marra, Fabio, Gastaldelli, Amalia, Francque, Sven, Kechagias, Stergios, Porthan, Kimmo, van Mil, Saskia, Papatheodoridis, George, Cortez-Pinto, Helena, Valenti, Luca, Petta, Salvatore, Miele, Luca, Geier, Andreas, Trautwein, Christian, Hockings, Paul, Newsome, Phil, Wenn, David, Chaumat, Pierre, Rosenquist, Christian, Trylesinski, Aldo, Ortiz, Pablo, Duffin, Kevin, Yunis, Carla, Miller, Melissa, Tuthill, Theresa, Ertle, Judith, Younes, Ramy, Alexander, Leigh, Ostroff, Rachel, Mikkelsen, Lars Friis, Brass, Clifford, Jennings, Lori, Balp, Maria-Magdalena, Martic, Miljen, Hanauer, Guido, Shankar, Sudha, Torstenson, Richard, Ehman, Richard, Kalutkiewicz, Michael, Pepin, Kay, Myers, Joel, Shevell, Diane, Ho, Gideon, Landgren, Henrik, Myers, Rob, Doward, Lynda, Whalley, Diane, and Twiss, James

Subjects
Hepatology, Gastroenterology, Internal Medicine, Immunology and Allergy, digestive system diseases
Abstract

Background & Aims: Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods: We profiled 2,083 serum miRNAs in a discovery cohort (183 cases with NAFLD representing the complete NAFLD spectrum and 10 population controls). miRNA libraries generated by HTG EdgeSeq were sequenced by Illumina NextSeq. Selected serum miRNAs were profiled in 372 additional cases with NAFLD and 15 population controls by quantitative reverse transcriptase PCR. Results: Levels of 275 miRNAs differed between cases and population controls. Fewer differences were seen within individual NAFLD stages, but miR-193a-5p consistently showed increased levels in all comparisons. Relative to NAFL/non-alcoholic steatohepatitis (NASH) with mild fibrosis (stage 0/1), 3 miRNAs (miR-193a-5p, miR-378d, and miR378d) were increased in cases with NASH and clinically significant fibrosis (stages 2–4), 7 (miR193a-5p, miR-378d, miR-378e, miR-320b, miR-320c, miR-320d, and miR-320e) increased in cases with NAFLD activity score (NAS) 5–8 compared with lower NAS, and 3 (miR-193a-5p, miR-378d, and miR-378e) increased but 1 (miR-19b-3p) decreased in steatosis, activity, and fibrosis (SAF) activity score 2–4 compared with lower SAF activity. The significant findings for miR-193a-5p were replicated in the additional cohort with NAFLD. Studies in Hep G2 cells showed that following palmitic acid treatment, miR-193a-5p expression decreased significantly. Gene targets for miR-193a-5p were investigated in liver RNAseq data for a case subgroup (n = 80); liver GPX8 levels correlated positively with serum miR-193a-5p. Conclusions: Serum miR-193a-5p levels correlate strongly with NAFLD activity grade and fibrosis stage. MiR-193a-5p may have a role in the hepatic response to oxidative stress and is a potential clinically tractable circulating biomarker for progressive NAFLD. Lay summary: MicroRNAs (miRNAs) are small pieces of nucleic acid that may turn expression of genes on or off. These molecules can be detected in the blood circulation, and their levels in blood may change in liver disease including non-alcoholic fatty liver disease (NAFLD). To see if we could detect specific miRNA associated with advanced stages of NAFLD, we carried out miRNA sequencing in a group of 183 patients with NAFLD of varying severity together with 10 population controls. We found that a number of miRNAs showed changes, mainly increases, in serum levels but that 1 particular miRNA miR-193a-5p consistently increased. We confirmed this increase in a second group of cases with NAFLD. Measuring this miRNA in a blood sample may be a useful way to determine whether a patient has advanced NAFLD without an invasive liver biopsy.

Published
2022

4. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis

Author

Selvaraj, Emmanuel Anandraj, Jayaswal, Arjun Narayan Ajmer, Zafarmand, Mohammad Hadi, Vali, Yasaman, Lee, Jenny A., Levick, Christina Kim, Young, Liam Arnold Joseph, Palaniyappan, Naaventhan, Liu, Chang-Hai, Aithal, Guruprasad Padur, Brosnan, M. Julia, Tuthill, Theresa A., Anstee, Quentin M., Neubauer, Stefan, Harrison, Stephen A., Bossuyt, Patrick M., and Pavlides, Michael

Subjects
Non-alcoholic fatty liver disease, Non-alcoholic steatohepatitis, Biomarkers, Liver fibrosis, Transient elastography, Shear wave elastography, Magnetic resonance elastography, Magnetic resonance imaging, Iron-corrected T1, Diffusion weighted imaging, deMI
Abstract

Background and Aims: Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), two-dimensional shear wave elastography (2DSWE), magnetic resonance elastography (MRE), and magnetic resonance imaging (MRI) are proposed as non-invasive tests for patients with non-alcoholic fatty liver disease (NAFLD). This study evaluated their diagnostic accuracy for liver fibrosis and non-alcoholic steatohepatitis (NASH).Methods: PubMED/MEDLINE, EMBASE and the Cochrane Library were searched for studies examining the diagnostic accuracy of these index tests against histology as the reference standard, in adult patients with NAFLD. Two authors independently screened and assessed methodological quality of studies and extracted data. Summary estimates of sensitivity, specificity and area under the curve (sAUC) were calculated for fibrosis stages and NASH, using a random effects bivariate logit-normal model.Results: We included 82 studies (14,609 patients). Meta-analysis for diagnosing fibrosis stages was possible in 53 VCTE, 11 MRE, 12 pSWE and four 2DSWE studies, and for diagnosing NASH in four MRE studies. sAUC for diagnosis of significant fibrosis were: 0.83 for VCTE, 0.91 for MRE, 0.86 for pSWE and 0.75 for 2DSWE. sAUC for diagnosis of advanced fibrosis were: 0.85 for VCTE, 0.92 for MRE, 0.89 for pSWE and 0.72 for 2DSWE. sAUC for diagnosis of cirrhosis were: 0.89 for VCTE, 0.90 for MRE, 0.90 for pSWE and 0.88 for 2DSWE. MRE had sAUC of 0.83 for diagnosis of NASH. Three (4%) studies reported intention-to-diagnose analyses and 15 (18%) studies reported diagnostic accuracy against pre-specified cut-offs.Conclusions: When elastography index tests are acquired successfully, they have acceptable diagnostic accuracy for advanced fibrosis and cirrhosis. The potential clinical impact of these index tests cannot be assessed fully as intention-to-diagnose analyses and validation of pre-specified thresholds are lacking.Lay summary:Non-invasive tests that measure liver stiffness or use magnetic resonance imaging (MRI) have been suggested as alternatives to liver biopsy in assessing the severity of liver scarring (fibrosis) and fatty inflammation (steatohepatitis) in patients with non-alcoholic fatty liver disease (NAFLD). In this study, we summarise the results of previously published studies on how accurately these non-invasive tests can diagnose liver fibrosis and inflammation, using liver biopsy as the reference. We found that some techniques that measure liver stiffness had a good performance for the diagnosis of severe liver scarring.

Published
2021

5. The diagnostic performance of novel techniques for the detection of acute myocarditis: a clinical study using cardiovascular magnetic resonance imaging

Author

Ferreira Vanessa, Piechnik Stefan K, Dall'Armellina Erica, Karamitsos Theodoros, Francis Jane M, Ntusi Ntobeko, Holloway Cameron, Choudhury Robin P, Kardos Attila, Robson Matthew D, Friedrich Matthias G, and Neubauer Stefan

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2013
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43. Dystrophinopathies are characterised by impaired cardiac metabolism, contractile dysfunction and fibrosis in patients with and without coxsackie B3 exposure

Author

Petersen Steffen, Schneider Jurgen, Clarke Kieran, Karamitsos Theodoros, Francis Jane, Pitcher Alex, Cochlinl Lowri, Holloway Cameron, Cox Pete, Banerjee Rajarshee, Franco Belen, Dass Sairia, Suttie Joseph, Robson Matthew, Watkins Hugh, and Neubauer Stefan

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2011
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46. Feasibility of ultrahigh field (7 Tesla) human cardiovascular magnetic resonance imaging to assess cardiac volumes and mass validated against 1.5 T and 3T field strengths

Author

Ugurbil Kamil, Weale Peter, Metzger Greg J, Francis Jane M, Snyder Carl J, Dass Sairia, van de Moortele Pierre-Francois, Pitcher Alex, DeLaBarre Lance, Suttie Joseph J, Robson Matthew D, Neubauer Stefan, and Vaughan Tommy

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2011
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49. Blood oxygen level-dependent magnetic resonance imaging at 3 Tesla in coronary artery disease: validation using quantitative coronary angiography and cardiovascular magnetic resonance perfusion imaging

Author

Banning Adrian, Camici Paolo G, Robson Matthew, Choudhury Robin P, Searle Nick, Francis Jane M, Bhamra-Ariza Paul, Karamitsos Theodoros D, Arnold Jayant R, Neubauer Stefan, Jerosch-Herold Michael, and Selvanayagam Joseph B

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2010
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