64 results on '"Negri M."'
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2. List of contributors
- Author
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Afroz, Shamima, primary, Alinovi, R., additional, Bano, Edwige, additional, Bedogni, E., additional, Bigi, F., additional, Cacchioli, A., additional, Cespedes, Fabiola Araujo, additional, Charkhkar, Hamid, additional, Choi, Ji-Hoon, additional, Cogan, Stuart F., additional, Coletti, C., additional, Cristofolini, L., additional, D'angelo, Pasquale, additional, Fabbri, F., additional, Fradetal, Louis, additional, Frewin, Christopher L., additional, Galli, C., additional, Guy, Owen J., additional, Iannotta, Salvatore, additional, Knaack, Gretchen L., additional, Lagonegro, P., additional, Macaluso, G.M., additional, Negri, M., additional, Nezafati, Maysam, additional, Noble, Katie, additional, Ollivier, Maelig, additional, Pancrazio, Joseph J., additional, Pinelli, S., additional, Ravanetti, F., additional, Rimoldi, T., additional, Romeo, Agostino, additional, Rossi, F., additional, Saddow, Stephen E., additional, Salviati, G., additional, Smerieri, A., additional, Stambouli, Valérie, additional, Tarabella, Giuseppe, additional, Thomas, Sylvia, additional, and Walker, Kelly-Ann D., additional
- Published
- 2016
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3. Fossil mollusc-faunas: Their bearing on the Holocene evolution of the Lower Central Plain of Bangkok (Thailand)
- Author
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Negri, M, NEGRI, MAURO PIETRO, Negri, M, and NEGRI, MAURO PIETRO
- Abstract
In this work, fossil molluscan assemblages are analyzed in order to reconstruct the evolution of the Northern Gulf of Thailand during the Holocene. The marine sediments (Bangkok Clay Formation) of the Lower Central Plain of Bangkok and the coastal plain of Phetchaburi were sampled at 16 localities, obtaining fossil shells and mangrove peat whose 14C ages range from 9000 to 2000 CYBP. A statistical treatment of abundance data returned four major groups, namely the Dendostrea rosacea association (intertidal mud), the Corbula fortisulcata-Mactra luzonica association (shallow infralittoral sandy mud), the Nuculana mauritiana-Timoclea scabra association (infralittoral sand spit) and the Timoclea scabra-Arcopagia pudica association (infralittoral mud). The data allowed both a stratigraphic correlation along two transects covering all of the Holocene basin and the creation of digitalized maps showing the presumable extension of the Thai paleogulf around the apex of Flandrian transgression event (about 5500 CYBP). © 2009 Elsevier Ltd. All rights reserved.
- Published
- 2009
4. Search for heavy long-lived charged R-hadrons with the ATLAS detector in 3.2 fb−1 of proton–proton collision data at s=13 TeV
- Author
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Aaboud, M., Aad, G., Abbott, B., Abdallah, J., Abdinov, O., Abeloos, B., Aben, R., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abreu, R., Abulaiti, Y., Acharya, B. S., Adamczyk, L., Adams, D. L., Adelman, J., Adersberger, M., Adomeit, S., Adye, T., Affolder, A. A., Agatonovic Jovin, T., Agricola, J., Aguilar Saavedra, J. A., Ahlen, S. P., Ahmadov, F., Aielli, G., Akerstedt, H., Åkesson, T. P. A., Akimov, A. V., Alberghi, G. L., Albert, J., Albrand, S., Alconada Verzini, M. J., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexander, G., Alexopoulos, T., Alhroob, M., Ali, B., Aliev, M., Alimonti, G., Alison, J., Alkire, S. P., Allbrooke, B. M. M., Allen, B. W., Allport, P. P., Aloisio, A., Alonso, A., Alonso, F., Alpigiani, C., Alstaty, M., Alvarez Gonzalez, B., Álvarez Piqueras, D., Alviggi, M. G., Amadio, B. T., Amako, K., Amaral Coutinho, Y., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amorim, A., Amoroso, S., Amundsen, G., Anastopoulos, C., Ancu, L. S., Andari, N., Andeen, T., Anders, C. F., Anders, G., Anders, J. K., Anderson, K. J., Andreazza, A., Andrei, V., Angelidakis, S., Angelozzi, I., Anger, P., Angerami, A., Anghinolfi, F., Anisenkov, A. V., Anjos, N., Annovi, A., Antel, C., Antonelli, M., Antonov, A., Anulli, F., Aoki, M., Aperio Bella, L., Arabidze, G., Arai, Y., Araque, J. P., Arce, A. T. H., Arduh, F. A., Arguin, J. F., Argyropoulos, S., Arik, M., Armbruster, A. J., Armitage, L. J., Arnaez, O., Arnold, H., Arratia, M., Arslan, O., Artamonov, A., Artoni, G., Artz, S., Asai, S., Asbah, N., Ashkenazi, A., Åsman, B., Asquith, L., Assamagan, K., Astalos, R., Atkinson, M., Atlay, N. B., Augsten, K., Avolio, G., Axen, B., Ayoub, M. K., Azuelos, G., Baak, M. A., Baas, A. E., Baca, M. J., Bachacou, H., Bachas, K., Backes, M., Backhaus, M., Bagiacchi, P., Bagnaia, P., Bai, Y., Baines, J. T., Baker, O. K., Baldin, E. M., Balek, P., Balestri, T., Balli, F., Balunas, W. K., Banas, E., Banerjee, S. w., Bannoura, A. A. E., Barak, L., Barberio, E. L., Barberis, D., Barbero, M., Barillari, T., Barisits, M. S, Barklow, T., Barlow, N., Barnes, S. L., Barnett, B. M., Barnett, R. M., Barnovska, Z., Baroncelli, A., Barone, G., Barr, A. J., Barranco Navarro, L., Barreiro, F., Barreiro Guimarães da Costa, J., Bartoldus, R., Barton, A. E., Bartos, P., Basalaev, A., Bassalat, A., Bates, R. L., Batista, S. J., Batley, J. R., Battaglia, M., Bauce, M., Bauer, F., Bawa, H. S., Beacham, J. B., Beattie, M. D., Beau, T., Beauchemin, P. H., Bechtle, P., Beck, H. P., Becker, K., Becker, M., Beckingham, M., Becot, C., Beddall, A. J., Beddall, A., Bednyakov, V. A., Bedognetti, M., Bee, C. P., Beemster, L. J., Beermann, T. A., Begel, M., Behr, J. K., Belanger Champagne, C., Bell, A. S., Bella, G., Bellagamba, L., Bellerive, A., Bellomo, M., Belotskiy, K., Beltramello, O., Belyaev, N. L., Benary, O., Benchekroun, D., Bender, M., Bendtz, K., Benekos, N., Benhammou, Y., Benhar Noccioli, E., Benitez, J., Benjamin, D. P., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Bergeaas Kuutmann, E., Berger, N., Beringer, J., Berlendis, S., Bernard, N. R., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Bertella, C., Bertoli, G., Bertolucci, F., Bertram, I. A., Bertsche, C., Bertsche, D., Besjes, G. J., Bessidskaia Bylund, O., Bessner, M., Besson, N., Betancourt, C., Bethke, S., Bevan, A. J., Bianchi, R. M., Bianchini, L., Bianco, M., Biebel, O., Biedermann, D., Bielski, R., Biesuz, N. V., Biglietti, M., Bilbao De Mendizabal, J., Billoud, T. R. V., Bilokon, H., Bindi, M., Binet, S., Bingul, A., Bini, C., Biondi, S., Bjergaard, D. M., Black, C. W., Black, J. E., Black, K. M., Blackburn, D., Blair, R. E., Blanchard, J. B., Blazek, T., Bloch, I., Blocker, C., Blum, W., Blumenschein, U., Blunier, S., Bobbink, G. J., Bobrovnikov, V. S., Bocchetta, S. S., Bocci, A., Bock, C., Boehler, M., Boerner, D., Bogaerts, J. A., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Boldyrev, A. S., Bomben, M., Bona, M., Boonekamp, M., Borisov, A., Borissov, G., Bortfeldt, J., Bortoletto, D., Bortolotto, V., Bos, K., Boscherini, D., Bosman, M., Bossio Sola, J. D., Boudreau, J., Bouffard, J., Bouhova Thacker, E. V., Boumediene, D., Bourdarios, C., Boutle, S. K., Boveia, A., Boyd, J., Boyko, I. R., Bracinik, J., Brandt, A., Brandt, G., Brandt, O., Bratzler, U., Brau, B., Brau, J. E., Braun, H. M., Breaden Madden, W. D., Brendlinger, K., Brennan, A. J., Brenner, L., Brenner, R., Bressler, S., Bristow, T. M., Britton, D., Britzger, D., Brochu, F. M., Brock, I., Brock, R., Brooijmans, G., Brooks, T., Brooks, W. K., Brosamer, J., Brost, E., Broughton, J. H., Bruckman de Renstrom, P. A., Bruncko, D., Bruneliere, R., Bruni, A., Bruni, G., Bruni, L. S., Brunt, B. H., Bruschi, M., Bruscino, N., Bryant, P., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Budagov, I. A., Buehrer, F., Bugge, M. K., Bulekov, O., Bullock, D., Burckhart, H., Burdin, S., Burgard, C. D., Burghgrave, B., Burka, K., Burke, S., Burmeister, I., Burr, J. T. P., Busato, E., Büscher, D., Büscher, V., Bussey, P., Butler, J. M., Buttar, C. M., Butterworth, J. M., Butti, P., Buttinger, W., Buzatu, A., Buzykaev, A. R., Cabrera Urbán, S., Caforio, D., Cairo, V. M., Cakir, O., Calace, N., Calafiura, P., Calandri, A., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Calvente Lopez, S., Calvet, D., Calvet, S., Calvet, T. P., Camacho Toro, R., Camarda, S., Camarri, P., Cameron, D., Caminal Armadans, R., Camincher, C., Campana, S., Campanelli, M., Camplani, A., Campoverde, A., Canale, V., Canepa, A., Cano Bret, M., Cantero, J., Cantrill, R., Cao, T., Capeans Garrido, M. D. M., Caprini, I., Caprini, M., Capua, M., Caputo, R., Carbone, R. M., Cardarelli, R., Cardillo, F., Carli, I., Carli, T., Carlino, G., Carminati, L., Caron, S., Carquin, E., Carrillo Montoya, G. D., Carter, J. R., Carvalho, J., Casadei, D., Casado, M. P., Casolino, M., Casper, D. W., Castaneda Miranda, E., Castelijn, R., Castelli, A., Castillo Gimenez, V., Castro, N. F., Catinaccio, A., Catmore, J. R., Cattai, A., Caudron, J., Cavaliere, V., Cavallaro, E., Cavalli, D., Cavalli Sforza, M., Cavasinni, Vincenzo, Ceradini, F., Cerda Alberich, L., Cerio, B. C., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cerv, M., Cervelli, A., Cetin, S. A., Chafaq, A., Chakraborty, D., Chan, S. K., Chan, Y. L., Chang, P., Chapman, J. D., Charlton, D. G., Chatterjee, A., Chau, C. C., Chavez Barajas, C. A., Che, S., Cheatham, S., Chegwidden, A., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chelstowska, M. A., Chen, C., Chen, H., Chen, K., Chen, S., Chen, X., Chen, Y., Cheng, H. C., Cheng, H. J., Cheng, Y., Cheplakov, A., Cheremushkina, E., Cherkaoui El Moursli, R., Chernyatin, V., Cheu, E., Chevalier, L., Chiarella, V., Chiarelli, G., Chiodini, G., Chisholm, A. S., Chitan, A., Chizhov, M. V., Choi, K., Chomont, A. R., Chouridou, S., Chow, B. K. B., Christodoulou, V., Chromek Burckhart, D., Chudoba, J., Chuinard, A. J., Chwastowski, J. J., Chytka, L., Ciapetti, G., Ciftci, A. K., Cinca, D., Cindro, V., Cioara, I. A., Ciocca, C., Ciocio, A., Cirotto, F., Citron, Z. H., Citterio, M., Ciubancan, M., Clark, A., Clark, B. L., Clark, M. R., Clark, P. J., Clarke, R. N., Clement, C., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., Colasurdo, L., Cole, B., Colijn, A. P., Collot, J., Colombo, T., Compostella, G., Conde Muiño, P., Coniavitis, E., Connell, S. H., Connelly, I. A., Consorti, V., Constantinescu, S., Conti, G., Conventi, F., Cooke, M., Cooper, B. D., Cooper Sarkar, A. M., Cormier, K. J. R., Cornelissen, T., Corradi, M., Corriveau, F., Corso Radu, A., Cortes Gonzalez, A., Cortiana, G., Costa, G., Costa, M. J., Costanzo, D., Cottin, G., Cowan, G., Cox, B. E., Cranmer, K., Crawley, S. J., Cree, G., Crépé Renaudin, S., Crescioli, F., Cribbs, W. A., Crispin Ortuzar, M., Cristinziani, M., Croft, V., Crosetti, G., Cueto, A., Cuhadar Donszelmann, T., Cummings, J., Curatolo, M., Cúth, J., Czirr, H., Czodrowski, P., D'Amen, G., D'Auria, S., D'Onofrio, M., Da Cunha Sargedas De Sousa, M. J., Da Via, C., Dabrowski, W., Dado, T., Dai, T., Dale, O., Dallaire, F., Dallapiccola, C., Dam, M., Dandoy, J. R., Dang, N. P., Daniells, A. C., Dann, N. S., Danninger, M., Dano Hoffmann, M., Dao, V., Darbo, G., Darmora, S., Dassoulas, J., Dattagupta, A., Davey, W., David, C., Davidek, T., Davies, M., Davison, P., Dawe, E., Dawson, I., Daya Ishmukhametova, R. K., De, K., de Asmundis, R., De Benedetti, A., De Castro, S., De Cecco, S., De Groot, N., de Jong, P., De la Torre, H., De Lorenzi, F., De Maria, A., De Pedis, D., De Salvo, A., De Sanctis, U., De Santo, A., De Vivie De Regie, J. B., Dearnaley, W. J., Debbe, R., Debenedetti, C., Dedovich, D. V., Dehghanian, N., Deigaard, I., Del Gaudio, M., Del Peso, J., Del Prete, T., Delgove, D., Deliot, F., Delitzsch, C. M., Deliyergiyev, M., Dell'Acqua, A., Dell'Asta, L., Dell'Orso, Mauro, Della Pietra, M., della Volpe, D., Delmastro, M., Delsart, P. A., Demarco, D. A., Demers, S., Demichev, M., Demilly, A., Denisov, S. P., Denysiuk, D., Derendarz, D., Derkaoui, J. E., Derue, F., Dervan, P., Desch, K., Deterre, C., Dette, K., Deviveiros, P. O., Dewhurst, A., Dhaliwal, S., Di Ciaccio, A., Di Ciaccio, L., Di Clemente, W. K., Di Donato, C., Di Girolamo, A., Di Girolamo, B., Di Micco, B., Di Nardo, R., Di Simone, A., Di Sipio, R., Di Valentino, D., Diaconu, C., Diamond, M., Dias, F. A., Diaz, M. A., Diehl, E. B., Dietrich, J., Diglio, S., Dimitrievska, A., Dingfelder, J., Dita, P., Dita, S., Dittus, F., Djama, F., Djobava, T., Djuvsland, J. I., do Vale, M. A. B., Dobos, D., Dobre, M., Doglioni, C., Dolejsi, J., Dolezal, Z., Dolgoshein, B. A., Donadelli, M., Donati, Simone, Dondero, P., Donini, J., Dopke, J., Doria, A., Dova, M. T., Doyle, A. T., Drechsler, E., Dris, M., Du, Y., Duarte Campderros, J., Duchovni, E., Duckeck, G., Ducu, O. A., Duda, D., Dudarev, A., Duffield, E. M., Duflot, L., Dührssen, M., Dumancic, M., Dunford, M., Duran Yildiz, H., Düren, M., Durglishvili, A., Duschinger, D., Dutta, B., Dyndal, M., Eckardt, C., Ecker, K. M., Edgar, R. C., Edwards, N. C., Eifert, T., Eigen, G., Einsweiler, K., Ekelof, T., El Kacimi, M., Ellajosyula, V., Ellert, M., Elles, S., Ellinghaus, F., Elliot, A. A., Ellis, N., Elmsheuser, J., Elsing, M., Emeliyanov, D., Enari, Y., Endner, O. C., Ennis, J. S., Erdmann, J., Ereditato, A., Ernis, G., Ernst, J., Ernst, M., Errede, S., Ertel, E., Escalier, M., Esch, H., Escobar, C., Esposito, B., Etienvre, A. I., Etzion, E., Evans, H., Ezhilov, A., Fabbri, F., Fabbri, L., Facini, G., Fakhrutdinov, R. M., Falciano, S., Falla, R. J., Faltova, J., Fang, Y., Fanti, M., Farbin, A., Farilla, A., Farina, C., Farina, E. M., Farooque, T., Farrell, S., Farrington, S. M., Farthouat, P., Fassi, F., Fassnacht, P., Fassouliotis, D., Faucci Giannelli, M., Favareto, A., Fawcett, W. J., Fayard, L., Fedin, O. L., Fedorko, W., Feigl, S., Feligioni, L., Feng, C., Feng, E. J., Feng, H., Fenyuk, A. B., Feremenga, L., Fernandez Martinez, P., Fernandez Perez, S., Ferrando, J., Ferrari, A., Ferrari, P., Ferrari, R., Ferreira de Lima, D. E., Ferrer, A., Ferrere, D., Ferretti, C., Ferretto Parodi, A., Fiedler, F., Filipčič, A., Filipuzzi, M., Filthaut, F., Fincke Keeler, M., Finelli, K. D., Fiolhais, M. C. N., Fiorini, L., Firan, A., Fischer, A., Fischer, C., Fischer, J., Fisher, W. C., Flaschel, N., Fleck, I., Fleischmann, P., Fletcher, G. T., Fletcher, R. R. M., Flick, T., Floderus, A., Flores Castillo, L. R., Flowerdew, M. J., Forcolin, G. T., Formica, A., Forti, A., Foster, A. G., Fournier, D., Fox, H., Fracchia, S., Francavilla, P., Franchini, M., Francis, D., Franconi, L., Franklin, M., Frate, M., Fraternali, M., Freeborn, D., Fressard Batraneanu, S. M., Friedrich, F., Froidevaux, D., Frost, J. A., Fukunaga, C., Fullana Torregrosa, E., Fusayasu, T., Fuster, J., Gabaldon, C., Gabizon, O., Gabrielli, A., Gach, G. P., Gadatsch, S., Gadomski, S., Gagliardi, G., Gagnon, L. G., Gagnon, P., Galea, C., Galhardo, B., Gallas, E. J., Gallop, B. J., Gallus, P., Galster, G., Gan, K. K., Gao, J., Gao, Y., Gao, Y. S., Garay Walls, F. M., García, C., García Navarro, J. E., Garcia Sciveres, M., Gardner, R. W., Garelli, N., Garonne, V., Gascon Bravo, A., Gasnikova, K., Gatti, C., Gaudiello, A., Gaudio, G., Gauthier, L., Gavrilenko, I. L., Gay, C., Gaycken, G., Gazis, E. N., Gecse, Z., Gee, C. N. P., Geich Gimbel, C. h., Geisen, M., Geisler, M. P., Gemme, C., Genest, M. H., Geng, C., Gentile, S., Gentsos, C., George, S., Gerbaudo, D., Gershon, A., Ghasemi, S., Ghazlane, H., Ghneimat, M., Giacobbe, B., Giagu, S., Giannetti, P., Gibbard, B., Gibson, S. M., Gignac, M., Gilchriese, M., Gillam, T. P. S., Gillberg, D., Gilles, G., Gingrich, D. M., Giokaris, N., Giordani, M. P., Giorgi, F. M., Giraud, P. F., Giromini, P., Giugni, D., Giuli, F., Giuliani, C., Giulini, M., Gjelsten, B. K., Gkaitatzis, S., Gkialas, I., Gkougkousis, E. L., Gladilin, L. K., Glasman, C., Glatzer, J., Glaysher, P. C. F., Glazov, A., Goblirsch Kolb, M., Godlewski, J., Goldfarb, S., Golling, T., Golubkov, D., Gomes, A., Gonçalo, R., Goncalves Pinto Firmino Da Costa, J., Gonella, G., Gonella, L., Gongadze, A., González de la Hoz, S., Gonzalez Parra, G., Gonzalez Sevilla, S., Goossens, L., Gorbounov, P. A., Gordon, H. A., Gorelov, I., Gorini, B., Gorini, E., Gorišek, A., Gornicki, E., Goshaw, A. T., Gössling, C., Gostkin, M. I., Goudet, C. R., Goujdami, D., Goussiou, A. G., Govender, N., Gozani, E., Graber, L., Grabowska Bold, I., Gradin, P. O. J., Grafström, P., Gramling, J., Gramstad, E., Grancagnolo, S., Gratchev, V., Gravila, P. M., Gray, H. M., Graziani, E., Greenwood, Z. D., Grefe, C., Gregersen, K., Gregor, I. M., Grenier, P., Grevtsov, K., Griffiths, J., Grillo, A. A., Grimm, K., Grinstein, S., Gris, P. h., Grivaz, J. F., Groh, S., Grohs, J. P., Gross, E., Grosse Knetter, J., Grossi, G. C., Grout, Z. J., Guan, L., Guan, W., Guenther, J., Guescini, F., Guest, D., Gueta, O., Guido, E., Guillemin, T., Guindon, S., Gul, U., Gumpert, C., Guo, J., Guo, Y., Gupta, R., Gupta, S., Gustavino, G., Gutierrez, P., Gutierrez Ortiz, N. G., Gutschow, C., Guyot, C., Gwenlan, C., Gwilliam, C. B., Haas, A., Haber, C., Hadavand, H. K., Haddad, N., Hadef, A., Haefner, P., Hageböck, S., Hajduk, Z., Hakobyan, H., Haleem, M., Haley, J., Halladjian, G., Hallewell, G. D., Hamacher, K., Hamal, P., Hamano, K., Hamilton, A., Hamity, G. N., Hamnett, P. G., Han, L., Hanagaki, K., Hanawa, K., Hance, M., Haney, B., Hanisch, S., Hanke, P., Hanna, R., Hansen, J. B., Hansen, J. D., Hansen, M. C., Hansen, P. H., Hara, K., Hard, A. S., Harenberg, T., Hariri, F., Harkusha, S., Harrington, R. D., Harrison, P. F., Hartjes, F., Hartmann, N. M., Hasegawa, M., Hasegawa, Y., Hasib, A., Hassani, S., Haug, S., Hauser, R., Hauswald, L., Havranek, M., Hawkes, C. M., Hawkings, R. J., Hayakawa, D., Hayden, D., Hays, C. P., Hays, J. M., Hayward, H. S., Haywood, S. J., Head, S. J., Heck, T., Hedberg, V., Heelan, L., Heim, S., Heim, T., Heinemann, B., Heinrich, J. J., Heinrich, L., Heinz, C., Hejbal, J., Helary, L., Hellman, S., Helsens, C., Henderson, J., Henderson, R. C. W., Heng, Y., Henkelmann, S., Henriques Correia, A. M., Henrot Versille, S., Herbert, G. H., Hernández Jiménez, Y., Herten, G., Hertenberger, R., Hervas, L., Hesketh, G. G., Hessey, N. P., Hetherly, J. W., Hickling, R., Higón Rodriguez, E., Hill, E., Hill, J. C., Hiller, K. H., Hillier, S. J., Hinchliffe, I., Hines, E., Hinman, R. R., Hirose, M., Hirschbuehl, D., Hobbs, J., Hod, N., Hodgkinson, M. C., Hodgson, P., Hoecker, A., Hoeferkamp, M. R., Hoenig, F., Hohn, D., Holmes, T. R., Homann, M., Hong, T. M., Hooberman, B. H., Hopkins, W. H., Horii, Y., Horton, A. J., Hostachy, J. Y., Hou, S., Hoummada, A., Howarth, J., Hrabovsky, M., Hristova, I., Hrivnac, J., Hryn'Ova, T., Hrynevich, A., Hsu, C., Hsu, P. J., Hsu, S. C., Hu, D., Hu, Q., Hu, S., Huang, Y., Hubacek, Z., Hubaut, F., Huegging, F., Huffman, T. B., Hughes, E. 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- Subjects
Nuclear and High Energy Physics ,High Energy Physics::Phenomenology ,High Energy Physics::Experiment ,Nuclear Experiment ,lcsh:Physics ,lcsh:QC1-999 - Abstract
A search for heavy long-lived charged R-hadrons is reported using a data sample corresponding to 3.2 fb−1 of proton–proton collisions at s=13 TeV collected by the ATLAS experiment at the Large Hadron Collider at CERN. The search is based on observables related to large ionisation losses and slow propagation velocities, which are signatures of heavy charged particles travelling significantly slower than the speed of light. No significant deviations from the expected background are observed. Upper limits at 95% confidence level are provided on the production cross section of long-lived R-hadrons in the mass range from 600 GeV to 2000 GeV and gluino, bottom and top squark masses are excluded up to 1580 GeV, 805 GeV and 890 GeV, respectively.
- Published
- 2016
5. Measurement of the W + W − production cross section in pp collisions at a centre-of-mass energy of s=13 TeV with the ATLAS experiment
- Author
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Aaboud, M., Aad, G., Abbott, B., Abdallah, J., Abdinov, O., Abeloos, B., Aben, R., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abreu, R., Abulaiti, Y., Acharya, B. S., Adachi, S., Adamczyk, L., Adams, D. L., Adelman, J., Adomeit, S., Adye, T., Affolder, A. A., Agatonovic-Jovin, T., Aguilar-Saavedra, J. A., Ahlen, S. P., Ahmadov, F., Aielli, G., Akerstedt, H., Ã…kesson, T. P. A., Akimov, A. V., Alberghi, G. L., Albert, J., Albrand, S., Alconada Verzini, M. J., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexander, G., Alexopoulos, T., Alhroob, M., Ali, B., Aliev, M., Alimonti, G., Alison, J., Alkire, S. P., Allbrooke, B. M. M., Allen, B. W., Allport, P. P., Aloisio, A., Alonso, A., Alonso, F., Alpigiani, C., Alshehri, A. A., Alstaty, M., Alvarez Gonzalez, B., Ãlvarez Piqueras, D., Alviggi, M. G., Amadio, B. T., Amaral Coutinho, Y., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amorim, A., Amoroso, S., Amundsen, G., Anastopoulos, C., Ancu, L. S., Andari, N., Andeen, T., Anders, C. F., Anders, G., Anders, J. K., Anderson, K. J., Andreazza, A., Andrei, V., Angelidakis, S., Angelozzi, I., Angerami, A., Anghinolfi, F., Anisenkov, A. V., Anjos, N., Annovi, A., Antel, C., Antonelli, M., Antonov, A., Antrim, D. J., Anulli, F., Aoki, M., Aperio Bella, L., Arabidze, G., Arai, Y., Araque, J. P., Arce, A. T. H., Arduh, F. A., Arguin, J. -. F., Argyropoulos, S., Arik, M., Armbruster, A. J., Armitage, L. J., Arnaez, O., Arnold, H., Arratia, M., Arslan, O., Artamonov, A., Artoni, G., Artz, S., Asai, S., Asbah, N., Ashkenazi, A., Ã…sman, B., Asquith, L., Assamagan, K., Astalos, R., Atkinson, M., Atlay, N. B., Augsten, K., Avolio, G., Axen, B., Ayoub, M. K., Azuelos, G., Baak, M. A., Baas, A. E., Baca, M. J., Bachacou, H., Bachas, K., Backes, M., Backhaus, M., Bagiacchi, P., Bagnaia, P., Bai, Y., Baines, J. T., Bajic, M., Baker, O. K., Baldin, E. M., Balek, P., Balestri, T., Balli, F., Balunas, W. 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K., Di Donato, C., Di Girolamo, A., Di Girolamo, B., Di Micco, B., Di Nardo, R., Di Simone, A., Di Sipio, R., Di Valentino, D., Diaconu, C., Diamond, M., Dias, F. A., Diaz, M. A., Diehl, E. B., Dietrich, J., DÃez Cornell, S., Dimitrievska, A., Dingfelder, J., Dita, P., Dita, S., Dittus, F., Djama, F., Djobava, T., Djuvsland, J. I., do Vale, M. A. B., Dobos, D., Dobre, M., Doglioni, C., Dolejsi, J., Dolezal, Z., Donadelli, M., Donati, S., Dondero, P., Donini, J., Dopke, J., Doria, A., Dova, M. T., Doyle, A. T., Drechsler, E., Dris, M., Du, Y., Duarte-Campderros, J., Duchovni, E., Duckeck, G., Ducu, O. A., Duda, D., Dudarev, A., Chr Dudder, A., Duffield, E. M., Duflot, L., Dã¼hrssen, M., Dumancic, M., Duncan, A. K., Dunford, M., Duran Yildiz, H., Dã¼ren, M., Durglishvili, A., Duschinger, D., Dutta, B., Dyndal, M., Eckardt, C., Ecker, K. M., Edgar, R. C., Edwards, N. 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M., Hayward, H. S., Haywood, S. J., Head, S. J., Heck, T., Hedberg, V., Heelan, L., Heim, S., Heim, T., Heinemann, B., Heinrich, J. J., Heinrich, L., Heinz, C., Hejbal, J., Helary, L., Hellman, S., Helsens, C., Henderson, J., Henderson, R. C. W., Heng, Y., Henkelmann, S., Henriques Correia, A. M., Henrot-Versille, S., Herbert, G. H., Herde, H., Herget, V., Hernández Jiménez, Y., Herten, G., Hertenberger, R., Hervas, L., Hesketh, G. G., Hessey, N. P., Hetherly, J. W., Higón-Rodriguez, E., Hill, E., Hill, J. C., Hiller, K. H., Hillier, S. J., Hinchliffe, I., Hines, E., Hinman, R. R., Hirose, M., Hirschbuehl, D., Hoad, X., Hobbs, J., Hod, N., Hodgkinson, M. C., Hodgson, P., Hoecker, A., Hoeferkamp, M. R., Hoenig, F., Hohn, D., Holmes, T. R., Homann, M., Honda, T., Hong, T. M., Hooberman, B. H., Hopkins, W. H., Horii, Y., Horton, A. J., Hostachy, J. -. Y., Hou, S., Hoummada, A., Howarth, J., Hoya, J., Hrabovsky, M., Hristova, I., Hrivnac, J., Hryn'Ova, T., Hrynevich, A., Hsu, P. 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Y., Jennens, D., Jenni, P., Jeske, C., Jã©zã©quel, S., Ji, H., Jia, J., Jiang, H., Jiang, Y., Jiang, Z., Jiggins, S., Jimenez Pena, J., Jin, S., Jinaru, A., Jinnouchi, O., Jivan, H., Johansson, P., Johns, K. A., Johnson, W. J., Jon-And, K., Jones, G., Jones, R. W. L., Jones, S., Jones, T. J., Jongmanns, J., Jorge, P. M., Jovicevic, J., Ju, X., Juste Rozas, A., Kã¶hler, M. K., Kaczmarska, A., Kado, M., Kagan, H., Kagan, M., Kahn, S. J., Kaji, T., Kajomovitz, E., Kalderon, C. W., Kaluza, A., Kama, S., Kamenshchikov, A., Kanaya, N., Kaneti, S., Kanjir, L., Kantserov, V. A., Kanzaki, J., Kaplan, B., Kaplan, L. S., Kapliy, A., Kar, D., Karakostas, K., Karamaoun, A., Karastathis, N., Kareem, M. J., Karentzos, E., Karnevskiy, M., Karpov, S. N., Karpova, Z. M., Karthik, K., Kartvelishvili, V., Karyukhin, A. N., Kasahara, K., Kashif, L., Kass, R. D., Kastanas, A., Kataoka, Y., Kato, C., Katre, A., Katzy, J., Kawade, K., Kawagoe, K., Kawamoto, T., Kawamura, G., Kazanin, V. 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Savic, C. Sawyer, L. Sawyer, J. Saxon, C. Sbarra, A. Sbrizzi, T. Scanlon, D.A. Scannicchio, M. Scarcella, V. Scarfone, J. Schaarschmidt, P. Schacht, B.M. Schachtner, D. Schaefer, L. Schaefer, R. Schaefer, J. Schaeffer, S. Schaepe, S. Schaetzel, U. Schäfer, A.C. Schaffer, D. Schaile, R.D. Schamberger, V. Scharf, V.A. Schegelsky, D. Scheirich, M. Schernau, C. Schiavi, S. Schier, C. Schillo, M. Schioppa, S. Schlenker, K.R. Schmidt-Sommerfeld, K. Schmieden, C. Schmitt, S. Schmitt, S. Schmitz, B. Schneider, U. Schnoor, L. Schoeffel, A. Schoening, B.D. Schoenrock, E. Schopf, M. Schott, J.F.P. Schouwenberg, J. Schovancova, S. Schramm, M. Schreyer, N. Schuh, A. Schulte, M.J. Schultens, H.-C. Schultz-Coulon, H. Schulz, M. Schumacher, B.A. Schumm, Ph. Schune, A. Schwartzman, T.A. Schwarz, H. Schweiger, Ph. Schwemling, R. Schwienhorst, J. Schwindling, T. Schwindt, G. Sciolla, F. Scuri, F. Scutti, J. Searcy, P. Seema, S.C. Seidel, A. Seiden, F. Seifert, J.M. Seixas, G. Sekhniaidze, K. Sekhon, S.J. Sekula, D.M. Seliverstov, N. Semprini-Cesari, C. Serfon, L. Serin, L. Serkin, M. Sessa, R. Seuster, H. Severini, T. Sfiligoj, F. Sforza, A. Sfyrla, E. Shabalina, N.W. Shaikh, L.Y. Shan, R. Shang, J.T. Shank, M. Shapiro, P.B. Shatalov, K. Shaw, S.M. Shaw, A. Shcherbakova, C.Y. Shehu, P. Sherwood, L. Shi, S. Shimizu, C.O. Shimmin, M. Shimojima, S. Shirabe, M. Shiyakova, A. Shmeleva, D. Shoaleh Saadi, M.J. Shochet, S. Shojaii, D.R. Shope, S. Shrestha, E. Shulga, M.A. Shupe, P. Sicho, A.M. Sickles, P.E. Sidebo, E. Sideras Haddad, O. Sidiropoulou, D. Sidorov, A. Sidoti, F. Siegert, Dj. Sijacki, J. Silva, S.B. Silverstein, V. Simak, Lj. Simic, S. Simion, E. Simioni, B. Simmons, D. Simon, M. Simon, P. Sinervo, N.B. Sinev, M. Sioli, G. Siragusa, S.Yu. Sivoklokov, J. Sjölin, M.B. Skinner, H.P. Skottowe, P. Skubic, M. Slater, T. Slavicek, M. Slawinska, K. Sliwa, R. Slovak, V. Smakhtin, B.H. Smart, L. Smestad, J. Smiesko, S.Yu. Smirnov, Y. Smirnov, L.N. Smirnova, O. Smirnova, J.W. Smith, M.N.K. Smith, R.W. Smith, M. Smizanska, K. Smolek, A.A. Snesarev, I.M. Snyder, S. Snyder, R. Sobie, F. Socher, A. Soffer, D.A. Soh, G. Sokhrannyi, C.A. Solans Sanchez, M. Solar, E.Yu. Soldatov, U. Soldevila, A.A. Solodkov, A. Soloshenko, O.V. Solovyanov, V. Solovyev, P. Sommer, H. Son, H.Y. Song, A. Sood, A. Sopczak, V. Sopko, V. Sorin, D. Sosa, C.L. Sotiropoulou, R. Soualah, A.M. Soukharev, D. South, B.C. Sowden, S. Spagnolo, M. Spalla, M. Spangenberg, F. Spanò, D. Sperlich, F. Spettel, R. Spighi, G. Spigo, L.A. Spiller, M. Spousta, R.D. St. Denis, A. Stabile, R. Stamen, S. Stamm, E. Stanecka, R.W. Stanek, C. Stanescu, M. Stanescu-Bellu, M.M. Stanitzki, S. Stapnes, E.A. Starchenko, G.H. Stark, J. Stark, P. Staroba, P. Starovoitov, S. Stärz, R. Staszewski, P. Steinberg, B. Stelzer, H.J. Stelzer, O. Stelzer-Chilton, H. Stenzel, G.A. Stewart, J.A. Stillings, M.C. Stockton, M. Stoebe, G. Stoicea, P. Stolte, S. Stonjek, A.R. Stradling, A. Straessner, M.E. Stramaglia, J. Strandberg, S. Strandberg, A. Strandlie, M. Strauss, P. Strizenec, R. Ströhmer, D.M. Strom, R. Stroynowski, A. Strubig, S.A. Stucci, B. Stugu, N.A. Styles, D. Su, J. Su, S. Suchek, Y. Sugaya, M. Suk, V.V. Sulin, S. Sultansoy, T. Sumida, S. Sun, X. Sun, J.E. Sundermann, K. Suruliz, C.J.E. Suster, M.R. Sutton, S. Suzuki, M. Svatos, M. Swiatlowski, S.P. Swift, I. Sykora, T. Sykora, D. Ta, C. Taccini, K. Tackmann, J. Taenzer, A. Taffard, R. Tafirout, N. Taiblum, H. Takai, R. Takashima, T. Takeshita, Y. Takubo, M. Talby, A.A. Talyshev, K.G. Tan, J. Tanaka, M. Tanaka, R. Tanaka, S. Tanaka, R. Tanioka, B.B. Tannenwald, S. Tapia Araya, S. Tapprogge, S. Tarem, G.F. Tartarelli, P. Tas, M. Tasevsky, T. Tashiro, E. Tassi, A. Tavares Delgado, Y. Tayalati, A.C. Taylor, G.N. Taylor, P.T.E. Taylor, W. Taylor, F.A. Teischinger, P. Teixeira-Dias, K.K. Temming, D. Temple, H. Ten Kate, P.K. Teng, J.J. Teoh, F. Tepel, S. Terada, K. Terashi, J. Terron, S. Terzo, M. Testa, R.J. Teuscher, T. Theveneaux-Pelzer, J.P. Thomas, J. Thomas-Wilsker, P.D. Thompson, A.S. Thompson, L.A. Thomsen, E. Thomson, M.J. Tibbetts, R.E. Ticse Torres, V.O. Tikhomirov, Yu.A. Tikhonov, S. Timoshenko, P. Tipton, S. Tisserant, K. Todome, T. Todorov, S. Todorova-Nova, J. Tojo, S. Tokár, K. Tokushuku, E. Tolley, L. Tomlinson, M. Tomoto, L. Tompkins, K. Toms, B. Tong, P. Tornambe, E. Torrence, H. Torres, E. Torró Pastor, J. Toth, F. Touchard, D.R. Tovey, T. Trefzger, A. Tricoli, I.M. Trigger, S. Trincaz-Duvoid, M.F. Tripiana, W. Trischuk, B. Trocmé, A. Trofymov, C. Troncon, M. Trottier-McDonald, M. Trovatelli, L. Truong, M. Trzebinski, A. Trzupek, J.C-L. Tseng, P.V. Tsiareshka, G. Tsipolitis, N. Tsirintanis, S. Tsiskaridze, V. Tsiskaridze, E.G. Tskhadadze, K.M. Tsui, I.I. Tsukerman, V. Tsulaia, S. Tsuno, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, T.T. Tulbure, A.N. Tuna, S.A. Tupputi, S. Turchikhin, D. Turgeman, I. Turk Cakir, R. Turra, P.M. Tuts, G. Ucchielli, I. Ueda, M. Ughetto, F. Ukegawa, G. Unal, A. Undrus, G. Unel, F.C. Ungaro, Y. Unno, C. Unverdorben, J. Urban, P. Urquijo, P. Urrejola, G. Usai, J. Usui, L. Vacavant, V. Vacek, B. Vachon, C. Valderanis, E. Valdes Santurio, N. Valencic, S. Valentinetti, A. Valero, L. Valery, S. Valkar, J.A. Valls Ferrer, W. Van Den Wollenberg, P.C. Van Der Deijl, H. van der Graaf, N. van Eldik, P. van Gemmeren, J. Van Nieuwkoop, I. van Vulpen, M.C. van Woerden, M. Vanadia, W. Vandelli, R. Vanguri, A. Vaniachine, P. Vankov, G. Vardanyan, R. Vari, E.W. Varnes, T. Varol, D. Varouchas, A. Vartapetian, K.E. Varvell, J.G. Vasquez, G.A. Vasquez, F. Vazeille, T. Vazquez Schroeder, J. Veatch, V. Veeraraghavan, L.M. Veloce, F. Veloso, S. Veneziano, A. Ventura, M. Venturi, N. Venturi, A. Venturini, V. Vercesi, M. Verducci, W. Verkerke, J.C. Vermeulen, A. Vest, M.C. Vetterli, O. Viazlo, I. Vichou, T. Vickey, O.E. Vickey Boeriu, G.H.A. Viehhauser, S. Viel, L. Vigani, M. Villa, M. Villaplana Perez, E. Vilucchi, M.G. Vincter, V.B. Vinogradov, C. Vittori, I. Vivarelli, S. Vlachos, M. Vlasak, M. Vogel, P. Vokac, G. Volpi, M. Volpi, H. von der Schmitt, E. von Toerne, V. Vorobel, K. Vorobev, M. Vos, R. Voss, J.H. Vossebeld, N. Vranjes, M. Vranjes Milosavljevic, V. Vrba, M. Vreeswijk, R. Vuillermet, I. Vukotic, P. Wagner, W. Wagner, H. Wahlberg, S. Wahrmund, J. Wakabayashi, J. Walder, R. Walker, W. Walkowiak, V. Wallangen, C. Wang, C. Wang, F. Wang, H. Wang, H. Wang, J. Wang, J. Wang, K. Wang, R. Wang, S.M. Wang, T. Wang, W. Wang, C. Wanotayaroj, A. Warburton, C.P. Ward, D.R. Wardrope, A. Washbrook, P.M. Watkins, A.T. Watson, M.F. Watson, G. Watts, S. Watts, B.M. Waugh, S. Webb, M.S. Weber, S.W. Weber, S.A. Weber, J.S. Webster, A.R. Weidberg, B. Weinert, J. Weingarten, C. Weiser, H. Weits, P.S. Wells, T. Wenaus, T. Wengler, S. Wenig, N. Wermes, M.D. Werner, P. Werner, M. Wessels, J. Wetter, K. Whalen, N.L. Whallon, A.M. Wharton, A. White, M.J. White, R. White, D. Whiteson, F.J. Wickens, W. Wiedenmann, M. Wielers, C. Wiglesworth, L.A.M. Wiik-Fuchs, A. Wildauer, F. Wilk, H.G. Wilkens, H.H. Williams, S. Williams, C. Willis, S. Willocq, J.A. Wilson, I. Wingerter-Seez, F. Winklmeier, O.J. Winston, B.T. Winter, M. Wittgen, T.M.H. Wolf, R. Wolff, M.W. Wolter, H. Wolters, S.D. Worm, B.K. Wosiek, J. Wotschack, M.J. Woudstra, K.W. Wozniak, M. Wu, M. Wu, S.L. Wu, X. Wu, Y. Wu, T.R. Wyatt, B.M. Wynne, S. Xella, Z. Xi, D. Xu, L. Xu, B. Yabsley, S. Yacoob, D. Yamaguchi, Y. Yamaguchi, A. Yamamoto, S. Yamamoto, T. Yamanaka, K. Yamauchi, Y. Yamazaki, Z. Yan, H. Yang, H. Yang, Y. Yang, Z. Yang, W-M. Yao, Y.C. Yap, Y. Yasu, E. Yatsenko, K.H. Yau Wong, J. Ye, S. Ye, I. Yeletskikh, E. Yildirim, K. Yorita, R. Yoshida, K. Yoshihara, C. Young, C.J.S. Young, S. Youssef, D.R. Yu, J. Yu, J.M. Yu, J. Yu, L. Yuan, S.P.Y. Yuen, I. Yusuff, B. Zabinski, G. Zacharis, R. Zaidan, A.M. Zaitsev, N. Zakharchuk, J. Zalieckas, A. Zaman, S. Zambito, L. Zanello, D. Zanzi, C. Zeitnitz, M. Zeman, A. Zemla, J.C. Zeng, Q. Zeng, O. Zenin, T. Ženiš, D. Zerwas, D. Zhang, F. Zhang, G. Zhang, H. Zhang, J. Zhang, L. Zhang, L. Zhang, M. Zhang, R. Zhang, R. Zhang, X. Zhang, Z. Zhang, X. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zhong, B. Zhou, C. Zhou, L. Zhou, L. Zhou, M. Zhou, N. Zhou, C.G. Zhu, H. Zhu, J. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, A. Zibell, D. Zieminska, N.I. Zimine, C. Zimmermann, S. Zimmermann, Z. Zinonos, M. Zinser, M. Ziolkowski, L. Živković, G. Zobernig, A. Zoccoli, M. zur Nedden, L. Zwalinski
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Nuclear and High Energy Physics ,Physics::Instrumentation and Detectors ,High Energy Physics::Phenomenology ,Physics::Accelerator Physics ,High Energy Physics::Experiment ,lcsh:Physics ,lcsh:QC1-999 - Abstract
The production of opposite-charge W-boson pairs in protonâproton collisions at s=13 TeV is measured using data corresponding to 3.16 fbâ1of integrated luminosity collected by the ATLAS detector at the CERN Large Hadron Collider in 2015. Candidate W-boson pairs are selected by identifying their leptonic decays into an electron, a muon and neutrinos. Events with reconstructed jets are not included in the candidate event sample. The cross-section measurement is performed in a fiducial phase space close to the experimental acceptance and is compared to theoretical predictions. Agreement is found between the measurement and the most accurate calculations available.
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- 2017
6. Fossil mollusc-faunas: Their bearing on the Holocene evolution of the Lower Central Plain of Bangkok (Thailand)
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M Negri and Negri, M
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geography ,geography.geographical_feature_category ,Peat ,Holocene ,Coastal plain ,Stratigraphy ,Intertidal zone ,Geology ,Flandrian transgression ,Thailand ,Paleontology ,Mollusca ,Earth-Surface Processe ,Paleoecology ,Flandrian interglacial ,Mangrove ,Transect ,Earth-Surface Processes - Abstract
In this work, fossil molluscan assemblages are analyzed in order to reconstruct the evolution of the Northern Gulf of Thailand during the Holocene. The marine sediments (Bangkok Clay Formation) of the Lower Central Plain of Bangkok and the coastal plain of Phetchaburi were sampled at 16 localities, obtaining fossil shells and mangrove peat whose 14C ages range from 9000 to 2000 CYBP. A statistical treatment of abundance data returned four major groups, namely the Dendostrea rosacea association (intertidal mud), the Corbula fortisulcata-Mactra luzonica association (shallow infralittoral sandy mud), the Nuculana mauritiana-Timoclea scabra association (infralittoral sand spit) and the Timoclea scabra-Arcopagia pudica association (infralittoral mud). The data allowed both a stratigraphic correlation along two transects covering all of the Holocene basin and the creation of digitalized maps showing the presumable extension of the Thai paleogulf around the apex of Flandrian transgression event (about 5500 CYBP). © 2009 Elsevier Ltd. All rights reserved.
- Published
- 2009
7. Effects of bioconversion by Battus polydamas on the chemical composition of Aristolochia spp. and evaluation of antimicrobial activity and biocompatibility.
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do Prado Schneidewind FCC, de Castilho PF, Galvão F, de Andrade Dos Santos JV, da Silva Dantas FG, Negri M, da Silva Pinto L, Moraes CAF, Freitas J, de Souza PRB, Nogueira CR, and de Oliveira KMP
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- Animals, Larva drug effects, Phytochemicals pharmacology, Phytochemicals isolation & purification, Microbial Sensitivity Tests, Humans, Antioxidants pharmacology, Bacillus cereus drug effects, Anti-Infective Agents pharmacology, Anti-Infective Agents chemistry, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Moths drug effects, Aristolochia chemistry, Plant Extracts pharmacology, Plant Extracts chemistry
- Abstract
Aristolochia plants are emblematic from an ethnopharmacological viewpoint and are know to possess numerous biological properties, including antiseptic. However, the medicinal potential of these species is debatable because of their representative chemical constituents, aristolochic acids (AAs) and aristolactams (ALs), which are associated, for instance, with nephropathy and cancer. These contrasting issues have stimulated the development of approaches intended to detoxification of aristoloquiaceous biomasses, among which is included the bioconversion method using larvae of the specialist phytophagous insect Battus polydamas, previously shown to be viable for chemical diversification and to reduce toxicity. Thus, eleven Aristolochia spp. were bioconverted, and the antimicrobial activities of the plant methanolic extracts and its respective bioconversion products were evaluated. The best results were found for Aristolochia esperanzae, Aristolochia gibertii, and Aristolochia ringens against Bacillus cereus, with MIC ranging from 7.8 to 31.25 μg/mL. These three species were selected for chemical, antioxidant, cytotoxic, hemolytic, and mutagenic analyses. Chemical analysis revealed 65 compounds, 21 of them possible bioconversion products. The extracts showed potential to inhibit the formation and degradation of B. cereus biofilms. Extracts of A. gibertii and its bioconverted biomass showed antioxidant activity comparable to dibutylhydroxytoluene (BHT) standard. Bioconversion decreased the hemolytic activity of A. esperanzae and the cytotoxicities of A. esperanzae and A. gibertii. None of the extracts was found to be mutagenic. The bioactivities of the fecal extracts were maintained, and biocompatibility was improved. Therefore, the results obtained in this study reveal positive expectations about the natural detoxification process of the Aristolochia species., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2023. Published by Elsevier B.V.)
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- 2024
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8. Adjunctive corticosteroid treatment for organizing pneumonia in COVID-19 patients with persistent respiratory failure.
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Segala FV, Sgalla G, Salvati F, Berardini L, Negri M, Nardella E, Potenza A, Murri R, and Fantoni M
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- Aged, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Male, Respiratory Insufficiency diagnosis, Respiratory Insufficiency virology, COVID-19 complications, COVID-19 therapy, Dexamethasone administration & dosage, Glucocorticoids administration & dosage, Methylprednisolone administration & dosage, Respiratory Insufficiency drug therapy
- Abstract
Since the beginning of COVID-19 pandemic, clinical, radiological and histopathological features consistent with viral-induced organizing pneumonia (OP) have been reported as hallmark characteristics of the disease. Here, we describe the case of ten patients with severe COVID-19 pneumonia treated with methylprednisolone 1mg/kg for showing clinical and radiological features suggestive of OP at least 20 days after symptom onset and despite standard treatment for COVID-19., (Copyright © 2021 Elsevier Ltd. All rights reserved.)
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- 2021
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9. Influence of shrub willow buffers strategically integrated in an Illinois corn-soybean field on soil health and microbial community composition.
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Zumpf C, Cacho J, Grasse N, Quinn J, Hampton-Marcell J, Armstrong A, Campbell P, Negri MC, and Lee DK
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- Illinois, Soil, Glycine max, Zea mays, Microbiota, Salix
- Abstract
Soil serves many important ecological functions and is an integral part of our existence as a society. However, concerns for soil health are growing globally, in part due to the negative impacts of agricultural management on soil resources. The production of perennial bioenergy crops on marginal land in row-crop production systems is one solution that could improve land-use efficiency and address the sustainability of cropland management. Because the relationship between crop management and the environment is complex, more research is needed to evaluate the potential benefits perennial bioenergy crop production has on soil health, as well as other ecosystem services. In this study, shrub willow buffers were strategically integrated into a corn-soybean cropping system with the main objective of reducing nitrate-N leaching from grain crop production while producing biomass for bioenergy. Two buffer systems (defined by landscape positions) were included for comparison, one on marginal land with exposure to nitrate-N leaching from upslope grain (southern plots) and one on fertile soils with less nitrate-N leaching potential (northern plots). Evaluation of soil (chemistry, bulk density, microbial community) and shrub willow vegetation properties (fine roots, leaf litter decomposition, and nutrient uptake dynamics), showed that landscape position plays an important role in (1) the dynamics of soil chemical properties, (2) shrub willow's influence and productivity, and (3) the provision of additional ecosystem services such as reductions in nitrous oxide emissions and nitrate-N leaching. In addition, the combination of crop type and landscape position (N-grain, N-willow, S-grain, and S-willow) influenced the species composition of the soil microbial community, resulting in unique and identifiable communities. These results highlight the potential application of shrub willow buffers for ecosystem service provision and support of ecosystem processes; however, understanding the relationship between the microbial community, crop type, and landscape is important for understanding the sustainability of the design., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Reference to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by Argonne National Laboratory, the U.S. government, or any agency thereof., (Copyright © 2021 Elsevier B.V. All rights reserved.)
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- 2021
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10. Synthesis, structural characterization, and prospects for new cobalt (II) complexes with thiocarbamoyl-pyrazoline ligands as promising antifungal agents.
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Dias BB, da Silva Dantas FG, Galvão F, Cupozak-Pinheiro WJ, Wender H, Pizzuti L, Rosa PP, Tenório KV, Gatto CC, Negri M, Casagrande GA, and de Oliveira KMP
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- Animals, Biofilms drug effects, Candida glabrata drug effects, Chlorocebus aethiops, Coordination Complexes pharmacology, Crystallography, X-Ray, HeLa Cells, Humans, Ligands, Microbial Sensitivity Tests, Molecular Structure, Spectrum Analysis methods, Vero Cells, Antifungal Agents chemistry, Antifungal Agents pharmacology, Cobalt chemistry, Coordination Complexes chemistry, Pyrazoles chemistry, Thiocarbamates chemistry
- Abstract
Candida spp. cause invasive fungal infections. One species, Candida glabrata, may present intrinsic resistance to conventional antifungal agents, thereby increasing mortality rates in hospitalized patients. In this context, metal complexes present an alternative for the development of new antifungal drugs owing to their biological and pharmacological activities demonstrated in studies in the last decades. Accordingly, in this study we have synthesized and characterized two new Co(II) complexes with thiocarbamoyl-pyrazoline ligands to assess their antimicrobial, mutagenic, and cytotoxic potential. For antimicrobial activity, the broth microdilution method was performed against ATCC strains of Candida spp. and fluconazole dose-dependent isolates of C. glabrata obtained from urine samples. The Ames test was used to assess mutagenic potential. The reduction method of the MTS reagent (3 [4,5-dimethylthiazol-2-yl]-5-[3-carboxymethoxyphenyl]-2-[4-sulfophenyl]-2H-tetrazolium) was performed with HeLa, SiHa, and Vero cells to determine cytotoxicity. Both complexes exhibited fungistatic and fungicidal activity for the yeasts used in the study, demonstrating greater potential for C. glabrata ATCC 2001 and the C. glabrata CG66 isolate with a Minimum Inhibitory Concentration MIC from 3.90 to 7.81 μg mL
-1 and fungicidal action from 7.81 to 15.62 μg mL-1 . The complexes inhibited and degraded biofilms by up to 90% and did not present mutagenic and cytotoxic potential at the concentrations evaluated for MIC. Thus, the complexes examined herein suggest promising alternatives for the development of new antifungal drugs., (Copyright © 2020 Elsevier Inc. All rights reserved.)- Published
- 2020
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11. Diagnosis and management of a fatal case of sepsis caused by Candida parapsilosis sensu stricto in a neonate with omphalocele.
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Santana S, Salci T, Andriato P, Bonfim-Mendonça P, Caparroz-Assef S, Negri M, and Svidzinski T
- Abstract
We present a fatal case of persistent neonatal candidemia by Candida parapsilosis following omphalocele, without other anomalies. Despite an encouraging initial prognosis, after surgical correction and closure of the abdominal wall the case became difficult to treat, as in addition to the exposure of the patient to multiple risk factors for candidemia, antifungal therapy apparently was not adequate.
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- 2018
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12. Mitigation strategies in the agro-food sector: The anaerobic digestion of tomato purée by-products. An Italian case study.
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Bacenetti J, Duca D, Negri M, Fusi A, and Fiala M
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- Anaerobiosis, Food Industry, Agriculture, Solanum lycopersicum, Waste Management methods
- Abstract
Tomato processing involves a significant production of residues, mainly constituted by discarded tomatoes, skins, seeds and pulp. Often, these residues are not valorized and represent an added cost for manufacturing companies because of disposal processes, with environmental issues due to the difficult management. The exploitation of these residual materials results complex as their availability is mainly concentrated in few months. A possible solution is the production of biogas employed in a Combine Heat and Power engine for energy production, in line with the 2020 targets of European Union in terms of promotion of energy from renewable resources and greenhouse gas emission reduction. The tomato by-product utilization for energy production as a strategy to reduce the environmental load of tomato purée was evaluated by means of Life Cycle Assessment. Two scenarios were considered: Baseline Scenario - tomato by-products are sent back to the tomato fields as organic fertilizers; Alternative Scenario - tomato by-products are employed in a nearby biogas plant for energy production. Methane production of tomato by-products was assessed by means of specific laboratory tests. The comparison between the two scenarios highlighted reductions for all the impact categories with the Alternative Scenario. The most important reductions are related to particulate matter (-5.3%), climate change (-6.4%) and ozone depletion (-13.4%). Although small, the reduction of the environmental impact cannot be neglected; for example for climate change, the anaerobic digestion of by-products allows a saving of GHG emissions that, over the whole year, is equal to 1.567 tons of CO2 eq. The results of this study could be up-scaled to the food industries with high heat demand producing considerable amounts of fermentable by-products employable as feedstock for biogas production., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2015
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13. Adhesion of Candida biofilm cells to human epithelial cells and polystyrene after treatment with silver nanoparticles.
- Author
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Monteiro DR, Negri M, Silva S, Gorup LF, de Camargo ER, Oliveira R, Barbosa DB, and Henriques M
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- Candida drug effects, Cell Adhesion drug effects, Cell Survival drug effects, Epithelial Cells drug effects, HeLa Cells, Humans, Microbial Viability drug effects, Biofilms drug effects, Candida cytology, Candida physiology, Epithelial Cells cytology, Metal Nanoparticles chemistry, Polystyrenes pharmacology, Silver pharmacology
- Abstract
This study investigated the adhesion to human epithelial cells and polystyrene surface of viable yeasts recovered from Candida biofilms treated with silver nanoparticles (SN). Biofilm resuspended Candida cells were added to HeLa cells or to empty wells of microtiter plates and the adhesion was verified using crystal violet staining. The adhesion of Candida cells was significantly reduced, mainly when biofilms were pretreated with 54 μg/mL SN. These new findings allow to conclude that SN may induce changes in viable yeasts, which can decrease the dissemination of Candida infections, mainly in susceptible patients., (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Published
- 2014
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14. Sanitation ability of anaerobic digestion performed at different temperature on sewage sludge.
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Scaglia B, D'Imporzano G, Garuti G, Negri M, and Adani F
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- Anaerobiosis, Animals, Colony Count, Microbial, Enterobacteriaceae isolation & purification, Feces microbiology, Hymenolepis cytology, Hymenolepis isolation & purification, Italy, Ovum cytology, Salmonella isolation & purification, Ammonia metabolism, Bioreactors, Methane metabolism, Sewage analysis, Waste Disposal, Fluid methods
- Abstract
A small amount of ammonia is used in full-scale plants to partially sanitize sewage sludge, thereby allowing successive biological processes to enable the high biological stability of the organic matter. Nevertheless, ammonia and methane are both produced during the anaerobic digestion (AD) of sludge. This paper describes the evaluation of a lab-scale study on the ability of anaerobic process to sanitize sewage sludge and produce biogas, thus avoiding the addition of ammonia to sanitize sludge. According to both previous work and a state of the art full-scale plant, ammonia was added to a mixture of sewage sludge at a rate so that the pH values after stirring were 8.5, 9 and 9.5. This procedure determined an ammonia addition lower than that generally indicated in the literature. The same sludge was also subjected to an AD process for 60 days under psychrophilic, mesophilic and thermophilic conditions. The levels of fecal coliform, Salmonella spp. helmints ova, pH, total N, ammonia fractions and biogas production were measured at different times during each process. The results obtained suggested that sludge sanitation can be achieved using an AD process; however, the addition of a small amount of ammonia was not effective in sludge sanitation because the buffer ability of the sludge reduced the pH and thus caused ammonia toxicity. Mesophilic and thermophilic AD sanitized better than psychrophilic AD did, but the total free ammonia concentration under the thermophilic condition inhibited biogas production. The mesophilic condition, however, allowed for both sludge sanitation and significant biogas production., (© 2013.)
- Published
- 2014
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15. Environmental assessment of two different crop systems in terms of biomethane potential production.
- Author
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Bacenetti J, Fusi A, Negri M, Guidetti R, and Fiala M
- Subjects
- Biomass, Italy, Seasons, Triticum growth & development, Zea mays growth & development, Agriculture methods, Environment, Methane metabolism, Renewable Energy, Triticum physiology, Zea mays physiology
- Abstract
The interest in renewable energy sources has gained great importance in Europe due to the need to reduce fossil energy consumption and greenhouse gas emissions, as required by the Renewable Energy Directive (RED) of the European Parliament. The production of energy from energy crops appears to be consistent with RED. The environmental impact related to this kind of energy primarily originates from crop cultivation. This research aimed to evaluate the environmental impact of different crop systems for biomass production: single and double crop. The environmental performances of maize and maize plus wheat were assessed from a life cycle perspective. Two alternative scenarios considering different yields, crop management, and climatic conditions, were also addressed. One normal cubic metre of potential methane was chosen as a functional unit. Methane potential production data were obtained through lab experimental tests. For both of the crop systems, the factors that have the greatest influence on the overall environmental burden are: fertilizer emissions, diesel fuel emissions, diesel fuel production, and pesticide production. Notwithstanding the greater level of methane potential production, the double crop system appears to have the worse environmental performance with respect to its single crop counterpart. This result is due to the bigger quantity of inputs needed for the double crop system. Therefore, the greater amount of biomass (silage) obtained through the double crop system is less than proportional to the environmental burden that results from the bigger quantity of inputs requested for double crop., (© 2013.)
- Published
- 2014
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16. Anaerobic digestion of different feedstocks: impact on energetic and environmental balances of biogas process.
- Author
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Bacenetti J, Negri M, Fiala M, and González-García S
- Subjects
- Anaerobiosis, Animals, Greenhouse Effect prevention & control, Greenhouse Effect statistics & numerical data, Italy, Manure, Power Plants, Silage, Swine, Zea mays, Biofuels, Environment
- Abstract
The possibility of limiting the global warming is strictly linked to the reduction of GHG emissions. Renewable energy both allows reducing emissions and permits to delay fossil fuel depletion. The anaerobic digestion of animal manure and energy crops is a promising way of reducing GHG emissions. In Italy agricultural biogas production was considerably increased; nowadays there are about 520 agricultural biogas plants. The increasing number of biogas plants, especially of those larger than 500 kW(e) (electrical power), involves a high consumption of energy crops, large transport distances of biomass and digestate and difficulties on thermal energy valorization. In this study the energetic (CED) and environmental (GHG emissions) profiles associated with the production of electricity derived from biogas have been identified. Three biogas plants located in Northern Italy have been analyzed. The study has been carried out considering a cradle-to-grave perspective and thus, special attention has been paid on the feedstock production and biogas production process. The influences on the results taking into account different plant sizes and feeding rate has been assessed in detail. Energy analysis was performed using the Cumulative Energy Demand method (CED). The climate change was calculated for a 100-year time frame based on GHG emissions indicated as CO2 equivalents (eq) and defined by the IPCC (2006). In comparison to the fossil reference system, the electricity production using biogas saves GHG emissions from 0.188 to 1.193 kg CO2eq per kWh(e). Electricity supply from biogas can also contribute to a considerable reduction of the use of fossil energy carriers (from -3.97 to 10.08 MJ(fossil) per kWh(e)). The electricity production from biogas has a big potential for energy savings and reduction of GHG emissions. Efficient utilization of the cogenerated heat can substantially improve the GHG balance of electricity production from biogas., (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Published
- 2013
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17. Achieving very low mercury levels in refinery wastewater by membrane filtration.
- Author
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Urgun-Demirtas M, Benda PL, Gillenwater PS, Negri MC, Xiong H, and Snyder SW
- Subjects
- Filtration instrumentation, Filtration methods, Industrial Waste, Membranes, Artificial, Waste Disposal, Fluid instrumentation, Water Purification instrumentation, Water Purification methods, Extraction and Processing Industry, Mercury isolation & purification, Petroleum, Waste Disposal, Fluid methods, Water Pollutants, Chemical isolation & purification
- Abstract
Microfiltration (MF), ultrafiltration (UF), nanofiltration (NF) and reverse osmosis (RO) membranes were evaluated for their ability to achieve the world's most stringent Hg discharge criterion (<1.3ng/L) in an oil refinery's wastewater. The membrane processes were operated at three different pressures to demonstrate the potential for each membrane technology to achieve the targeted effluent mercury concentrations. The presence of mercury in the particulate form in the refinery wastewater makes the use of MF and UF membrane technologies more attractive in achieving very low mercury levels in the treated wastewater. Both NF and RO were also able to meet the target mercury concentration at lower operating pressures (20.7bar). However, higher operating pressures (≥34.5bar) had a significant effect on NF and RO flux and fouling rates, as well as on permeate quality. SEM images of the membranes showed that pore blockage and narrowing were the dominant fouling mechanisms for the MF membrane while surface coverage was the dominant fouling mechanism for the other membranes. The correlation between mercury concentration and particle size distribution was also investigated to understand mercury removal mechanisms by membrane filtration. The mean particle diameter decreased with filtration from 1.1±0.0μm to 0.74±0.2μm after UF., (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Published
- 2012
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18. Rituximab and subcutaneous 2-chloro-2'-deoxyadenosine as therapy in untreated and relapsed Waldenström's macroglobulinemia.
- Author
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Laszlo D, Andreola G, Rigacci L, Fabbri A, Rabascio C, Pinto A, Negri M, and Martinelli G
- Subjects
- Adult, Aged, Antibodies, Monoclonal, Murine-Derived administration & dosage, Antineoplastic Combined Chemotherapy Protocols adverse effects, Cladribine administration & dosage, Drug Administration Schedule, Female, Humans, Injections, Subcutaneous, Male, Middle Aged, Prospective Studies, Recurrence, Rituximab, Treatment Outcome, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Waldenstrom Macroglobulinemia drug therapy
- Abstract
With the aim to assess the efficacy of subcutaneous cladribine in combination with rituximab, 29 newly diagnosed/pretreated WM patients were enrolled in a multicenter phase II trial. Intended therapy consisted of rituximab on day 1 followed by s.c. cladribine 0.1 mg/kg for 5 consecutive days, administered monthly for 4 cycles. The expression of genes involved in cladribine metabolism was evaluated. With a median follow-up of 50 months the ORR rate observed was 89.6% without any difference between newly or pretreated patients (P=.522). The therapy was well tolerated; no major infections were observed, no patients developed transformation to high-grade NHL nor myelodysplasia. Low expression levels of hCNT1 correlated with the failure to achieve a CR (P=.024). The combination of rituximab/cladribine is safe and effective in WM patients requiring treatment. The pharmacogenomic analysis suggests that hCNT1 might be beneficial in predicting clinical response to such a combination treatment.
- Published
- 2011
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19. Groundwater remediation by an in situ biobarrier: a bench scale feasibility test for methyl tert-butyl ether and other gasoline compounds.
- Author
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Saponaro S, Negri M, Sezenna E, Bonomo L, and Sorlini C
- Subjects
- Aerobiosis, Benzene metabolism, Benzene Derivatives metabolism, Feasibility Studies, Methyl Ethers metabolism, Toluene metabolism, Xylenes metabolism, Biodegradation, Environmental, Gasoline microbiology, Water Pollutants, Chemical metabolism
- Abstract
Most gasoline contains high percentages of methyl tert-butyl ether (MTBE) as an additive. The physico-chemical properties of this substance (high water solubility, low sorption in soil) result in high mobility and dissolved concentrations in soil. In situ permeable biological barriers (biobarriers, BBs) can remediate MTBE polluted groundwater by allowing pure cultures or microbial consortia to degrade MTBE when aerobic conditions are present, either by direct metabolism or cometabolism. Lab-scale batch and column tests were carried out to assess a selected microbial consortium in biodegrading MTBE and other gasoline compounds (benzene B, toluene T, ethylbenzene E, xylenes X) and to measure the parameters affecting the efficacy of a BB treatment of polluted groundwater. During the aerobic phase of the batch tests, the simultaneous biodegradation of MTBE, tert-butyl alcohol (TBA), B, T, E and o-X was observed. The rapid biodegradation of BTEXs resulted in decreased oxygen availability, but MTBE degradation was nevertheless measured in the presence of BTEXs. Stationary concentrations of MTBE and TBA were measured when anoxic conditions occurred in the systems. Values for a first order kinetic removal process were obtained for MTBE (0.031+/-0.001 d(-1)), B (0.045+/-0.002 d(-1)) and T (0.080+/-0.004 d(-1)) in the inoculated column tests. The estimate of the BB design parameters suggested that inoculation could significantly modify (double) the longitudinal dispersivity value of the biomass support medium. No effect was observed in the retardation factors for MTBE, B and T.
- Published
- 2009
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20. Resecting the great saphenous stump with endothelial inversion decreases neither neovascularization nor thigh varicosity recurrence.
- Author
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Heim D, Negri M, Schlegel U, and De Maeseneer M
- Subjects
- Adult, Female, Femoral Vein diagnostic imaging, Humans, Male, Middle Aged, Neovascularization, Pathologic diagnostic imaging, Neovascularization, Pathologic etiology, Prospective Studies, Recurrence, Saphenous Vein diagnostic imaging, Severity of Illness Index, Suture Techniques, Time Factors, Treatment Outcome, Ultrasonography, Doppler, Duplex, Varicose Veins diagnostic imaging, Vascular Surgical Procedures adverse effects, Endothelium, Vascular surgery, Femoral Vein surgery, Groin blood supply, Saphenous Vein surgery, Thigh blood supply, Varicose Veins surgery, Vascular Surgical Procedures methods
- Abstract
Background: Neovascularization at the saphenofemoral junction is one of the principal causes of recurrent varicose veins after great saphenous vein surgery. Because angiogenic stimulation from the exposed endothelium of the great saphenous vein stump is considered an important trigger for this process, we hypothesized that complete resection of the stump with endothelial inversion might lessen grade 2 groin neovascularization and thereby decrease recurrence of thigh varicosities., Methods: Two groups of consecutive patients with primary varicose veins of the great saphenous vein were studied. Group A was a historical control group of 70 limbs (48 patients) in which conventional flush ligation was performed at the level of the saphenofemoral junction. Group B was a prospectively studied clinical trial cohort of 65 limbs (45 patients), wherein the great saphenous vein stump was completely resected using a side-biting clamp to isolate the saphenofemoral junction, and the resulting common femoral vein venotomy was closed with a running inverting suture. Early postoperative follow-up was performed at 6 weeks. Clinical examinations and duplex ultrasound scans were performed after 2 years of follow-up. Grade 2 groin neovascularization was defined by the presence of >3 mm tortuous new refluxing veins, typically communicating with recurrent varicosities in the thigh., Results: After 2 years, recurrent varicose veins were present in the thighs of 13 of 65 limbs (20%) in group A and in 22 of 61 limbs (36%) of group B (P = .049). Grade 2 neovascularization was present at the saphenofemoral junction in six of 65 limbs (9%) of group A and in 12 of 61 limbs (20%) of group B (P = .127)., Conclusion: Complete resection of the great saphenous vein stump and inversion suturing of the common femoral vein venotomy, instead of simple flush ligation at the level of the saphenofemoral junction, do not appear to decrease grade 2 neovascularization and related thigh varicosity recurrence after great saphenous vein stripping for primary varicose veins.
- Published
- 2008
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21. Interrelations between fat distribution, muscle lipid content, adipocytokines, and insulin resistance: effect of moderate weight loss in older women.
- Author
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Mazzali G, Di Francesco V, Zoico E, Fantin F, Zamboni G, Benati C, Bambara V, Negri M, Bosello O, and Zamboni M
- Subjects
- Abdominal Fat anatomy & histology, Abdominal Fat metabolism, Absorptiometry, Photon methods, Adiponectin blood, Adipose Tissue metabolism, Aged, Aged, 80 and over, C-Reactive Protein metabolism, Female, Humans, Leptin blood, Middle Aged, Muscle, Skeletal anatomy & histology, Obesity blood, Obesity physiopathology, Waist-Hip Ratio, Adipose Tissue anatomy & histology, Body Composition physiology, Insulin Resistance, Lipids analysis, Muscle, Skeletal chemistry, Weight Loss physiology
- Abstract
Background: Interrelations between fat distribution, muscle lipid infiltration, adipocytokines, insulin resistance, and moderate weight loss have not been investigated in obese older subjects., Objective: The objective was to evaluate relations between fat distribution, muscle lipid content, adipocytokines, and insulin resistance in older women and the effects of moderate weight loss., Design: In 35 healthy women aged 58-83 y, body mass index, waist circumference, sagittal abdominal diameter (SAD), and body composition measured by dual-energy X-ray absorptiometry were evaluated. A midthigh single computed tomography scan was performed to determine subcutaneous adipose tissue (AT), intermuscular AT (IAT), muscular tissue, and muscle lipid infiltration, evaluated as low-density lean tissue. Metabolic variables, insulin resistance measured by homeostasis model assessment, adiponectin, leptin, and high-sensitivity C-reactive protein were measured in all subjects and after weight loss in a subgroup of 15 obese women., Results: Waist circumference and SAD were positively correlated with leptin and insulin resistance and negatively correlated with adiponectin. Adiponectin was associated negatively with insulin resistance and positively with HDL cholesterol, whereas leptin was positively associated with insulin resistance and triacylglycerols. Midthigh subcutaneous AT was associated with insulin resistance and leptin, whereas IAT was associated with triacylglycerols. Stepwise regression with insulin resistance as the dependent variable and body mass index, SAD, triacylglycerols, HDL cholesterol, adiponectin, leptin, high-sensitivity C-reactive protein, and midthigh subcutaneous AT as independent variables showed that SAD entered the regression first (R(2) = 0.492) followed by adiponectin (R(2) = 0.63). After moderate weight loss, midthigh subcutaneous AT, IAT, low-density lean tissue, leptin, and insulin resistance decreased significantly; no significant changes in adiponectin were observed., Conclusions: Fat distribution indexes and adiponectin are independently associated with insulin resistance. Even in older women, moderate weight loss improves body fat distribution, muscle lipid infiltration, and insulin resistance. Moderate weight loss results in a significant decrease in leptin but no changes in adiponectin.
- Published
- 2006
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22. Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase.
- Author
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Tondi D, Powers RA, Caselli E, Negri MC, Blázquez J, Costi MP, and Shoichet BK
- Subjects
- Combinatorial Chemistry Techniques, Crystallography, X-Ray, Drug Design, Enzyme Inhibitors chemical synthesis, Enzyme Inhibitors pharmacology, Molecular Structure, beta-Lactamases chemistry, Bacterial Proteins, Enzyme Inhibitors chemistry, beta-Lactamase Inhibitors
- Abstract
Background: Group I beta-lactamases are a major cause of antibiotic resistance to beta-lactams such as penicillins and cephalosporins. These enzymes are only modestly affected by classic beta-lactam-based inhibitors, such as clavulanic acid. Conversely, small arylboronic acids inhibit these enzymes at sub-micromolar concentrations. Structural studies suggest these inhibitors bind to a well-defined cleft in the group I beta-lactamase AmpC; this cleft binds the ubiquitous R1 side chain of beta-lactams. Intriguingly, much of this cleft is left unoccupied by the small arylboronic acids., Results: To investigate if larger boronic acids might take advantage of this cleft, structure-guided in-parallel synthesis was used to explore new inhibitors of AmpC. Twenty-eight derivatives of the lead compound, 3-aminophenylboronic acid, led to an inhibitor with 80-fold better binding (2; K(i) 83 nM). Molecular docking suggested orientations for this compound in the R1 cleft. Based on the docking results, 12 derivatives of 2 were synthesized, leading to inhibitors with K(i) values of 60 nM and with improved solubility. Several of these inhibitors reversed the resistance of nosocomial Gram-positive bacteria, though they showed little activity against Gram-negative bacteria. The X-ray crystal structure of compound 2 in complex with AmpC was subsequently determined to 2.1 A resolution. The placement of the proximal two-thirds of the inhibitor in the experimental structure corresponds with the docked structure, but a bond rotation leads to a distinctly different placement of the distal part of the inhibitor. In the experimental structure, the inhibitor interacts with conserved residues in the R1 cleft whose role in recognition has not been previously explored., Conclusions: Combining structure-based design with in-parallel synthesis allowed for the rapid exploration of inhibitor functionality in the R1 cleft of AmpC. The resulting inhibitors differ considerably from beta-lactams but nevertheless inhibit the enzyme well. The crystal structure of 2 (K(i) 83 nM) in complex with AmpC may guide exploration of a highly conserved, largely unexplored cleft, providing a template for further design against AmpC beta-lactamase.
- Published
- 2001
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23. High serum levels of secretory immunoglobullin A in chronic pancreatitis.
- Author
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Frulloni L, Negri M, Brunelli S, Bovo P, Vaona B, Calore B, Liani C, Di Francesco V, and Cavallini G
- Subjects
- Adult, Alanine Transaminase blood, Biomarkers analysis, Chronic Disease, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Severity of Illness Index, gamma-Glutamyltransferase blood, Immunoglobulin A analysis, Pancreatitis physiopathology
- Abstract
Background and Aim: Elevated levels of secretory immunoglobulin A have been reported in patients with cholestatic hepatitis. Secretory immunoglobulin A is present in the biliary and pancreatic tract. Chronic pancreatitis is a disease characterized by dilatation of Wirsung's duct. The aim of the study was to evaluate secretory immunoglobulin A levels in patients suffering from chronic pancreatitis., Patients and Methods: The study population consisted of 66 consecutive chronic pancreatitis patients (55 male, 11 female; mean age 49.6+/-10 years), 26 patients suffering from acute recurrent pancreatitis (9 males, 17 females; mean age 39.6+/-10.6 years) and 90 healthy controls, pair-matched for sex and age with the chronic pancreatitis patients. Secretory immunoglobulin A was determined by enzyme-linked immunosorbent assay, as were serum alanine transaminase and GGT., Results: Secretory immunoglobulin A levels were significantly higher in chronic pancreatitis patients (35+/-23.7 mg/l) than in those acute recurrent pancreatitis group (16.1+/- 7.9) and in healthy controls (11.8+/-4.9 mg/l) (p<0.0001). Secretory immunoglobulin A was significantly higher in chronic pancreatitis patients with steatorrhoea, diabetes and calcifications and in those undergoing pancreatic surgery. Of 61 chronic pancreatitis patients, 14 (23%) had pathological GGT. When only chronic pancreatitis patients with normal GGT levels were analysed, the differences in secretory immunoglobulin A levels between groups of patients and between chronic pancreatitis subgroups remained statistically significant., Conclusions: This study demonstrates that secretory immunoglobulin A is elevated in chronic pancreatitis. Its value in the staging of patients needs to be further evaluated.
- Published
- 2000
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- View/download PDF
24. Perspectives of oral cephalosporins in upper respiratory tract infections.
- Author
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Negri MC, Morosini MI, Loza E, and Baquero F
- Subjects
- Administration, Oral, Child, Haemophilus influenzae type b drug effects, Humans, Moraxella catarrhalis drug effects, Otitis Media drug therapy, Penicillins administration & dosage, Penicillins therapeutic use, Streptococcus pyogenes drug effects, Cephalosporins administration & dosage, Haemophilus Infections drug therapy, Neisseriaceae Infections drug therapy, Respiratory Tract Infections drug therapy, Streptococcal Infections drug therapy
- Published
- 2000
- Full Text
- View/download PDF
25. Antibiotic resistance in hospital infections: the role of newer cephalosporins.
- Author
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Negri MC, Morosini MI, Blázquez J, and Baquero F
- Subjects
- Cefepime, Ceftazidime therapeutic use, Cephalosporins therapeutic use, Cross Infection microbiology, Humans, beta-Lactamases biosynthesis, beta-Lactamases physiology, Ceftazidime pharmacokinetics, Cephalosporins pharmacokinetics, Cross Infection drug therapy, beta-Lactam Resistance
- Published
- 2000
- Full Text
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26. Modulation of sleep interictal epileptiform discharges in partial epilepsy of childhood.
- Author
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Nobili L, Baglietto MG, Beelke M, De Carli F, De Negri E, Rosadini G, De Negri M, and Ferrillo F
- Subjects
- Brain physiopathology, Child, Child, Preschool, Electroencephalography, Female, Humans, Male, Polysomnography, Sleep physiology, Epilepsies, Partial physiopathology
- Abstract
Objective: NREM sleep increases the Interictal Epileptic Discharges (IEDs) in the majority of children affected by partial epilepsy (both symptomatic or cryptogenetic). Experimental data revealed that the normal sleep oscillations, leading to the appearance of spindles and delta waves on the surface EEG during NREM sleep, might develop into paroxysmal synchronization. Spectral analysis enables the quantitative description of the dynamics of delta (slow wave activity, SWA, 0,5-4,5 Hz) and sigma activity (SA, 12.0-16.0 Hz) and can be used to assess the relationship between SA, SWA and IEDs during sleep., Design and Methods: We have performed overnight continuous EEG-polysomnographic studies in 7 patients (mean age 7.2+/-1.3). The temporal series of SWA and SA were obtained from a spike-free derivation lead. The IEDs count was performed on the most active lead. Relationships between sigma and SWA and time series of IEDs were tested by means of correlation techniques after data normalization., Results: Our results revealed a significant higher correlation between IEDs and SA with respect to SWA in all the subjects, in total sleep time. The same analysis limited to NREM sleep highlights the better correlation between SA and IEDs., Conclusions: Our data suggest that the neural mechanisms involved in the generation of sleep spindles facilitate the IEDs production in childhood partial epilepsies at least in those strongly activated by sleep.
- Published
- 1999
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27. Selective removal of plutonium 238 from a canal sediment using a carbonate-chelant soil washing technology (ACT*DE*CON).
- Author
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Negri MC, Swift NA, Carfagno D, Neff RA, and North J
- Subjects
- Decontamination economics, Hazardous Waste, Humans, Ohio, Reproducibility of Results, Water Purification economics, Carbonates chemistry, Chelating Agents chemistry, Decontamination methods, Plutonium chemistry, Soil Pollutants, Radioactive analysis, Water Pollutants, Radioactive analysis, Water Purification methods
- Abstract
The Mound laboratory site in Miamisburg, OH, a former plutonium processing facility, contains approximately 40000 yd(3) (30,580 m3) of plutonium- and thorium-contaminated soils and sediments at levels that require remediation. Existing applicable remediation technologies are unsatisfactory, because they are expensive and do not provide volume reduction. ACT*DE*CON is a chemical soil leaching technology for the treatment of soils that utilizes contaminant dissolution via dilute selective solutions to remove radionuclides. In bench-scale tests, process parameters were developed for the optimal treatment of the Miami Erie Canal soil at the Mound site, combining the maximum plutonium removal with an acceptable amount of soil dissolution and minimizing the costs of reagents. Parameters evaluated included soil to extractant mass ratio, temperature, rinse solution composition, kinetics, and the application of several dewatering aids. Plutonium removal rates of >95% were achieved, and the residual plutonium in the treated soil proved to be very immobile-confirming that the process had removed the most accessible species of the radionuclide. Currently being tested at Mound is an engineering scale-up that includes an attrition scrubber, a counter-current extractor, and a reverse osmosis system. Economic evaluations based on bench-scale results put the treatment cost at US$278/yd(3) (US$364/m3), compared to US$350/yd(3) (US$458/m3) for the 'box-and-bury' baseline alternative treatment system., (Copyright 1999 Published by Elsevier Science B.V.)
- Published
- 1999
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- View/download PDF
28. A quantified analysis of sleep electroencephalography in anorectic adolescents.
- Author
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Nobili L, Baglietto MG, De Carli F, Savoini M, Schiavi G, Zanotto E, Ferrillo F, and De Negri M
- Subjects
- Adolescent, Female, Humans, Polysomnography methods, Anorexia Nervosa psychology, Electroencephalography, Sleep, REM physiology
- Abstract
Background: Previous studies on sleep characteristics in anorexia nervosa have led to controversial results. This may be due to either the heterogeneity of the samples studied or to an intrinsic inadequacy of the scoring criteria. To obtain a more detailed analysis we have investigated sleep characteristics in a group of adolescents affected by anorexia nervosa using spectral analysis techniques., Methods: After a baseline night, the sleep-electroencephalograms of 10 adolescent anorectic girls (age +/- SD = 14 +/- 2 years) and 10 age-matched control subjects were recorded and processed by a fast Fourier transformation routine., Results: Anorectics showed an increased number of awakenings and wakefulness after sleep onset and a reduction of sleep efficiency and slow-wave sleep. Spectral analysis results revealed a significant reduction in the power spectral values of slow-wave activity (SWA; 0.5-4.5 Hz) band in all NREM-REM cycles of sleep and in the undisturbed and stable stage 4. Moreover the anorectic group was characterized by a concentration of SWA in the first NREM-REM cycle with an abrupt decay in the second part of the night. A positive correlation (r2 = .58, p < .01) between body mass index and the amount of SWA was found., Conclusions: Sleep of anorectic patients seems to be characterized by a weakness of SWA producing mechanisms. The positive correlation between body mass index and the amount of SWA appears to be consistent with the neurobiological consequences of the malnutrition state.
- Published
- 1999
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29. Relationship of sleep interictal epileptiform discharges to sigma activity (12-16 Hz) in benign epilepsy of childhood with rolandic spikes.
- Author
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Nobili L, Ferrillo F, Baglietto MG, Beelke M, De Carli F, De Negri E, Schiavi G, Rosadini G, and De Negri M
- Subjects
- Child, Child, Preschool, Electroencephalography, Female, Humans, Male, Time Factors, Brain physiopathology, Epilepsy physiopathology, Sleep physiology
- Abstract
Objective: The activation of interictal epileptic discharges (IEDs) by NREM sleep is a well-known phenomenon in benign epilepsy of childhood with rolandic spikes (BECRS). The activating properties of NREM sleep on IEDs have been attributed to increased synchronization within thalamocortical neurons. During NREM sleep two synchronizing mechanisms lead to the appearance of spindles and delta waves on the EEG. Spectral analysis technique is a suitable method that can be used to quantitatively describe the dynamics of delta (slow wave activity (SWA) 0.5-4.0 Hz) and sigma activity (12.0-16.0 Hz) during sleep., Methods: In order to define more accurately the relationship between synchronizing mechanisms (spindles and delta activities) and IEDs during sleep in BECRS, we have performed overnight continuous EEG polysomnography studies in 9 patients (mean age 7.4 +/- 2.5 years). The temporal series of SWA and sigma values, derived from spectral analysis, have been obtained from a spike-free derivation lead. The IEDs count has been performed on the most active lead. Relationships between sigma and SWA and time series of IEDs were tested by means of correlation techniques after data normalization., Results: Our results revealed a significant higher correlation between IEDs and sigma activity with respect to SWA in all the subjects, in total sleep time. The same analysis limited to NREM sleep highlights the better correlation between sigma and IEDs., Conclusions: Data suggest that during sleep of BECRS patients, IEDs are more sensitive to the promoting action of the spindle-generating mechanism than to the SWA-producing one.
- Published
- 1999
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- View/download PDF
30. Benzodiazepine (BDZ) treatment of benign childhood epilepsy with centrotemporal spikes (BECCT)
- Author
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De Negri M, Baglietto MG, and Gaggero R
- Subjects
- Anticonvulsants administration & dosage, Child, Clonazepam administration & dosage, Electroencephalography, Epilepsy physiopathology, GABA Modulators administration & dosage, Humans, Anticonvulsants therapeutic use, Clonazepam therapeutic use, Epilepsy drug therapy, GABA Modulators therapeutic use
- Published
- 1997
31. Electrical status epilepticus during sleep (ESES). Different clinical syndromes: towards a unifying view?
- Author
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De Negri M
- Subjects
- Child, Electrophysiology, Humans, Sleep physiology, Status Epilepticus physiopathology
- Abstract
'Electrical status epilepticus during sleep' (ESES) is a typical childhood process of generalization of paroxysmal activity. Notwithstanding a number of intermediate forms, three syndromes included in the 1989 ILAE classification can be considered as prototypes: the 'continuous spike-waves during sleep' (CSWS syndrome), the 'acquired aphasia with convulsive disorder in children' (L-Kl syndrome) and the 'benign epilepsy of childhood with rolandic spikes' (BECRS), which can be considered as the benign end of the spectrum. The pathognomonic clinical and EEG features of these conditions are described. They can probably be considered, in a unifying view, to be based on a common pathogenetic factor. They are associated with neuropsychological and/or mental disturbances with differences probably due to the idiopathic or symptomatic origin of the underlying epileptic condition, the cortical area of the primary focal paroxysmal activity, the patient's age and the severity and duration of the paroxysmal dysfunction. Possible hypotheses on the physiopathogeneses of ESES and correlated neuropsychological disorders are summarized. Short cycles (3-4 weeks) of relatively high daily doses of diazepam (DZP) (0.5 mg/kg body weight) following a rectal DZP bolus of 1 mg/kg b.w. seem to be effective in the majority of ESES conditions. The somewhat underestimated problem of neuropsychological disorders correlated with ESES in BECRS is also considered.
- Published
- 1997
32. Sequential use of G-CSF and GM-CSF after heart-lung transplantation.
- Author
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Ippoliti G, Negri M, Rovati B, Grossi P, and Viganó M
- Subjects
- Bone Marrow drug effects, Female, Humans, Leukocyte Count drug effects, Middle Aged, Neutropenia immunology, Opportunistic Infections immunology, Granulocyte Colony-Stimulating Factor administration & dosage, Granulocyte-Macrophage Colony-Stimulating Factor administration & dosage, Heart-Lung Transplantation immunology, Neutropenia therapy, Opportunistic Infections therapy
- Published
- 1997
33. Occlusion of unilateral carotid artery in Down syndrome.
- Author
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Gaggero R, Donati PT, Curia R, and De Negri M
- Subjects
- Angiography, Arterial Occlusive Diseases diagnosis, Brain blood supply, Cerebrovascular Disorders complications, Child, Diagnosis, Differential, Down Syndrome pathology, Humans, Moyamoya Disease diagnosis, Arterial Occlusive Diseases complications, Carotid Arteries pathology, Carotid Artery Diseases complications, Down Syndrome complications
- Abstract
The association between moyamoya phenomena and Down syndrome (DS) is reported in the literature. This paper reports a case of DS, which at age 9 presented right hemiparesis, secondary to the occlusion of the left internal carotid artery; cerebral angiography (CAG) showed a collateral circulation that mimicks the moyamoya phenomenon. Clinical recovery was almost complete; a second CAG after 15 months showed a persistent occlusion of the left internal carotid artery and an opacification of the left middle cerebral artery from abnormal vessels; but the collateral circulation is not enhanced. This case proves that in DS cerebrovascular occlusions may present moyamoya-like phenomena. These differ however from the true moyamoya disease in a number of aspects: the arterial occlusion is unilateral, the evolution is favorable and revascularization does not occur through the peculiar abnormal vessels of the moyamoya syndrome.
- Published
- 1996
- Full Text
- View/download PDF
34. Treatment of electrical status epilepticus by short diazepam (DZP) cycles after DZP rectal bolus test.
- Author
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De Negri M, Baglietto MG, Battaglia FM, Gaggero R, Pessagno A, and Recanati L
- Subjects
- Administration, Oral, Adolescent, Age Factors, Anticonvulsants administration & dosage, Child, Child, Preschool, Diazepam administration & dosage, Electroencephalography, Electrophysiology, Female, Humans, Infant, Male, Status Epilepticus psychology, Suppositories, Anticonvulsants therapeutic use, Diazepam therapeutic use, Status Epilepticus diagnosis, Status Epilepticus drug therapy
- Abstract
The effects of rapid rectal diazepam introduction (DZP test) were investigated in 43 patients (age range 5 months-14 years) with electrical status epilepticus (ESE) undergoing EEG monitoring. A remission of the paroxysmal activity was obtained in 58% of cases, a negative response in 42%, particularly in hypsarrhythmic patterns. DZP test responders were aged over 12 months with organized paroxysmal EEG patterns, in particular with ESE during sleep (ESES). The patients who responded to the DZP test underwent short cycles (3-4 weeks) of relatively high dosage DZP (0.5-0.75 mg/kg). The response to treatment was positive in 64%, particularly in ESES conditions. 56% of responders to the DZP test but not to DZP therapy (five out of nine patients) presented a significant mental retardation; maturational factors were also likely to be present.
- Published
- 1995
- Full Text
- View/download PDF
35. Hyperkinetic behaviour, attention deficit disorder, conduct disorder and instabilité psychomotrice: identity, analogies, and misunderstandings. Commentary to Gordon's paper (Brain Dev 1994; 15: 169-72).
- Author
-
De Negri M
- Subjects
- Attention Deficit Disorder with Hyperactivity physiopathology, Attention Deficit Disorder with Hyperactivity psychology, Child, France, Humans, Motor Activity, Posture, Terminology as Topic, Attention Deficit Disorder with Hyperactivity classification
- Abstract
'Hyperkinetic behaviour', 'attention deficit disorder' and 'conduct disorder' with antisocial aspects or delinquency are concepts frequently superimposed. They can be traced back to the classic nosological entity, 'instabilité psychomotrice', still used in French psychiatric nosography. In this paper, the different components of the condition are analyzed (emotional, attentional, posturo-motoric and behavioural) both in normal subjects and in cases of mild encephalopathies, and for different age groups. A criticism is advanced towards the undifferentiated approach to the problem in the most current literature.
- Published
- 1995
- Full Text
- View/download PDF
36. A simple method for the evaluation of receptor binding capacity of modified cytokines.
- Author
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Chianelli M, Signore A, Hicks R, Testi R, Negri M, and Beverley PC
- Subjects
- Antibodies, Monoclonal metabolism, Binding, Competitive, Evaluation Studies as Topic, Flow Cytometry, Fluorescein-5-isothiocyanate pharmacology, Fluorescence, Humans, Interleukin-2 metabolism, Kinetics, Leukocytes, Mononuclear drug effects, Leukocytes, Mononuclear metabolism, Leukocytes, Mononuclear ultrastructure, Methods, Phytohemagglutinins pharmacology, Stimulation, Chemical, Cytokines metabolism, Receptors, Interleukin-2 metabolism
- Abstract
We have developed a flow cytometric method to evaluate the binding of interleukin-2 analogues to receptors. The method relies on competition for binding between a fluorescein-conjugated monoclonal antibody (MoAb) directed against the human interleukin-2 receptor alpha chain (fluorescein isothiocyanate (FITC) anti-IL-2R) and the test protein. IL-2R positive cells are incubated with FITC-anti-IL-2R MoAb in the presence of native IL-2 or IL-2 iodinated by either the chloramine-T or the lactoperoxidase-glucose-oxidase method. The binding of IL-2 is indicated by decreased fluorescence. This method is suitable for measuring the binding capacity of modified IL-2 molecules and avoids the need for radioactive tracers. It provides a simple and reproducible technique, which can be extended readily to the study of the receptor binding capacity of cytokines conjugated with toxins, drugs or other molecules.
- Published
- 1993
- Full Text
- View/download PDF
37. Cognitive impairment and epilepsy.
- Author
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De Negri M and Baglietto MG
- Subjects
- Child, Electroencephalography, Humans, Cognition Disorders complications, Epilepsy complications
- Published
- 1993
- Full Text
- View/download PDF
38. Italian Society of Child Neuropsychiatry.
- Author
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De Negri M
- Subjects
- Child Psychiatry, Italy, Neurology, Pediatrics, Societies, Medical
- Published
- 1993
- Full Text
- View/download PDF
39. Electrical status epilepticus in childhood: treatment with short cycles of high dosage benzodiazepine (preliminary note).
- Author
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De Negri M, Baglietto MG, and Biancheri R
- Subjects
- Adolescent, Benzodiazepines blood, Benzodiazepines therapeutic use, Child, Child, Preschool, Diazepam, Dose-Response Relationship, Drug, Female, Humans, Male, Status Epilepticus diagnosis, Benzodiazepines administration & dosage, Electroencephalography, Status Epilepticus drug therapy, Status Epilepticus physiopathology
- Abstract
A treatment of electrical status epilepticus during childhood with relatively high doses of benzodiazepines (BZ) in short cycles (3 weeks) is proposed for subjects shown to be responsive to BZs (diazepam bolus test: DZP test). This treatment gave positive results in 7 out of 8 patients responsive to the DZP test (87%).
- Published
- 1993
- Full Text
- View/download PDF
40. Developmental dysphasias, epilepsy, and Landau-Kleffner syndrome.
- Author
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De Negri M
- Subjects
- Child, Preschool, Humans, Syndrome, Aphasia physiopathology, Developmental Disabilities physiopathology, Epilepsy physiopathology
- Published
- 1993
- Full Text
- View/download PDF
41. Levels of plasma factor VII and factor VII activated forms as a function of plasma triglyceride levels.
- Author
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Negri M, Arigliano PL, Talamini G, Carlini S, Manzato F, and Bonadonna G
- Subjects
- Adult, Female, Humans, Male, Middle Aged, Factor VII metabolism, Factor VIIa metabolism, Triglycerides blood
- Abstract
It has been shown that triglyceride levels are one of the determinants of factor VII levels. In this study we have simultaneously evaluated, in a group of 102 healthy individuals, the different forms of factor VII, namely factor VII mass, factor VII coagulant activity, activated factor VII double-chain form and factor VII-phospholipid complex, in relation to triglyceridaemia. The data showed a highly significant correlation of factor VII mass, factor VII coagulant activity and factor VII-phospholipid complex with triglycerides. No correlation was observed between the activated factor VII double-chain form and triglycerides. These data, together with analysis of the linear and orthogonal regression slopes, suggest that increase of plasma factor VII coagulant activity as a function of plasma triglyceride levels is attributable to an increase in both mass and activity of factor VII and that the increase in activity is dependent on an increase of factor VII-phospholipid complex rather than activated factor VII double-chain form. The ratio between the slopes of the regression straight line of factor VII mass and factor VII-phospholipid complex in relation to triglycerides was 2.23 (95% confidence limits 1.74-2.50), thus indicating that the contribution of factor VII mass is prevalent over that of the factor VII-phospholipid complex.
- Published
- 1993
- Full Text
- View/download PDF
42. Pulse oximetry in the evaluation of the painful hand after arteriovenous fistula creation.
- Author
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Halevy A, Halpern Z, Negri M, Hod G, Weissgarten J, Averbukh Z, and Modai D
- Subjects
- Arteriovenous Shunt, Surgical instrumentation, Brachiocephalic Trunk, Catheters, Indwelling, Humans, Oxygen blood, Pain physiopathology, Renal Dialysis, Arteriovenous Shunt, Surgical adverse effects, Hand blood supply, Ischemia diagnosis, Oximetry
- Abstract
Five patients with a side-to-side arteriovenous fistula complaining of pain, numbness, and cold sensation were evaluated by pulse oximetry. Low SaO2 was noticed in all five. Closure of a major proximal venous collateral vessel eliminated the steal and resulted in SaO2 correction and was followed by clinical amelioration. Pulse oximetry proved to be a helpful adjunct in the evaluation of the painful hand after creation of an arteriovenous fistula. By applying the pulse oximeter to the patient's affected limb, we were able to determine whether the pain was a result of ischemia and if the correction of the steal improved oxygenation.
- Published
- 1991
43. A photometric assay for hydrogen peroxide production by polymorphonuclear leucocytes.
- Author
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Negri M, Bellavite P, Lauciello C, Guzzo P, and Zatti M
- Subjects
- Arachidonic Acid pharmacology, Glutathione Peroxidase metabolism, Glutathione Reductase metabolism, Humans, N-Formylmethionine Leucyl-Phenylalanine pharmacology, NADP metabolism, Photometry, Tetradecanoylphorbol Acetate pharmacology, Hydrogen Peroxide metabolism, Neutrophils metabolism
- Published
- 1991
- Full Text
- View/download PDF
44. Rapid diazepam introduction (venous or rectal) in childhood epilepsy: taxonomic and therapeutic considerations.
- Author
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De Negri M, Gaggero R, Veneselli E, Pessagno A, Baglietto MG, and Pallecchi A
- Subjects
- Administration, Rectal, Child, Child, Preschool, Diazepam therapeutic use, Electroencephalography, Epilepsy etiology, Epilepsy physiopathology, Female, Humans, Infant, Infusions, Intravenous, Male, Diazepam administration & dosage, Epilepsy drug therapy
- Abstract
Rapid diazepam (DZP) introduction was investigated in 24 children with different types of cryptogenic or symptomatic generalized epilepsy and EEG epileptic "status" with EEG and pharmacologic monitoring. In 12 cases DZP was given intravenously and in another 12 by the rectal route. In general, intravenous administration proved more rapid and more effective as to high blood levels of DZP and the arrest of the paroxysmal activity. However, when the results were correlated to the different forms of paroxysmal EEG activity it was apparent that cases with a typical hypsarrhythmic EEG pattern under the age of 12 months and cases with unorganized paroxysmal activity over the age of 12 months are insensitive or only slightly sensitive to both intravenous and rectal introduction. A number of taxonomic and therapeutic considerations are presented.
- Published
- 1991
- Full Text
- View/download PDF
45. Expression of HOX homeogenes in human neuroblastoma cell culture lines.
- Author
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Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, and Simeone A
- Subjects
- Amino Acid Sequence, Base Sequence, Humans, Molecular Sequence Data, Neuroblastoma genetics, Tretinoin pharmacology, Tumor Cells, Cultured, Gene Expression Regulation, Neoplastic genetics, Genes, Homeobox genetics, Neuroblastoma pathology
- Abstract
Mammalian genes containing a class-I homeobox (HOX genes) are highly expressed in the embryonic nervous system. As a first step towards the molecular analysis of the role these genes play in neural cells, we studied the expression of four human HOX genes in five neuroblastoma (NB) cell lines - SK-N-BE, CHP-134, IMR-32, SK-N-SH and LAN-1 - during the process of differentiation induced by treatment with retinoic acid (RA). The four genes, HOX1D, 2F, 3E and 4B, located at corresponding positions in the four HOX loci, share a high degree of sequence similarity with the Drosophila Deformed homeotic gene and constitute a homology group, group 10. One of these genes, HOX1D, is not expressed in the cells used, whereas the other three are highly expressed in untreated and RA-induced NB cells, even though the expression pattern in the various lines is slightly different for the three genes. Our analysis reveals a complex and specific expression pattern in these lines, paving the way to an identification of different NB-cell populations by means of specific HOX gene expression schemes. On the other hand, in every line studied, morphological maturation toward a neuronal differentiated phenotype appears to be associated with increased HOX gene expression.
- Published
- 1990
- Full Text
- View/download PDF
46. Child ataxias: a developmental perspective.
- Author
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De Negri M and Rolando S
- Subjects
- Cerebellum growth & development, Child, Humans, Ataxia physiopathology, Cerebellar Ataxia physiopathology, Cerebellum physiopathology
- Abstract
In children, the conditions defined as "ataxia" form a very heterogeneous group. They also often differ from the "ataxias" of adults. In many cases this can be attributed to their different etiology, but probably it is also due to the peculiar functional and physiopathologic characteristics of the cerebellar system during the developmental period. In this article we will attempt to critically analyze this subject, with reference to the data published in the literature, to the results of experimental neurophysiologic investigations and, in part, to our own clinical observations.
- Published
- 1990
- Full Text
- View/download PDF
47. Computed EEG topography (CET) and childhood epilepsy: two years experience.
- Author
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De Negri M, Gaggero R, and Baglietto MG
- Subjects
- Adolescent, Brain physiopathology, Child, Child, Preschool, Epilepsy physiopathology, Fourier Analysis, Humans, Infant, Diagnosis, Computer-Assisted, Electroencephalography, Epilepsy diagnosis
- Abstract
The statistical data obtained with the use of computed EEG topography (CET) in a diagnostic study on 65 epileptic children are reported briefly. The CET technique has proved to be particularly useful in establishing the focal origin of paroxystic activity in a high percentage of cases of generalized epilepsies presumed to be primary (33%) or secondary (88%), and for localizing areas of brain function abnormality not detected by other diagnostic techniques.
- Published
- 1990
- Full Text
- View/download PDF
48. [Prognosis of febrile convulsions according to age of onset and response to preventive treatment].
- Author
-
Gaggero R and De Negri M
- Subjects
- Age Factors, Child, Child, Preschool, Diazepam therapeutic use, Humans, Infant, Phenobarbital therapeutic use, Prognosis, Seizures, Febrile drug therapy, Seizures, Febrile prevention & control, Valproic Acid therapeutic use, Anticonvulsants therapeutic use, Epilepsy etiology, Seizures, Febrile complications
- Published
- 1983
49. Generalized epilepsy in childhood: some notes from a developmental perspective.
- Author
-
De Negri M
- Subjects
- Brain growth & development, Child, Child, Preschool, Electroencephalography, Humans, Infant, Brain physiopathology, Epilepsy physiopathology
- Abstract
Efforts to establish more detailed classification of childhood epilepsy have increased our knowledge in this field, but have also led to a tendency of excessive subdivision, especially in generalized forms. This paper emphasizes the need for the reconsideration of a number of basic factors that favour a more unitary physiopathogenetic and clinical interpretation: 1) the electroclinical pattern is age-related; 2) the electroclinical paroxysmal expressiveness is greatest in childhood; 3) two types of manifestations can be distinguished in the process of spread and generalization (a benzodiazepine-sensitive complex associated with a more regular and organized EEG pattern, and a corticotropin-sensitive complex associated with an irregular, unorganized EEG pattern).
- Published
- 1988
- Full Text
- View/download PDF
50. [Modalities and side effects of ACTH therapy of diffuse epilepsy in children].
- Author
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Doria L, Pisaturo C, and De Negri M
- Subjects
- Brain Diseases diagnostic imaging, Child, Child, Preschool, Electroencephalography, Female, Humans, Hydrocortisone blood, Infant, Male, Tomography, X-Ray Computed, Adrenocorticotropic Hormone adverse effects, Anticonvulsants adverse effects, Brain Diseases chemically induced, Child Behavior Disorders chemically induced, Epilepsy drug therapy
- Published
- 1983
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