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Background: One of the most prevalent cancers in women worldwide is breast cancer. Breast cancer therapy is preferable to prevention. Breast cancer occurs for a variety of molecular reasons, making chemotherapy and/or radiotherapy treatment highly difficult and frequently creating unfavorable side effects. For millennia, practically every disease has been treated using plant extracts, and breast cancer is no exception. Because of their minimal toxicity, herbal medications are reliable for the treatment of cancer. In addition, the majority of breast cancer-stricken women readily embrace herbal treatments due to their accessibility and affordability. Many plants and the chemicals found in them have been found to exhibit promising anticancer properties versus breast cancer cells in both in vivo and in vitro studies over the past ten years. The poor stability, water solubility, and bioavailability of natural products usually prevent the clinical translation of these drugs, despite the positive preclinical outcomes. There have been efforts to get beyond these restrictions, especially by using nano-based drug delivery methods (NDDSs). The present work aims to comprehensively review the formulation, challenges, and advantages in the development of Nano formulation of Phytoconstituents for Breast Cancer. Main text: This study focuses on the tumor-targeting mechanisms of NDDSs, the benefits, and drawbacks of the main classes of NDDSs for treating breast cancer, as well as the pathophysiology of breast cancer, modern treatments, and phytoconstituents that have shown promise in treating breast cancer. Conclusion: The current review gathered information on the latest treatments, advantages, and disadvantages of NDDS in Breast Cancer. The review also elaborates on the importance of developing of a Targeted delivery system of Phytoconstituents for Breast Cancer.