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1. Experience of the national cohort of pregnant women with HIV and their children in Spain: temporal trends in vertical transmission of HIV and associated infections

Author: Marta Illán Ramos, Arantxa Berzosa Sánchez, Itziar Carrasco García, Asunción Diaz Franco, Inmaculada Jarrín Vera, Luis Prieto Tato, Rosa Polo Rodríguez, Mª Luisa Navarro Gómez, and José Tomás Ramos Amador
Subjects: VIH, Transmisión vertical, Infección perinatal, Tratamiento antirretroviral, Pediatrics, RJ1-570
Abstract: Introduction: The vertical transmission rate (VTR) of HIV has decreased to less than 2% in high-income countries, in spite of which perinatal infections continue to occur. We present data from the national cohort of pregnant women living with HIV and their children in Spain. The objectives were to describe the characteristics of this population, evaluate the VTR of HIV, the safety of antiretroviral therapy (ART) and the prevalence of coinfection. Patients and methods: Multicentre prospective, observational and descriptive study with participation of 62 hospitals. The sample included pegnant women living with HIV whose children were born between January 2020 and December 2022. We collected prospective data on the characteristics of mothers and children using an online questionnaire (REDCap web application). Results: The study included 414 mother-child dyads. Most mothers were immigrants (227/349; 65.1%). The main route of HIV infection was heterosexual transmission (160/402; 39.8%), followed by vertical transmission (44/402; 10.9%). The diagnosis was made before conception in 313/389 women (80.4%), 394/402 (98%) received ART during pregnancy and 356/402 (89.3%) had an undetectable viral load at the time of delivery. The delivery was vaginal in 230/388 children (59.3%). The proportion of preterm birth was 11.1%. The most frequent neonatal prophylaxis approach was monotherapy with zidovudine (358/414; 86.5%). There were 3 cases of vertical transmission of HIV (95% CI, 0%–1.54%). Only one newborn was breastfed. Conclusions: At present, most women living with HIV in Spain receive the diagnosis before conception, are of foreign ancestry and achieve good control of the infection. Although the VTR is very low in Spain, there are still infections that could be prevented with early diagnosis and treatment. Resumen: Introducción: La tasa de transmisión materno-infantil (TMI) del VIH ha disminuido a menos del 2% en países desarrollados, a pesar de lo cual siguen produciéndose infecciones. Se presentan los datos de la Cohorte Nacional Española de mujeres embarazadas que viven con VIH y sus hijos. Los objetivos fueron describir sus características, evaluar la TMI de VIH, la seguridad del tratamiento antirretroviral (TAR) y la prevalencia de coinfecciones. Pacientes y métodos: Estudio descriptivo, observacional, prospectivo y multicéntrico con participación de 62 hospitales. Se incluyeron las embarazadas cuyos hijos nacieron entre enero 2020 y diciembre 2022. Se recogieron prospectivamente características de las madres y niños en REDCap. Resultados: Hubo 414 pares madre-niño. Las madres fueron migrantes 227/349 (65,1%). La principal vía de adquisición del VIH fue la heterosexual (160/402; 39,8%), seguido de la TMI (44/402; 10,9%). En 313/389 (80,4%) el diagnóstico fue previo al embarazo, 394/402 (98%) recibieron TAR durante la gestación y 356/402 (89,3%) presentaba carga viral indetectable al parto. Hubo 230/388 (59,3%) neonatos nacidos por parto vaginal. La tasa de prematuridad fue 11,1%. La profilaxis neonatal más empleada (358/414; 86,5%) fue monoterapia con zidovudina. Hubo 3 casos de TMI del VIH (0,72% (IC 95%; 0%–1,54%), todos ellos con infección intraútero. Todos menos 1 recibieron lactancia artificial. Conclusiones: Actualmente las mujeres que viven con VIH en nuestro medio son migrantes, diagnosticadas mayoritariamente antes de la gestación, y logran adecuada situación inmunovirológica. Aunque la tasa de TMI es muy baja en nuestro país continúan ocurriendo infecciones prevenibles con diagnóstico y tratamiento más precoces.
Published: 2024
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2. Suffering in children and adolescents in paediatric palliative care in Spain: psychometric properties of the qESNA scale

Author: Daniel Toro-Pérez, Joaquin T. Limonero, Catalina Bolancé, Montserrat Guillen, Sergi Navarro-Vilarrubí, and Ester Camprodon-Rosanas
Subjects: Cuidados paliativos pediátricos, Sufrimiento, Enfermedades limitantes para la vida, Enfermedades amenazantes para la vida, Evaluación psicológica, Propiedades psicométricas, Pediatrics, RJ1-570
Abstract: Objective: To analyze the psychometric properties of the qESNA scale and its usefulness to assess the suffering of paediatric patients with life-limiting and/or life-threatening diseases (children with LLTC) in clinical practice. Methods: Cross-sectional and longitudinal study in 58 patients in Spain (female, 32.8%; mean age, 15.6 [SD, 4.5]; age range, 8–23 years), with administration of the qESNA scale along with other scales to assess anxiety, depression, emotion regulation and psychosocial functioning. We performed exploratory and confirmatory factor analyses and calculated goodness-of-fit indices were calculated; we assessed reliability by means of the Cronbach alpha and temporal stability and convergent validity through the intraclass correlation coefficient with scales used to assess psychological disorders and the specificity and sensitivity through ROC curves. Results: The factor analysis identified a 14-item scale with 3 factors, a comparative fit index of 0.93, a Tucker-Lewis index of 0.91 and a root mean square error of approximation of 0.07. The Cronbach alpha was 0.85 and the intraclass correlation coefficient was 0.66. The convergent validity was high for the correlation to the risk of depression (−0.69) and of anxiety (−0.60) and emotional changes (−0.59). The analysis of the ROC curves showed that a score of less than 81 would be indicative of suffering, with a sensitivity of 83.33% and a specificity of 93.48%. Conclusions: This study confirmed that the psychometric properties of the qESNA scale are good and the scale’s usefulness as an instrument to detect emotional suffering in children with life-limiting or life-threatening illnesses in clinical practice. Resumen: Objetivo: Analizar las propiedades psicométricas de la escala qESNA y su utilidad clínica para evaluar el sufrimiento de pacientes infantojuveniles con enfermedades limitantes y/o amenazantes para la vida (niños con LLTC). Métodos: 58 pacientes en población española (mujeres = 32.8%; edad media = 15.6 ± 4.5 [8–23 años]), respondieron a la escala qESNA en un diseño transversal y longitudinal junto con otras escalas que evaluaban ansiedad, depresión, alteraciones emocionales y funcionamiento psicosocial. Se realizaron análisis factoriales exploratorios y confirmatorios, y calcularon índices de bondad de ajuste; la fiabilidad se obtuvo a partir del alfa de Cronbach y de estabilidad temporal; la validez convergente mediante coeficientes de correlación intraclase con escalas sobre alteraciones psicológicas; y el análisis de especificidad y sensibilidad a través de las curvas ROC. Resultados: El análisis factorial identificó una escala de 14 ítems con 3 factores, con un índice de ajuste comparativo de 0.93, índice de Tucker-Lewis de 0.91 y error cuadrático medio de aproximación de 0.07. El alfa de Cronbach fue de 0.85 y el coeficiente correlación intraclases de 0.66. La validez convergente fue alta en la correlación con el riesgo de depresión (-0.69) y ansiedad de (-0.60) y las alteraciones emocionales (-0.59). Los análisis de curvas ROC indican que una puntuación
Published: 2024
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3. Evaluation of parameters in the removal of azo Red 40 dye using electrocoagulation

Author: Angel Villabona-Ortíz, Candelaria Tejada-Tovar, and Diego Navarro-Romero
Subjects: Electrocoagulator, Azo dyes, Electrochemistry, Red 40, Sludges, Chemical engineering, TP155-156
Abstract: The objective of the present investigation was to evaluate the parameters that affect the efficiency of electrocoagulation in a batch system to remove the azo-benzoic dye Red 40 present in synthetic wastewater by determining the effect of the operational parameters of voltage and treatment time. A 12×6 cm iron electrode holder was constructed with PVC pipes and screws separated by 2 cm, and a 1 L beaker was used as the electrocoagulation cell. Synthetic wastewater samples of red 40 were characterized, where UV–VIS was used to measure absorbance before and after being treated in the electrocoagulation cell. The effects of voltages (10, 15, and 20 V) and treatment times up to 60 min were evaluated. As a result, a higher removal of 93.85 % was obtained at 60 min when a voltage of 10 V was used with a lower change in temperature and energy consumption of only 14.08 kJ. The increase in conductivity and pH by values greater than 1600 µs/cm and 11, respectively, indicate the presence of diluted iron at the end of treatment; therefore, if complemented with other treatment methods such as filtration to remove excess iron produced, can be used in treatment plants and reduce their environmental impact, for this research the FTIR analysis showed that the sludge has a dye composition with hydroxides of metals along with a slight trace of dye degradation.
Published: 2024
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4. Risk factors for progression in patients with KDOQI stage 3 Chronic Kidney Disease (PROGRESER study)

Author: Alberto Martínez-Castelao, José Luis Górriz Teruel, Luis D’Marco, Enrique Garrigós, Gema Fernández-Fresnedo, Eugenia Espinel Garuz, Secundino Cigarrán Guldris, Jesús Arteaga Coloma, Nicolas Roberto Robles Pérez-Monteoliva, José Rafael Esteban de la Rosa, Luis Javier Nieto Iglesias, Alberto Ortiz Arduán, and Juan Francisco Navarro-González
Subjects: Enfermedad renal crónica, Diabetes mellitus, Progresión, Riesgo cardiovascular, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Introduction: The PROGRESER study is a multicentre, prospective, observational, 3-year follow-up study of a cohort of patients with stage 3 chronic kidney disease (CKD) from different nephrology departments of hospitals in the Spanish healthcare system. The primary study objective was to analyse risk factors for CKD progression, identifying possible differences between patients with and without diabetes mellitus (DM). The secondary objective was to analyse if the cardiovascular risk factors were also associated with CKD progression. Patients and methods: A total of 462 patients (342 men and 120 women; mean age 66.5 ± 11.5 years) were recruited from 25 participating sites in Spain. Clinical, epidemilogical and analytical data were recorder in an electronic registrer each six months. Biological samples were obtained and frozen for a biobank record at baseline and at 18 and 36 months. Results: The initial mean glomerular filtration rate estimated by MDRD and after that reestimated by CKD-EPI was 43.9 ± 7.9 mL/min/1.73 m2; and 29 ± 6,8 mL/min/1,73 m2 at 3 years. 27.3% of patients had microalbuminuria and 22.5% had macroalbuminuria. Two-thirds of the patients (66.2%) presented renal damage progression according to the study criteria (decrease of more than 15% in eGFR over the baseline value). 38.7% presented a reduction in eGFR ≥ 30%; 20.3% had a reduction in eGFR ≥40%; 10.4% had a reduction ≥50% and 6.9% had a reduction ≥57%. Of the 199 diabetics, 134 (67.3%) suffered renal damage progression. Of the 263 non-diabetics, 172 (65.3%) presented progression (p = 0.456). 27.3% of patients had microalbuminuria and 22.5% proteinuria. The study found that CKD progression to a higher stage was not greater in diabetic compared to non-diabetic patients. Multivariate analysis revealed that the presence of arterial hypertension bordered on significance as a progression factor in non-diabetic patients (p = 0.07), and that, in diabetic patients, lower calcium levels and elevated intact parathyroid hormone levels at baseline were associated with progression. Conclusion: in our study we have not found new factors for progression of renal damage, different from the yet well known traditional factors. DM “per se” was not a differential factor for progression in relation with non DM patients. Progression of renal damage in patients with CKD—3 KDOQI may be interpreted in a multifactorial context. The search for new biomarkers, different from traditional ones, is necessary to establish new therapeutic strategies to prevent the progression of CKD. Resumen: Introdución: PROGRESER es un studio multicéntrio, prospectivo, observacional, con tres años de seguimiento, de una cohorte de pacientes con enfermedad renal crónica (ERC)-3 KDOQI, incluidos en servicios de Nefrología del Sistema Nacional de Salud en 14 Comunidades Autónomas (CCAA) de España. El objetivo primario fue analizar los factores de riesgo asociados con la progresión de la ERC, para identificar posibles diferencias entre pacientes con y sin Diabetes Mellitus (DM). El objetivo secundario fue investigar si los factores de riesgo cardiovascular (CV) están asociados con dicha progresión. Material y métodos: Se incluyeron 462 pacientes, (342 hombres y 120 mujeres, con edad media de 66.5 ± 11.5 años), reclutados en 25 centros. Se recogieron datos epidemiológicos, clínicos y analíticos cada seis meses, registrados en cuaderno electrónico. Se recogieron y congelaron muestras biológicas para biobanco basales y a 18 y 36 meses. Resultados: El filtrado glomerular estimado (FGe), calculado inicialmente mediante la ecuación Modification of Diet in Renal Disease (MDRD) y después recalculado mediante CKD-EPI, fue 43.9 ± 7.9 mL/min/1.73 m2 en el momento basal y 29,9 ± 6,8 mL/min/1,73 m2 a los tres años de seguimiento.Dos tercios de los pacientes (66.2 %) presentaron progresión del daño renal según criterio del estudio (descenso mayor del 15 % del FGe sobre el valor basal). Un 38.7 % presentaron una reducción del FGe ≥ 30 %; un 20.3 % tuvieron una reducción del FGe ≥40%; un 10.4 % tuvieron una reduccion ≥50% y un 6.9 % una reducción ≥57%. De los 199 diabéticos, 134 (67,3 %) presentaron progresión. De los 263 no diabéticos, 172 (65,3%) presentaron progresión (p = 0,456). El 27.3% de pacientes presentaban microalbuminuria y el 22.5% proteinuria. El estudio mostró que la progresión de un estadio a otros más avanzados no fue superior en los pacientes con DM respecto a los no diabéticos. El análisis multivariante reveló que la presencia de Hipertensión Arterial (HTA) se aproximó a la significación estadística (p = 0.07) asociado a la progresión en los pacientes sin DM y que en los pacientes con DM unos niveles basales de calcio más bajos y de PTH-i más elevados sobre el valor basal tuvieron significación estadística como factores de progresión de la ERC. Conclusión: Nuestro estudio no ha revelado nuevos factores de progresión de daño renal con relación a los factores clásicos ya conocidos. No hemos encontrado diferencias significativas en cuanto a la progresión en pacientes con y sin DM La progresión del daño renal en pacientes con ERC-3 KDOQI debe interpretarse en un contexto multifactorial. Se precisa la búsqueda de nuevos biomarcadores, diferentes de los tradicionales, para establecer nuevas estrategias terapéuticas para prevenir la progresión de la ERC.
Published: 2024
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5. Prediabetes and CKD: Does a causal relationship exist

Author: Jorge Rico Fontalvo, María José Soler, Rodrigo Daza Arnedo, Guillermo Navarro-Blackaller, Ramón Medina-González, Tomas Rodríguez Yánez, Maria Cardona-Blanco, Jose Cabrales-Juan, Isabella Uparrela-Gulfo, and Jonathan S. Chávez-Iñiguez
Subjects: Prediabetes, Enfermedad renal crónica, Albuminuria, Hiperglicemia, Diseases of the genitourinary system. Urology, RC870-923
Abstract: The relationship between diabetes and the development of kidney complications is well known, but the understanding of prediabetes and insulin resistance with impaired kidney function has been scarcely assessed. Various factors could explain this phenomenon, from the lack of standardization in the definitions of prediabetes, to the erratic and inconsistent evidence in large-scale epidemiological and cohort studies. It seems that the pathophysiological pathway of prediabetes could be related to inflammation and neurohormonal hyperactivation, factors present even before the onset of diabetes, which might be the main drivers of glomerular hyperfiltration, albuminuria, and impaired glomerular filtration rate. It is possible that existing treatments for the management of diabetes, as metformin or SGLT2 inhibitors may also be useful in patients with prediabetes with evidence of functional and structural kidney damage. The purpose of this review is to summarize the evidence regarding the relationship between prediabetes (preDM) and the development of CKD. Resumen: La relación entre diabetes y el desarrollo de complicaciones renales es bien conocida; sin embargo la asociación entre prediabetes y la resistencia a la insulina con el daño en la función renal apenas ha sido evaluada. Varios factores podrían explicar este fenómeno, desde la falta de estandarización en las definiciones de prediabetes, hasta la errática e inconsistente evidencia en estudios epidemiológicos y de cohortes a gran escala. Parece que las vías fisiopatológicas en la prediabetes podrían estar relacionadas con inflamación y la hiperactivación del sistema neuro-hormonal, factores presentes incluso antes de la aparición de la diabetes, que podrían ser los principales impulsores de la hiperfiltración glomerular, albuminuria y alteración de la tasa de filtración glomerular. Es posible que los tratamientos existentes para el control de la diabetes, como metformina o los inhibidores SGLT2 también pueden ser útiles en pacientes con prediabetes con evidencia de daño renal funcional o estructural. El propósito de esta revisión es resumir la evidencia sobre la relación entre la prediabetes (preDM) y el desarrollo de la ERC.
Published: 2024
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6. What does the finding of amyloid casts in multiple myeloma mean?

Author: Laura Medina Zahonero, Elena Landete Hernández, David Roldán Cortés, Juan A. Martín Navarro, Fabio L. Procaccini, Jorge Muñoz Rodríguez, Francisco Díaz-Crespo, Verónica Rubio Menéndez, and Roberto Alcázar Arroyo
Subjects: Diseases of the genitourinary system. Urology, RC870-923
Published: 2024
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7. Psychological Aspects of Nerve Gap Reconstruction: Addressing Patient Perspectives and Expectations

Author: Stephen DeMartini, BS, Amanda Faust, BS, Brendan Navarro, BS, and Christopher J. Dy, MD, MPH
Subjects: Expectation, Gap, Nerve, Perspective, Reconstruction, Surgery, RD1-811
Abstract: Purpose: Preoperative expectations play a major role in determining patient satisfaction after surgery. The aim of this study was to characterize patient’s preoperative expectations and postoperative perceptions of nerve gap repair surgery. Methods: We conducted a search of Embase, Scopus, and Web of Science databases for peer-reviewed articles that studied patient expectations, perceptions, and impressions of nerve gap repair in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies related to lumbar plexus radiculopathy, reimplantation, or patient satisfaction scores without patient testimony were excluded. Primary and secondary outcomes were patient’s preoperative expectations and postoperative perceptions of nerve gap repair surgery, respectively. Results: We included 11 studies evaluating a total of 462 patients. One study evaluated only patient expectations, six studies evaluated only patient perspectives, and four studies evaluated both. Patients were generally overly optimistic in their expectations of surgery. Postoperative satisfaction ranged from 82% to 86%, and 81% to 87% of patients would choose to undergo their surgery again knowing what they know now. Conclusions: Patient expectations in nerve gap repair are optimistic, and at times unrealistic. Patient satisfaction with nerve gap repair is high and subject to influence from preoperative education and postoperative outcomes of functional and sensory recovery. Clinical relevance: Surgeons should be aware that patient expectations of their postoperative outcomes can have substantial impacts on their perceived management and overall satisfaction. More emphasis should be placed on preoperative education and expectation management to optimize patient satisfaction.
Published: 2024
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8. Factores de progresión en pacientes con ERC-3 KDOQI (estudio PROGRESER)

Author: Alberto Martínez-Castelao, José Luis Górriz Teruel, Luis D. Marco, Enrique Garrigós, Gema Fernández-Fresnedo, Eugenia Espinel Garuz, Secundino Cigarrán Guldris, Jesús Arteaga Coloma, Nicolas Roberto Robles Pérez-Monteoliva, Rafael José Esteban De la Rosa, Luis Javier Nieto Iglesias, Alberto Ortiz Arduán, and Juan Francisco Navarro-González
Subjects: Chronic kidney disease, Diabetes mellitus, Diabetic kidney disease, Progression, Cardiovascular risk., Diseases of the genitourinary system. Urology, RC870-923
Abstract: Resumen: Introducción: PROGRESER es un estudio multicéntrico, prospectivo, observacional, con tres años de seguimiento, de una cohorte de pacientes con enfermedad renal crónica (ERC)-3 KDOQI, incluidos en servicios de Nefrología del Sistema Nacional de Salud en 14 comunidades autónomas de España. El objetivo primario fue analizar los factores de riesgo asociados con la progresión de la ERC, para identificar posibles diferencias entre pacientes con y sin diabetes mellitus (DM). El objetivo secundario fue investigar los factores asociados con hospitalizaciones y mortalidad. Material y métodos: Se incluyeron 462 pacientes (342 hombres y 120 mujeres, con una edad media de 66,5 ± 11,5 años), reclutados en 25 centros. Se recogieron datos epidemiológicos, clínicos y analíticos cada seis meses, registrados en cuaderno electrónico. Se recogieron y congelaron muestras biológicas para biobanco basales y a 18 y 36 meses. Resultados: El filtrado glomerular estimado (FGe), calculado inicialmente mediante la ecuación Modification of Diet in Renal Disease (MDRD) y después recalculado mediante CKD-EPI fue de 43,9 ± 7,9 mL/min/1,73 m2 en el momento basal y de 29,9 ± 6,8 mL/min/1,73 m2 a los tres años de seguimiento.Dos tercios de los pacientes (66,2%) presentaron progresión del daño renal según criterio del estudio (descenso mayor del 15% del FGe sobre el valor basal). Un 38,7% presentaron una reducción del FGe ≥ 30%; un 20,3% tuvieron una reducción del FGe ≥ 40%; un 10,4% tuvieron una reducción ≥ 50% y un 6,9%, una reducción ≥ 57%. De los 199 diabéticos, 134 (67,3%) presentaron progresión. De los 263 no diabéticos, 172 (65,3%) presentaron progresión (p = 0,456). El 27,3% de pacientes presentaban microalbuminuria y el 22,5%, proteinuria. El estudio mostró que la progresión de un estadio a otros más avanzados no fue superior en los pacientes con DM respecto a los no diabéticos. El análisis multivariante reveló que la presencia de hipertensión arterial (HTA) se aproximó a la significación estadística (p = 0,07) asociado a la progresión en los pacientes sin DM, y que en los pacientes con DM unos niveles basales de calcio más bajos y de PTH-i más elevados sobre el valor basal tuvieron significación estadística como factores de progresión de la ERC. Conclusión: Nuestro estudio no ha revelado nuevos factores de progresión de daño renal con relación a los factores clásicos ya conocidos. No hemos encontrado diferencias significativas en cuanto a la progresión en pacientes con y sin DM. La progresión del daño renal en pacientes con ERC-3 KDOQI debe interpretarse en un contexto multifactorial. Se precisa la búsqueda de nuevos biomarcadores, diferentes de los tradicionales, para establecer nuevas estrategias terapéuticas para prevenir la progresión de la ERC. Abstract: Introduction: The PROGRESER study is a multicentre, prospective, observational, 3-year follow-up study of a cohort of patients with stage 3 chronic kidney disease (CKD) from different nephrology departments of hospitals in the Spanish healthcare system. The primary study objective was to analyse risk factors for CKD progression, identifying possible differences between patients with and without diabetes mellitus (DM). The secondary objective was to analyse the factors associated with hospitalizations and mortality. Patients and methods: A total of 462 patients (342 men and 120 women; mean age 66.5 ± 11.5 years) were recruited from 25 participating sites in Spain. Clinical, epidemiological and analytical data were recorder in an electronic register each six months. Biological samples were obtained and frozen for a biobank record at baseline and at 18 and 36 months. Results: The initial mean glomerular filtration rate estimated by MDRD and after that reestimated by CKD-EPI was 43.9 ± 7.9 mL/min/1.73 m2; and 29 ± 6,8 mL/min/1,73 m2 at 3 years. 27.3% of patients had microalbuminuria and 22.5% had macroalbuminuria. Two-thirds of the patients (66.2%) presented renal damage progression according to the study criteria (decrease of more than 15% in eGFR over the baseline value). 38.7% presented a reduction in eGFR ≥ 30%; 20.3% had a reduction in eGFR ≥ 40%; 10.4% had a reduction ≥ 50% and 6.9% had a reduction ≥ 57%. Of the 199 diabetics, 134 (67.3%) suffered renal damage progression. Of the 263 non-diabetics, 172 (65.3%) presented progression (P = .456). 27.3% of patients had microalbuminuria and 22.5% proteinuria. The study found that CKD progression to a higher stage was not greater in diabetic compared to non-diabetic patients. Multivariate analysis revealed that the presence of arterial hypertension bordered on significance as a progression factor in non-diabetic patients (P = .07), and that, in diabetic patients, lower calcium levels and elevated intact parathyroid hormone levels at baseline were associated with progression. Conclusion: In our study we have not found new factors for progression of renal damage, different from the yet well known traditional factors. DM per se was not a differential factor for progression in relation with non DM patients. Progression of renal damage in patients with CKD-3 KDOQI may be interpreted in a multifactorial context. The search for new biomarkers, different from traditional ones, is necessary to establish new therapeutic strategies to prevent the progression of CKD.
Published: 2024
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9. ¿Qué significa el hallazgo de cilindros de amiloide en el mieloma múltiple?

Author: Laura Medina Zahonero, Elena Landete Hernández, David Roldán Cortés, Juan A. Martín Navarro, Fabio L. Procaccini, Jorge Muñoz Rodríguez, Francisco Díaz-Crespo, Verónica Rubio Menéndez, and Roberto Alcázar Arroyo
Subjects: Diseases of the genitourinary system. Urology, RC870-923
Published: 2024
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10. Conceptual RF design of 750 MHz IH cavities for β = 0.10–0.15 ion beams in medical accelerators

Author: Jorge Giner Navarro, Gabriela Moreno, Daniel Gavela, Concepción Oliver, Pedro Calvo, Miguel León, Ángel Rodríguez, Ricardo López, José Miguel Carmona, and María Alvarado
Subjects: Accelerator, Linac, Interdigital H-mode, DTL, Low-beta, Efficiency, Nuclear engineering. Atomic power, TK9001-9401
Abstract: In light of the potential interest of Interdigital H-mode (IH) cavities for accelerating carbon ion beams beyond 5 MeV/u, we are reviewing the key geometric elements of the regular cells and end cells to optimize performance in terms of power efficiency, achievable voltage, and dipole field correction.
Published: 2024
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11. Real-world outcomes in patients with malignancy and moderate-to-severe psoriasis treated with guselkumabCapsule Summary

Author: Tamara Gracia Cazaña, MD, PhD, Josep Riera Monroig, MD, Rosa Izu, MD, PhD, Ignacio Yanguas, MD, PhD, Marta Lorda Espés, MD, PhD, María Pilar Sánchez Salas, MD, Miguel Fernando García Gil, MD, Alba Navarro Bielsa, MD, Beatriz Aldea Manrique, MD, Manuel Almenara Blasco, MD, Francisco Javier García-Latasa de Araníbar, MD, PhD, Victoria Fuentelsaz, MD, PhD, Ana Morales Callaghan, MD, PhD, and Mariano Ara-Martín, MD, PhD
Subjects: individualized medicine, malignancies, psoriasis, Dermatology, RL1-803
Abstract: Background: The treatment of psoriasis in patients with a personal history of cancer is a matter of debate and limited evidence is available to guide clinicians. Objectives: To report a multicenter real-life experience of a group of patients with psoriasis undergoing treatment with guselkumab and a history of cancer. Methods: We conducted a multicenter retrospective Spanish study enrolling patients with moderate-to-severe plaque psoriasis and neoplasia being treated with guselkumab for their psoriasis. Results: Twenty patients with moderate-to-severe psoriasis and at least 12 weeks of ongoing treatment were included. For the analysis, a 52 week follow-up period was evaluated in terms of efficacy and safety. Most of the malignancies in these patients were solid tumors. The percentage of patients achieving psoriasis area and severity index ≤3 at week 12 and week 52 was 80% and 87.5%, respectively, whereas 68.8% of patients achieved psoriasis area and severity index ≤1. A 52-week survival rate of 100% in the study population was observed (n = 20), including those patients with concomitant active cancers (n = 14). No adverse effects or dropouts related to guselkumab safety profile were detected. Limitations: Modest sample size and the retrospective nature of the study. Conclusion: Guselkumab not only demonstrates high effectiveness in treating psoriasis but also exhibits a favorable safety profile in patients with neoplasms.
Published: 2024
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12. Transfer learning of species co-occurrence patterns between plant communities

Author: Johannes Hirn, Verónica Sanz, José Enrique García, Marta Goberna, Alicia Montesinos-Navarro, José Antonio Navarro-Cano, Ricardo Sánchez-Martín, Alfonso Valiente-Banuet, and Miguel Verdú
Subjects: Generative artificial intelligence, Patchy vegetation, Plant communities, Restoration ecology, Species co-occurrence, Variational autoencoders, Information technology, T58.5-58.64, Ecology, QH540-549.5
Abstract: Aim: The use of neural networks (NNs) is spreading to all areas of life, and Ecology is no exception. However, the data-hungry nature of NNs can leave out many small, valuable datasets. Here we show how to apply transfer learning to rescue small datasets that can be invaluable in understanding patterns of species co-occurrence. Location: Semiarid plant communities in Spain and México. Time period: 2016–2022. Major taxa studied: Angiosperms. Methods: Based on a large sample of plant species co-occurrence in vegetation patches in a semi-arid area of eastern Spain, we fit a generative artificial intelligence (AI) model that correctly reproduces which species live with which in these patches. Subsequently, we train the same type of model on two communities for which we only have smaller datasets (another semi-arid community in eastern Spain, and a tropical community in Mexico). Results: When we transfer the knowledge learnt from the large dataset directly to the other two, the predictions improve for the community more similar to our reference one. As for the more dissimilar community, improving the accuracy of the transfer requires a further tuning of the model to the local data. In particular, the knowledge transferred relates primarily to species frequency and, to a lesser extent, to their phylogenetic relationships, which are known to be determinants of species interaction patterns. Main conclusions: This AI-based approach can be performed for communities similar or not so similar to the reference community, opening the door to systematic transfer learning for accurate predictions on small datasets. Interestingly, this transfer operates by matching unrelated species between the origin and target datasets, implying that arbitrary datasets can then be transferred to, or even combined in order to augment each other, irrespective of the species involved, potentially allowing such models to be applied to a wide range of plant communities in different climates.
Published: 2024
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13. Search for pair production of boosted Higgs bosons via vector-boson fusion in the bb¯bb¯ final state using pp collisions at s=13TeV with the ATLAS detector

Author: G. Aad, E. Aakvaag, B. Abbott, S. Abdelhameed, K. Abeling, N.J. Abicht, S.H. Abidi, M. Aboelela, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B.S. Acharya, A. Ackermann, C. Adam Bourdarios, L. Adamczyk, S.V. Addepalli, M.J. Addison, J. Adelman, A. Adiguzel, T. Adye, A.A. Affolder, Y. Afik, M.N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W.S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, M. Akbiyik, T.P.A. Åkesson, A.V. Akimov, D. Akiyama, N.N. Akolkar, S. Aktas, K. Al Khoury, G.L. Alberghi, J. Albert, P. Albicocco, G.L. Albouy, S. Alderweireldt, Z.L. Alegria, M. Aleksa, I.N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H.M.J. Ali, S. Ali, S.W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B.M.M. Allbrooke, J.F. Allen, C.A. Allendes Flores, P.P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, Z.M.K. Alsolami, M. Alvarez Estevez, A. Alvarez Fernandez, M. Alves Cardoso, M.G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C.G. Ames, D. Amidei, K.J. Amirie, S.P. Amor Dos Santos, K.R. Amos, S. An, V. Ananiev, C. Anastopoulos, T. Andeen, J.K. Anders, A.C. Anderson, S.Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A.V. Anisenkov, A. Annovi, C. Antel, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, M.A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, S.J. Arbiol Val, C. Arcangeletti, A.T.H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N.A. Asbah, R.A. Ashby Pickering, K. Assamagan, R. Astalos, K.S.V. Astrand, S. Atashi, R.J. Atkin, M. Atkinson, H. Atmani, P.A. Atmasiddha, K. Augsten, S. Auricchio, A.D. Auriol, V.A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, T.M. Baer, P. Bagnaia, M. Bahmani, D. Bahner, K. Bai, J.T. Baines, L. Baines, O.K. Baker, E. Bakos, D. 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Xie, S. Xin, A. Xiong, J. Xiong, D. Xu, H. Xu, L. Xu, R. Xu, T. Xu, Y. Xu, Z. Xu, B. Yabsley, S. Yacoob, Y. Yamaguchi, E. Yamashita, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H.J. Yang, H.T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B. Yeo, M.R. Yexley, T.P. Yildirim, P. Yin, K. Yorita, S. Younas, C.J.S. Young, C. Young, C. Yu, Y. Yu, J. Yuan, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, Z.K. Zak, T. Zakareishvili, N. Zakharchuk, S. Zambito, J.A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J.C. Zeng, D.T. Zenger, Jr, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D.F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zheng, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C.G. Zhu, J. Zhu, X. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, N.I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T.G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Physics, QC1-999
Abstract: A search for Higgs boson pair production via vector-boson fusion is performed in the Lorentz-boosted regime, where a Higgs boson candidate is reconstructed as a single large-radius jet, using 140 fb−1 of proton–proton collision data at s=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. Only Higgs boson decays into bottom quark pairs are considered. The search is particularly sensitive to the quartic coupling between two vector bosons and two Higgs bosons relative to its Standard Model prediction, κ2V. This study constrains κ2V to 0.55
Published: 2024
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14. Measurement of the polarizations of prompt and non-prompt Image 1 and ψ(2S) mesons produced in pp collisions at s=13TeV

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, T. Van Laer, P. Van Mechelen, N. Breugelmans, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, F. Heyen, S. Lowette, I. Makarenko, D. Müller, S. Tavernier, M. Tytgat, G.P. Van Onsem, S. Van Putte, D. Vannerom, B. Bilin, B. Clerbaux, A.K. Das, G. De Lentdecker, H. Evard, L. Favart, P. Gianneios, J. Jaramillo, A. Khalilzadeh, F.A. Khan, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, M.A. Shahzad, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, G. Gokbulut, Y. Hong, J. Knolle, L. Lambrecht, D. Marckx, K. Mota Amarilo, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, J. De Favereau De Jeneret, C. Delaere, I.S. Donertas, A. Giammanco, A.O. Guzel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, T.T. Tran, S. Wertz, G.A. Alves, M. Alves Gallo Pereira, E. Coelho, G. Correia Silva, C. Hensel, T. Menezes De Oliveira, C. Mora Herrera, A. Moraes, P. Rebello Teles, M. Soeiro, A. Vilela Pereira, W.L. Aldá Júnior, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, M. Macedo, J. Martins, L. Mundim, H. Nogima, J.P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, B. Lopes Da Costa, I. Maietto Silverio, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, T. Javaid, L. Yuan, Z. Hu, Z. Liang, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. Ban, S. Deng, B. Guo, C. Jiang, A. Levin, C. Li, Q. Li, Y. Mao, S. Qian, S.J. Qian, X. Qin, X. Sun, D. Wang, H. Yang, L. Zhang, Y. Zhao, C. Zhou, S. Yang, Z. You, K. Jaffel, N. Lu, G. Bauer, B. Li, J. Zhang, X. Gao, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, F. Ramirez, C. Rendón, M. Rodriguez, A.A. Ruales Barbosa, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, A. Petkovic, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, K. Jakovcic, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, A. Hadjiagapiou, C. Leonidou, J. Mousa, C. Nicolaou, L. Paizanos, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. 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Dittmer, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, K. Kennedy, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, S. Malik, A.S. Bakshi, S. Chandra, R. Chawla, A. Gu, L. Gutay, M. Jones, A.W. Jung, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. 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Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Quarkonium production, Quarkonium polarization, Physics, QC1-999
Abstract: The polarizations of prompt and non-prompt Image 2 and ψ(2S) mesons are measured in proton-proton collisions at s=13 TeV, using data samples collected by the CMS experiment in 2017 and 2018, corresponding to a total integrated luminosity of 103.3fb−1. Based on the analysis of the dimuon decay angular distributions in the helicity frame, the polar anisotropy, λϑ, is measured as a function of the transverse momentum, pT, of the charmonium states, in the 25–120 and 20–100 GeV ranges for the Image 2 and ψ(2S), respectively. The non-prompt polarizations agree with predictions based on the hypothesis that, for pT≳25GeV, the non-prompt Image 2 and ψ(2S) are predominantly produced in two-body B meson decays. The prompt results clearly exclude strong transverse polarizations, even for pT exceeding 30 times the Image 2 mass, where λϑ tends to an asymptotic value around 0.3. Taken together with previous measurements, by CMS and LHCb at s=7 TeV, the prompt polarizations show a significant variation with pT, at low pT.
Published: 2024
Full Text: View/download PDF

15. Measurement of the production cross section of a Higgs boson with large transverse momentum in its decays to a pair of τ leptons in proton-proton collisions at s=13TeV

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, L. Yuan, Z. Hu, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, G. Bauer, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, H. Abdalla, Y. Assran, M.A. Mahmoud, Y. Mohammed, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. Garcia, J. Havukainen, K.T.S. Kallonen, R. 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Askew, N. Bower, R. Habibullah, V. Hagopian, R. Hashmi, R.S. Kim, T. Kolberg, G. Martinez, H. Prosper, P.R. Prova, O. Viazlo, M. Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, E. Yanes, M.R. Adams, A. Baty, C. Bennett, R. Cavanaugh, S. Dittmer, R. Escobar Franco, O. Evdokimov, C.E. Gerber, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, A. Baden, A. Belloni, A. Bethani, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, J. Bendavid, W. Busza, I.A. Cali, Y. Chen, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, Z. Shi, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, M. Bryson, D.R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, G.P. Van Onsem, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. 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Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, I. Azhgirey, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, M. Chadeeva, V. Chekhovsky, R. Chistov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, O. Kodolova, D. Konstantinov, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Petrushanko, S. Polikarpov, V. Popov, O. Radchenko, R. Ryutin, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, A. Volkov, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Higgs boson, Tau lepton, Physics, QC1-999
Abstract: A measurement of the production cross section of a Higgs boson with transverse momentum greater than 250GeV is presented where the Higgs boson decays to a pair of τ leptons. It is based on proton-proton collision data collected by the CMS experiment at the CERN LHC at a center-of-mass energy of 13TeV. The data sample corresponds to an integrated luminosity of 138fb−1. Because of the large transverse momentum of the Higgs boson the τ leptons from its decays are boosted and produced spatially close, with their decay products overlapping. Therefore, a dedicated algorithm was developed to reconstruct and identify them. The observed (expected) significance of the measured signal with respect to the standard model background-only hypothesis is 3.5 (2.2) standard deviations. The product of the production cross section and branching fraction is measured to be 1.64−0.54+0.68 times the standard model expectation. The fiducial differential production cross section is also measured as functions of the Higgs boson and leading jet transverse momenta. This measurement extends the probed large-transverse-momentum region in the ττ final state beyond 600GeV.
Published: 2024
Full Text: View/download PDF

16. KS0 and Λ(Λ‾) two-particle femtoscopic correlations in PbPb collisions at sNN=5.02TeV

Author: A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, P.S. Hussain, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, T. Kello, H. Rejeb Sfar, P. Van Mechelen, E.S. Bols, J. D'Hondt, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, A. Morton, D. Müller, A.R. Sahasransu, S. Tavernier, W. Van Doninck, S. Van Putte, D. Vannerom, B. Clerbaux, G. De Lentdecker, L. Favart, D. Hohov, J. Jaramillo, K. Lee, M. Mahdavikhorrami, I. Makarenko, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, D. Dobur, J. Knolle, L. Lambrecht, G. Mestdach, C. Rendón, A. Samalan, K. Skovpen, M. Tytgat, N. Van Den Bossche, B. Vermassen, L. Wezenbeek, A. Benecke, G. Bruno, F. Bury, C. Caputo, P. David, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, K. Mondal, A. Taliercio, T.T. Tran, P. Vischia, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, A. Moraes, P. Rebello Teles, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, V. Dos Santos Sousa, S. Fonseca De Souza, J. Martins, C. Mora Herrera, K. Mota Amarilo, L. Mundim, H. Nogima, A. Santoro, S.M. Silva Do Amaral, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, T. Ivanov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Thakur, T. Cheng, T. Javaid, M. Mittal, L. Yuan, M. Ahmad, G. Bauer, Z. Hu, S. Lezki, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, V. Milosevic, F. Monti, R. Sharma, J. Tao, J. Thomas-Wilsker, J. Wang, H. Zhang, J. Zhao, A. Agapitos, Y. An, Y. Ban, A. Levin, C. Li, Q. Li, X. Lyu, Y. Mao, S.J. Qian, X. Sun, D. Wang, J. Xiao, H. Yang, M. Lu, Z. You, N. Lu, X. Gao, D. Leggat, H. Okawa, Y. Zhang, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, I. Puljak, Z. Antunovic, M. Kovac, T. Sculac, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, M. Roguljic, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, A.A. Abdelalim, E. Salama, M.A. Mahmoud, Y. Mohammed, S. Bhowmik, R.K. Dewanjee, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, P. Eerola, H. Kirschenmann, K. 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Benelli, B. Burkle, X. Coubez, D. Cutts, M. Hadley, U. Heintz, J.M. Hogan, T. Kwon, G. Landsberg, K.T. Lau, D. Li, J. Luo, M. Narain, N. Pervan, S. Sagir, F. Simpson, E. Usai, W.Y. Wong, X. Yan, D. Yu, W. Zhang, S. Abbott, J. Bonilla, C. Brainerd, R. Breedon, M. Calderon De La Barca Sanchez, M. Chertok, J. Conway, P.T. Cox, R. Erbacher, G. Haza, F. Jensen, O. Kukral, G. Mocellin, M. Mulhearn, D. Pellett, B. Regnery, Y. Yao, F. Zhang, M. Bachtis, R. Cousins, A. Datta, J. Hauser, M. Ignatenko, M.A. Iqbal, T. Lam, E. Manca, W.A. Nash, D. Saltzberg, B. Stone, V. Valuev, R. Clare, J.W. Gary, M. Gordon, G. Hanson, O.R. Long, N. Manganelli, W. Si, S. Wimpenny, J.G. Branson, S. Cittolin, S. Cooperstein, D. Diaz, J. Duarte, R. Gerosa, L. Giannini, J. Guiang, R. Kansal, V. Krutelyov, R. Lee, J. Letts, M. Masciovecchio, F. Mokhtar, M. Pieri, M. Quinnan, B.V. Sathia Narayanan, V. Sharma, M. Tadel, E. Vourliotis, F. Würthwein, Y. Xiang, A. Yagil, N. Amin, C. Campagnari, M. Citron, G. Collura, A. 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Chlebana, K.F. Di Petrillo, J. Dickinson, V.D. Elvira, Y. Feng, J. Freeman, A. Gandrakota, Z. Gecse, L. Gray, D. Green, S. Grünendahl, D. Guerrero, O. Gutsche, R.M. Harris, R. Heller, T.C. Herwig, J. Hirschauer, L. Horyn, B. Jayatilaka, S. Jindariani, M. Johnson, U. Joshi, T. Klijnsma, B. Klima, K.H.M. Kwok, S. Lammel, D. Lincoln, R. Lipton, T. Liu, C. Madrid, K. Maeshima, C. Mantilla, D. Mason, P. McBride, P. Merkel, S. Mrenna, S. Nahn, J. Ngadiuba, D. Noonan, S. Norberg, V. Papadimitriou, N. Pastika, K. Pedro, C. Pena, F. Ravera, A. Reinsvold Hall, L. Ristori, E. Sexton-Kennedy, N. Smith, A. Soha, L. Spiegel, S. Stoynev, J. Strait, L. Taylor, S. Tkaczyk, N.V. Tran, L. Uplegger, E.W. Vaandering, I. Zoi, P. Avery, D. Bourilkov, L. Cadamuro, P. Chang, V. Cherepanov, R.D. Field, E. Koenig, M. Kolosova, J. Konigsberg, A. Korytov, E. Kuznetsova, K.H. Lo, K. Matchev, N. Menendez, G. Mitselmakher, A. Muthirakalayil Madhu, N. Rawal, D. Rosenzweig, S. Rosenzweig, K. Shi, Z. Wu, T. Adams, A. Askew, N. Bower, R. Habibullah, V. Hagopian, T. Kolberg, G. Martinez, H. Prosper, O. Viazlo, M. Wulansatiti, R. Yohay, J. Zhang, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, F. Yumiceva, M.R. Adams, R. Cavanaugh, S. Dittmer, O. Evdokimov, C.E. Gerber, D.J. Hofman, D.S. Lemos, A.H. Merrit, C. Mills, G. Oh, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, X. Wang, Z. Ye, M. Alhusseini, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, O. Amram, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, S. Kyriacou, P. Maksimovic, J. Roskes, S. Sekhar, M. Swartz, T.Á. Vámi, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, S. Duric, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, T. Mitchell, A. Modak, K. Nam, D. Roy, F. Rebassoo, D. Wright, E. Adams, A. Baden, O. Baron, A. Belloni, A. Bethani, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, L. Wang, K. Wong, W. Busza, I.A. Cali, Y. Chen, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, P. Harris, M. Hu, D. Kovalskyi, J. Krupa, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, Z. Shi, G.S.F. Stephans, Z. Wang, B. Wyslouch, T.J. Yang, R.M. Chatterjee, B. Crossman, J. Hiltbrand, B.M. Joshi, C. Kapsiak, M. Krohn, Y. Kubota, D. Mahon, J. Mans, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, M. Bryson, D.R. Claes, C. Fangmeier, L. Finco, F. Golf, C. Joo, R. Kamalieddin, I. Kravchenko, I. Reed, J.E. Siado, G.R. Snow, W. Tabb, A. Wightman, F. Yan, A.G. Zecchinelli, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, M. Morris, D. Nguyen, J. Pekkanen, S. Rappoccio, A. Williams, G. Alverson, E. Barberis, Y. Haddad, Y. Han, A. Krishna, J. Li, J. Lidrych, G. Madigan, B. Marzocchi, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, J. Bueghly, Z. Chen, A. Gilbert, K.A. Hahn, Y. Liu, N. Odell, M.H. Schmitt, M. Velasco, R. Band, R. Bucci, M. Cremonesi, A. Das, R. Goldouzian, M. Hildreth, K. Hurtado Anampa, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, K. Mohrman, C. Moore, Y. Musienko, R. Ruchti, A. Townsend, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, A. Lesauvage, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, S. Higginbotham, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, R. Chawla, S. Das, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, A. Purohit, J.F. Schulte, M. Stojanovic, J. Thieman, F. Wang, R. Xiao, W. Xie, J. Dolen, N. Parashar, D. Acosta, A. Baty, T. Carnahan, S. Dildick, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, C. Fallon, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, P. Parygin, E. Popova, R. Taus, G.P. Van Onsem, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, H. Wang, H. Acharya, A.G. Delannoy, S. Fiorendi, T. Holmes, E. Nibigira, S. Spanier, O. Bouhali, M. Dalchenko, A. Delgado, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, S. Malhotra, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, W. Johns, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, G. Cummings, J. Hakala, R. Hirosky, A. Ledovskoy, A. Li, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, M. Chadeeva, V. Chekhovsky, M. Danilov, A. Dermenev, T. Dimova, I. Dremin, V. Epshteyn, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, A. Kaminskiy, L. Kardapoltsev, V. Karjavine, A. Karneyeu, L. Khein, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, O. Kodolova, D. Konstantinov, V. Korenkov, V. Korotkikh, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, A. Litomin, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, I. Ovtin, V. Palichik, V. Perelygin, S. Petrushanko, V. Popov, O. Radchenko, V. Rusinov, M. Savina, V. Savrin, D. Selivanova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, A. Snigirev, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, I. Vardanyan, A. Vorobyev, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Heavy ion, V0, Femtoscopy, Scattering parameters, Physics, QC1-999
Abstract: Two-particle correlations are presented for KS0, Image 1, and Image 2 strange hadrons as a function of relative momentum in lead-lead collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV. The dataset corresponds to an integrated luminosity of 0.607nb−1 and was collected using the CMS detector at the CERN LHC. These correlations are sensitive to quantum statistics and to final-state interactions between the particles. The source size extracted from the KS0KS0 correlations is found to decrease from 4.6 to 1.6fm in going from central to peripheral collisions. Strong interaction scattering parameters (i.e., scattering length and effective range) are determined from the Image 3 and Image 4 (including their charge conjugates) correlations using the Lednický–Lyuboshitz model and are compared to theoretical and other experimental results.
Published: 2024
Full Text: View/download PDF

17. Searches for violation of Lorentz invariance in top quark pair production using dilepton events in 13 TeV proton-proton collisions

Author: A. Hayrapetyan, A. Tumasyan, W. Adam, J.W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, P.S. Hussain, M. Jeitler, N. Krammer, A. Li, D. Liko, I. Mikulec, J. Schieck, R. Schöfbeck, D. Schwarz, M. Sonawane, S. Templ, W. Waltenberger, C.-E. Wulz, M.R. Darwish, T. Janssen, P. Van Mechelen, E.S. Bols, J. D'Hondt, S. Dansana, A. De Moor, M. Delcourt, H. El Faham, S. Lowette, I. Makarenko, D. Müller, A.R. Sahasransu, S. Tavernier, M. Tytgat, G.P. Van Onsem, S. Van Putte, D. Vannerom, B. Clerbaux, A.K. Das, G. De Lentdecker, L. Favart, P. Gianneios, D. Hohov, J. Jaramillo, A. Khalilzadeh, K. Lee, M. Mahdavikhorrami, A. Malara, S. Paredes, L. Pétré, N. Postiau, L. Thomas, M. Vanden Bemden, C. Vander Velde, P. Vanlaer, M. De Coen, D. Dobur, Y. Hong, J. Knolle, L. Lambrecht, G. Mestdach, K. Mota Amarilo, C. Rendón, A. Samalan, K. Skovpen, N. Van Den Bossche, J. van der Linden, L. Wezenbeek, A. Benecke, A. Bethani, G. Bruno, C. Caputo, C. Delaere, I.S. Donertas, A. Giammanco, K. Jaffel, Sa. Jain, V. Lemaitre, J. Lidrych, P. Mastrapasqua, K. Mondal, T.T. Tran, S. Wertz, G.A. Alves, E. Coelho, C. Hensel, T. Menezes De Oliveira, A. Moraes, P. Rebello Teles, M. Soeiro, W.L. Aldá Júnior, M. Alves Gallo Pereira, M. Barroso Ferreira Filho, H. Brandao Malbouisson, W. Carvalho, J. Chinellato, E.M. Da Costa, G.G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, R. Gomes De Souza, J. Martins, C. Mora Herrera, L. Mundim, H. Nogima, J.P. Pinheiro, A. Santoro, A. Sznajder, M. Thiel, A. Vilela Pereira, C.A. Bernardes, L. Calligaris, T.R. Fernandez Perez Tomei, E.M. Gregores, P.G. Mercadante, S.F. Novaes, B. Orzari, Sandra S. Padula, A. Aleksandrov, G. Antchev, R. Hadjiiska, P. Iaydjiev, M. Misheva, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, A. Petrov, E. Shumka, S. Keshri, S. Thakur, T. Cheng, Q. Guo, T. Javaid, L. Yuan, Z. Hu, J. Liu, K. Yi, G.M. Chen, H.S. Chen, M. Chen, F. Iemmi, C.H. Jiang, A. Kapoor, H. Liao, Z.-A. Liu, R. Sharma, J.N. Song, J. Tao, C. Wang, J. Wang, Z. Wang, H. Zhang, A. Agapitos, Y. Ban, A. Levin, C. Li, Q. Li, Y. Mao, S.J. Qian, X. Sun, D. Wang, H. Yang, L. Zhang, C. Zhou, Z. You, N. Lu, G. Bauer, X. Gao, D. Leggat, H. Okawa, Z. Lin, C. Lu, M. Xiao, C. Avila, D.A. Barbosa Trujillo, A. Cabrera, C. Florez, J. Fraga, J.A. Reyes Vega, J. Mejia Guisao, F. Ramirez, M. Rodriguez, J.D. Ruiz Alvarez, D. Giljanovic, N. Godinovic, D. Lelas, A. Sculac, M. Kovac, T. Sculac, P. Bargassa, V. Brigljevic, B.K. Chitroda, D. Ferencek, S. Mishra, A. Starodumov, T. Susa, A. Attikis, K. Christoforou, S. Konstantinou, J. Mousa, C. Nicolaou, F. Ptochos, P.A. Razis, H. Rykaczewski, H. Saka, A. Stepennov, M. Finger, M. Finger, Jr., A. Kveton, E. Ayala, E. Carrera Jarrin, H. Abdalla, Y. Assran, A. Lotfy, M.A. Mahmoud, K. Ehataht, M. Kadastik, T. Lange, S. Nandan, C. Nielsen, J. Pata, M. Raidal, L. Tani, C. Veelken, H. Kirschenmann, K. Osterberg, M. Voutilainen, S. Bharthuar, E. Brücken, F. 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Wulansatiti, R. Yohay, J. Zhang, B. Alsufyani, M.M. Baarmand, S. Butalla, T. Elkafrawy, M. Hohlmann, R. Kumar Verma, M. Rahmani, E. Yanes, M.R. Adams, A. Baty, C. Bennett, R. Cavanaugh, R. Escobar Franco, O. Evdokimov, C.E. Gerber, D.J. Hofman, J.h. Lee, D.S. Lemos, A.H. Merrit, C. Mills, S. Nanda, G. Oh, B. Ozek, D. Pilipovic, R. Pradhan, T. Roy, S. Rudrabhatla, M.B. Tonjes, N. Varelas, Z. Ye, M. Alhusseini, D. Blend, K. Dilsiz, L. Emediato, G. Karaman, O.K. Köseyan, J.-P. Merlo, A. Mestvirishvili, J. Nachtman, O. Neogi, H. Ogul, Y. Onel, A. Penzo, C. Snyder, E. Tiras, B. Blumenfeld, L. Corcodilos, J. Davis, A.V. Gritsan, L. Kang, S. Kyriacou, P. Maksimovic, M. Roguljic, J. Roskes, S. Sekhar, M. Swartz, A. Abreu, L.F. Alcerro Alcerro, J. Anguiano, P. Baringer, A. Bean, Z. Flowers, D. Grove, J. King, G. Krintiras, M. Lazarovits, C. Le Mahieu, C. Lindsey, J. Marquez, N. Minafra, M. Murray, M. Nickel, M. Pitt, S. Popescu, C. Rogan, C. Royon, R. Salvatico, S. Sanders, C. Smith, G. Wilson, B. Allmond, A. Ivanov, K. Kaadze, A. Kalogeropoulos, Y. Maravin, K. Nam, J. Natoli, D. Roy, G. Sorrentino, F. Rebassoo, D. Wright, A. Baden, A. Belloni, Y.M. Chen, S.C. Eno, N.J. Hadley, S. Jabeen, R.G. Kellogg, T. Koeth, Y. Lai, S. Lascio, A.C. Mignerey, S. Nabili, C. Palmer, C. Papageorgakis, M.M. Paranjpe, L. Wang, J. Bendavid, W. Busza, I.A. Cali, M. D'Alfonso, J. Eysermans, C. Freer, G. Gomez-Ceballos, M. Goncharov, G. Grosso, P. Harris, D. Hoang, D. Kovalskyi, J. Krupa, L. Lavezzo, Y.-J. Lee, K. Long, C. Mironov, C. Paus, D. Rankin, C. Roland, G. Roland, S. Rothman, G.S.F. Stephans, B. Wyslouch, T.J. Yang, B. Crossman, B.M. Joshi, C. Kapsiak, M. Krohn, D. Mahon, J. Mans, B. Marzocchi, S. Pandey, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M.A. Wadud, L.M. Cremaldi, K. Bloom, D.R. Claes, G. Haza, J. Hossain, C. Joo, I. Kravchenko, J.E. Siado, W. Tabb, A. Vagnerini, A. Wightman, F. Yan, D. Yu, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, M. Morris, D. Nguyen, S. Rappoccio, H. Rejeb Sfar, A. Williams, G. Alverson, E. Barberis, J. Dervan, Y. Haddad, Y. Han, A. Krishna, J. Li, M. Lu, G. Madigan, R. Mccarthy, D.M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, B. Wang, D. Wood, J. Bueghly, Z. Chen, S. Dittmer, K.A. Hahn, Y. Liu, Y. Miao, D.G. Monk, M.H. Schmitt, A. Taliercio, M. Velasco, G. Agarwal, R. Band, R. Bucci, S. Castells, A. Das, R. Goldouzian, M. Hildreth, K.W. Ho, K. Hurtado Anampa, T. Ivanov, C. Jessop, K. Lannon, J. Lawrence, N. Loukas, L. Lutton, J. Mariano, N. Marinelli, I. Mcalister, T. McCauley, C. Mcgrady, C. Moore, Y. Musienko, H. Nelson, M. Osherson, A. Piccinelli, R. Ruchti, A. Townsend, Y. Wan, M. Wayne, H. Yockey, M. Zarucki, L. Zygala, A. Basnet, B. Bylsma, M. Carrigan, L.S. Durkin, C. Hill, M. Joyce, M. Nunez Ornelas, K. Wei, B.L. Winer, B.R. Yates, F.M. Addesa, H. Bouchamaoui, P. Das, G. Dezoort, P. Elmer, A. Frankenthal, B. Greenberg, N. Haubrich, G. Kopp, S. Kwan, D. Lange, A. Loeliger, D. Marlow, I. Ojalvo, J. Olsen, A. Shevelev, D. Stickland, C. Tully, A.S. Bakshi, V.E. Barnes, S. Chandra, R. Chawla, S. Das, A. Gu, L. Gutay, M. Jones, A.W. Jung, D. Kondratyev, A.M. Koshy, M. Liu, G. Negro, N. Neumeister, G. Paspalaki, S. Piperov, V. Scheurer, J.F. Schulte, M. Stojanovic, J. Thieman, A.K. Virdi, F. Wang, W. Xie, J. Dolen, N. Parashar, A. Pathak, D. Acosta, T. Carnahan, K.M. Ecklund, P.J. Fernández Manteca, S. Freed, P. Gardner, F.J.M. Geurts, W. Li, O. Miguel Colin, B.P. Padley, R. Redjimi, J. Rotter, E. Yigitbasi, Y. Zhang, A. Bodek, P. de Barbaro, R. Demina, J.L. Dulemba, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, N. Parmar, P. Parygin, E. Popova, R. Taus, K. Goulianos, B. Chiarito, J.P. Chou, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, D. Jaroslawski, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, H. Routray, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S.A. Thayil, S. Thomas, J. Vora, H. Wang, H. Acharya, D. Ally, A.G. Delannoy, S. Fiorendi, S. Higginbotham, T. Holmes, A.R. Kanuganti, N. Karunarathna, L. Lee, E. Nibigira, S. Spanier, D. Aebi, M. Ahmad, O. Bouhali, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, S. Luo, R. Mueller, D. Overton, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, A. Hussain, Y. Kazhykarim, K. Lamichhane, A. Mankel, T. Peltola, I. Volobouev, A. Whitbeck, E. Appelt, Y. Chen, S. Greene, A. Gurrola, W. Johns, R. Kunnawalkam Elayavalli, A. Melo, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, J. Viinikainen, B. Cardwell, B. Cox, J. Hakala, R. Hirosky, A. Ledovskoy, C. Neu, C.E. Perez Lara, P.E. Karchin, A. Aravind, K. Black, T. Bose, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, C.K. Koraka, A. Lanaro, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, A. Mohammadi, G. Parida, D. Pinna, A. Savin, V. Shang, W.H. Smith, D. Teague, H.F. Tsoi, W. Vetens, A. Warden, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, V. Blinov, E. Boos, V. Borshch, D. Budkouski, V. Bunichev, V. Chekhovsky, R. Chistov, M. Danilov, A. Dermenev, T. Dimova, D. Druzhkin, M. Dubinin, L. Dudko, A. Ershov, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Gribushin, Y. Ivanov, V. Kachanov, V. Karjavine, A. Karneyeu, V. Kim, M. Kirakosyan, D. Kirpichnikov, M. Kirsanov, V. Klyukhin, V. Korenkov, A. Kozyrev, N. Krasnikov, A. Lanev, P. Levchenko, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Oreshkin, V. Palichik, V. Perelygin, M. Perfilov, S. Polikarpov, V. Popov, O. Radchenko, M. Savina, V. Savrin, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, S. Slabospitskii, V. Smirnov, D. Sosnov, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, I. Tlisova, A. Toropin, L. Uvarov, A. Uzunian, P. Volkov, A. Vorobyev, G. Vorotnikov, N. Voytishin, B.S. Yuldashev, A. Zarubin, I. Zhizhin, and A. Zhokin
Subjects: CMS, Top quark, Beyond standard model, Lorentz symmetry, Physics, QC1-999
Abstract: A search for violation of Lorentz invariance in the production of top quark pairs (tt‾) is presented. The measured normalized differential tt‾ production cross section, as a function of the sidereal time, is examined for potential modulations induced by Lorentz-invariance breaking operators in an effective field theory extension of the standard model (SM). The cross section is measured from collision events collected by the CMS detector at a center-of-mass-energy of 13 TeV, corresponding to an integrated luminosity of 77.8 fb−1, and containing one electron and one muon. The results are found to be compatible with zero, in agreement with the SM, and are used to place upper limits at 68% confidence level on the magnitude of the Lorentz-violating couplings ranging from 1–8×10−3. This is the first precision test of the isotropy in special relativity with top quarks at the LHC, restricting further the bounds on such couplings by up to two orders of magnitude with respect to previous searches conducted at the Tevatron.
Published: 2024
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18. Colombian surgical outcomes study insights on perioperative mortality rate, a main indicator of the lancet commission on global surgery – a prospective cohort studyResearch in context

Author: Carlos J. Pérez Rivera, Nicolás Lozano-Suárez, Alejandro Velandia-Sánchez, Maria Paula Vargas-Cuellar, Luisa Fernanda Rojas-Serrano, Camilo A. Polanía-Sandoval, Daniela Lara-Espinosa, Laura García-Zambrano, Maria Paz Bohórquez-Tarazona, Silvia Valentina Agudelo-Mendoza, Paulo A. Cabrera-Rivera, Leonardo Briceno-Ayala, Camilo Andres Polania-Sandoval, María Paula Vargas-Cuéllar, Paulo Andrés Cabrera-Rivera, Danna Cruz-Reyes, Juan Guillermo Barrera Carvajal, Luis Felipe Cabrera-Vargas, Oscar Guevara, Laura Cristina Arce Polania, Laura Natalia Buendía Barrios, María Isabel Cristina Camargo Areyanes, Felipe Casas, Valeria Cormane Alfaro, Juan P. García-Méndez, Bayron Guerra, Sharon V. Idarraga-Ayala, Akram Kadamani Abiyomaa, Christopher Montoya, Manuel Santiago Mosquera Paz, María Alejandra Pineda, Juliana Pinzón-Luna, Isabella Roa Bastidas, Carlos Fernando Roman Ortega, Juan D. Saavedra Henao, Laura Carolina SanJuan-Arias, Vanessa Barreto, Julian Corso, Mariana Maksoud-Garcia, Eliana Pineda Mateus, Alejandra Vega Zabaraín, Fabien Mantilla-Sylvain, Nicolas Perez, Sergio Alzate-Ricaurte, Monica Bejarano, Isabella Caicedo Holguin, Alberto Federico García, Stefania Rodriguez Sanchez, Felipe Bernal Santos, Carlos Luna Jaspe, Maria Camila Luna-Jaspe Roa, Maria Paula OLIVERA Bolívar, MariaFernanda Valdivieso Diaz, Yuli Agudelo, Maria Paula Castillo-Aristizábal, Juan Pablo Hoyos Burgos, Maria Clara Maria Clara Mendoza Arango, Gabriel Arroyave, Felipe Buitrago Preciado, Lina María Cardona González, Juan Camilo Correa-Cote, Karen Lorena Franco Arias, Juan Felipe Llano Sierra, Gustavo López, Cesar Mancero, Sebastian Parra, Beatriz Ramirez Gonzalez, Daniela Sierra, Maria Camila Amaya Muñoz, Ashley Blanco-Ramírez, Paul Anthony Camacho, Jorge Campillo, Andrea Ximena Carvajal Mejia, María Alejandra González Yamil, Juan Carlos Osorno Villegas, Eduardo Rubio, Santiago Sánchez Herrera, Sebastian Sanchez Herrera, Tatiana Agudelo, Valentina Andrade, Laura Arango Pérez, Anibal Ariza-Gutiérrez, Jacobo Berrio, Natalia Cantillo Torres, Maria Valeria Chamorro-Rodríguez, Lucia Conde, Oscar Hernando Feo Lee, María Camila González Nieto, Laura Cecilia Ibañez-Pintor, Catalina Ochoa, Juan Ospina, Juan José Pérez-Ocampo, Esteban Portilla Rojas, Daniela Saaibi Rey, Eduardo Serrano, Sharon Michelle Solorza Velásquez, Angélica María Toro Cubides, Raúl Aguiar, Diego Armando Beltrán Rincón, Juan Sebastian Figueroa, Rafael Figueroa-Casanova, Maria Fernanda Gonzalez Mosos, Marcia Gabriela Gómez, Susana Osorno, Laura Laura Palacio, Jose Venegas, Liliana Marcela Caicedo Ramírez, Diana Catalina Cardona Gomez, Daniel Alejandro Fernandez Bolaños, Adriana Fernández-Diago, Victor David Olave Montaño, César Pastás, Silvia Marcela Amorocho, Jorge Barbosa-Santibañez, Vladimir Baron, Alejandra Cartagena-Alvarado, Maria Castillo, Maria Carolina Castillo-Florez, Omar David Dimian Mayorga, Elena Leonor Delgado-Nieto, Ernesto Fajardo, Omar Leonardo Gomez Polania, Tania Gonzalez, Daniel Felipe Guzman Mesa, Andres Isaza-Restrepo, Jaime A. Leal, Camilo Medina, Jorge Navarro-Alean, Maria Antonia Ocampo, Guillermo Oliveros, Maria Ortiz, Jorge I. Ortiz-Mahecha, Katherine Parra Abaunza, Felipe Antonio Pulido Reyes, Natalia Rivera-Rincón, Carlos Alfonso Rodriguez Pinedo, Lizeth Rodriguez Sanchez, Juan Javier Romero, Juan Carlos Sabogal Olarte, Javier Mauricio Salgado Tovar, Guillermo Andrés Torres, Linda Vallejo, Felipe Vargas-Barato, Ana María Vargas Patiño, Juan Pablo Villate León, Miguel Angel Montañez Aldana, Chiara Norato, Hugo Rojas Borda, Miguel Á Romero Núñez, Alejandro Sánchez, Jose Támara López, Jose Támara P, Wilmer Fernando Botache Capera, Rolando Medina Rojas, Juan Torres, Gina Catalina Trujillo, Gabriela Estefanía Cubillos Saavedra, Francisco García-Laverde, Jussef Camilo Naffah Enciso, Julian Arango Betancur, Adriana Cortés-Coronado, Susana Sepúlveda Tamayo, Valentina Arboleda Cardenas, Luis Guillermo García-Barrero, Jhonatan Enrique Garzón-Galindo, Lina Fernanda Torres Parada, Alejandro Arias Quintero, David Cano, Kevin Fernando Montoya Quintero, Santiago Nieto Muñoz, Paula Saza Mejía, Jesus David Gomez Barrios, 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Jaime Lorduy Gómez, Carlos Torres Madrid, Walter Torres Villa, Juan Sebastian Luengas Orozco, Camilo Avendaño Capriles, Carolina Diaz Blanco, Maria Lucía Brieva Hoyos, Paola Andrea Cantillo Moreno, Sofía Carolina Granados Mendoza, José Dario Vizcaino Lara, Karla Lizeth Babativa Peñuela, Paula Andrea Jiménez Bahamón, Jhonier Estiven Maldonado Rico, Duvan Ernesto Martínez Cortes, José Alfredo Orjuela Aragón, Lizeth Daniela Castro Roa, Julieth Sarmiento Gallego, Marta Maria Herazo Meza, Anlly Caterin Hernández Castillo, Rosa Gabriela Rojas Moncada, Lucia Fernanda Casanova Bermeo, Oscar Fernando Cortés Otero, Nicolás Diaz Pinilla, Harrison Rene Herrera Delgado, Simon Alberto Macías Segura, David Ramiro Muñoz Castrillón, Luis Ramiro Nuñez Romero, Cesar Andrés Polania Andrade, Hector Alejandro Valdez Toro, Ana María Cardozo Parrado, Jose Gonzalo Moros, Paula Andrea Nieto, Jorge Mario Patarroyo, Jose Luis Perilla Martínez, María del Pilar Torres Gutierrez, Erika Johana Benito Flórez, Mariana Vergel Gómez, Diana Ximena Robayo Rodriguez, Diego Fernando Salcedo Miranda, Maria Alejandra Triviño Cortés, William Baquero Sastre, Juan Sebastian Bonett, Eliana Cortes, Pedro Fernando Duque, Carlos Enrique Gutierrez, Piedad Echeverry, Andrés Felipe Motta Amar, Lorena Torres, Jeremias Carvajal Bautista, David Mauricio Figueroa Bohórquez, Manuel Latorre Quintana, Diego Fernando Olivera Briñez, Marcel Leonardo Quintero Contreras, Raúl Vera Gamboa, Mariana Arias Zapata, Cristhian Daniel Benavides Caipe, Luisa Fernanda Betancur Acevedo, Valentina Botero Zuluaga, Vanessa Figueroa-Espinoza, Arbey Leandro Londoño-Patiño, Santiago Moncayo-Gonzalez, Laura Sofia Puerta Suárez, Paula Camila Vargas-Arboleda, Lisbet Sofia Gonzalez Cera, Katerine Henao Toro, Leobardo de Jesus Ortiz Pino, Sergio Andrés Vasquez Vargas, Lency Naranjo Zuluaga, Jaime Chamorro Garzón, Adriana Paola Franco Rodriguez, Nataly Johana Acosta Alape, Andrés Felipe Arbelaez Mariño, Juan José Mora Herrera, Javier Felipe Ayala Muñoz, Yeiny Carina Camacho Pinzon, José Francisco Cárdenas Chacón, Liliana Andrea Peña Arenas, Gustavo Adolfo Rodriguez Camargo, Carlos Alberto Sánchez Arango, Daniel Mauricio Bolaños Ñañez, Diana Sofía Garcés-Palacios, María Alejandra Ñañez Pantoja, Omar Alejandro Ortega-Valencia, María Paula Gamboa Bernal, Juan David Lotero Gómez, Juan Sebastián Martínez-Gutiérrez, Daniel Morales-Gómez, Lina Pardo-Jiménez, Leon Miguel Fonseca Galindo, Angélica Maria Garcia Ramirez, Juan David Saurith Ramirez, Ivan Ricardo Barrero Montoya, Santiago Cadena Espitia, Salomé Pallares Rojas, Laura Camila Zapata Berrio, Diana Andrea Benavides Rodríguez, Juan Carlos Gonzalez, Sharon Valentina Idarraga, Óscar Eduardo Márquez Rodríguez, Ivi Yohana Marrugo Prieto, Laura Vanessa Soledad Machado, Rubén Luna, Nicolás Navarro Pulido, Federico Javier Nuñez Ricardo, Andrea Elena García López, Fernando Girón Luque, Nasly Patiño Jaramillo, Néstor Fabian Pedraza Alonso, Javier Yecid Acuña Acuña Rivera JY, Oscar Alexander Guevara Cruz, Juan Sebastián Martínez Buitrago, Nathalia Montoya Oviedo, Marcia Roxana Santafe Guerrero, Juanita Carolina Chaves Cortés, Francisco Mauricio Rincón Tello, Diana Fernanda Bejarano Ramirez, Nicolas Andres Cortes Mejia, Camilo Ernesto Garzon Mesa, Alejandra Moncada Pabon, Diego Rymel Triviño Alvarez, Alonso Vera Torres, Maria Alejandra Cote Martinez, Juan Manuel Machado Rodriguez, Gonzalo Nuñez Martinez, Laura Naranjo Osuna, Andres Felipe Roldan Garay, Daniel Amado, Jaime Camacho-Mackenzie, Maria Ceballos Mora, Sara Cifuentes-Navarrete, Andrea Donoso-Samper, Manuel A. Ferro, Juan C. Gómez-Cáceres, Sebastián Gómez-Galán, Ana G. Leiva, Juan Lisarazo, Maria G. López-Castaño, Sofía Martínez-Gil, M.J. Montoya, Santiago Niño-Basto, Sergio Andrés Ortigoza-Espitia, Gustavo Páez, Jesús William Ramos-Anaya, María J. Rozo, Juan P. Umana, Andres Motta Amar, Andrés Felipe Barrera Vargas, Javier Dario Maldonado Escalante, German Ricardo Molina Marroquin, and Silvia Alejandra Prada Lievano
Subjects: Global health, Public health, Surgery, Health policy, Hospital mortality, Public aspects of medicine, RA1-1270
Abstract: Summary: Background: Surgical care holds significant importance in healthcare, especially in low and middle-income countries, as at least 50% of the 4.2 million deaths within the initial 30 days following surgery take place in these countries. The Lancet Commission on Global Surgery proposed six indicators to enhance surgical care. In Colombia, studies have been made using secondary data. However, strategies to reduce perioperative mortality have not been implemented. This study aims to describe the fourth indicator, perioperative mortality rate (POMR), with primary data in Colombia. Methods: A multicentre prospective cohort study was conducted across 54 centres (hospitals) in Colombia. Each centre selected a 7-day recruitment period between 05/2022 and 01/2023. Inclusion criteria involved patients over 18 years of age undergoing surgical procedures in operating rooms. Data quality was ensured through a verification guideline and statistical analysis using mixed-effects multilevel modelling with a case mix analysis of mortality by procedure-related, patient-related, and hospital-related conditions. Findings: 3807 patients were included with a median age of 48 (IQR 32–64), 80.3% were classified as ASA I or II, and 27% of the procedures had a low-surgical complexity. Leading procedures were Orthopedics (19.2%) and Gynaecology/Obstetrics (17.7%). According to the Clavien–Dindo scale, postoperative complications were distributed in major complications (11.7%, 10.68–12.76) and any complication (31.6%, 30.09–33.07). POMR stood at 1.9% (1.48–2.37), with elective and emergency surgery mortalities at 0.7% (0.40–1.23) and 3% (2.3–3.89) respectively. Interpretation: The POMR was higher than the ratio reported in previous national studies, even when patients had a low–risk profile and low-complexity procedures. The present research represents significant public health progress with valuable insights for national decision-makers to improve the quality of surgical care. Funding: This work was supported by Universidad del Rosario and Fundación Cardioinfantil-Instituto de Cardiología grant number CTO-057-2021, project-ID IV-FGV017.
Published: 2024
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19. Search for pair-produced higgsinos decaying via Higgs or Z bosons to final states containing a pair of photons and a pair of b-jets with the ATLAS detector

Author: G. Aad, B. Abbott, K. Abeling, N.J. Abicht, S.H. Abidi, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, A.C. Abusleme Hoffman, B.S. Acharya, C. Adam Bourdarios, L. Adamczyk, L. Adamek, S.V. Addepalli, M.J. Addison, J. Adelman, A. Adiguzel, T. Adye, A.A. Affolder, Y. Afik, M.N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W.S. Ahmed, S. Ahuja, X. Ai, G. Aielli, M. Ait Tamlihat, B. Aitbenchikh, I. Aizenberg, M. Akbiyik, T.P.A. Åkesson, A.V. Akimov, D. Akiyama, N.N. Akolkar, K. Al Khoury, G.L. Alberghi, J. Albert, P. Albicocco, G.L. Albouy, S. Alderweireldt, M. Aleksa, I.N. Aleksandrov, C. Alexa, T. Alexopoulos, A. Alfonsi, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H.M.J. Ali, S. Ali, S.W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B.M.M. Allbrooke, J.F. Allen, C.A. Allendes Flores, P.P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, M. Alvarez Estevez, A. Alvarez Fernandez, M.G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C.G. Ames, D. Amidei, S.P. Amor Dos Santos, K.R. Amos, V. Ananiev, C. Anastopoulos, T. Andeen, J.K. Anders, S.Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A.V. Anisenkov, A. Annovi, C. Antel, M.T. Anthony, E. Antipov, M. Antonelli, D.J.A. Antrim, F. Anulli, M. Aoki, T. Aoki, J.A. Aparisi Pozo, M.A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, N. Aranzabal, C. Arcangeletti, A.T.H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, A.J. Armbruster, O. Arnaez, H. Arnold, Z.P. Arrubarrena Tame, G. Artoni, H. Asada, K. Asai, S. Asai, N.A. Asbah, K. Assamagan, R. Astalos, S. Atashi, R.J. Atkin, M. Atkinson, N.B. Atlay, H. Atmani, P.A. Atmasiddha, K. Augsten, S. Auricchio, A.D. Auriol, V.A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, P. Bagnaia, M. Bahmani, A.J. Bailey, V.R. Bailey, J.T. Baines, L. Baines, C. Bakalis, O.K. Baker, E. Bakos, D. Bakshi Gupta, R. Balasubramanian, E.M. Baldin, P. Balek, E. Ballabene, F. Balli, L.M. Baltes, W.K. Balunas, J. Balz, E. Banas, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, M. Barakat, E.L. Barberio, D. Barberis, M. Barbero, G. Barbour, K.N. Barends, T. Barillari, M-S. Barisits, T. Barklow, P. Baron, D.A. Baron Moreno, A. Baroncelli, G. Barone, A.J. Barr, J.D. Barr, L. Barranco Navarro, F. Barreiro, J. Barreiro Guimarães da Costa, U. Barron, M.G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A.E. Barton, P. Bartos, A. Basan, M. Baselga, A. Bassalat, M.J. Basso, C.R. Basson, R.L. Bates, S. Batlamous, J.R. Batley, B. Batool, M. Battaglia, D. Battulga, M. Bauce, M. Bauer, P. Bauer, L.T. Bazzano Hurrell, J.B. Beacham, T. Beau, P.H. Beauchemin, F. Becherer, P. Bechtle, H.P. Beck, K. Becker, A.J. Beddall, V.A. Bednyakov, C.P. Bee, L.J. Beemster, T.A. Beermann, M. Begalli, M. Begel, A. Behera, J.K. Behr, J.F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, N.L. Belyaev, D. Benchekroun, F. Bendebba, Y. Benhammou, M. Benoit, J.R. Bensinger, S. Bentvelsen, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F.U. Bernlochner, F. Bernon, T. Berry, P. Berta, A. Berthold, I.A. Bertram, S. Bethke, A. Betti, A.J. Bevan, M. Bhamjee, S. Bhatta, D.S. Bhattacharya, P. Bhattarai, V.S. Bhopatkar, R. Bi, R.M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, T.R.V. Billoud, M. Bindi, A. Bingul, C. Bini, A. Biondini, C.J. Birch-sykes, G.A. Bird, M. Birman, M. Biros, T. Bisanz, E. Bisceglie, D. Biswas, A. Bitadze, K. Bjørke, I. Bloch, C. Blocker, A. Blue, U. Blumenschein, J. Blumenthal, G.J. Bobbink, V.S. Bobrovnikov, M. Boehler, B. Boehm, D. Bogavac, A.G. Bogdanchikov, C. Bohm, V. Boisvert, P. Bokan, T. Bold, M. Bomben, M. Bona, M. Boonekamp, C.D. Booth, A.G. Borbély, I.S. Bordulev, H.M. Borecka-Bielska, L.S. Borgna, G. Borissov, D. Bortoletto, D. Boscherini, M. Bosman, J.D. 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Wosiek, K.W. Woźniak, S. Wozniewski, K. Wraight, C. Wu, J. Wu, M. Wu, S.L. Wu, X. Wu, Y. Wu, Z. Wu, J. Wuerzinger, T.R. Wyatt, B.M. Wynne, S. Xella, L. Xia, M. Xia, J. Xiang, X. Xiao, M. Xie, X. Xie, S. Xin, J. Xiong, D. Xu, H. Xu, L. Xu, R. Xu, T. Xu, Y. Xu, Z. Xu, B. Yabsley, S. Yacoob, N. Yamaguchi, Y. Yamaguchi, E. Yamashita, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H.J. Yang, H.T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, Y.C. Yap, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B. Yeo, M.R. Yexley, P. Yin, K. Yorita, S. Younas, C.J.S. Young, C. Young, Y. Yu, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, T. Zakareishvili, N. Zakharchuk, S. Zambito, J.A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J.C. Zeng, D.T. Zenger, Jr, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D.F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, P. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C.G. Zhu, J. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, V. Zhulanov, N.I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T.G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Physics, QC1-999
Abstract: A search is presented for the pair production of higgsinos χ˜ in gauge-mediated supersymmetry models, where the lightest neutralinos χ˜10 decay into a light gravitino G˜ in association with either a Higgs h or a Z boson. The search is performed with the ATLAS detector at the Large Hadron Collider using 139 fb−1 of proton–proton collisions at a centre-of-mass energy of s=13TeV. It targets final states in which a Higgs boson decays into a photon pair, while the other Higgs or Z boson decays into a bb¯ pair, with missing transverse momentum associated with the two gravitinos. Search regions dependent on the amount of missing transverse momentum are defined by the requirements that the diphoton mass should be consistent with the mass of the Higgs boson, and the bb¯ mass with the mass of the Higgs or Z boson. The main backgrounds are estimated with data-driven methods using the sidebands of the diphoton mass distribution. No excesses beyond Standard Model expectations are observed and higgsinos with masses up to 320GeV are excluded, assuming a branching fraction of 100% for χ˜10→hG˜. This analysis excludes higgsinos with masses of 130GeV for branching fractions to hG˜ as low as 36%, thus providing complementarity to previous ATLAS searches in final states with multiple leptons or multiple b-jets, targeting different decays of the electroweak bosons.
Published: 2024
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20. Search for heavy Majorana neutrinos in e±e± and e±μ± final states via WW scattering in pp collisions at s=13 TeV with the ATLAS detector

Author: G. Aad, E. Aakvaag, B. Abbott, S. Abdelhameed, K. Abeling, N.J. Abicht, S.H. Abidi, M. Aboelela, A. Aboulhorma, H. Abramowicz, H. Abreu, Y. Abulaiti, B.S. Acharya, A. Ackermann, C. Adam Bourdarios, L. Adamczyk, S.V. Addepalli, M.J. Addison, J. Adelman, A. Adiguzel, T. Adye, A.A. Affolder, Y. Afik, M.N. Agaras, J. Agarwala, A. Aggarwal, C. Agheorghiesei, A. Ahmad, F. Ahmadov, W.S. Ahmed, S. Ahuja, X. Ai, G. Aielli, A. Aikot, M. Ait Tamlihat, B. Aitbenchikh, M. Akbiyik, T.P.A. Åkesson, A.V. Akimov, D. Akiyama, N.N. Akolkar, S. Aktas, K. Al Khoury, G.L. Alberghi, J. Albert, P. Albicocco, G.L. Albouy, S. Alderweireldt, Z.L. Alegria, M. Aleksa, I.N. Aleksandrov, C. Alexa, T. Alexopoulos, F. Alfonsi, M. Algren, M. Alhroob, B. Ali, H.M.J. Ali, S. Ali, S.W. Alibocus, M. Aliev, G. Alimonti, W. Alkakhi, C. Allaire, B.M.M. Allbrooke, J.F. Allen, C.A. Allendes Flores, P.P. Allport, A. Aloisio, F. Alonso, C. Alpigiani, Z.M.K. Alsolami, M. Alvarez Estevez, A. Alvarez Fernandez, M. Alves Cardoso, M.G. Alviggi, M. Aly, Y. Amaral Coutinho, A. Ambler, C. Amelung, M. Amerl, C.G. Ames, D. Amidei, K.J. Amirie, S.P. Amor Dos Santos, K.R. Amos, S. An, V. Ananiev, C. Anastopoulos, T. Andeen, J.K. Anders, A.C. Anderson, S.Y. Andrean, A. Andreazza, S. Angelidakis, A. Angerami, A.V. Anisenkov, A. Annovi, C. Antel, E. Antipov, M. Antonelli, F. Anulli, M. Aoki, T. Aoki, M.A. Aparo, L. Aperio Bella, C. Appelt, A. Apyan, S.J. Arbiol Val, C. Arcangeletti, A.T.H. Arce, E. Arena, J-F. Arguin, S. Argyropoulos, J.-H. Arling, O. Arnaez, H. Arnold, G. Artoni, H. Asada, K. Asai, S. Asai, N.A. Asbah, R.A. Ashby Pickering, K. Assamagan, R. Astalos, K.S.V. Astrand, S. Atashi, R.J. Atkin, M. Atkinson, H. Atmani, P.A. Atmasiddha, K. Augsten, S. Auricchio, A.D. Auriol, V.A. Austrup, G. Avolio, K. Axiotis, G. Azuelos, D. Babal, H. Bachacou, K. Bachas, A. Bachiu, F. Backman, A. Badea, T.M. Baer, P. Bagnaia, M. Bahmani, D. Bahner, K. Bai, J.T. Baines, L. Baines, O.K. Baker, E. Bakos, D. Bakshi Gupta, L.E. Balabram Filho, V. Balakrishnan, R. Balasubramanian, E.M. Baldin, P. Balek, E. Ballabene, F. Balli, L.M. Baltes, W.K. Balunas, J. Balz, I. Bamwidhi, E. Banas, M. Bandieramonte, A. Bandyopadhyay, S. Bansal, L. Barak, M. Barakat, E.L. Barberio, D. Barberis, M. Barbero, M.Z. Barel, K.N. Barends, T. Barillari, M-S. Barisits, T. Barklow, P. Baron, D.A. Baron Moreno, A. Baroncelli, G. Barone, A.J. Barr, J.D. Barr, F. Barreiro, J. Barreiro Guimarães da Costa, U. Barron, M.G. Barros Teixeira, S. Barsov, F. Bartels, R. Bartoldus, A.E. Barton, P. Bartos, A. Basan, M. Baselga, A. Bassalat, M.J. Basso, S. Bataju, R. Bate, R.L. Bates, S. Batlamous, B. Batool, M. Battaglia, D. Battulga, M. Bauce, M. Bauer, P. Bauer, L.T. Bazzano Hurrell, J.B. Beacham, T. Beau, J.Y. Beaucamp, P.H. Beauchemin, P. Bechtle, H.P. Beck, K. Becker, A.J. Beddall, V.A. Bednyakov, C.P. Bee, L.J. Beemster, T.A. Beermann, M. Begalli, M. Begel, A. Behera, J.K. Behr, J.F. Beirer, F. Beisiegel, M. Belfkir, G. Bella, L. Bellagamba, A. Bellerive, P. Bellos, K. Beloborodov, D. Benchekroun, F. Bendebba, Y. Benhammou, K.C. Benkendorfer, L. Beresford, M. Beretta, E. Bergeaas Kuutmann, N. Berger, B. Bergmann, J. Beringer, G. Bernardi, C. Bernius, F.U. Bernlochner, F. Bernon, A. Berrocal Guardia, T. Berry, P. Berta, A. Berthold, S. Bethke, A. Betti, A.J. Bevan, N.K. Bhalla, S. Bhatta, D.S. Bhattacharya, P. Bhattarai, K.D. Bhide, V.S. Bhopatkar, R.M. Bianchi, G. Bianco, O. Biebel, R. Bielski, M. Biglietti, C.S. Billingsley, M. Bindi, A. Bingul, C. Bini, A. Biondini, G.A. Bird, M. Birman, M. Biros, S. Biryukov, T. Bisanz, E. Bisceglie, J.P. Biswal, D. Biswas, I. Bloch, A. Blue, U. Blumenschein, J. Blumenthal, V.S. Bobrovnikov, M. Boehler, B. Boehm, D. Bogavac, A.G. Bogdanchikov, C. Bohm, V. Boisvert, P. Bokan, T. Bold, M. Bomben, M. Bona, M. Boonekamp, C.D. Booth, A.G. Borbély, I.S. Bordulev, H.M. Borecka-Bielska, G. Borissov, D. Bortoletto, D. Boscherini, M. Bosman, J.D. Bossio Sola, K. Bouaouda, N. Bouchhar, L. Boudet, J. Boudreau, E.V. Bouhova-Thacker, D. Boumediene, R. Bouquet, A. Boveia, J. Boyd, D. Boye, I.R. Boyko, L. Bozianu, J. Bracinik, N. Brahimi, G. Brandt, O. Brandt, F. Braren, B. Brau, J.E. Brau, R. Brener, L. Brenner, R. Brenner, S. Bressler, G. Brianti, D. Britton, D. Britzger, I. Brock, G. Brooijmans, E.M. Brooks, E. Brost, L.M. Brown, L.E. Bruce, T.L. Bruckler, P.A. Bruckman de Renstrom, B. Brüers, A. Bruni, G. Bruni, M. Bruschi, N. Bruscino, T. Buanes, Q. Buat, D. Buchin, A.G. Buckley, O. Bulekov, B.A. Bullard, S. Burdin, C.D. Burgard, A.M. Burger, B. Burghgrave, O. Burlayenko, J.T.P. Burr, J.C. Burzynski, E.L. Busch, V. Büscher, P.J. Bussey, J.M. Butler, C.M. Buttar, J.M. Butterworth, W. Buttinger, C.J. Buxo Vazquez, A.R. Buzykaev, S. Cabrera Urbán, L. Cadamuro, D. Caforio, H. Cai, Y. Cai, V.M.M. Cairo, O. Cakir, N. Calace, P. Calafiura, G. Calderini, P. Calfayan, G. Callea, L.P. Caloba, D. Calvet, S. Calvet, M. Calvetti, R. Camacho Toro, S. Camarda, D. Camarero Munoz, P. Camarri, M.T. Camerlingo, D. Cameron, C. Camincher, M. Campanelli, A. Camplani, V. Canale, A.C. Canbay, E. Canonero, J. Cantero, Y. Cao, F. Capocasa, M. Capua, A. Carbone, R. Cardarelli, J.C.J. Cardenas, G. Carducci, T. Carli, G. Carlino, J.I. Carlotto, B.T. Carlson, E.M. Carlson, J. Carmignani, L. Carminati, A. Carnelli, M. Carnesale, S. Caron, E. Carquin, S. Carrá, G. Carratta, A.M. Carroll, T.M. Carter, M.P. Casado, M. Caspar, F.L. Castillo, L. Castillo Garcia, V. Castillo Gimenez, N.F. Castro, A. Catinaccio, J.R. Catmore, T. Cavaliere, V. Cavaliere, N. Cavalli, L.J. Caviedes Betancourt, Y.C. Cekmecelioglu, E. Celebi, S. Cella, F. Celli, M.S. Centonze, V. Cepaitis, K. Cerny, A.S. Cerqueira, A. Cerri, L. Cerrito, F. Cerutti, B. Cervato, A. Cervelli, G. Cesarini, S.A. Cetin, D. Chakraborty, J. Chan, W.Y. Chan, J.D. Chapman, E. Chapon, B. Chargeishvili, D.G. Charlton, M. Chatterjee, C. Chauhan, Y. Che, S. Chekanov, S.V. Chekulaev, G.A. Chelkov, A. Chen, B. Chen, H. Chen, J. Chen, M. Chen, S. Chen, S.J. Chen, X. Chen, Y. Chen, C.L. Cheng, H.C. Cheng, S. Cheong, A. Cheplakov, E. Cheremushkina, E. Cherepanova, R. Cherkaoui El Moursli, E. Cheu, K. Cheung, L. Chevalier, V. Chiarella, G. Chiarelli, N. Chiedde, G. Chiodini, A.S. Chisholm, A. Chitan, M. Chitishvili, M.V. Chizhov, K. Choi, Y. Chou, E.Y.S. Chow, K.L. Chu, M.C. Chu, X. Chu, Z. Chubinidze, J. Chudoba, J.J. Chwastowski, D. Cieri, K.M. Ciesla, V. Cindro, A. Ciocio, F. Cirotto, Z.H. Citron, M. Citterio, D.A. Ciubotaru, A. Clark, P.J. Clark, N. Clarke Hall, C. Clarry, J.M. Clavijo Columbie, S.E. Clawson, C. Clement, J. Clercx, Y. Coadou, M. Cobal, A. Coccaro, R.F. Coelho Barrue, R. Coelho Lopes De Sa, S. Coelli, L.S. Colangeli, B. Cole, J. Collot, P. Conde Muiño, M.P. Connell, S.H. Connell, E.I. Conroy, F. Conventi, H.G. Cooke, A.M. Cooper-Sarkar, F.A. Corchia, A. Cordeiro Oudot Choi, L.D. Corpe, M. Corradi, F. Corriveau, A. Cortes-Gonzalez, M.J. Costa, F. Costanza, D. Costanzo, B.M. Cote, J. Couthures, G. Cowan, K. Cranmer, D. Cremonini, S. Crépé-Renaudin, F. Crescioli, M. Cristinziani, M. Cristoforetti, V. Croft, J.E. Crosby, G. Crosetti, A. Cueto, H. Cui, Z. Cui, W.R. Cunningham, F. Curcio, J.R. Curran, P. Czodrowski, M.M. Czurylo, M.J. Da Cunha Sargedas De Sousa, J.V. Da Fonseca Pinto, C. Da Via, W. Dabrowski, T. Dado, S. Dahbi, T. Dai, D. Dal Santo, C. Dallapiccola, M. Dam, G. D'amen, V. D'Amico, J. Damp, J.R. Dandoy, D. Dannheim, M. Danninger, V. Dao, G. Darbo, S.J. Das, F. Dattola, S. D'Auria, A. D'avanzo, C. David, T. Davidek, I. Dawson, H.A. Day-hall, K. De, R. De Asmundis, N. De Biase, S. De Castro, N. De Groot, P. de Jong, H. De la Torre, A. De Maria, A. De Salvo, U. De Sanctis, F. De Santis, A. De Santo, J.B. De Vivie De Regie, D.V. Dedovich, J. Degens, A.M. Deiana, F. Del Corso, J. Del Peso, F. Del Rio, L. Delagrange, F. Deliot, C.M. Delitzsch, M. Della Pietra, D. Della Volpe, A. Dell'Acqua, L. Dell'Asta, M. Delmastro, P.A. Delsart, S. Demers, M. Demichev, S.P. Denisov, L. D'Eramo, D. Derendarz, F. Derue, P. Dervan, K. Desch, C. Deutsch, F.A. Di Bello, A. Di Ciaccio, L. Di Ciaccio, A. Di Domenico, C. Di Donato, A. Di Girolamo, G. Di Gregorio, A. Di Luca, B. Di Micco, R. Di Nardo, K.F. Di Petrillo, M. Diamantopoulou, F.A. Dias, T. Dias Do Vale, M.A. Diaz, F.G. Diaz Capriles, M. Didenko, E.B. Diehl, S. Díez Cornell, C. Diez Pardos, C. Dimitriadi, A. Dimitrievska, J. Dingfelder, I-M. Dinu, S.J. Dittmeier, F. Dittus, M. Divisek, F. Djama, T. Djobava, C. Doglioni, A. Dohnalova, J. Dolejsi, Z. Dolezal, K. Domijan, K.M. Dona, M. Donadelli, B. Dong, J. Donini, A. D'Onofrio, M. D'Onofrio, J. Dopke, A. Doria, N. Dos Santos Fernandes, P. Dougan, M.T. Dova, A.T. Doyle, M.A. Draguet, I.M. Drapeau, E. Dreyer, I. Drivas-koulouris, M. Drnevich, M. Drozdova, D. Du, T.A. du Pree, F. Dubinin, M. Dubovsky, E. Duchovni, G. Duckeck, O.A. Ducu, D. Duda, A. Dudarev, E.R. Duden, M. D'uffizi, L. Duflot, M. Dührssen, I. Duminica, A.E. Dumitriu, M. Dunford, S. Dungs, K. Dunne, A. Duperrin, H. Duran Yildiz, M. Düren, A. Durglishvili, B.L. Dwyer, G.I. Dyckes, M. Dyndal, B.S. Dziedzic, Z.O. Earnshaw, G.H. Eberwein, B. Eckerova, S. Eggebrecht, E. Egidio Purcino De Souza, L.F. Ehrke, G. Eigen, K. Einsweiler, T. Ekelof, P.A. Ekman, S. El Farkh, Y. El Ghazali, H. El Jarrari, A. El Moussaouy, V. Ellajosyula, M. Ellert, F. Ellinghaus, N. Ellis, J. Elmsheuser, M. Elsawy, M. Elsing, D. Emeliyanov, Y. Enari, I. Ene, S. Epari, P.A. Erland, D. Ernani Martins Neto, M. Errenst, M. Escalier, C. Escobar, E. Etzion, G. Evans, H. Evans, L.S. Evans, A. Ezhilov, S. Ezzarqtouni, F. Fabbri, L. Fabbri, G. Facini, V. Fadeyev, R.M. Fakhrutdinov, D. Fakoudis, S. Falciano, L.F. Falda Ulhoa Coelho, F. Fallavollita, G. Falsetti, J. Faltova, C. Fan, Y. Fan, Y. Fang, M. Fanti, M. Faraj, Z. Farazpay, A. Farbin, A. Farilla, T. Farooque, S.M. Farrington, F. Fassi, D. Fassouliotis, M. Faucci Giannelli, W.J. Fawcett, L. Fayard, P. Federic, P. Federicova, O.L. Fedin, M. Feickert, L. Feligioni, D.E. Fellers, C. Feng, M. Feng, Z. Feng, M.J. Fenton, L. Ferencz, R.A.M. Ferguson, S.I. Fernandez Luengo, P. Fernandez Martinez, M.J.V. Fernoux, J. Ferrando, A. Ferrari, P. Ferrari, R. Ferrari, D. Ferrere, C. Ferretti, D. Fiacco, F. Fiedler, P. Fiedler, A. Filipčič, E.K. Filmer, F. Filthaut, M.C.N. Fiolhais, L. Fiorini, W.C. Fisher, T. Fitschen, P.M. Fitzhugh, I. Fleck, P. Fleischmann, T. Flick, M. Flores, L.R. Flores Castillo, L. Flores Sanz De Acedo, F.M. Follega, N. Fomin, J.H. Foo, A. Formica, A.C. Forti, E. Fortin, A.W. Fortman, M.G. Foti, L. Fountas, D. Fournier, H. Fox, P. Francavilla, S. Francescato, S. Franchellucci, M. Franchini, S. Franchino, D. Francis, L. Franco, V. Franco Lima, L. Franconi, M. Franklin, G. Frattari, Y.Y. Frid, J. Friend, N. Fritzsche, A. Froch, D. Froidevaux, J.A. Frost, Y. Fu, S. Fuenzalida Garrido, M. Fujimoto, K.Y. Fung, E. Furtado De Simas Filho, M. Furukawa, J. Fuster, A. Gaa, A. Gabrielli, P. Gadow, G. Gagliardi, L.G. Gagnon, S. Gaid, S. Galantzan, E.J. Gallas, B.J. Gallop, K.K. Gan, S. Ganguly, Y. Gao, F.M. Garay Walls, B. Garcia, C. García, A. Garcia Alonso, A.G. Garcia Caffaro, J.E. García Navarro, M. Garcia-Sciveres, G.L. Gardner, R.W. Gardner, N. Garelli, D. Garg, R.B. Garg, J.M. Gargan, C.A. Garner, C.M. Garvey, V.K. Gassmann, G. Gaudio, V. Gautam, P. Gauzzi, J. Gavranovic, I.L. Gavrilenko, A. Gavrilyuk, C. Gay, G. Gaycken, E.N. Gazis, A.A. Geanta, C.M. Gee, A. Gekow, C. Gemme, M.H. Genest, A.D. Gentry, S. George, W.F. George, T. Geralis, P. Gessinger-Befurt, M.E. Geyik, M. Ghani, K. Ghorbanian, A. Ghosal, A. Ghosh, B. Giacobbe, S. Giagu, T. Giani, P. Giannetti, A. Giannini, S.M. Gibson, M. Gignac, D.T. Gil, A.K. Gilbert, B.J. Gilbert, D. Gillberg, G. Gilles, L. Ginabat, D.M. Gingrich, M.P. Giordani, P.F. Giraud, G. Giugliarelli, D. Giugni, F. Giuli, I. Gkialas, L.K. Gladilin, C. Glasman, G.R. Gledhill, G. Glemža, M. Glisic, I. Gnesi, Y. Go, M. Goblirsch-Kolb, B. Gocke, D. Godin, B. Gokturk, S. Goldfarb, T. Golling, M.G.D. Gololo, D. Golubkov, J.P. Gombas, A. Gomes, G. Gomes Da Silva, A.J. Gomez Delegido, R. Gonçalo, L. Gonella, A. Gongadze, F. Gonnella, J.L. Gonski, R.Y. González Andana, S. González de la Hoz, R. Gonzalez Lopez, C. Gonzalez Renteria, M.V. Gonzalez Rodrigues, R. Gonzalez Suarez, S. Gonzalez-Sevilla, L. Goossens, B. Gorini, E. Gorini, A. Gorišek, T.C. Gosart, A.T. Goshaw, M.I. Gostkin, S. Goswami, C.A. Gottardo, S.A. Gotz, M. Gouighri, V. Goumarre, A.G. Goussiou, N. Govender, I. Grabowska-Bold, K. Graham, E. Gramstad, S. Grancagnolo, C.M. Grant, P.M. Gravila, F.G. Gravili, H.M. Gray, M. Greco, M.J. Green, C. Grefe, A.S. Grefsrud, I.M. Gregor, K.T. Greif, P. Grenier, S.G. Grewe, A.A. Grillo, K. Grimm, S. Grinstein, J.-F. Grivaz, E. Gross, J. Grosse-Knetter, J.C. Grundy, L. Guan, J.G.R. Guerrero Rojas, G. Guerrieri, R. Gugel, J.A.M. Guhit, A. Guida, E. Guilloton, S. Guindon, F. Guo, J. Guo, L. Guo, Y. Guo, R. Gupta, S. Gurbuz, S.S. Gurdasani, G. Gustavino, M. Guth, P. Gutierrez, L.F. Gutierrez Zagazeta, M. Gutsche, C. Gutschow, C. Gwenlan, C.B. Gwilliam, E.S. Haaland, A. Haas, M. Habedank, C. Haber, H.K. Hadavand, A. Hadef, S. Hadzic, A.I. Hagan, J.J. Hahn, E.H. Haines, M. Haleem, J. Haley, J.J. Hall, G.D. Hallewell, L. Halser, K. Hamano, M. Hamer, G.N. Hamity, E.J. Hampshire, J. Han, K. Han, L. Han, S. Han, Y.F. Han, K. Hanagaki, M. Hance, D.A. Hangal, H. Hanif, M.D. Hank, J.B. Hansen, P.H. Hansen, K. Hara, D. Harada, T. Harenberg, S. Harkusha, M.L. Harris, Y.T. Harris, J. Harrison, N.M. Harrison, P.F. Harrison, N.M. Hartman, N.M. Hartmann, R.Z. Hasan, Y. Hasegawa, S. Hassan, R. Hauser, C.M. Hawkes, R.J. Hawkings, Y. Hayashi, S. Hayashida, D. Hayden, C. Hayes, R.L. Hayes, C.P. Hays, J.M. Hays, H.S. Hayward, F. He, M. He, Y. He, N.B. Heatley, V. Hedberg, A.L. Heggelund, N.D. Hehir, C. Heidegger, K.K. Heidegger, J. Heilman, S. Heim, T. Heim, J.G. Heinlein, J.J. Heinrich, L. Heinrich, J. Hejbal, A. 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Safarzadeh Samani, S. Saha, M. Sahinsoy, A. Saibel, M. Saimpert, M. Saito, T. Saito, A. Sala, D. Salamani, A. Salnikov, J. Salt, A. Salvador Salas, D. Salvatore, F. Salvatore, A. Salzburger, D. Sammel, E. Sampson, D. Sampsonidis, D. Sampsonidou, J. Sánchez, V. Sanchez Sebastian, H. Sandaker, C.O. Sander, J.A. Sandesara, M. Sandhoff, C. Sandoval, L. Sanfilippo, D.P.C. Sankey, T. Sano, A. Sansoni, L. Santi, C. Santoni, H. Santos, A. Santra, E. Sanzani, K.A. Saoucha, J.G. Saraiva, J. Sardain, O. Sasaki, K. Sato, C. Sauer, E. Sauvan, P. Savard, R. Sawada, C. Sawyer, L. Sawyer, C. Sbarra, A. Sbrizzi, T. Scanlon, J. Schaarschmidt, U. Schäfer, A.C. Schaffer, D. Schaile, R.D. Schamberger, C. Scharf, M.M. Schefer, V.A. Schegelsky, D. Scheirich, M. Schernau, C. Scheulen, C. Schiavi, M. Schioppa, B. Schlag, K.E. Schleicher, S. Schlenker, J. Schmeing, M.A. Schmidt, K. Schmieden, C. Schmitt, N. Schmitt, S. Schmitt, L. Schoeffel, A. Schoening, P.G. Scholer, E. Schopf, M. Schott, J. Schovancova, S. Schramm, T. Schroer, H-C. Schultz-Coulon, M. Schumacher, B.A. Schumm, Ph. Schune, A.J. Schuy, H.R. Schwartz, A. Schwartzman, T.A. Schwarz, Ph. Schwemling, R. Schwienhorst, F.G. Sciacca, A. Sciandra, G. Sciolla, F. Scuri, C.D. Sebastiani, K. Sedlaczek, S.C. Seidel, A. Seiden, B.D. Seidlitz, C. Seitz, J.M. Seixas, G. Sekhniaidze, L. Selem, N. Semprini-Cesari, D. Sengupta, V. Senthilkumar, L. Serin, M. Sessa, H. Severini, F. Sforza, A. Sfyrla, Q. Sha, E. Shabalina, A.H. Shah, R. Shaheen, J.D. Shahinian, D. Shaked Renous, L.Y. Shan, M. Shapiro, A. Sharma, A.S. Sharma, P. Sharma, P.B. Shatalov, K. Shaw, S.M. Shaw, Q. Shen, D.J. Sheppard, P. Sherwood, L. Shi, X. Shi, C.O. Shimmin, J.D. Shinner, I.P.J. Shipsey, S. Shirabe, M. Shiyakova, M.J. Shochet, J. Shojaii, D.R. Shope, B. Shrestha, S. Shrestha, M.J. Shroff, P. Sicho, A.M. Sickles, E. Sideras Haddad, A.C. Sidley, A. Sidoti, F. Siegert, Dj. Sijacki, F. Sili, J.M. Silva, I. Silva Ferreira, M.V. Silva Oliveira, S.B. Silverstein, S. Simion, R. Simoniello, E.L. Simpson, H. Simpson, L.R. Simpson, N.D. Simpson, S. Simsek, S. Sindhu, P. Sinervo, S. Singh, S. Sinha, M. Sioli, I. Siral, E. Sitnikova, J. Sjölin, A. Skaf, E. Skorda, P. Skubic, M. Slawinska, V. Smakhtin, B.H. Smart, S.Yu. Smirnov, Y. Smirnov, L.N. Smirnova, O. Smirnova, A.C. Smith, D.R. Smith, E.A. Smith, H.A. Smith, J.L. Smith, R. Smith, M. Smizanska, K. Smolek, A.A. Snesarev, S.R. Snider, H.L. Snoek, S. Snyder, R. Sobie, A. Soffer, C.A. Solans Sanchez, E.Yu. Soldatov, U. Soldevila, A.A. Solodkov, S. Solomon, A. Soloshenko, K. Solovieva, O.V. Solovyanov, P. Sommer, A. Sonay, W.Y. Song, A. Sopczak, A.L. Sopio, F. Sopkova, J.D. Sorenson, I.R. Sotarriva Alvarez, V. Sothilingam, O.J. Soto Sandoval, S. Sottocornola, R. Soualah, Z. Soumaimi, D. South, N. Soybelman, S. Spagnolo, M. Spalla, D. Sperlich, G. Spigo, S. Spinali, B. Spisso, D.P. Spiteri, M. Spousta, E.J. Staats, R. Stamen, A. Stampekis, M. Standke, E. Stanecka, W. Stanek-Maslouska, M.V. Stange, B. Stanislaus, M.M. Stanitzki, B. Stapf, E.A. Starchenko, G.H. Stark, J. Stark, P. Staroba, P. Starovoitov, S. Stärz, R. Staszewski, G. Stavropoulos, J. Steentoft, P. Steinberg, B. Stelzer, H.J. Stelzer, O. Stelzer-Chilton, H. Stenzel, T.J. Stevenson, G.A. Stewart, J.R. Stewart, M.C. Stockton, G. Stoicea, M. Stolarski, S. Stonjek, A. Straessner, J. Strandberg, S. Strandberg, M. Stratmann, M. Strauss, T. Strebler, P. Strizenec, R. Ströhmer, D.M. Strom, R. Stroynowski, A. Strubig, S.A. Stucci, B. Stugu, J. Stupak, N.A. Styles, D. Su, S. Su, W. Su, X. Su, D. Suchy, K. Sugizaki, V.V. Sulin, M.J. Sullivan, D.M.S. Sultan, L. Sultanaliyeva, S. Sultansoy, T. Sumida, S. Sun, O. Sunneborn Gudnadottir, N. Sur, M.R. Sutton, H. Suzuki, M. Svatos, M. Swiatlowski, T. Swirski, I. Sykora, M. Sykora, T. Sykora, D. Ta, K. Tackmann, A. Taffard, R. Tafirout, J.S. Tafoya Vargas, Y. Takubo, M. Talby, A.A. Talyshev, K.C. Tam, N.M. Tamir, A. Tanaka, J. Tanaka, R. Tanaka, M. Tanasini, Z. Tao, S. Tapia Araya, S. Tapprogge, A. Tarek Abouelfadl Mohamed, S. Tarem, K. Tariq, G. Tarna, G.F. Tartarelli, M.J. Tartarin, P. Tas, M. Tasevsky, E. Tassi, A.C. Tate, G. Tateno, Y. Tayalati, G.N. Taylor, W. Taylor, R. Teixeira De Lima, P. Teixeira-Dias, J.J. Teoh, K. Terashi, J. Terron, S. Terzo, M. Testa, R.J. Teuscher, A. Thaler, O. Theiner, N. Themistokleous, T. Theveneaux-Pelzer, O. Thielmann, D.W. Thomas, J.P. Thomas, E.A. Thompson, P.D. Thompson, E. Thomson, R.E. Thornberry, C. Tian, Y. Tian, V. Tikhomirov, Yu.A. Tikhonov, S. Timoshenko, D. Timoshyn, E.X.L. Ting, P. Tipton, A. Tishelman-Charny, S.H. Tlou, K. Todome, S. Todorova-Nova, S. Todt, L. Toffolin, M. Togawa, J. Tojo, S. Tokár, K. Tokushuku, O. Toldaiev, R. Tombs, M. Tomoto, L. Tompkins, K.W. Topolnicki, E. Torrence, H. Torres, E. Torró Pastor, M. Toscani, C. Tosciri, M. Tost, D.R. Tovey, I.S. Trandafir, T. Trefzger, A. Tricoli, I.M. Trigger, S. Trincaz-Duvoid, D.A. Trischuk, B. Trocmé, A. Tropina, L. Truong, M. Trzebinski, A. Trzupek, F. Tsai, M. Tsai, A. Tsiamis, P.V. Tsiareshka, S. Tsigaridas, A. Tsirigotis, V. Tsiskaridze, E.G. Tskhadadze, M. Tsopoulou, Y. Tsujikawa, I.I. Tsukerman, V. Tsulaia, S. Tsuno, K. Tsuri, D. Tsybychev, Y. Tu, A. Tudorache, V. Tudorache, A.N. Tuna, S. Turchikhin, I. Turk Cakir, R. Turra, T. Turtuvshin, P.M. Tuts, S. Tzamarias, E. Tzovara, F. Ukegawa, P.A. Ulloa Poblete, E.N. Umaka, G. Unal, A. Undrus, G. Unel, J. Urban, P. Urrejola, G. Usai, R. Ushioda, M. Usman, Z. Uysal, V. Vacek, B. Vachon, T. Vafeiadis, A. Vaitkus, C. Valderanis, E. Valdes Santurio, M. Valente, S. Valentinetti, A. Valero, E. Valiente Moreno, A. Vallier, J.A. Valls Ferrer, D.R. Van Arneman, T.R. Van Daalen, A. Van Der Graaf, P. Van Gemmeren, M. Van Rijnbach, S. Van Stroud, I. Van Vulpen, P. Vana, M. Vanadia, W. Vandelli, E.R. Vandewall, D. Vannicola, L. Vannoli, R. Vari, E.W. Varnes, C. Varni, T. Varol, D. Varouchas, L. Varriale, K.E. Varvell, M.E. Vasile, L. Vaslin, G.A. Vasquez, A. Vasyukov, L.M. Vaughan, R. Vavricka, T. Vazquez Schroeder, J. Veatch, V. Vecchio, M.J. Veen, I. Veliscek, L.M. Veloce, F. Veloso, S. Veneziano, A. Ventura, S. Ventura Gonzalez, A. Verbytskyi, M. Verducci, C. Vergis, M. Verissimo De Araujo, W. Verkerke, J.C. Vermeulen, C. Vernieri, M. Vessella, M.C. Vetterli, A. Vgenopoulos, N. Viaux Maira, T. Vickey, O.E. Vickey Boeriu, G.H.A. Viehhauser, L. Vigani, M. Villa, M. Villaplana Perez, E.M. Villhauer, E. Vilucchi, M.G. Vincter, A. Visibile, C. Vittori, I. Vivarelli, E. Voevodina, F. Vogel, J.C. Voigt, P. Vokac, Yu. Volkotrub, J. Von Ahnen, E. Von Toerne, B. Vormwald, V. Vorobel, K. Vorobev, M. Vos, K. Voss, M. Vozak, L. Vozdecky, N. Vranjes, M. Vranjes Milosavljevic, M. Vreeswijk, N.K. Vu, R. Vuillermet, O. Vujinovic, I. Vukotic, S. Wada, C. Wagner, J.M. Wagner, W. Wagner, S. Wahdan, H. Wahlberg, M. Wakida, J. Walder, R. Walker, W. Walkowiak, A. Wall, E.J. Wallin, T. Wamorkar, A.Z. Wang, C. Wang, H. Wang, J. Wang, P. Wang, R. Wang, S.M. Wang, S. Wang, T. Wang, W.T. Wang, W. Wang, X. Wang, Y. Wang, Z. Wang, A. Warburton, R.J. Ward, N. Warrack, S. Waterhouse, A.T. Watson, H. Watson, M.F. Watson, E. Watton, G. Watts, B.M. Waugh, J.M. Webb, C. Weber, H.A. Weber, M.S. Weber, S.M. Weber, C. Wei, Y. Wei, A.R. Weidberg, E.J. Weik, J. Weingarten, C. Weiser, C.J. Wells, T. Wenaus, B. Wendland, T. Wengler, N.S. Wenke, N. Wermes, M. Wessels, A.M. Wharton, A.S. White, A. White, M.J. White, D. Whiteson, L. Wickremasinghe, W. Wiedenmann, M. Wielers, C. Wiglesworth, D.J. Wilbern, H.G. Wilkens, J.J.H. Wilkinson, D.M. Williams, H.H. Williams, S. Williams, S. Willocq, B.J. Wilson, P.J. Windischhofer, F.I. Winkel, F. Winklmeier, B.T. Winter, J.K. Winter, M. Wittgen, M. Wobisch, T. Wojtkowski, Z. Wolffs, J. Wollrath, M.W. Wolter, H. Wolters, M.C. Wong, E.L. Woodward, S.D. Worm, B.K. Wosiek, K.W. Woźniak, S. Wozniewski, K. Wraight, C. Wu, M. Wu, S.L. Wu, X. Wu, Y. Wu, Z. Wu, J. Wuerzinger, T.R. Wyatt, B.M. Wynne, S. Xella, L. Xia, M. Xia, J. Xiang, M. Xie, S. Xin, A. Xiong, J. Xiong, D. Xu, H. Xu, L. Xu, R. Xu, T. Xu, Y. Xu, Z. Xu, B. Yabsley, S. Yacoob, Y. Yamaguchi, E. Yamashita, H. Yamauchi, T. Yamazaki, Y. Yamazaki, J. Yan, S. Yan, Z. Yan, H.J. Yang, H.T. Yang, S. Yang, T. Yang, X. Yang, Y. Yang, Z. Yang, W-M. Yao, H. Ye, J. Ye, S. Ye, X. Ye, Y. Yeh, I. Yeletskikh, B.K. Yeo, M.R. Yexley, T.P. Yildirim, P. Yin, K. Yorita, S. Younas, C.J.S. Young, C. Young, C. Yu, Y. Yu, J. Yuan, M. Yuan, R. Yuan, L. Yue, M. Zaazoua, B. Zabinski, E. Zaid, Z.K. Zak, T. Zakareishvili, N. Zakharchuk, S. Zambito, J.A. Zamora Saa, J. Zang, D. Zanzi, O. Zaplatilek, C. Zeitnitz, H. Zeng, J.C. Zeng, D.T. Zenger, Jr, O. Zenin, T. Ženiš, S. Zenz, S. Zerradi, D. Zerwas, M. Zhai, D.F. Zhang, J. Zhang, K. Zhang, L. Zhang, P. Zhang, R. Zhang, S. Zhang, T. Zhang, X. Zhang, Y. Zhang, Z. Zhang, H. Zhao, T. Zhao, Y. Zhao, Z. Zhao, A. Zhemchugov, J. Zheng, K. Zheng, X. Zheng, Z. Zheng, D. Zhong, B. Zhou, H. Zhou, N. Zhou, Y. Zhou, C.G. Zhu, J. Zhu, X. Zhu, Y. Zhu, X. Zhuang, K. Zhukov, N.I. Zimine, J. Zinsser, M. Ziolkowski, L. Živković, A. Zoccoli, K. Zoch, T.G. Zorbas, O. Zormpa, W. Zou, and L. Zwalinski
Subjects: Physics, QC1-999
Abstract: A search for heavy Majorana neutrinos in scattering of same-sign W boson pairs in proton–proton collisions at s=13 TeV at the LHC is reported. The dataset used corresponds to an integrated luminosity of 140 fb−1, collected with the ATLAS detector during 2015–2018. The search is performed in final states including a same-sign ee or eμ pair and at least two jets with large invariant mass and a large rapidity difference. No significant excess of events with respect to the Standard Model background predictions is observed. The results are interpreted in a benchmark scenario of the Phenomenological Type-I Seesaw model. New constraints are set on the values of the |VeN|2 and |VeNVμN⁎| parameters for heavy Majorana neutrino masses between 50 GeV and 20 TeV, where VℓN is the matrix element describing the mixing of the heavy Majorana neutrino mass eigenstate with the Standard Model neutrino of flavour ℓ=e,μ. The sensitivity to the Weinberg operator is investigated and constraints on the effective ee and eμ Majorana neutrino masses are reported. The statistical combination of the ee and eμ channels with the previously published μμ channel is performed.
Published: 2024
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21. Cervical pneumatocele: A case report and review of the literature

Author: Ricardo Navarro, MD, Alberto Pedraza, MD, Ping Quach, MD, and Daniel Masri, MD
Subjects: Thyroidectomy, Pneumatocele, Trachea, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract: A thyroidectomy is a safe and low-risk procedure done for a wide variety of thyroid disorders. Complications of a thyroidectomy are commonly due to damage of structures adjacent to the thyroid gland. In this case report, we present the case of a 39-year-old patient with a cervical pneumatocele a month after thyroidectomy for thyroid papillary carcinoma. The symptoms included neck swelling when speaking that resolved with rest. A follow-up neck CT scan found a collection of air anterior to the trachea most compatible with cervical pneumatocele. Exploratory surgery ensued and a pneumatocele arising from a tracheal subcutaneous fistula was cauterized. On follow-up laryngoscopy a month later, no further complications were found, and the patient reported resolution of symptoms. Tracheal injury following thyroidectomy is a rare complication and CT imaging can be helpful in diagnosing these complications and expediting management.
Published: 2024
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22. Ecosystem services potential and soil conservation policies with emphasis on degraded pastures in Brazil

Author: Adriana Monteiro da Costa, Maise Soares de Moura, Isadora Fonseca Navarro, Victor Cordeiro da Silva, Teresa Cristina Tarlé Pissarra, Carlos Alberto Valera, Luís Filipe Sanches Fernandes, and Fernando Antonio Leal Pacheco
Subjects: EU mission, Soil governance, Conservation use potential, Soil services, PronaSolos, Geography (General), G1-922, Environmental sciences, GE1-350
Abstract: Different global agendas have discussed the role of soils in mitigating and reducing global problems related to climate change, food security, biodiversity and erosion, among others. With this in mind, the aim was to draw up an overview of the main soil agendas in Europe and Brazil, analysing their impact on the establishment of legal frameworks for soil use and conservation. In Brazil, pastures are seen as an important alternative for converting degraded areas into ecosystem services. To this end, a literature review was carried out using databases on the Scopus, Web of Science, Science Direct and Scielo platforms, as well as consulting documents from the European Union Missions in Horizon Europe and Brazilian legislation on the subject. In a pilot river basin, the Potential for Conservation Use (PCU) method was applied, which is used in Brazil to assess the impacts of different uses on the natural capital of soils, serving as a metric to guide public soil conservation policies. It was concluded that, on the European scene, discussions on soils have taken place in an integrated and organised way, with actions to mobilise different players in society. In Brazil, even though there are important legal frameworks, actions are still restricted and disjointed, pointing to the need for progress in soil governance. In both scenarios, there is a need for scientifically validated metrics at regional scales that can contribute to a harmonised database capable of subsidising the development of efficient public policies to advance soil conservation at a global level.
Published: 2024
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23. The low-FODMAP diet

Author: Paula Lucas Zapata, Esther García Navarro, and Carmen Ribes Koninckx
Subjects: Dieta, FODMAP, Alimentos, Síntomas, Tratamiento, Pediatrics, RJ1-570
Abstract: In this article we present a protocol for the use of the low-FODMAP diet in paediatric patients and review of the current evidence on its efficacy. These short-chain carbohydrates, which can be fermented by the intestinal microbiota, are found in a wide variety of foods, mainly of plant origin. The low-FODMAP diet is a therapeutic tool used for the management of gastrointestinal disorders such as irritable bowel syndrome. The sources we used were PubMed, Web of Science, Google Scholar and institutional websites. Following consumption of FODMAP-rich foods, a series of end products are generated that are not absorbed, giving rise to symptoms. Before starting a low-FODMAP diet, it is important to carry out a diagnostic evaluation including any applicable tests. Treatment is structured in 3 phases: elimination, reintroduction and personalization phase. In the first phase, FODMAP-rich foods are eliminated for 2–3 weeks. In the second phase, lasting 8 weeks, FODMAP-rich foods are gradually reintroduced. The last phase consists in customizing the diet according to individual tolerance. This article details which foods contain FODMAPs and possible substitutes. In addition, specific food diary/intake tracking and educational materials are provided in a series of appendices to facilitate adherence to the diet. Although most studies have been conducted in adults, there is also some evidence on the beneficial effects in the paediatric age group, with a reduction of symptoms, especially in patients with functional gastrointestinal disorders. Nevertheless, more research is required on the subject. Resumen: En este artículo presentamos un protocolo para el uso de la dieta baja en FODMAPs en pacientes pediátricos y una revisión sobre la evidencia actual de su eficacia. Estos hidratos de carbono de cadena corta, fermentables por el microbiota intestinal, se encuentran fundamentalmente en gran variedad de alimentos de origen vegetal. La dieta baja en FODMAPs es una herramienta terapéutica utilizada en trastornos digestivos como el síndrome del intestino irritable. Los recursos utilizados han sido PubMed, Web of Science, Google Scholar y páginas web oficiales. Tras el consumo de alimentos ricos en FODMAPs, se generan unos productos finales que no se absorben, causando sintomatología. Antes de comenzar dicha dieta, es importante realizar una aproximación diagnóstica a través de las pruebas complementarias pertinentes. El tratamiento se divide en 3 fases: eliminación, reintroducción y personalización. En la primera se eliminan los alimentos ricos en FODMAPs durante 2–3 semanas. La segunda dura 8 semanas, y en ese período se introducen de nuevo de forma gradual alimentos ricos en FODMAPs. La última fase consiste en personalizar la dieta según la tolerancia individual. En este artículo se detallan aquellos alimentos que contienen dichos compuestos y los posibles sustitutos. Además, en una serie de Anexos se incluyen registros dietéticos específicos, y material didáctico para facilitar el cumplimiento de la dieta. Pese a que la mayoría de estudios se han realizado en población adulta, se ha observado que en edad pediátrica también tiene efectos beneficiosos. No obstante, se requiere más investigación al respecto.
Published: 2024
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24. Hiperaldosteronismo e hiperparatiroidismo. Una amistad inquietante

Author: Juan A. Martín Navarro, Laura Medina Zahonero, Fabio L. Procaccini, Raquel Barba Teba, Verónica Rubio Menéndez, Esther Valle Álvarez, Miryam Elena Polo Cánovas, Mayra Ortega-Díaz, Marta Puerta Carretero, Rafael Lucena Valverde, Patricia Muñoz Ramos, Roberto Alcázar Arroyo, and Patricia de Sequera Ortiz
Subjects: Hyperaldosteronism, Hyperparathyroidism, Calcium-sensing receptor, Blood pressure, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Resumen: Clásicamente, asociamos la acción de la aldosterona con la estabilidad del volumen circulante eficaz y el control de la presión arterial y la acción de la parathormona con el control del metabolismo óseo mineral y la normalidad de la calcemia y la fosforemia. Sin embargo, la relación entre estos dos ejes hormonales trasciende estos ámbitos y podemos definir una interrelación bidireccional entre ambos, que determina la patogenia de las alteraciones en el metabolismo calcio-fósforo y el control de la presión arterial, lo que implica consecuencias en la evolución y el tratamiento de los pacientes. La exposición de dos casos clínicos nos permite mostrar la fisiopatología de esta relación. Abstract: Classically, aldosterone actions are associated with the stability of the effective circulating volume and with blood pressure control, while parathormone actions are linked to bone mineral metabolism, calcium, and phosphate homeostasis. Nevertheless, the relationship between these two hormonal axes surpasses these areas. A bidirectional interrelation between calcium-phosphorus metabolism and blood pressure control can lead to alterations in both. This can have significant implications for the evolution and treatment of patients. To illustrate this relationship, we present two clinical cases that demonstrate the pathophysiology involved.
Published: 2024
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25. A comprehensive survey on the security of low power wide area networks for the Internet of Things

Author: Giovanni Stanco, Annalisa Navarro, Flavio Frattini, Giorgio Ventre, and Alessio Botta
Subjects: LPWAN, IoT, Security, Sigfox, NB-IoT, LoRaWAN, Information technology, T58.5-58.64
Abstract: While the spreading of the Internet of Things continues beyond expectations, the security of networking technologies used in this context remains an open issue. This paper provides a comprehensive overview of the state of the art on the security of Low Power Wide Area Networks (LPWANs), with a focus on Sigfox, LoRaWAN, and Narrowband Internet of Things. The paper covers five main areas: (1) security requirements and their implementation in these networks, such as authentication, encryption, access control, and key management; (2) categorization of attacks and threat modeling, with the identification of the attack vectors and the presentation of an attack categorization and analysis; (3) a detailed explanation of attacks documented on Sigfox, LoRaWAN, and Narrowband Internet of Things, examining the underlying vulnerabilities exploited, outlining potential consequences, and discussing countermeasures proposed to mitigate these attacks; (4) security enhancements proposed to address vulnerabilities in each network; (5) the integration of LPWANs with 5G and the consequent security challenges. This survey constitutes an important and missing resource for the study and the development of secure Internet of Things solutions based on Low Power Wide Area Networks, raising awareness of potential threats, and guiding future research efforts towards strengthening the security of these networks and of the broader IoT landscape.
Published: 2024
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26. Vacunación frente a la gripe estacional en la infancia y la adolescencia. Recomendaciones del Comité Asesor de Vacunas e Inmunizaciones de la Asociación Española de Pediatría (CAV-AEP) para la temporada 2024-2025

Author: Javier Álvarez Aldeán, Franciso José Álvarez García, María Garcés-Sánchez, Elisa Garrote Llanos, Antonio Iofrío de Arce, Marisa Luisa Navarro Gómez, Valentín Pineda Solas, Irene Rivero Calle, Jesús Ruiz-Contreras, Ignacio Salamanca de la Cueva, and Pepe Serrano Marchuet
Subjects: Flu vaccine, Child, Adolescent, Pregnant, Health worker, CAV-AEP, Pediatrics, RJ1-570
Abstract: Resumen: La gripe es una amenaza constante que en ocasiones puede producir cuadros clínicos graves. Las mayores tasas de incidencia por grupos de edad ocurren en los menores de 15 años, especialmente en los menores de 5 años, en los que además las tasas de hospitalización son similares a las de las personas de 65 años en adelante. Además, los niños son los principales vectores de transmisión de la enfermedad. En España están autorizadas cinco vacunas antigripales en la edad pediátrica: tres inactivadas tetravalentes procedentes de cultivos en huevos embrionados, una inactivada tetravalente procedente de cultivos celulares, y una atenuada tetravalente de administración intranasal, que para la temporada 2024-2025 pasará a ser trivalente, al no incluir el linaje B Yamagata, como recomienda la OMS. El CAV-AEP recomienda la vacunación sistemática en: niños de 6 a 59 meses, niños y adolescentes pertenecientes a grupos de riesgo, personas que puedan transmitir la gripe a los grupos que tienen riesgo de gripe complicada, y convivientes o entorno familiar de menores de 6 meses. A partir de los 2 años de edad se recomienda preferentemente la vacuna atenuada intranasal por su mayor aceptabilidad y por facilitar la mejora de las coberturas. El CAV-AEP considera también que la vacunación antigripal de niños y adolescentes de 5-18 años sanos es una medida recomendable, por cuanto les proporciona protección individual y favorece la protección familiar y comunitaria. Es especialmente importante la vacunación antigripal de todos los profesionales sanitarios y la vacunación de las gestantes en cualquier momento del embarazo. Abstract: The flu is a constant threat that can sometimes cause severe forms of disease. The highest incidence rates by age group occur in children under 15 years of age, especially in those under 5 years, in whom the rate of hospitalization is also similar to the population aged 65 years and older. In addition, children are the main transmitters of the infection. In Spain, five influenza vaccines are authorized for the paediatric age group: three inactivated tetravalent vaccines harvested from fertilised eggs, one tetravalent inactivated vaccine obtained from cell cultures, and one attenuated tetravalent vaccine for intranasal administration, which will become trivalent in the 2024-2025 season by excluding the B Yamagata lineage as recommended by the WHO. The CAV-AEP recommends systematic vaccination in children aged 6 to 59 months, children and adolescents belonging to risk groups, people who can transmit the flu to groups at risk of complicated flu, and household contacts or close family of infants under 6 months. From 2 years of age, the intranasal attenuated vaccine is preferred due to its greater acceptability and thus contribution to greater vaccination coverage. The CAV-AEP also considers that vaccination against influenza of healthy children and adolescents aged 5 to 18 years is advisable, as it provides individual protection and promotes protection at the family and community levels. It is especially important to vaccinate all health care professionals against influenza as well as pregnant women at any time during the pregnancy.
Published: 2024
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27. Reimagining general surgery resident selection: Collaborative innovation through design thinking

Author: Tejas S. Sathe, MD, Joseph C. L'Huillier, MD, Rebecca Moreci, MD, Sarah Lund, MD, Riley Brian, MD, Caitlin Silvestri, MD, Connie Gan, MD, Colleen McDermott, MD MPH, Angie Atkinson, MD, Sergio M. Navarro, MD, Justine Broecker, MD, John M. Woodward, MD, Tawni Johnston, MD, Nicholas Laconi, MD, Jonathan Williams, MD, and Steven Thornton, MD
Subjects: Resident selection, Design thinking, Surgical education, Collaboration, Academic Surgery, Surgery, RD1-811
Abstract: Introduction: The process by which surgery residency programs select applicants is complex, opaque, and susceptible to bias. Despite attempts by program directors and educational researchers to address these issues, residents have limited ability to affect change within the process at present. Here, we present the results of a design thinking brainstorm to improve resident selection and propose this technique as a framework for surgical residents to creatively solve problems and generate actionable changes. Methods: Members of the Collaboration of Surgical Education Fellows (CoSEF) used the design thinking framework to brainstorm ways to improve the resident selection process. Members participated in one virtual focus group focused on identifying pain points and developing divergent solutions to those pain points. Pain points and solutions were subsequently organized into themes. Finally, members participated in a second virtual focus group to design prototypes to test the proposed solutions. Results: Sixteen CoSEF members participated in one or both focus groups. Participants identified twelve pain points and 57 potential solutions. Pain points and solutions were grouped into the three themes of transparency, fairness, and applicant experience. Members subsequently developed five prototype ideas that could be rapidly developed and tested to improve resident selection. Conclusions: The design thinking framework can help surgical residents come up with creative ideas to improve pain points within surgical training. Furthermore, this framework can supplement existing quantitative and qualitative methods within surgical education research. Future work will be needed to implement the prototypes devised during our sessions and turn them into complete interventions. Key message: In this paper, we demonstrate the results of a resident-led design thinking brainstorm on improving resident selection in which our team identified twelve pain points in resident selection, ideated 57 solutions, and developed five prototypes for further testing. In addition to sharing our results, we believe design thinking can be a useful framework for creative problem solving within surgical education.
Published: 2024
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28. Assessing topographic features and population abundance in an Antarctic penguin colony through UAV-based deep-learning models

Author: Oleg Belyaev, Alejandro Román, Josabel Belliure, Gabriel Navarro, Luis Barbero, and Antonio Tovar-Sánchez
Subjects: UAV, Deep-learning, Chinstrap penguin, Pygoscelis antarcticus, Breeding site features, Vapour col, Physical geography, GB3-5030, Environmental sciences, GE1-350
Abstract: Penguins play an essential biochemical role in the Antarctic ecosystem, being the study of their dynamics of utmost importance to understand their environment, behaviour and populational trends in the current climate change scenario. In this study, we used multi-rotor Unmanned Aerial Vehicles (UAVs) along the coast of the chinstrap penguin (Pygoscelis antarcticus) colony of Vapour Col (Deception Island, Antarctica) to map potential sites of biochemical interactions with the surrounding sea water. Several runoff discharge points were identified, where a precise placing of environmental sampling station is suggested. Additionally, UAVs were used in combination with Object Detection Architectures to obtain the chinstrap colony population size. Applying a simulation for clutch initiation dates due to our off-laying peak count, we obtained an estimated range of 13,250 to 22,000 breeding pairs in the 2021/2022 breeding season, also suggesting an alternative approach using chinstrap chicks as proxy to estimate adult numbers. This research shows the utility of UAV-deep learning for environment characterization and wildlife monitoring, providing a solid framework for upcoming studies in the area.
Published: 2024
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29. Coupled bio-solar photocatalytic treatment for reclamation of water polluted with pharmaceutical and pesticide residues: Impact on tomato irrigation

Author: Marina Aliste, Virginia Hernández, Abderrazak El Aatik, Gabriel Pérez-Lucas, José Fenoll, and Simón Navarro
Subjects: Pesticide, Pharmaceutical, Wastewater treatment plant, Advanced Oxidation Processes, Water reuse, Tomato crop, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350
Abstract: Reusing reclaimed water for crop irrigation can mitigate water scarcity in agriculture; however, contaminants such as pharmaceuticals and pesticides in wastewater pose risks. This study investigated the impact of a coupled bio-solar photocatalytic treatment on the reclamation of water polluted with seven pharmaceuticals and seven pesticides for irrigation of two tomato crop cycles. Pollutant residues were removed using natural sunlight and TiO2/Na2S2O8 in a pilot plant located in Murcia, Spain. Efficient removal (> 96 %) of all target pollutants was achieved in the effluent after coupled treatment. Reclaimed water was then used to irrigate the tomato crops, and several yield and quality parameters were analysed to evaluate the effects on the harvested tomatoes. No significant differences were observed in the total yield, number and mean fruit weight, size, pericarp firmness, external colour, and nutritional data between the crops irrigated with reclaimed, control, and polluted water. However, differences in the degree of ripeness were observed. None of the investigated pollutants was detected above the limit of quantification in tomato samples irrigated with reclaimed water, except for venlafaxine (0.028 µg kg−1) in the second crop cycle. When the crop was irrigated with polluted water, different pollutant residues were detected in soil (10) and tomato (4) samples. The results suggest that coupled bio-solar photocatalytic treatment is an effective method for reclaiming water polluted with pharmaceutical and pesticide residues, and the reclaimed water can be safely used for tomato irrigation without compromising crop yield and quality.
Published: 2024
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30. Development of a prognostic model to predict 90-day mortality in hospitalised cancer patients (PROMISE tool): a prospective observational studyResearch in context

Author: Oriol Mirallas, Berta Martin-Cullell, Víctor Navarro, Kreina Sharela Vega, Jordi Recuero-Borau, Diego Gómez-Puerto, Daniel López-Valbuena, Clara Salva de Torres, Laura Andurell, Anna Pedrola, Roger Berché, Fiorella Palmas, José María Ucha, Guillermo Villacampa, Alejandra Rezqallah, Judit Sanz-Beltran, Rafael Bach, Sergio Bueno, Cristina Viaplana, Gaspar Molina, Alberto Hernando-Calvo, Juan Aguilar-Company, María Roca, Eva Muñoz-Couselo, Alex Martínez-Martí, Ada Alonso, Simeon Eremiev, Teresa Macarulla, Ana Oaknin, Cristina Saura, Elena Élez, Enriqueta Felip, Ángeles Peñuelas, Rosa Burgos, Patricia Gómez Pardo, Elena Garralda, Josep Tabernero, Sònia Serradell, Sònia Servitja, David Paez, Rodrigo Dienstmann, and Joan Carles
Subjects: Prognostic factors, Hospital oncology service, 90-day mortality, PROMISE tool, LASSO method, Public aspects of medicine, RA1-1270
Abstract: Summary: Background: Prognostic factors for ambulatory oncology patients have been described, including Eastern Cooperative Oncology Group (ECOG), tumor stage and malnutrition. However, there is no firm evidence on which variables best predict mortality in hospitalized patients receiving active systemic treatment. Our main goal was to develop a predictive model for 90-day mortality upon admission. Methods: Between 2020 and 2022, we prospectively collected data from three sites for cancer patients with hospitalizations. Those with metastatic disease receiving systemic therapy in the 6 months before unplanned admission were eligible to this study. The least absolute shrinkage and selection operator (LASSO) method was used to select the most relevant factors to predict 90-day mortality at admission. A multivariable logistic regression was fitted to create the PROgnostic Score for Hospitalized Cancer Patients (PROMISE) score. The score was developed in a single-center training cohort and externally validated. Findings: Of 1658 hospitalized patients, 1009 met eligibility criteria. Baseline demographics, patient and disease characteristics were similar across cohorts. Lung cancer was the most common tumor type in both cohorts. Factors associated with higher 90-day mortality included worse ECOG, stable/progressive disease, low levels of albumin, increased absolute neutrophil count, and high lactate dehydrogenase. The c-index after bootstrap correction was 0.79 (95% CI, 0.75–0.82) and 0.74 (95% CI, 0.68–0.80) in the training and validation cohorts, respectively. A web tool (https://promise.vhio.net/) was developed to facilitate the clinical deployment of the model. Interpretation: The PROMISE tool demonstrated high performance for identifying metastatic cancer patients who are alive 90 days after an unplanned hospitalization. This will facilitate healthcare providers with rational clinical decisions and care planning after discharge. Funding: Merck S.L.U., Spain.
Published: 2024
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31. Assessment of the sentiments expressed by traumatic brain injury patients and caregivers: A qualitative study based on in-depth interviews

Author: Raquel Mena-Marcos, Eleuterio A. Sánchez-Romero, Blanca Navarro-Main, Alfonso Lagares-Gómez-Abascal, Laura Jiménez-Ortega, and Juan Nicolás Cuenca-Zaldívar
Subjects: Traumatic brain injury, Multidisciplinary management, Sentiments, Perspectives, Structural topic model, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Introduction: Traumatic Brain Injury (TBI) is a significant public health concern that causes death, disability, and economic burden. Its repercussions affect physical, cognitive, emotional, and behavioral aspects of long-term care needs. Despite improvements in communication among multidisciplinary teams, the management of TBI remains fragmented. Objective: This study aimed to assess patients and caregivers’ experiences through sentiment analysis. Materials and methods: A qualitative cross-sectional study utilized structured topic modeling (STM) to analyze in-depth interview data. The study involved 29 patients with TBI and 27 caregivers in Madrid (Spain), using a survey design. The interviews were conducted, transcribed, and coded independently over 5 months. Sentiments such as anticipation, fear, and emotional concerns were analyzed using three dictionaries. The STM analysis identified four key concepts: desire for independence, potential improvement, need for injury information, and psychological consequences. STM diagnostic graphs were used to determine the number of topics relevant to the evaluation of patient and caregiver concerns. Furthermore, an analysis was conducted across four topics. Results: The average age of the patients was 44.2 ± 14.9 years (69 % males). Regarding TBI severity, 59 % of patients had severe TBI, whereas the remaining 41 % had experienced moderate TBI. Among the caregivers, the majority were parents (30 %), partners (24 %), or siblings (24 % each). Among the 51 participants, sentiments were analyzed using three dictionaries. While there were no significant age differences (Z = 0.24, p = 0.815), the STM model was adjusted for significant sex differences (p = 0.017) between patients and relatives. Anticipation and fear prevailed in both groups, highlighting the shared emotional patterns. Discussion: The analysis of diagnostic graphs indicated the optimal number of topics for evaluation, emphasizing key concerns across different phases of TBI. Patients' main worries shifted from physical symptoms to limitations in daily life and independence. Caregivers highlighted the importance of staff interactions, misinformation challenges, and the need for psychological care. Conclusion: Key patient concerns, including dependency on daily activities, limitations in autonomy, and caregiver burden, emphasize crucial areas for enhancement in multidisciplinary treatment. Moreover, the lack of long-term psychological support is a significant barrier to optimal patient and caregiver well-being.
Published: 2024
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32. Giant sarcoma of the prostate stroma: Clinical, radiological and histopathological analysis of a rare prostatic cancer

Author: Alan de Jesus Martinez Salas, Alfredo Valero-Gomez, Aldo Daniel Jimenez Garcia, Iñigo Navarro-Ruesga, Daniel Calvo-Mena, and Stefan Zilli-Hernandez
Subjects: Prostate cancer, Prostate sarcoma, Sarcoma, Prostatectomy, Transurethral resection of prostate, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Prostate sarcoma is extremely rare, comprising less than 0.1 % of prostate cancers.A 61-year-old male presented to the emergency department with urinary retention and hematuria. Upon resolution of urinary retention, abdominal computed tomography showed a giant prostatic tumor, of approximately 1700 cubic centimeters, causing bilateral ureteric obstruction, and invasion of rectum and sigmoid colon. Laparotomy due to bowel obstruction showed peritoneal carcinomatosis. Palliative chemotherapy was initiated; however, he died due to hematological toxicity related to doxorubicin.Radical surgery is the ideal treatment; in cases of advanced or metastatic disease, adjuvant or palliative chemotherapy or radiotherapy withholds little or no benefit.
Published: 2024
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33. Cell surface morphology mimicking nano-bio platform for immune cell stimulation

Author: Beena Varghese, José Alfredo González-Navarro, Valentino Libero Pio Guerra, Margarita Faizulina, Daria Artemieva, Tomáš Chum, Tejaswini Rama Bangalore Ramakrishna, Marek Cebecauer, and Petr Kovaříček
Subjects: Immunology, Biotechnology, Cell biology, Science
Abstract: Summary: Studying the complex realm of cellular communication and interactions by fluorescence microscopy requires sample fixation on a transparent substrate. To activate T cells, which are pivotal in controlling the immune system, it is important to present the activating antigen in a spatial arrangement similar to the nature of the antigen-presenting cell, including the presence of ligands on microvilli. Similar arrangement is predicted for some other immune cells. In this work, immune cell-stimulating platform based on nanoparticle-ligand conjugates have been developed using a scalable, affordable, and broadly applicable technology, which can be readily deployed without the need for state-of-the-art nanofabrication instruments. The validation of surface biofunctionalization was performed by combination of fluorescence and atomic force microscopy techniques. We demonstrate that the targeted system serves as a biomimetic scaffold on which immune cells make primary contact with the microvilli-mimicking substrate and exhibit stimulus-specific activation.
Published: 2024
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34. VP3.15 reduces acute cerebellum damage after germinal matrix-intraventricular hemorrhage of the preterm newborn

Author: Isabel Atienza-Navarro, Angel del Marco, Maria de los Angeles Garcia-Perez, Alvaro Raya-Marin, Carmen Gil, Ana Martinez, Isabel Benavente-Fernandez, Simon Lubian-Lopez, and Monica Garcia-Alloza
Subjects: Preterm newborn, Germinal matrix-intraventricular hemorrhage, VP3.15, Glycogen synthase kinase-3β inhibitor, Phosphodiesterase 7 inhibitor, Therapeutics. Pharmacology, RM1-950
Abstract: Germinal matrix-intraventricular hemorrhage (GM-IVH) is one of the most common complications of the preterm newborn. The pathology of the GM-IVH is not completely understood and even regions distant from the lesion area are severely affected. It has been suggested that cerebellar diaschisis may underlie the neurodevelopmental problems that many of these kids show, including cerebral palsy, attention deficit disorders or hyperactivity. Additionally, GM-IVH has no successful treatment. VP3.15 is a dual action phosphodiesterase 7 (PDE7) and glycogen synthase kinase-3β (GSK-3β) inhibitor that limits neuroinflammation and neuronal loss. Therefore, it might also provide a relevant tool to reduce complications associated with GM-IVH. We have used a murine model of GM-IVH to analyze the short and long-term effects of VP3.15 in brain pathology and behavioral complications. In our hands, the induction of unilateral GM-IVH to P7 CD1 mice results in a short-term (P14) compromise of the cerebellar neuronal population and Purkinje cells arborization, an increase of microglia burden in the nuclei and an overall increase of punctuate cerebellar hemorrhages. Whereas brain alterations are no longer observed in the long term (P110), these animals present overt hyperactivity when analyzed in the adulthood, supporting the long-term behavioral impairment. Also, hyperactivity significantly correlates with ipsi and contralateral cerebellar sizes, neuronal densities and myelin basic protein levels. Importantly, treatment with VP3.15 significantly reduces neuronal loss, Purkinje cells simplification, the presence of cerebellar hemorrhages, as well as hyperactivity. Altogether, our data support the neuroprotective effects of VP3.15 in GM-IVH of the PT.
Published: 2024
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35. Effects of dietary free fatty acid content and degree of fat saturation on tibia bone properties of laying hens

Author: M. Palomar, M.D. Soler, C. Benavides-Reyes, A.B. Rodríguez-Navarro, J.A. García-Bautista, A. Orozco, and C. Garcés-Narro
Subjects: acid oil, bone quality, calcium, fat by-product, fatty acid distillate, Animal culture, SF1-1100
Abstract: ABSTRACT: Acid oils and fatty acid distillates are fat by-products of the refining process of edible oils and are characterized by their high proportion of free fatty acids (FFA). While lipids are essential in poultry diets, their chemical structure may interfere with calcium absorption. Therefore, this study investigated the effects of dietary FFA content and the degree of fat saturation on bone metabolism in commercial layers. For 15-wk, a total of 144 laying hens (19-wk-old) were randomly assigned to 8 treatments (6 replicates with 3 birds each), which were obtained by gradually replacing crude soybean oil (rich in unsaturated fatty acids [UFA]) with soybean acid oil (rich in UFA and FFA), or crude palm oil (rich in saturated fatty acids [SFA]) with palm fatty acid distillate (rich in SFA and FFA). Following a 2 × 4 factorial design, 4 UFA-rich and 4 SFA-rich diets were created with varying FFA content: 10, 20, 30, and 45%. Tibiae (6 birds/treatment) were collected at the end of the trial for the assessment of mineral composition, morphological properties, and mechanical characteristics. The data were analyzed using a 2-way ANOVA with the GLM procedure. Orthogonal polynomial contrasts were employed to determine the linear effect of increasing %FFA, with statistical significance set at P < 0.05. The degree of saturation was found to negatively impact on calcium and phosphorus bone content, with higher levels found in soybean-based diets (P < 0.001). A significant interaction was observed for medullary bone mineral content, showing a linear decrease as the dietary %FFA increased (P < 0.05) in palm diets. In contrast, morphological and mechanical bone traits, total ash content, and cortical bone mineral composition remained unaffected (P > 0.05). These results suggest that the degree of fat saturation exerts a greater impact than FFA content on bone mineral metabolism, supporting the commercial use of fat by-products rich in FFA in laying hen diets, at least during the early stages of the laying cycle.
Published: 2024
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36. The mitochondrial Na+/Ca2+ exchanger NCLX is implied in the activation of hypoxia-inducible factors

Author: Carmen Choya-Foces, Elisa Navarro, Cristóbal de los Ríos, Manuela G. López, Javier Egea, Pablo Hernansanz-Agustín, and Antonio Martínez-Ruiz
Subjects: Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract: Eukaryotic cells and organisms depend on oxygen for basic living functions, and they display a panoply of adaptations to situations in which oxygen availability is diminished (hypoxia). A number of these responses in animals are mediated by changes in gene expression programs directed by hypoxia-inducible factors (HIFs), whose main mechanism of stabilization and functional activation in response to decreased cytosolic oxygen concentration was elucidated two decades ago. Human acute responses to hypoxia have been known for decades, although their precise molecular mechanism for oxygen sensing is not fully understood. It is already known that a redox component, linked with reactive oxygen species (ROS) production of mitochondrial origin, is implied in these responses. We have recently described a mechanism by which the mitochondrial sodium/calcium exchanger, NCLX, participates in mitochondrial electron transport chain regulation and ROS production in response to acute hypoxia.Here we show that NCLX is also implied in the response to hypoxia mediated by the HIFs. By using a NCLX inhibitor and interference RNA we show that NCLX activity is necessary for HIF-α subunits stabilization in hypoxia and for HIF-1-dependent transcriptional activity. We also show that hypoxic mitochondrial ROS production is not required for HIF-1α stabilization under all circumstances, suggesting that the basal cytosolic redox state or other mechanism(s) could be operating in the NCLX-mediated response to hypoxia that operates through HIF-α stabilization. This finding provides a link between acute and medium-term responses to hypoxia, reinforcing a central role of mitochondrial cell signalling in the response to hypoxia.
Published: 2024
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37. Biomechanical analysis of spinal misalignment during Vehicular extrication maneuvers performed by professional rescue teams

Author: Manuel Pons Claramonte, Manuel Pardo Ríos, Ana Nicolás Carrillo, Alberto Nieto Navarro, Itziar Baztán Ferreros, and Sergio Nieto Caballero
Subjects: Emergency medical services, Accidents traffic, Rescue work, Rescue personnel, biomechanical analysis, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Objective: To compare spinal misalignment and execution time of 3 rescue maneuvers for casualties in traffic accidents. Materials and methods: Biomechanical analysis using inertial sensors to measure the range of spinal misalignment and execution time of 3 maneuvers: 1) standard manual rescue (SMR); 2) rapid extrication device (RED); 3) extrication device (ED). The sample consisted of 117 rescue professionals (firefighters) from 14 Autonomous Communities in Spain. The total range of motion and the execution time of maneuvers were compared using ANOVA. Results: The highest range of cervical flexion-extension movement was recorded with RED (30° ± 9°). There were no statistically significant differences between SMR (21° ± 9°) and ED (21° ± 10°). In dorsal flexion-extension, the highest range of movement was with RED (36° ± 10°), followed by ED (30° ± 7°), with the lowest found for SMR (26° ± 11°). RED presented the least restriction of cervical (p
Published: 2024
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38. Mapping the intellectual structure of microfinance and women's empowerment: A bibliometric analysis

Author: Jenny Maldonado-Castro, Rocío Gallego-Losada, and Antonio Montero-Navarro
Subjects: Microfinance institutions, Women's empowerment, Bibliometric analysis, Sustainable development goals, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: The Sustainable Development Goals (SDGs) emphasize promoting and protecting women's rights and privileges. As a result, an increasing body of academic literature describes the various actions taken by different stakeholders to empower women. Amongst the initiatives implemented in many nations, microfinance and financial inclusion programs play a major role. This article aims to present an overview and synthesis of the research on the notion and practices of microfinance and its influence on entrepreneur women's empowerment. In order to do so, this study uses bibliometric techniques over a selection of papers extracted from the Web of Science database, to disentangle the knowledge structure of this academic field. According to our findings, the study of microfinance and women's empowerment is growing, with 470 publications, 963 authors, 67 nations and 36 research areas. Research topics include poverty reduction, gender issues in entrepreneurship, microfinance and women empowerment, and women in microcredit. An additional bibliographic coupling analysis has revealed the hottest research topics, showing the main gaps in the literature that suggest potential directions for future research.
Published: 2024
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39. Process-based metrics inform sustainable marine management after a catastrophic natural event

Author: Nestor E. Bosch, Sandra Navarro Mayoral, Fernando Espino, Francisco Otero-Ferrer, Ricardo Haroun, and Fernando Tuya
Subjects: Conservation planning, Ecological succession, Ecosystem functioning, Functional traits, Productivity, Ecology, QH540-549.5
Abstract: Understanding temporal dynamics in ecological communities is key to develop management plans that target sustainability. Process-based metrics quantify dynamic properties of ecological communities, and thereof have been recently advocated as a promising tool to guide management strategies. To date, however, their empirical application has been limited, hindering their utility to inform conservation planning in response to a range of natural and human-driven disturbances. Here, we compare the succession of fish communities after a catastrophic natural event, a volcanic eruption and the formation of nascent reefs, through the lens of complementary static (species richness, abundance, and biomass) and process-based (productivity and turnover) metrics. We found markedly contrasting dynamics between these metrics, particularly when looking at fish biomass and productivity. During incipient stages of community development, fish productivity increased exponentially, whereas the recovery of fish biomass considerably lagged behind, underscoring high rates of biomass replacement (i.e., turnover) in the system. This buffering response (higher production per unit of biomass) was best predicted by average community body size, highlighting the role of compensatory ecological mechanisms during primary ecological succession. Traits related to resource acquisition, particularly the harnessing of planktonic energy subsidies, further enhanced predicted fish biomass and productivity at local scales. This study therefore supports the burgeoning call to inform conservation and management planning through complementary metrics that give a nuanced understanding on ecosystem functioning.
Published: 2024
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40. Assessment of a training course for cookery students regarding celiac disease and gluten-free diet

Author: Maialen Vázquez-Polo, Virginia Navarro, Gesala Perez-Junkera, Arrate Lasa, Idoia Larretxi, Jonatan Miranda, Jon Esparta, and Itziar Churruca
Subjects: Catering, Education, Students, celiac disease, Gluten-free diet, Cross-contact, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Celiac disease (CD) has a significant impact on the quality of life for those affected, particularly in social settings. One major challenge for these individuals is dining out, as they must constantly avoid cross-contact with gluten, contend with a limited range of restaurant options, and often encounter unknowledgeable or misinformed staff. This study aims to evaluate the effectiveness of an educational program designed to enhance the understanding of CD and gluten-free diet (GFD) among future catering staff, thereby improving the social experiences of individuals with CD. A 3-h theoretical and practical session was developed for professional cookery students, focusing on predefined competencies and learning outcomes related to GFD. The study involved a sample of 100 students from Vitoria-Gasteiz, Spain. Following the intervention, students demonstrated increased knowledge regarding gluten content in foods and the application of GFD principles, including cross-contact prevention. However, during the practical activity, the gluten-free dish they prepared was not safe for CD patients to consume. Additionally, the students' perception of the difficulty in providing a GFD remained unchanged. Future sessions should emphasise the importance of interpreting food labels and practising cross-contact prevention. The strong interest in training hospitality students to promote social inclusion of CD patients highlights the need for more programmes to enhance their dining options and safety.
Published: 2024
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41. Sweet cherries modulate thyroid hormones and hepatic glucose metabolism in F344 rats in a photoperiod-dependent manner

Author: Francesca Manocchio, María Josefina Ruiz de Azua, Èlia Navarro-Masip, Diego Morales, Gerard Aragonès, Cristina Torres-Fuentes, Begoña Muguerza, and Francisca Isabel Bravo
Subjects: Fruit, Phenolic hallmark, Photoperiod, (poly)phenols, Seasonal rhythms, Nutrition. Foods and food supply, TX341-641
Abstract: Sweet cherry intake affects oxidative stress and hepatic lipid metabolism, depending on composition, mainly (poly)phenol profile and daylight length. Thyroid hormones (TH) respond to daylight changes and regulate the hepatic glucose metabolism. This study investigated whether cherries with different phenolic hallmarks exhibit seasonal responses to TH and hepatic glucose metabolism. Fischer 344 rats fed a standard diet were chronically exposed to L6 (6 h light), L12 (12 h light), and L18 (18 h light) photoperiods and were supplemented with two sweet cherries (Ch1 and Ch2). Serum TH levels and glucose metabolism-related metabolites were affected by both the cherry composition and photoperiod. Thus, Ch1 and Ch2 reduced serum T3 levels in L6, whereas Ch2 increased it in L18, nullifying the photoperiod effect. Moreover, although photoperiod was the main factor affecting the hepatic expression of gluconeogenesis-related genes, Ch1 exerted effects mainly on L6 photoperiod and Ch2 on L18, tending to cancel out the photoperiod effects.
Published: 2024
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42. Post-surgery sequelae unrelated to disease progression and chemotherapy revealed in follow-up of patients with stage III colon cancerResearch in context

Author: Alexia Mirandola, Andrei Kudriavtsev, Catalina Isabel Cofre Muñoz, Raquel Comas Navarro, Marco Macagno, Saidi Daoud, Cynthia Sanchez, Brice Pastor, Ekaterina Pisareva, Mireia Sanchis Marin, Javier Gonzalo Ruiz, Alejandro Piris, Ariadna Garcia Rodriguez, Nadia Saoudi Gonzalez, Ana Vivancos, Virginia Quarà, Alfredo Mellano, Felice Borghi, Giorgio Corti, Caterina Marchiò, Anna Sapino, Alice Bartolini, Giovanni Crisafulli, Alberto Bardelli, Massimo Di Maio, Gerald Lossaint, Florence Frayssinoux, Evelyne Crapez, Marc Ychou, Ramon Salazar Soler, Elisabetta Fenocchio, Paula X. Fernandez Calotti, Thibault Mazard, Cristina Santos Vivas, Elena Elez, Federica Di Nicolantonio, and Alain R. Thierry
Subjects: Diagnostic, Tumour biology, Colorectal cancer, Circulating DNA, Neutrophil extracellular traps, Post-surgery, Medicine, Medicine (General), R5-920
Abstract: Summary: Background: We studied the poorly-known dynamics of circulating DNA (cir-nDNA), as monitored prospectively over an extended post-surgery period, in patients with cancer. Methods: On patients with stage III colon cancer (N = 120), using personalised molecular tags we carried out the prospective, multicenter, blinded cohort study of the post-surgery serial analysis of cir-nDNA concentration. 74 patients were included and 357 plasma samples tested. Findings: During post-operative follow-up, the patients’ median cir-nDNA concentration was greater (P 18 months post-surgery, the data suggest that the persistence of NETs formation is not due to the adjuvant CT. Interpretation: (1), Given the inter-patient heterogeneity, the post-surgery cir-nDNA level cannot be considered a reliable value, and caution must be exercised when determining mutation allele frequency or the mutation status; and (2), specific studies must be undertaken to investigate the possible clinical impact of the persistent, low-grade inflammation resulting from elevated NETs levels, such as observed in these post-surgery patients, given that such levels are known to potentially induce adverse cardiovascular or thrombotic events. Funding: This work was supported by the H2020 European ERA-NET grant on Translational Cancer Research (TRANSCAN-2).
Published: 2024
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43. Methodology to assess the impact of urban vegetation on the energy consumption of residential buildings. Case study in a Mediterranean city

Author: C. Prades-Gil, J.D. Viana-Fons, X. Masip, A. Cazorla-Marín, and T. Gómez-Navarro
Subjects: Landsat-8, Nature-based solutions, Heating & Cooling, GIS, Engineering (General). Civil engineering (General), TA1-2040
Abstract: The global growth of urban areas is unstoppable, and this growth is accompanied by an intensification of urban heat island effects, exacerbating the challenges of climate change and sustainable urban development in warm climates. In this context, understanding the intricate dynamics of these phenomena and their implications on the thermal behaviour of buildings becomes paramount. This study focuses on València, a Spanish city characterized by a Mediterranean climate, where the interplay between ground temperature variations, vegetation levels, and the thermal demands of buildings is investigated.Land surface temperature measurements derived from satellite data, specifically from the Landsat-8 mission, provide a valuable lens through which to assess the heat island effect. These measurements are harmonized with data collected from local weather stations to establish a robust foundation for evaluating the thermal dynamics of the urban environment. European standards, coupled with Geographic Information System technologies, enable the simulation of temperature variations, and facilitate a nuanced analysis of their impact on the thermal demands of a building.Moreover, recognizing the crucial role played by the urban climate in the influencing of heating and cooling needs, this study explores nature-based solutions implemented in València. By leveraging satellite-derived temperature and vegetation data over an extended period, it is possible to identify actions and elements that contribute positively to mitigating UHI effects and improving the overall climatic conditions. Results indicate that vegetation has a notable impact on local temperature, with distinct patterns observed in different seasons. The research incorporated the simulation of climate scenarios, introducing varying levels of vegetation. Results demonstrated a substantial reduction in cooling demand, particularly during the summer months. Buildings with a lower exterior surface-to-volume ratio exhibited a more pronounced reduction in energy consumption.
Published: 2024
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44. Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling

Author: Gemma Navarro, Marc Gómez-Autet, Paula Morales, Joan Biel Rebassa, Claudia Llinas del Torrent, Nadine Jagerovic, Leonardo Pardo, and Rafael Franco
Subjects: GPCR, cannabinoid CB2 receptor, homobivalent ligand, molecular dynamics, cAMP, arrestin, Therapeutics. Pharmacology, RM1-950
Abstract: G protein-coupled receptors (GPCRs) exist within a landscape of interconvertible conformational states and in dynamic equilibrium between monomers and higher-order oligomers, both influenced by ligand binding. Here, we show that a homobivalent ligand formed by equal chromenopyrazole moieties as pharmacophores, connected by 14 methylene units, can modulate the dynamics of the cannabinoid CB2 receptor (CB2R) homodimerization by simultaneously binding both protomers of the CB2R-CB2R homodimer. Computational and pharmacological experiments showed that one of the ligand pharmacophores binds to the orthosteric site of one protomer, and the other pharmacophore to a membrane-oriented pocket between transmembranes 1 and 7 of the partner protomer. This results in unique pharmacological properties, including increased potency in Gi-mediated signaling and enhanced recruitment of β-arrestin. Thus, by modulating dimerization dynamics, it may be possible to fine-tune CB2R activity, potentially leading to improved therapeutic outcomes.
Published: 2024
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45. Predicting weight dispersion in seabass aquaculture using Discrete Event System simulation and Machine Learning modeling

Author: Luiz Claudio Navarro, Ana Azevedo, Aníbal Matos, Anderson Rocha, and Rodrigo Ozório
Subjects: Aquaculture, Fish weight dispersion, Discrete event systems, Machine learning, European seabass, Fish growth modeling, Aquaculture. Fisheries. Angling, SH1-691
Abstract: Marine aquaculture, particularly in the Mediterranean region, faces the challenge of minimizing growth dispersion, which has a direct impact on the production cycle, market value and sustainability of the sector. Conventional grading methods are resource intensive and potentially detrimental to fish health. The current study presented an innovative approach in predicting fish weight dispersion in European seabass (Dicentrarchus labrax) aquaculture. Seabass is one of the two major fish species cultivated on the Mediterranean coast, with a fattening cycle of 18–24 months. During this period, several grading operations are carried out to minimize growth dispersion. The intricate feed-fish-water system, characterized by complex interactions among feeding regimes, fish behavior, individual metabolism and environmental factors, is the focus of the study. The comprehensive, five-step methodology addresses this complexity. The process begins with a Discrete Event System (DES) model that simulates the feed-fish-water dynamics, taking into account individual fish metabolism. This is followed by the development of a surrogate machine learning (ML) regressor model, which is trained on DES simulation data to efficiently predict growth distribution. The model is then calibrated and customized for specific fish stocks and production tanks. The preliminary results from 21 tanks in two trials with European seabass (D. labrax) showed the effectiveness of the method. The results from the simulation models achieved a R2 of 99.9 % and a Mean Absolute Percentage Error (MAPE) of 1.1 % for the prediction of mean final weight and a R2 of 90.3 % with a MAPE of 8.1 % for the standard deviation of final weight. In summary, this study represents a significant advance in the planning and management of seabass aquaculture. Given the lack of effective prediction tools in the aquaculture industry, the proposed methodology has the potential to reduce risks and inefficiencies, thus possibly optimizing aquaculture practices by increasing sustainability and profitability.
Published: 2024
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46. UNITY: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings

Author: F. Abate, A. Adu-Amankwah, KA Ae-Ngibise, F Agbokey, VA Agyemang, CT Agyemang, C. Akgun, J. Ametepe, T. Arichi, KP Asante, S. Balaji, L. Baljer, PJ Basser, J. Beauchemin, C. Bennallick, Y. Berhane, Y. Boateng-Mensah, NJ Bourke, L. Bradford, MMK Bruchhage, R.Cano Lorente, P. Cawley, M. Cercignani, V. D Sa, A.de Canha, N.de Navarro, DC Dean, III, J. Delarosa, KA Donald, A. Dvorak, AD Edwards, D. Field, H. Frail, B. Freeman, T. George, J. Gholam, J. Guerrero-Gonzalez, JV Hajnal, R. Haque, W. Hollander, Z. Hoodbhoy, M. Huentelman, SK Jafri, DK Jones, F. Joubert, T. Karaulanov, MP Kasaro, S. Knackstedt, S. Kolind, B. Koshy, R. Kravitz, S.Lecurieux Lafayette, AC Lee, B. Lena, N. Lepore, M. Linguraru, E. Ljungberg, Z. Lockart, E. Loth, P. Mannam, KM Masemola, R. Moran, D. Murphy, FL Nakwa, V. Nankabirwa, CA Nelson, K. North, S. Nyame, R. O Halloran, J. O'Muircheartaigh, BF Oakley, H. Odendaal, CM Ongeti, D. Onyango, SA Oppong, F. Padormo, D. Parvez, T. Paus, MS Pepper, KS Phiri, M. Poorman, JE Ringshaw, J. Rogers, M. Rutherford, H. Sabir, L. Sacolick, M. Seal, ML Sekoli, T. Shama, K. Siddiqui, N. Sindano, MB Spelke, PE Springer, FE Suleman, PC Sundgren, R. Teixeira, W. Terekegn, M. Traughber, MG Tuuli, J.van Rensburg, F. Váša, S. Velaphi, P. Velasco, IM Viljoen, M. Vokhiwa, A. Webb, C. Weiant, N. Wiley, P. Wintermark, K. Yibetal, SCL Deoni, and SCR Williams
Subjects: Neurodevelopment, Child Health, Global Health, Healthy Development, Environmental Adversity, Low Field Magnetic Resonance Imaging, Neurophysiology and neuropsychology, QP351-495
Abstract: Measures of physical growth, such as weight and height have long been the predominant outcomes for monitoring child health and evaluating interventional outcomes in public health studies, including those that may impact neurodevelopment. While physical growth generally reflects overall health and nutritional status, it lacks sensitivity and specificity to brain growth and developing cognitive skills and abilities. Psychometric tools, e.g., the Bayley Scales of Infant and Toddler Development, may afford more direct assessment of cognitive development but they require language translation, cultural adaptation, and population norming. Further, they are not always reliable predictors of future outcomes when assessed within the first 12–18 months of a child’s life. Neuroimaging may provide more objective, sensitive, and predictive measures of neurodevelopment but tools such as magnetic resonance (MR) imaging are not readily available in many low and middle-income countries (LMICs). MRI systems that operate at lower magnetic fields (< 100mT) may offer increased accessibility, but their use for global health studies remains nascent. The UNITY project is envisaged as a global partnership to advance neuroimaging in global health studies. Here we describe the UNITY project, its goals, methods, operating procedures, and expected outcomes in characterizing neurodevelopment in sub-Saharan Africa and South Asia.
Published: 2024
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47. Rule-based energy management strategies for PEMFC-based micro-CHP systems: A comparative analysis

Author: Santiago Navarro, Juan M. Herrero, Xavier Blasco, and Alberto Pajares
Subjects: Micro-CHP, EMS, Techno-economic model, PEMFC, Operating strategy, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Commercial PEMFC-based micro-CHP systems are operated by rule-based energy management strategies. Each of these strategies constitutes a different way to meet the household energy demand (following the heat demand, following the electricity demand, the maximum of the two, etc.). Previous studies demonstrate that which of them is the best —i.e. the one that manages to meet the demand at the lowest operating cost— depends on the particular scenario in which the micro-CHP system works (gas and electricity prices, annual energy demands, ability to export electricity to the grid, etc.). This paper aims to explore this dependence relationship and to deepen our understanding of it. To this end, a parametric analysis is conducted and the performances achieved by four rule-based operating strategies are compared. The parameters whose influence is studied, and through which the scenario is jointly characterized, are: (1) energy prices (electricity and natural gas), (2) feed-in tariff, (3) stack degradation, (4) climate and (5) heat to power ratio of the demand. The results show this dependence relationship in a clear and more comprehensive way, and offer a better understanding of its nature. From this improved understanding it can be inferred, among other things, that adapting the strategy to the scenario can generate annual savings of up to 14.5 percentage points. Moreover, this enhanced characterization of that dependence relationship can be useful for the design of a new operating strategy, a strategy that, without falling into the complexity that an optimal energy management approach (based on linear programming) involves, manages to exploit the savings potential of micro-CHP systems, thus facilitating their future mass commercialization.
Published: 2024
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48. Predicting the involvement of polyQ- and polyA in protein-protein interactions by their amino acid context

Author: Pablo Mier and Miguel A. Andrade-Navarro
Subjects: Homorepeat, Polyglutamine, Polyalanine, Protein-protein interaction, Machine learning, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Homorepeats, specifically polyglutamine (polyQ) and polyalanine (polyA), are often implicated in protein-protein interactions (PPIs). So far, a method to predict the participation of homorepeats in protein interactions is lacking. We propose a machine learning approach to identify PPI-involved polyQ and polyA regions within the human proteome based on known interacting regions. Using the dataset of human homorepeats, we identified 157 polyQ and 745 polyA regions potentially involved in PPIs. Machine learning models, trained on amino acid context and homorepeat length, demonstrated high precision (0.90–0.98) but variable recall (0.42–0.85). Random forest outperformed other models (AUC polyQ = 0.686, AUC polyA = 0.732) using the positions surrounding the homorepeat −10 to +10. Integrating paralog information marginally improved predictions but was excluded for model simplicity. Further optimization revealed that for polyQ, using amino acid surrounding positions from −6 to +6 increased AUC to 0.715. For polyA, no improvement was found. Incorporating coiled coil overlap information enhanced polyA predictions (AUC = 0.745) but not polyQ. Finally, we applied these models to predict PPI involvement across all polyQ and polyA regions, identifying potential interactions. Case studies illustrated the method's predictive capacity, highlighting known interacting regions with high scores and elucidating potential false negatives.
Published: 2024
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49. Assessing risk indicators of intimate partner femicide considering victim's coping strategies to violence: A dynamic multilevel linear mixed model based on genetic algorithms

Author: Esperanza Garcia-Vergara, Francisco Fernández-Navarro, David Becerra-Alonso, and Nerea Almeda
Subjects: Intimate partner violence, Intimate partner homicide, Femicide, Domestic violence, Risk factors, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Intimate partner femicide (IPF) is a grave social and health concern affecting women worldwide, with approximately 30,000 deaths annually at the hands of their current or former intimate partners. Previous studies have focused on identifying risk factors for IPF and developing risk assessment tools to identify high-risk cases. However, an important aspect that has been overlooked in these studies is victims' coping strategies in response to intimate partner violence. Understanding victims' coping strategies can provide valuable insights into how they deal with the abuse and can inform the development of effective interventions and prevention strategies. This study aims to address this gap by developing a multilevel linear mixed model (LMM) to analyze the impact of engagement and disengagement coping on the likelihood of IPF and identify common and specific IPF risk indicators for these coping strategies. A total of 491 Spanish cases of violence against women by current or former intimate partners were analyzed from penal sentences issued by Spanish provincial and supreme courts from 2019 to 2022. The LMM model obtained from the study has competitive performance in identifying IPF and non-IPF cases, including risk indicators of prior history of injuries, history of sexual aggression, frequency and escalation of violence, physical violence, place of crime, lonely place of crime, and community presence. Victims with engagement coping and disengagement coping share some risk indicators, while others belong to just one category. Overall, the results suggest that victims with disengagement coping are more predisposed to suffer IPF than victims with engagement coping. This evidenced-based knowledge emphasizes the significance of considering coping strategies in predicting and preventing IPF, with further implications discussed at the end of this paper.
Published: 2024
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50. Modeling the performance of electronic expansion valves in heat pumps under soft faults

Author: Belén Llopis-Mengual and Emilio Navarro-Peris
Subjects: Heat pump, Refrigerant charge, EEV, Liquid line restriction, Fault modeling, Soft fault, Technology
Abstract: Heat pumps can have soft faults that cause them to keep operating but not as efficiently as they should. Detecting them is essential for proper maintenance. Nowadays, heat pumps usually include as expansion device electronic expansion valves (EEV), which generally control the superheat (SH) at the outlet of the evaporator. When soft faults occur, such as an undercharge or liquid line restrictions, the EEV opens to continue controlling the SH but becomes fully open at some point. Therefore, its behavior becomes a fixed orifice, and it can no longer continue to control. This study models the performance of the EEV for different conditions in heat pumps under soft faults, and it is validated with an experimental campaign in which the EEV opening is measured at different operating conditions and refrigerant charge levels. The evolution of the main system variables affected by the imposed fault levels of undercharge, overcharge, and liquid line restrictions are also analyzed.
Published: 2024
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