1. Impact of body mass index in liver transplantation for nonalcoholic fatty liver disease and alcoholic liver disease.
- Author
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O'Neill S, Napetti S, Cornateanu S, Sutherland AI, Wigmore S, Oniscu GC, and Adair A
- Subjects
- Adult, Aged, Chi-Square Distribution, Female, Graft Survival, Humans, Kaplan-Meier Estimate, Liver Diseases, Alcoholic diagnosis, Liver Diseases, Alcoholic mortality, Male, Middle Aged, Multivariate Analysis, Non-alcoholic Fatty Liver Disease diagnosis, Non-alcoholic Fatty Liver Disease mortality, Postoperative Complications etiology, Proportional Hazards Models, Retrospective Studies, Risk Factors, Scotland, Time Factors, Treatment Outcome, Body Mass Index, Liver Diseases, Alcoholic surgery, Liver Transplantation adverse effects, Liver Transplantation mortality, Non-alcoholic Fatty Liver Disease surgery
- Abstract
Background: This study evaluates long-term outcomes and body mass index (BMI) following liver transplantation (LT) for non-alcoholic fatty liver disease (NAFLD) in comparison with alcoholic liver disease (ALD)., Methods: Patient and graft survival were compared using Kaplan Meier curves and log rank test. Multivariable analysis of recipient and donor characteristics was performed as determinants of patient survival. BMI at listing was compared with BMI post-LT., Results: Patient survival at 1-, 3-, 5- and 10 years post-LT was similar in the ALD group (n = 195) compared with the NAFLD group (n = 84) (93% vs. 93%, 91% vs. 89%, 86% vs. 77%, 64% vs. 66% respectively, p = 0.21). One patient in the NAFLD group was re-transplanted and none in the ALD group therefore graft survival was also similar (p = 0.20). Multivariable analysis didn't identify any significant predictors of reduced survival. In comparison with the ALD group, BMI was significantly higher in the NAFLD group at listing (31 vs. 27, p < 0.001), 3-months post-LT (28 vs. 26, p < 0.05) and 6-months post-LT (29 vs. 27, p < 0.05) but was equivalent by 5-years post-LT (29 vs. 30, p = 0.80)., Conclusions: NAFLD patients had similar patient and graft survival post-LT compared to ALD. NAFLD patients returned to listing BMI by one-year post-LT but by 5-years post-LT there was no difference in BMI between the groups., (Copyright © 2017 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2017
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