1. Chromosomal translocations involving the IGH@ locus in B-cell precursor acute lymphoblastic leukemia: 29 new cases and a review of the literature.
- Author
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Chapiro E, Radford-Weiss I, Cung HA, Dastugue N, Nadal N, Taviaux S, Barin C, Struski S, Talmant P, Vandenberghe P, Mozziconacci MJ, Tigaud I, Lefebvre C, Penther D, Bastard C, Lippert E, Mugneret F, Romana S, Bernard OA, Harrison CJ, Russell LJ, and Nguyen-Khac F
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, CCAAT-Enhancer-Binding Proteins genetics, Child, Child, Preschool, Chromosomes, Human, Pair 14, Cloning, Molecular, Female, Humans, In Situ Hybridization, Fluorescence, Inhibitor of Differentiation Proteins genetics, Male, Middle Aged, Proto-Oncogene Proteins c-bcl-2 genetics, Real-Time Polymerase Chain Reaction, Receptors, Erythropoietin genetics, Immunoglobulin Heavy Chains genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics, Translocation, Genetic
- Abstract
Chromosomal translocations involving the immunoglobulin heavy chain locus (IGH@) are recurrent but rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and various partner genes have been described. Here, we report a new series of 29 cases of BCP-ALL with IGH@ translocations. The partner gene was identified by fluorescence in situ hybridization and/or molecular cloning in 20 patients. Members of the CEBP gene family (n = 11), BCL2 (n = 3), ID4 (n = 3), EPOR (n = 2), and TRA/D@ (n = 1) were identified and demonstrated by quantitative real-time reverse transcriptase-polymerase chain reaction to be markedly up-regulated. The present cases, added to those already reported, confirm the diversity of the partner genes, which, apart from BCL2, are specific to BCP-ALL. Collectively, patients with IGH@ translocations may represent a novel sub-group of BCP-ALL occurring in adolescents and young adults., (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Published
- 2013
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