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Your search keyword '"Mikael Chetboun"' showing total 3 results
Start Over Author "Mikael Chetboun" Publisher elsevier
3 results on '"Mikael Chetboun"'

1. Optimizing primary graft function in islet allotransplantation: The Lille experience

Author

Mikael Chetboun, Julie Kerr-Conte, Robert Caiazzo, François Pattou, Christian Noel, Violeta Raverdy, Kristell Le Mapihan, Marie-Christine Vantyghem, Valery Gmyr, and Thomas Hubert

Subjects
endocrine system, Type 1 diabetes, geography, Kidney, medicine.medical_specialty, geography.geographical_feature_category, endocrine system diseases, business.industry, medicine.medical_treatment, Urology, Immunosuppressive regimen, medicine.disease, Islet, Graft function, Transplantation, medicine.anatomical_structure, medicine, Beta cell, business, Allotransplantation
Abstract

Islet allotransplantation has been shown to be effective in restoring endogenous insulin secretion. Many initial reports showed, however, a sharp decline of islet graft function with time. In the late 1990s we hypothesized that islet transplantation success could be significantly prolonged by increasing islet primary graft function, through the deliberate repetition of islet infusions. We report here the favorable long-term outcome of this strategy in patients with type 1 diabetes and severe hypoglycemia unawareness or after a kidney graft with the Edmonton immunosuppressive regimen. Our results suggest that optimizing initial graft function is essential for the long-term success of beta cell replacement.

Published
2020
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2. In vivo quality control of human islets in the immunodeficient mouse to predict islet function in man: A retrospective study in 87 clinical transplants

Author

Julien Thevenet, Marie-Christine Vantyghem, Mikael Chetboun, Thomas Hubert, Alan Apete, Gianni Pasquetti, Julie Kerr-Conte, François Pattou, Caroline Bonner, Valery Gmyr, and Nathalie Delalleau

Subjects
endocrine system, geography, medicine.medical_specialty, geography.geographical_feature_category, Sterility, business.industry, Urology, Retrospective cohort study, Islet, Transplantation, In vivo, medicine, Potency, Beta (finance), business, Immunodeficient Mouse
Abstract

Objective. This retrospective study in 87 clinical islet transplants sought to determine if the quantitative in vivo islet potency assay (QIVIPA) based on human c-peptide measurement in normoglycemic immunodeficient mice transplanted with 1% of clinical islet transplant (n = 165) could predict islet function in man after transplantation (tx). Since each recipient receives a mean of 2.7 grafts in our center, the ultimate goal of this work was to prospectively determine the functional islet mass required in 1–3 transplants in the QIVIPA mice to achieve optimal long-term islet function (beta score ≥ 7) in man. Methods. Islet preparations that met in vitro release criteria (200,000 IEQ, viability ≥ 80%, sterility) were transplanted in severe type 1 diabetic patients (n = 87). 2% of the preparation was used for in vitro quality controls, and 2% for in vivo controls: tx under the kidney capsule of two normoglycemic nude or RAG2 mice where fasting c-peptide and glycemia were measured over 30 days. Human islet function was defined by immediate graft function (hCP increase 7 days after tx), primary graft function (PGF = beta score 1 month after the last tx) and beta score at 1 year. Results. The QIVIPA model is robust and reproducible with two mice transplanted per human islet preparation (P Conclusion. Evidence from this retrospective study on 87 clinical islet transplants in 165 mice suggests that in vivo quantitative islet potency assays like QIVIPA in normoglycemic immunodeficient are a key indicator of the quality of manufactured clinical graft preparations as they predict islet function in man, both early function at 7 days post tx, PGF (beta score 1 month after the last tx), and 1-year beta score even when multiple grafts are transplanted per recipient.

Published
2020
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3. Contributors

Author

Peter Abrams, Joel T. Adler, Rodolfo Alejandro, Mohamed Alibashe-Ahmed, Ana Alvarez, Takayuki Anazawa, Axel Andres, Barbara Antonioli, Alan Apete, David A. Axelrod, Lionel Badet, David Baidal, Kaylene Barrera, Pierre-Yves Benhamou, Thierry Berney, Alain Gerald Bertoni, Federico Bertuzzi, Ugo Boggi, Caroline Bonner, Adel Bozorgzadeh, Julien Branchereau, Jonathan Bromberg, George W. Burke, Fanny Buron, Robert Caiazzo, Rossana Caldara, Stephanie S. Camhi, Diego Cantarovich, Massimo Cardillo, D. Castanares-Zapatero, Pierre Cattan, Suresh Rama Chandran, Erin Chang, Linda Chen, Mikael Chetboun, Pratik Choudhary, Gaetano Ciancio, Maria Pia Cicalese, Antonio Citro, C. Collienne, Caterina Conte, Claire Counter, Khaled Z. Dajani, Carly M. Darden, Francesco De Cobelli, Eelco J.P. de Koning, Hector De Leon, Nathalie Delalleau, Laura DiChiacchio, Jason B. Doppenberg, Cinthia B. Drachenberg, Erica Dugnani, Ty B. Dunn, Marten A. Engelse, Ahmed Farag, Alan Farney, Anne Elizabeth Farrow, Ibrahim Fathi, Jose Figueiro, Anneliese Flatt, Georgia Fousteri, Jonathan A. Fridell, Peter J. Friend, Giacomo Gastaldi, Valery Gmyr, Javier Gonzalez, Jeevan Prakash Gopal, Frans K. Gorus, Masafumi Goto, Mitsukazu Gotoh, Michel Greget, Dominique Grenet, Paolo Antonio Grossi, Rainer W.G. Gruessner, Angelika C. Gruessner, David I. Harriman, Wayne J. Hawthorne, Jarl Hellman, Brenda Lee Holbert, Thomas Hubert, Sara Iacopi, Marco Infante, Peter Jacob, Paul Johnson, Raja Kandaswamy, Georges Karam, Dixon B. Kaufman, W.F. Kendall Jr, Clark D. Kensinger, Norma S. Kenyon, Julie Kerr-Conte, Delphine Kervella, Laurence Kessler, Romain Kessler, Bart Keymeulen, Olle Korsgren, Sandrine Lablanche, Muhaib Lakhani, Neeraj Lalwani, P.F. Laterre, Michael C. Lawrence, Frances Tangherlini Lee, Roger Lehmann, Elina Linetsky, Barbara Ludwig, Torbjörn Lundgren, Xunrong Luo, SriGita Madiraju, Paola Maffi, Paola Magistretti, Kristell Le Mapihan, James F. Markmann, Geert Martens, Paulo N. Martins, Francesco Antonio Mazzotta, Kavya Chitra Mekala, Raffaella Melzi, Alessia Mercalli, Paolo Monti, Mahmoud Morsi, Irene Mosca, M. Mourad, Anand S. Rathnasamy Muthusamy, Rita Nano, Bashoo Naziruddin, Christian Noel, John O’Callaghan, Jon S. Odorico, Anne Olland, E.C. Opara, Giuseppe Orlando, Nathalia Padilla, John C. Papadimitriou, Vassilios E. Papalois, Klearchos K. Papas, Gianni Pasquetti, François Pattou, Silvia Pellegrini, Nadine Pernin, Vittorio Grazio Perrone, Lorenzo Piemonti, Rutger Ploeg, John A. Powelson, Alberto Pugliese, Shanthini K. Rajan, Karthik V. Ramanathan, Violeta Raverdy, Robert R. Redfield, John Renz, Michael R. Rickels, Charles G. Rickert, Camillo Ricordi, Jeffrey Rogers, Joseph R. Scalea, Jesse D. Schold, Hanne Scholz, Antonio Secchi, Oscar K. Serrano, A.M. James Shapiro, Sidharth Sharma, Edward Sharples, James A.M. Shaw, Sanjay Sinha, Carlo Socci, Jean-Paul G. Squifflet, Peter G. Stock, Robert J. Stratta, David E.R. Sutherland, Manfredi Tesauro, Olivier Thaunat, Julien Thévenet, Christoph Troppmann, Marie-Christine Vantyghem, Francesco Vendrame, Massimo Venturini, Rodrigo Vianna, Fabio Vistoli, Bengt von Zur-Mühlen, X. Wittebole, Anne Wojtusciszyn, Arya Zarinsefat, and Asha Zimmerman

Published
2020
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