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Start Over Author "Micheletti, M." Publisher elsevier
10 results on '"Micheletti, M."'

2. A study of the effect of molecular and aerosol conditions in the atmosphere on air fluorescence measurements at the Pierre Auger Observatory

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J. ABRAHAM, P. ABREU, M. AGLIETTA, E. J. AHN, D. ALLARD, I. ALLEKOTTE, J. ALLEN, J. ALVAREZ MUNIZ, M. AMBROSIO, L. ANCHORDOQUI, S. ANDRINGA, T. ANTICIC, A. ANZALONE, C. ARAMO, E. ARGANDA, K. ARISAKA, F. ARQUEROS, H. ASOREY, P. ASSIS, J. AUBLIN, M. AVE, G. AVILA, T. BACKER, D. BADAGNANI, M. BALZER, K. B. BARBER, A. F. BARBOSA, S. L. C. BARROSO, B. BAUGHMAN, P. BAULEO, J. BEATTY, B. R. BECKER, K. H. BECKER, A. BELLETOILE, J. A. BELLIDO, S. BENZVI, C. BERAT, T. BERGMANN, X. BERTOU, P. L. BIERMANN, P. BILLOIR, O. BLANCH BIGAS, F. BLANCO, M. BLANCO, H. BLUMER, M. BOHACOVA, D. BONCIOLI, C. BONIFAZI, R. BONINO, N. BORODAI, J. BRACK, P. BROGUEIRA, W. C. BROWN, R. BRUIJN, P. BUCHHOLZ, A. BUENO, R. E. BURTON, N. BUSCA, K. S. CABALLERO MORA, L. CARAMETE, R. CARUSO, A. CASTELLINA, O. CATALANO, G. CATALDI, L. CAZON, R. CESTER, J. CHAUVIN, A. CHIAVASSA, J. A. CHINELLATO, A. CHOU, J. CHUDOBA, R. W. CLAY, E. COLOMBO, R. CONCEICAO, F. CONTRERAS, H. COOK, M. COOPER, J. COPPENS, A. CORDIER, U. COTTI, S. COUTU, C. E. COVAULT, A. CREUSOT, A. CRISS, J. CRONIN, A. CURUTIU, S. DAGORET CAMPAGNE, R. DALLIER, K. DAUMILLER, B. R. DAWSON, R. M. DE, ALMEIDA, M. DEDOMENICO, C. DEDONATO, S. J. DEJONG, G. DELAVEGA, W. J. M. DEMELLOJUNIOR, J. DEMELLONETO, V. DESOUZAM, K. D. DEVRIES, G. DECERPRIT, L. DELPERAL, O. DELIGNY, A. DELLASELVA, C. DELLEFRATTE, H. DEMBINSKI, C. DIGIULIO, J. C. DIAZ, M. CASTRO, P. N. DIEP, C. DOBRIGKEIT, J. C. DOLIVO, P. N. DONG, A. DOROFEEV, J. C. DOSANJOS, M. DOVA, D. DURSO, I. DUTAN, M. A. DUVERNOIS, J. EBR, R. ENGEL, M. ERDMANN, C. O, A. ETCHEGOYEN, P. FACALSANLUIS, H. FALCKE, G. FARRAR, A. C. FAUTH, N. FAZZINI, A. FERRERO, B. FICK, A. FILEVICH, A. FILIPCIC, I. FLECK, S. FLIESCHER, C. E. FRACCHIOLLA, E. D. FRAENKEL, U. FROHLICH, W. FULGIONE, R. F. GAMARRA, S. GAMBETTA, B. GARCIA, D. GAMEZ, D. GARCIA PINTO, X. GARRIDO, G. GELMINI, H. GEMMEKEAG, P. L. GHIA, U. GIACCARI, M. GILLER, H. GLASS, L. GOGGIN, M. S. GOLD, G. GOLUP, F. GOMEZALBARRACIN, M. BERISSO, P. GONC ALVES, D. GONZALEZ, J. G. GONZALEZ, D. GORA, A. GORGI, P. GOUFFON, S. R. GOZZINI, E. GRASHORN, S. GREBE, M. GRIGAT, A. F. GRILLO, Y. GUARDINCERRI, F. GUARINO, G. P. GUEDES, J. D. HAGUE, V. HALENKA, P. HANSEN, D. HARARI, S. HARMSMA, J. L. HARTON, A. HAUNGS, T. HEBBEKER, D. HECK, A. E. HERVE, C. HOJVAT, V. C. HOLMES, P. HOMOLA, J. R. HORANDEL, A. HORNEFFER, M. HRABOVSKY, T. HUEGE, M. HUSSAIN, M. IARLORI, A. INSOLIA, F. IONITA, A. ITALIANO, S. JIRASKOVA, K. KADIJA, M. KADUCAK, K. H. KAMPERT, T. KAROVA, P. KASPER, B. KEGL, B. KEILHAUER, A. KEIVANI, J. KELLEY, E. KEMPO, R. M. KIECKHAFER, H. O. KLAGES, M. KLEIFGES, J. KLEINFELLER, R. KNAPIK, J. KNAPP, D. H. KOANG, A. KRIEGER, O. KROMER, D. KRUPPKE HANSEN, F. KUEHN, D. KUEMPEL, K. KULBARTZ, N. KUNKA, A. KUSENKO, G. LAROSA, C. LACHAUD, B. LAGO, P. LAUTRIDOU, M. S. A. B. LEAO, D. LEBRUN, P. LEBRUN, J. LEE, M. A. LEIGUIDEOLIVEIRA, A. LEMIERE, A. LETESSIER SELVON, I. LHENRY YVON, R. LOPEZ, A. LOPEZAGUERA, K. LOUEDEC, J. LOZANOBAHILO, A. LUCERO, M. LUDWIG, H. LYBERIS, M. C. MACCARONE, C. MACOLINO, S. MALDERA, D. MANDAT, P. MANTSCH, A. G. MARIAZZI, V. MARIN, I. C. MARIS, H. FALCON, O. BRAVO, H. J. MATHES, J. MATTHEWS, G. MATTHIAE, D. MAURIZIO, P. O. MAZUR, M. MCEWENBP, G. MEDINA TANCO, M. MELISSAS, D. MELO, E. MENICHETTI, A. MENSHIKOV, C. MEURER, S. MICANOVIC, M. I. MICHELETTI, W. MILLER, L. MIRAMONTI, S. MOLLERACH, M. MONASOR, D. MONNIERRAGAIGNE, F. MONTANET, B. MORALES, C. MORELLO, E. BA, J. C. MORENO, C. MORRIS, M. MOSTAFA, S. MUELLER, M. MULLER, R. MUSSA, G. NAVARRA, J. L. NAVARRO, S. NAVAS, P. NECESAL, L. NELLEN, P. NHUNG, N. NIERSTENHOEFER, D. NITZ, D. NOSEK, L. NOZKA, M. NYKLICEK, J. OEHLSCHLAGER, A. OLINTO, P. OLIVA, V. BR, M. ORTIZ, N. PACHECO, D. PAKKSELMI DEI, M. PALATKA, J. PALLOTTA, N. PALMIERI, G. PARENTE, E. PARIZOT, S. PARLATI, A. PARRA, J. PARRISIUS, R. PARSONS, S. PASTOR, T. PAUL, V. PAVLIDOU, K. PAYET, M. PECH, J. PEKALA, R. PELAYO, I. PEPE, R. PESCE, E. PETERMANN, S. PETRERA, P. PETRINCA, A. PETROLINI, Y. PETROV, J. PETROVIC, C. PFENDNER, R. PIEGAIA, T. PIEROG, M. PIMENTA, V. PIRRONELLO, M. PLATINO, V. H. PONCE, M. PONTZ, P. PRIVITERA, M. PROUZA, E. J. QUEL, J. RAUTENBERG, O. RAVEL, D. RAVIGNANI, A. REDONDO, B. REVENU, F. A. S. REZENDE, J. RIDKY, S. RIGGI, M. RISSE, P. RISTORI, C. RIVIERE, V. RIZI, C. ROBLEDO, G. RODRIGUEZ, J. RODRIGUEZMARTINO, J. RODRIGUEZROJO, I. RODRIGUEZ CABO, M. D. RODRIGUEZ FRIAS, G. ROS, J. ROSADO, T. ROSSLER, M. ROTH, B. ROUILLE DORFEUIL, E. ROULET, A. C. ROVERO, F. SALAMIDA, H. SALAZAR, G. SALINA, F. SANCHEZ, M. SANTANDER, C. E. SANTO, E. SANTO, E. M. SANTOS, F. SARAZIN, S. SARKAR, R. SATO, N. SCHARF, V. SCHERINI, H. SCHIELER, P. SCHIFFER, A. SCHMIDT, F. SCHMIDT, T. SCHMIDT, O. SCHOLTEN, H. SCHOORLEMMER, J. SCHOVANCOVA, P. SCHOVANEK, F. SCHROEDER, S. SCHULTE, F. SCHUSSLER, D. SCHUSTER, S. J. SCIUTTO, M. SCUDERI, A. SEGRETO, D. SEMIKOZ, R. SHELLARD, I. SIDELNIK, B. B. SIFFERT, G. SIGL, A. SMIAKOWSKI, R. SMIDA, G. R. SNOW, P. SOMMERS, J. SOROKIN, H. SPINKA, R. SQUARTINI, J. STASIELAK, M. STEPHAN, E. STRAZZERI, A. STUTZ, F. SUAREZ, T. SUOMIJARVI, A. D. SUPANITSKY, T. SUSA, M. S. SUTHERLAND, J. SWAIN, Z. SZADKOWSKI, A. TAMASHIRO, A. TAMBURRO, A. TAPIA, T. TARUTINA, O. TAS CAU, R. TCACIUC, D. TCHERNIAKHOVSKI, D. TEGOLO, N. T. THAO, D. THOMAS, J. TIFFENBERG, C. TIMMERMANS, W. TKACZYK, C. J. TODEROPEIXOTO, B. TOME, A. TONACHINI, P. TRAVNICEK, D. B. TRIDAPALLI, G. TRISTRAM, E. TROVATO, M. TUEROS, R. ULRICH, M. UNGER, M. URBAN, J. GALICIA, I. VALINO, L. VALORE, A. M. VANDENBERG, J. R. VAZQUEZ, R. A. VAZQUEZ, D. VEBERIC, T. VENTERS, V. VERZI, M. VIDELA, L. VILLASENOR, S. VOROBIOV, L. VOYVODIC, H. WAHLBERG, P. WAHRLICH, O. WAINBERG, D. WARNER, A. A. WATSON, S. WESTERHOFF, B. J. WHELAN, G. WIECZOREK, L. WIENCKE, B. WILCZYNSKA, H. WILCZYNSKI, C. WILLIAMS, T. WINCHEN, M. G. WINNICK, B. WUNDHEILER, T. YAMAMOTO, P. YOUNK, G. YUAN, A. YUSHKOV, E. ZAS, D. ZAVRTANIK, M. ZAVRTANIK, I. ZAW, A. ZEPEDA, M. ZIOLKOWSKI, BLEVE, Carla, COLUCCIA, MARIA RITA, DE MITRI, Ivan, MARSELLA, GIOVANNI, MARTELLO, Daniele, PERRONE, Lorenzo, SETTIMO, MARIANGELA, APC - Astrophysique des Hautes Energies (APC - AHE), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), APC - THEORIE, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut für theoretische Physik, Universität Hamburg (UHH)-Universität Hamburg (UHH), PIERRE AUGER, KVI - Center for Advanced Radiation Technology, Research unit Astroparticle Physics, Guarino, Fausto, D'Urso, Domenico, Valore, Laura, M., Ambrosio, Aramo, Carla, DELLA SELVA, Angelo, C., Moura, Yushkov, Alexey, The Pierre Auger, Collaboration, Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut für theoretische Physik, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut für theoretische Physik, Abraham, J., Abreu, P., Aglietta, M., Aguirre, C., Ahn, E., Allard, D., Allekotte, I., Allen, J., Alvarez-Muñiz, J., Ambrosio, M., Anchordoqui, L., Andringa, S., Anzalone, A., Aramo, C., Arganda, E., Arisaka, K., Arqueros, F., Asch, T., Asorey, H., Assis, P., Aublin, J., Ave, M., Avila, G., Bäcker, T., Badagnani, D., Barber, K., Barbosa, A., Barroso, S., Baughman, B., Bauleo, P., Beatty, J., Beau, T., Becker, B., Becker, K., Bellétoile, A., Bellido, J., Benzvi, S., Berat, C., Bertou, X., Biermann, P., Billoir, P., Blanch-Bigas, O., Blanco, F., Bleve, C., Blümer, H., Boháčová, M., Boncioli, D., Bonifazi, C., Bonino, R., Borodai, N., Brack, J., Brogueira, P., Brown, W., Bruijn, R., Buchholz, P., Bueno, A., Burton, R., Busca, N., Caballero-Mora, K., Caramete, L., Caruso, R., Castellina, A., Catalano, O., Cazon, L., Cester, R., Chauvin, J., Chiavassa, A., Chinellato, J., Chou, A., Chudoba, J., Chye, J., Clay, R., Colombo, E., Conceição, R., Contreras, F., Cook, H., Coppens, J., Cordier, A., Cotti, U., Coutu, S., Covault, C., Creusot, A., Criss, A., Cronin, J., Curutiu, A., Dagoret-Campagne, S., Dallier, R., Daumiller, K., Dawson, B., de Almeida, R., De Domenico, M., De Donato, C., de Jong, S., De La Vega, G., de Mello Junior, W., de Mello Neto, J., De Mitri, I., de Souza, V., de Vries, K., Decerprit, G., del Peral, L., Deligny, O., Della Selva, A., Delle Fratte, C., Dembinski, H., Di Giulio, C., Diaz, J., Diep, P., Dobrigkeit, C., D'Olivo, J., Dong, P., Dorofeev, A., dos Anjos, J., Dova, M., D'Urso, D., Dutan, I., Duvernois, M., Ebr, J., Engel, R., Erdmann, M., Escobar, C., Etchegoyen, A., Facal San Luis, P., Falcke, H., Farrar, G., Fauth, A., Fazzini, N., Ferrer, F., Ferrero, A., Fick, B., Filevich, A., Filipčič, A., Fleck, I., Fliescher, S., Fracchiolla, C., Fraenkel, E., Fulgione, W., Gamarra, R., Gambetta, S., García, B., García Gámez, D., Garcia-Pinto, D., Garrido, X., Gelmini, G., Gemmeke, H., Ghia, P., Giaccari, U., Giller, M., Glass, H., Goggin, L., Gold, M., Golup, G., Gomez Albarracin, F., Gómez Berisso, M., Gonçalves, P., Gonzalez, D., Gonzalez, J., Góra, D., Gorgi, A., Gouffon, P., Gozzini, S., Grashorn, E., Grebe, S., Grigat, M., Grillo, A., Guardincerri, Y., Guarino, F., Guedes, G., Gutiérrez, J., Hague, J., Halenka, V., Hansen, P., Harari, D., Harmsma, S., Harton, J., Haungs, A., Healy, M., Hebbeker, T., Hebrero, G., Heck, D., Hojvat, C., Holmes, V., Homola, P., Hörandel, J., Horneffer, A., Hrabovský, M., Huege, T., Hussain, M., Iarlori, M., Insolia, A., Ionita, F., Italiano, A., Jiraskova, S., Kaducak, M., Kampert, K., Karova, T., Kasper, P., Kégl, B., Keilhauer, B., Kelley, J., Kemp, E., Kieckhafer, R., Klages, H., Kleifges, M., Kleinfeller, J., Knapik, R., Knapp, J., Koang, D., Krieger, A., Krömer, O., Kruppke-Hansen, D., Kuehn, F., Kuempel, D., Kulbartz, K., Kunka, N., Kusenko, A., La Rosa, G., Lachaud, C., Lago, B., Lautridou, P., Leão, M., Lebrun, D., Lebrun, P., Lee, J., Leigui de Oliveira, M., Lemiere, A., Letessier-Selvon, A., Lhenry-Yvon, I., López, R., Lopez Agüera, A., Louedec, K., Lozano Bahilo, J., Lucero, A., Ludwig, M., Lyberis, H., Maccarone, M., Macolino, C., Maldera, S., Mandat, D., Mantsch, P., Mariazzi, A., Maris, I., Marquez Falcon, H., Marsella, G., Martello, D., Martínez Bravo, O., Mathes, H., Matthews, J., Matthiae, G., Maurizio, D., Mazur, P., Mcewen, M., Mcneil, R., Medina-Tanco, G., Melissas, M., Melo, D., Menichetti, E., Menshikov, A., Meurer, C., Micheletti, M., Miller, W., Miramonti, L., Mollerach, S., Monasor, M., Monnier Ragaigne, D., Montanet, F., Morales, B., Morello, C., Moreno, J., Morris, C., Mostafá, M., Moura, C., Mueller, S., Muller, M., Mussa, R., Navarra, G., Navarro, J., Navas, S., Necesal, P., Nellen, L., Newman-Holmes, C., Nhung, P., Nierstenhoefer, N., Nitz, D., Nosek, D., Nožka, L., Nyklicek, M., Oehlschläger, J., Olinto, A., Oliva, P., Olmos-Gilbaja, V., Ortiz, M., Pacheco, N., Pakk Selmi-Dei, D., Palatka, M., Pallotta, J., Palmieri, N., Parente, G., Parizot, E., Parlati, S., Parsons, R., Pastor, S., Paul, T., Pavlidou, V., Payet, K., Pech, M., Pȩkala, J., Pepe, I., Perrone, L., Pesce, R., Petermann, E., Petrera, S., Petrinca, P., Petrolini, A., Petrov, Y., Petrovic, J., Pfendner, C., Piegaia, R., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Ponce, V., Pontz, M., Privitera, P., Prouza, M., Quel, E., Rautenberg, J., Ravel, O., Ravignani, D., Redondo, A., Revenu, B., Rezende, F., Ridky, J., Riggi, S., Risse, M., Rivière, C., Rizi, V., Robledo, C., Rodriguez, G., Rodriguez Martino, J., Rodriguez Rojo, J., Rodriguez-Cabo, I., Rodríguez-Frías, M., Ros, G., Rosado, J., Rossler, T., Roth, M., Rouillé-d'Orfeuil, B., Roulet, E., Rovero, A., Salamida, F., Salazar, H., Salina, G., Sánchez, F., Santander, M., Santo, C., Santos, E., Sarazin, F., Sarkar, S., Sato, R., Scharf, N., Scherini, V., Schieler, H., Schiffer, P., Schmidt, A., Schmidt, F., Schmidt, T., Scholten, O., Schoorlemmer, H., Schovancova, J., Schovánek, P., Schroeder, F., Schulte, S., Schüssler, F., Schuster, D., Sciutto, S., Scuderi, M., Segreto, A., Semikoz, D., Settimo, M., Shellard, R., Sidelnik, I., Siffert, B., Sigl, G., Śmiałkowski, A., Šmída, R., Snow, G., Sommers, P., Sorokin, J., Spinka, H., Squartini, R., Strazzeri, E., Stutz, A., Suarez, F., Suomijärvi, T., Supanitsky, A., Sutherland, M., Swain, J., Szadkowski, Z., Tamashiro, A., Tamburro, A., Tarutina, T., Taşcǎu, O., Tcaciuc, R., Tcherniakhovski, D., Tegolo, D., Thao, N., Thomas, D., Ticona, R., Tiffenberg, J., Timmermans, C., Tkaczyk, W., Todero Peixoto, C., Tomé, B., Tonachini, A., Torres, I., Travnicek, P., Tridapalli, D., Tristram, G., Trovato, E., Tueros, M., Ulrich, R., Unger, M., Urban, M., Valdés Galicia, J., Valiño, I., Valore, L., van den Berg, A., Vázquez, J., Vázquez, R., Veberič, D., Velarde, A., Venters, T., Verzi, V., Videla, M., Villaseñor, L., Vorobiov, S., Voyvodic, L., Wahlberg, H., Wahrlich, P., Wainberg, O., Warner, D., Watson, A., Westerhoff, S., Whelan, B., Wieczorek, G., Wiencke, L., Wilczyńska, B., Wilczyński, H., Winchen, T., Winnick, M., Wu, H., Wundheiler, B., Yamamoto, T., Younk, P., Yuan, G., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zaw, I., Zepeda, A., Ziolkowski, M., J., Abraham, P., Abreu, M., Aglietta, E. J., Ahn, D., Allard, I., Allekotte, J., Allen, J., ALVAREZ MUNIZ, L., Anchordoqui, S., Andringa, T., Anticic, A., Anzalone, C., Aramo, E., Arganda, K., Arisaka, F., Arquero, H., Asorey, P., Assi, J., Aublin, M., Ave, G., Avila, T., Backer, D., Badagnani, M., Balzer, K. B., Barber, A. F., Barbosa, S. L. C., Barroso, B., Baughman, P., Bauleo, J., Beatty, B. R., Becker, K. H., Becker, A., Belletoile, J. A., Bellido, S., Benzvi, C., Berat, T., Bergmann, X., Bertou, P. L., Biermann, P., Billoir, O., BLANCH BIGAS, F., Blanco, M., Blanco, Bleve, Carla, H., Blumer, M., Bohacova, D., Boncioli, C., Bonifazi, R., Bonino, N., Borodai, J., Brack, P., Brogueira, W. C., Brown, R., Bruijn, P., Buchholz, A., Bueno, R. E., Burton, N., Busca, K. S., CABALLERO MORA, L., Caramete, R., Caruso, A., Castellina, O., Catalano, G., Cataldi, L., Cazon, R., Cester, J., Chauvin, A., Chiavassa, J. A., Chinellato, A., Chou, J., Chudoba, R. W., Clay, E., Colombo, Coluccia, MARIA RITA, R., Conceicao, F., Contrera, H., Cook, M., Cooper, J., Coppen, A., Cordier, U., Cotti, S., Coutu, C. E., Covault, A., Creusot, A., Cri, J., Cronin, A., Curutiu, S., DAGORET CAMPAGNE, R., Dallier, K., Daumiller, B. R., Dawson, R. M., De, Almeida, M., Dedomenico, C., Dedonato, S. J., Dejong, G., Delavega, W. J. M., Demellojunior, J., Demelloneto, DE MITRI, Ivan, V., Desouzam, K. D., Devrie, G., Decerprit, L., Delperal, O., Deligny, A., Dellaselva, C., Dellefratte, H., Dembinski, C., Digiulio, J. C., Diaz, M., Castro, P. N., Diep, C., Dobrigkeit, J. C., Dolivo, P. N., Dong, A., Dorofeev, J. C., Dosanjo, M., Dova, D., Durso, I., Dutan, M. A., Duvernoi, J., Ebr, R., Engel, M., Erdmann, C., O, A., Etchegoyen, P., Facalsanlui, H., Falcke, G., Farrar, A. C., Fauth, N., Fazzini, A., Ferrero, B., Fick, A., Filevich, A., Filipcic, I., Fleck, S., Fliescher, C. E., Fracchiolla, E. D., Fraenkel, U., Frohlich, W., Fulgione, R. F., Gamarra, S., Gambetta, B., Garcia, D., Gamez, D., GARCIA PINTO, X., Garrido, G., Gelmini, H., Gemmekeag, P. L., Ghia, U., Giaccari, M., Giller, H., Gla, L., Goggin, M. S., Gold, G., Golup, F., Gomezalbarracin, M., Berisso, P., GONC ALVES, D., Gonzalez, J. G., Gonzalez, D., Gora, A., Gorgi, P., Gouffon, S. R., Gozzini, E., Grashorn, S., Grebe, M., Grigat, A. F., Grillo, Y., Guardincerri, F., Guarino, G. P., Guede, J. D., Hague, V., Halenka, P., Hansen, D., Harari, S., Harmsma, J. L., Harton, A., Haung, T., Hebbeker, D., Heck, A. E., Herve, C., Hojvat, V. C., Holme, P., Homola, J. R., Horandel, A., Horneffer, M., Hrabovsky, T., Huege, M., Hussain, M., Iarlori, A., Insolia, F., Ionita, A., Italiano, S., Jiraskova, K., Kadija, M., Kaducak, K. H., Kampert, T., Karova, P., Kasper, B., Kegl, B., Keilhauer, A., Keivani, J., Kelley, E., Kempo, R. M., Kieckhafer, H. O., Klage, M., Kleifge, J., Kleinfeller, R., Knapik, J., Knapp, D. H., Koang, A., Krieger, O., Kromer, D., KRUPPKE HANSEN, F., Kuehn, D., Kuempel, K., Kulbartz, N., Kunka, A., Kusenko, G., Larosa, C., Lachaud, B., Lago, P., Lautridou, M. S. A. B., Leao, D., Lebrun, P., Lebrun, J., Lee, M. A., Leiguideoliveira, A., Lemiere, A., LETESSIER SELVON, I., LHENRY YVON, R., Lopez, A., Lopezaguera, K., Louedec, J., Lozanobahilo, A., Lucero, M., Ludwig, H., Lyberi, M. C., Maccarone, C., Macolino, S., Maldera, D., Mandat, P., Mantsch, A. G., Mariazzi, V., Marin, I. C., Mari, H., Falcon, Marsella, Giovanni, Martello, Daniele, O., Bravo, H. J., Mathe, J., Matthew, G., Matthiae, D., Maurizio, P. O., Mazur, M., Mcewenbp, G., MEDINA TANCO, M., Melissa, D., Melo, E., Menichetti, A., Menshikov, C., Meurer, S., Micanovic, M. I., Micheletti, W., Miller, L., Miramonti, S., Mollerach, M., Monasor, D., Monnierragaigne, F., Montanet, B., Morale, C., Morello, E., Ba, J. C., Moreno, C., Morri, M., Mostafa, S., Mueller, M., Muller, R., Mussa, G., Navarra, J. L., Navarro, S., Nava, P., Necesal, L., Nellen, P., Nhung, N., Nierstenhoefer, D., Nitz, D., Nosek, L., Nozka, M., Nyklicek, J., Oehlschlager, A., Olinto, P., Oliva, V., Br, M., Ortiz, N., Pacheco, D., PAKKSELMI DEI, M., Palatka, J., Pallotta, N., Palmieri, G., Parente, E., Parizot, S., Parlati, A., Parra, J., Parrisiu, R., Parson, S., Pastor, T., Paul, V., Pavlidou, K., Payet, M., Pech, J., Pekala, R., Pelayo, I., Pepe, Perrone, Lorenzo, R., Pesce, E., Petermann, S., Petrera, P., Petrinca, A., Petrolini, Y., Petrov, J., Petrovic, C., Pfendner, R., Piegaia, T., Pierog, M., Pimenta, V., Pirronello, M., Platino, V. H., Ponce, M., Pontz, P., Privitera, M., Prouza, E. J., Quel, J., Rautenberg, O., Ravel, D., Ravignani, A., Redondo, B., Revenu, F. A. S., Rezende, J., Ridky, S., Riggi, M., Risse, P., Ristori, C., Riviere, V., Rizi, C., Robledo, G., Rodriguez, J., Rodriguezmartino, J., Rodriguezrojo, I., RODRIGUEZ CABO, M. D., RODRIGUEZ FRIAS, G., Ro, J., Rosado, T., Rossler, M., Roth, B., ROUILLE DORFEUIL, E., Roulet, A. C., Rovero, F., Salamida, H., Salazar, G., Salina, F., Sanchez, M., Santander, C. E., Santo, E., Santo, E. M., Santo, F., Sarazin, S., Sarkar, R., Sato, N., Scharf, V., Scherini, H., Schieler, P., Schiffer, A., Schmidt, F., Schmidt, T., Schmidt, O., Scholten, H., Schoorlemmer, J., Schovancova, P., Schovanek, F., Schroeder, S., Schulte, F., Schussler, D., Schuster, S. J., Sciutto, M., Scuderi, A., Segreto, D., Semikoz, Settimo, Mariangela, R., Shellard, I., Sidelnik, B. B., Siffert, G., Sigl, A., Smiakowski, R., Smida, G. R., Snow, P., Sommer, J., Sorokin, H., Spinka, R., Squartini, J., Stasielak, M., Stephan, E., Strazzeri, A., Stutz, F., Suarez, T., Suomijarvi, A. D., Supanitsky, T., Susa, M. S., Sutherland, J., Swain, Z., Szadkowski, A., Tamashiro, A., Tamburro, A., Tapia, T., Tarutina, O., TAS CAU, R., Tcaciuc, D., Tcherniakhovski, D., Tegolo, N. T., Thao, D., Thoma, J., Tiffenberg, C., Timmerman, W., Tkaczyk, C. J., Toderopeixoto, B., Tome, A., Tonachini, P., Travnicek, D. B., Tridapalli, G., Tristram, E., Trovato, M., Tuero, R., Ulrich, M., Unger, M., Urban, J., Galicia, I., Valino, L., Valore, A. M., Vandenberg, J. R., Vazquez, R. A., Vazquez, D., Veberic, T., Venter, V., Verzi, M., Videla, L., Villasenor, S., Vorobiov, L., Voyvodic, H., Wahlberg, P., Wahrlich, O., Wainberg, D., Warner, A. A., Watson, S., Westerhoff, B. J., Whelan, G., Wieczorek, L., Wiencke, B., Wilczynska, H., Wilczynski, C., William, T., Winchen, M. G., Winnick, B., Wundheiler, T., Yamamoto, P., Younk, G., Yuan, A., Yushkov, E., Za, D., Zavrtanik, M., Zavrtanik, I., Zaw, A., Zepeda, and M., Ziolkowski

Subjects
Angstrom exponent, Astronomy, Astrophysics, 01 natural sciences, Auger, CROSS-SECTIONS, COSMIC-RAY SHOWERS, Observatory, DEPENDENCE, High-Energy Cosmic Ray, 010303 astronomy & astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Lidar, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], ANGSTROM EXPONENT, Pierre Auger Observatory, Bi-static lidar, ELECTRONS, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, MULTIPLE-SCATTERING, Light emission, Física nuclear, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, LIGHT-EMISSION, Astrophysics - Cosmology and Nongalactic Astrophysics, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Cosmology and Nongalactic Astrophysics (astro-ph.CO), Extensive air shower, FOS: Physical sciences, Cosmic ray, SURFACE DETECTOR, Air fluorescence method, 0103 physical sciences, Extensive air showers, RECONSTRUCTION, Aerosol, Instrumentation and Methods for Astrophysics (astro-ph.IM), Cosmic rays, Aerosols, Calorimeter (particle physics), Atmospheric effect, 010308 nuclear & particles physics, Atmosphere, Física, Astronomy and Astrophysics, NITROGEN, Air shower, Fluorescence Telescopes, 13. Climate action, Experimental High Energy Physics, AEROSSOL
Abstract

The air fluorescence detector of the Pierre Auger Observatory is designed to perforin calorimetric measurements of extensive air showers created by Cosmic rays of above 10(18) eV. To correct these measurements for the effects introduced by atmospheric fluctuations, the Observatory contains a group Of monitoring instruments to record atmospheric conditions across the detector site, ail area exceeding 3000 km(2). The atmospheric data are used extensively in the reconstruction of air showers, and are particularly important for the correct determination of shower energies and the depths of shower maxima. This paper contains a summary of the molecular and aerosol conditions measured at the Pierre Auger Observatory since the start of regular operations in 2004, and includes a discussion of the impact of these measurements oil air shower reconstructions. Between 10(18) and 10(20) eV, the systematic Uncertainties due to all atmospheric effects increase from 4% to 8% in measurements of shower energy, and 4 g cm(-2) to 8 g cm(-2) in measurements of the shower maximum., The successful installation and commissioning of the Pierre Auger Observatory would not have been possible without the strong commitment and effort from the technical and administrative staff in Malargüe. We are very grateful to the following agencies and organizations for financial support: Comisión Nacional de Energía Atómica, Fundación Antorchas, Gobierno De La Provincia de Mendoza, Municipalidad de Malargüe, NDM Holdings and Valle Las Leñas, in gratitude for their continuing cooperation over land access, Argentina; the Australian Research Council; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (FINEP), Fundaçao de Amparo à Pesquisa do Estado de Rio de Janeiro (FAPERJ), Fundaçao de Amparo à Pesquisa do Estado de Sao Paulo (FAPESP), Ministério de Ciência e Tecnologia (MCT), Brazil; AVCR AV0Z10100502 and AV0Z10100522, GAAV KJB300100801 and KJB100100904, MSMT-CR LA08016, LC527, 1M06002, and MSM0021620859, Czech Republic; Centre de Calcul IN2P3/CNRS, Centre National de la Recherche Scientifique (CNRS), Conseil Régional Ile-de-France, Département Physique Nucléaire et Corpusculaire (PNC-IN2P3/CNRS), Département Sciences de l’Univers (SDU-INSU/CNRS), France; Bundesministerium für Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), Finanzministerium Baden- Württemberg, Helmholtz-Gemeinschaft Deutscher Forschungszentren (HGF), Ministerium für Wissenschaft und Forschung, Nordrhein-Westfalen, Ministerium für Wissenschaft, Forschung und Kunst, Baden-W¨urttemberg, Germany; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell’Istruzione,dell’Università e della Ricerca (MIUR), Italy; Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico; Ministerie van Onderwijs, Cultuur en Wetenschap, Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), Stichting voor Fundamenteel Onderzoek der Materie (FOM), Netherlands; Ministry of Science and Higher Education, Grant Nos. 1 P03 D 014 30, N202 090 31/0623, and PAP/218/2006, Poland; Fundaçao para a Ciência e a Tecnologia, Portugal; Ministry for Higher Education, Science, and Technology, Slovenian Research Agency, Slovenia; Comunidad de Madrid, Consejería de Educación de la Comunidad de Castilla La Mancha, FEDER funds, Ministerio de Ciencia e Innovación, Xunta de Galicia, Spain; Science and Technology Facilities Council, United Kingdom; Department of Energy, Contract No. DE-AC02-07CH11359, National Science Foundation, Grant No. 0450696, The Grainger Foundation USA; ALFA-EC / HELEN, European Union 6th Framework Program, Grant No. MEIF-CT-2005-025057, European Union 7th Framework Program, Grant No. PIEF-GA-2008-220240, and UNESCO.

Published
2010

3. Advances in human mesenchymal stromal cell-based therapies - Towards an integrated biological and engineering approach.

Author

Wyrobnik TA, Ducci A, and Micheletti M

Abstract

Recent advances of stem cell-based therapies in clinical trials have raised the need for large-scale manufacturing platforms that can supply clinically relevant doses to meet an increasing demand. Promising results have been reported using stirred-tank bioreactors, where human Mesenchymal Stromal Cells (hMSCs) were cultured in suspension on microcarriers (MCs), although the formation of microcarrier-cell-aggregates might still limit mass transfer and determine a heterogeneous distribution of hMSCs. A variety of MCs, bioreactor-impeller configurations, and agitation conditions have been established in an attempt to overcome the trade-off of ensuring good suspension while keeping the stresses to a minimum. While understanding and controlling the fluid flow environment of bioreactors has been initially under-appreciated, it has recently gained in popularity in the mission of providing ideal culture environments across different scales. This review article aims to provide a comprehensive overview of how rigorous engineering characterisation studies improved the outcome of biological process development and scale-up efforts. Reconciling these two disciplines is crucial to propose tailored bioprocessing solutions that can provide improved growth environments across a range of scales for the allogeneic cell therapies of the future., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2020
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4. Microscale bioprocess optimisation.

Author

Micheletti M and Lye GJ

Subjects
Equipment Design, Flow Injection Analysis instrumentation, Flow Injection Analysis methods, Pilot Projects, Bioreactors, Cell Culture Techniques instrumentation, Cell Culture Techniques methods, Cell Physiological Phenomena, Microfluidic Analytical Techniques instrumentation, Microfluidic Analytical Techniques methods, Signal Transduction physiology
Abstract

Microscale processing techniques offer the potential to speed up the delivery of new drugs to the market, reducing development costs and increasing patient benefit. These techniques have application across both the chemical and biopharmaceutical sectors. The approach involves the study of individual bioprocess operations at the microlitre scale using either microwell or microfluidic formats. In both cases the aim is to generate quantitative bioprocess information early on, so as to inform bioprocess design and speed translation to the manufacturing scale. Automation can enhance experimental throughput and will facilitate the parallel evaluation of competing biocatalyst and process options.

Published
2006
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5. [How WHI study influences women doctors' behaviour towards menopause].

Author

Jamin C, Raccah-Tebeka B, Chevallier T, and Micheletti MC

Subjects
Female, Humans, Surveys and Questionnaires, Attitude of Health Personnel, Estrogen Replacement Therapy, Menopause, Physicians, Women, Women's Health
Abstract

Objective: A survey entitled FEMME was conducted during 2002 in order to evaluate among French women doctors their own actual or future menopause perception and this before the WHI publication. The results of this American trial possibly modified the perception of these French women doctors. Therefore the same experts group conducted a new survey, from May to September 2003. The main aim of this survey was to evaluate the possible changes in the medical management of the actual or future menopause of these women, and secondarily to evaluate the changes in their patients' behaviour towards hormone replacement therapy (HRT)., Population and Methods: Postal auto administered questionnaires were sent to the same 10 000 French women doctors (GP or gynaecologist) whatever their menopausal status or their age. 1365 women doctors (respectively 18,5 or 11% of the gynaecologists or GPs contacted) were volunteers to participate in this survey. Among them, 1120 (84,9%) had already participated in the first part of this survey which took place before the WHI publication., Results: 80% of these women doctors have been informed on WHI results principally by professional press or conferences. 70,9% changed their own actual or future menopause perception as follows. No additional selection of non hormonal treatment have been mentioned in comparison with the first part of the survey. On the other hand for HRT, selections of free estrogen plus progestin associations increased whereas those of fixed combinations decreased: this might be linked to the greater variety of estrogen doses, types of progestin and schedules of treatment (mostly with bleeding) offered by this kind of associations. Finally, duration of HRT is included between three and ten years in most cases., Discussion and Conclusion: Thus, unlike most of their patients, these women's physicians always preferred hormonal treatment for their own actual or future menopause. Only the conditions of these treatments have changed.

Published
2006
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6. [Methodology of the inquiry MISSION (menopause, breast cancer risk, morbidity and prevalence)].

Author

Chevallier T, Daurès JP, Micheletti MC, and Reginster JY

Subjects
Cohort Studies, Female, France epidemiology, Humans, Prevalence, Research Design, Risk Factors, Breast Neoplasms epidemiology, Breast Neoplasms mortality, Estrogen Replacement Therapy, Menopause
Abstract

Objective: The ambition of this article is to detail and to explain the methodology of the study named MISSION (Menopause: breast cancer risk, morbidity and prevalence). The aims of MISSION are to determine the prevalence of breast cancer and global morbidity in France among menopausal women treated or not with hormone replacement therapy (HRT) and followed by a gynecologist., Material and Method: 6600 menopausal women [3300 with HRT -- ie for estrogen: only estradiol via oral or transdermal administration; for progestogen: natural progesterone or assimiled or one pregnane derived (excluding medroxyprogesterone acetate) or non-pregnane derived -- and 3300 without HRT] will be enrolled in France between January 5 2004 and February 28 2005 by 825 gynecologists, members or not of the National Federation of Medical Gynecologists (FNCGM). This study design is a historico-prospective with case randomization. MISSION is conducted by a Theramex-Merck Laboratories initiative in collaboration with a WHO (World Health Organization) Collaborating Center for Public Health Aspects of Rheumatic Diseases and a multidisciplinary expert group., Conclusion: First results of this study will contribute to better knowledge of women health.

Published
2005
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7. [Comparison of changes in biochemical markers of bone turnover after 6 months of hormone replacement therapy with either transdermal 17 beta-estradiol or equine conjugated estrogen plus nomegestrol acetate].

Author

Collette J, Viethel P, Dethor M, Chevallier T, Micheletti MC, Foidart JM, and Reginster JY

Subjects
Administration, Cutaneous, Administration, Oral, Alkaline Phosphatase metabolism, Estradiol administration & dosage, Estrogens administration & dosage, Female, Humans, Megestrol administration & dosage, Middle Aged, Norpregnadienes administration & dosage, Postmenopause, Predictive Value of Tests, Biomarkers urine, Bone Remodeling, Bone and Bones metabolism, Hormone Replacement Therapy
Abstract

Objective: To compare changes in biochemical markers of bone turnover in postmenopausal women who received sequential discontinuous hormone replacement therapy (HRT) with either transdermal 17 beta-estradiol gel (group 1) or oral equine sulfoconjugated estrogen (group 2), plus nomegestrol acetate., Patients and Method: Prospective, open, randomized, controlled trial, conducted on 3 parallel groups of 106 postmenopausal women. All treated groups received estrogen therapy for 25 consecutive days every month. The estrogen used was either 1.5 mg/day of transdermal 17 beta-estradiol gel (group 1) [N = 42, average age (AA) = 51.6 years, average duration of menopause (ADM = 21.5 months)], or 0.625 mg/day of oral equine sulfoconjugated estrogen (group 2) [N = 39, AA = 51.3 years, ADM = 16.8 months]. In all cases nomegestrol acetate 5 mg/day was added for 12 consecutive days every month. The control group comprised 25 patients, [AA = 53.4 years, ADM = 33.7 months]. Two bone resorption markers: urinary cross-linked N-telopeptide and C-telopeptide of type I collagen (U-NTX/Cr, U-CTX/Cr), and a bone formation marker: serum bone specific alkaline phosphatase activity were measured before and 6 months after treatment start., Results: Significant decreases from baseline values were observed for the 3 biochemical markers in both treated groups compared with control (P < 0.001). There were no significant differences in changes between the 2 treated groups for the 3 biochemical markers. The mean percentage change in the 3 biochemical markers was: from -9.3 to -45.5% in group 1, from -20.5 to -39% in group 2, and from -3.3 to 2% in control group. In group 1, the mean percentage decreases in U-CTX reached optimal threshold of bone turnover change (-45%) which is considered by the International Osteoporosis Foundation as clinically relevant because it predicts an increase in BMD greater than 3% when treatment is maintained over a long term., Discussion and Conclusion: Both treated groups induced a significant comparable decrease of bone turnover markers after 6 months of intervention, compared with control. The group treated with cyclic administration of transdermal 17 beta-estradiol (1.5 mg/day) and nomegestrol acetate (5 mg/day) showed a bone resorption markers decrease corresponding to the threshold of clinical relevance described in the international literature and predictive of positive BMD response in long term.

Published
2003
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8. [Determination of acceptability of 2 cutaneous estradiol gels, in a dose of 1.5 mg daily].

Author

De Lunardo MC, Chevallier T, Herbrecht F, Micheletti MC, Parneix-Spake A, Jouin H, and Zartarian M

Subjects
Administration, Cutaneous, Female, Humans, Middle Aged, Patient Satisfaction, Estradiol administration & dosage, Gels, Postmenopause
Abstract

Objective: The aim was to compare acceptability of a percutaneous 0. 1% estradiol gel (Gel A, Estreva(R) Gel, Laboratoire Théramex, Monaco) to that of an 0.06% estradiol gel (Gel B, Oestrodose(R), Laboratoires Besins-Iscovesco) in its new formulation and packaging., Material and Methods: This randomized, crossed, simple-blind study was carried out in 48 volunteer healthy postmenopausal women. The volunteers applied on one forearm 1.5 mg/day of cutaneous estradiol in the form of either gel, according to randomized allocation, for four days without free period between the two therapeutic periods. The application and drying times of the two gels were measured during the first application; gel subjective women assessment was collected at the beginning and at the end of the study., Results: Mean application and drying times with Gel A are significantly reduced, compared to Gel B (p=0.0259 and p=0.0001, respectively) with drying time 61% shorter; these data are confirmed by subjective women evaluation. The two gels are not significantly different regarding several criteria as consistency, ease of application and sensation of lasting stickiness. However, a significant difference is found in favour of Gel A on the following items: practicality of application (p=0.007), ease of penetration (p<0.001), quantity of gel to apply (p<0.001) after the first application. After four days of administration, a same significant difference is observed concerning practicality of the gel (p=0.0078), duration of use (p<0. 001), packaging, women opinion on the gel (p=0.022) and the product, gel and packaging (p<0.001). At the end of the study, gel A utilization is considered by women more practical (p=0.001) with an easier application (p<0.001) and less restricting while applying (p=0.001), compared to Gel B; 72.9% of women prefer the Gel A and 12. 5% of women prefer the Gel B., Conclusion: A better acceptability of the 0.1% estradiol gel and of its packaging compared to that of the 0.06% estradiol gel in this new formulation and packaging is observed in this study.

Published
2000

9. [Evaluation of the efficacity and speed of action of sertaconazole nitrate suppository and cream combined treatment for vulvovaginal candidiasis].

Author

Quereux C, Gelas B, Chevallier T, Petit F, and Micheletti MC

Subjects
Administration, Intravaginal, Adolescent, Adult, Antifungal Agents therapeutic use, Female, Humans, Imidazoles adverse effects, Imidazoles therapeutic use, Prospective Studies, Suppositories, Thiophenes adverse effects, Thiophenes therapeutic use, Treatment Outcome, Vaginal Creams, Foams, and Jellies, Vulva, Antifungal Agents administration & dosage, Candidiasis, Vulvovaginal drug therapy, Imidazoles administration & dosage, Thiophenes administration & dosage
Abstract

Objective: To assess efficacy and speed of action of a monodose sertaconazole vaginal suppository administered as a single treatment or combined with sertaconazole cream applied to the vulvar area., Methods: This prospective, multicentric, randomised open study was conducted on 77 women with vulvovaginal candidiasis confirmed by mycological examination. They were either treated with one sertaconazole monodose vaginal suppository only (group O) or treated with the suppository combined with sertaconazole cream applied to the vulvar area for 7 days (group OC). The patients who were not clinically cured at D7 received a second phase of treatment., Results: Clinical cure rates were higher in group OC than in group O at D7 (76% versus 68%), and D14 (100% versus 80%). The efficacy on symptoms was faster in group OC, with 78% of the patients relieved of pruritus as early as D2 versus 61% in group O, although these differences were not significant. Clinical local tolerance was very good, with 95% of patients not experiencing any local side effects., Conclusion: When candidiasis is both vulvar and vaginal, the combination of sertaconazole cream with a monodose sertaconazole vaginal suppository tends to improve clinical cure at D7 and D14 and to relieve more patients as early as D2 than the vaginal suppository used as a single treatment.

Published
2000

10. [Biological and clinical safety of nomegestrol acetate administered alone then associated in inverse sequence with transdermal 17 beta estradiol, in women at risk of dyslipoproteinemia type IIa].

Author

Zartarian M, Chevallier T, Micheletti MC, Leber C, and Jamin C

Subjects
Administration, Cutaneous, Adolescent, Adult, Blood Pressure, Female, Humans, Middle Aged, Contraceptives, Oral, Sequential administration & dosage, Estradiol administration & dosage, Hyperlipoproteinemia Type II complications, Megestrol, Norpregnadienes administration & dosage, Progesterone Congeners administration & dosage
Abstract

In this study including 26 patients with dyslipoproteinemia classified IIa, we evaluated biochemical and clinical safety of Nomegestrol acetate (Lutenyl) used for its antigonadotrophin property. It was administered alone, during 3 cycles at the dose of 5 mg/d for 21 days by cycle and then it was associated (at the same sequence and dose), without any wash out, for the next 6 cycles, with a 17 beta estradiol patch (Estraderm TTS 50), 50 micrograms/d from the 11th to the 21st day of each cycle. Nomegestrol acetate, alone, had no significant effect on glycemia, antithrombin III, triglycerides, total cholesterol, apoprotein A1, and LpA1 values compared to those at baseline but apoprotein B and Lp (a) values tended to decrease slightly. Serum progesterone levels were collapsed, and FSH values were low. Weight and blood pressure remained constant. Adding 17 beta estradiol enabled to significantly decrease and normalize the apoprotein B values after the first 3 cycles compared to the baseline values, then these values remained constant during the next 3 cycles. There was no effect on the other parameters (except for a significant increase in plasmatic estradiol values) on the antigonadotrophin property of Nomegestrol acetate, nor on weight and blood pressure which remained constant. Moreover, we observed an important decrease in the rate of amenorrheic cycles compared to those with Nomegestrol acetate alone.

Published
1998

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