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Your search keyword '"Michele A. Miller"' showing total 14 results
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14 results on '"Michele A. Miller"'

1. Identification and molecular characterization of Mycobacterium bovis DNA in GeneXpert® MTB/RIF ultra-positive, culture-negative sputum from a rural community in South Africa

Author

Wynand J. Goosen, Sashen Moodley, Giovanni Ghielmetti, Yumna Moosa, Thando Zulu, Theresa Smit, Leanie Kleynhans, Tanya J. Kerr, Elizabeth M. Streicher, Willem A. Hanekom, Robin M. Warren, Emily B. Wong, and Michele A. Miller

Subjects
Hluhluwe-iMfolozi park, Mycobacterium bovis, Spoligotyping, Tuberculosis control, Wildlife-livestock-human interface, Zoonotic transmission, Medicine (General), R5-920
Abstract

This study investigated the presence of Mycobacterium bovis (M. bovis) DNA in archived human sputum samples previously collected from residents who reside adjacent to the M. bovis-endemic Hluhluwe-iMfolozi wildlife park, South Africa (SA). Sixty-eight sputum samples were GeneXpert MTB/RIF Ultra-positive for M. tuberculosis complex (MTBC) DNA but culture negative for M. tuberculosis. Amplification and Sanger sequencing of hsp65 and rpoB genes from DNA extracted from stored heat-inactivated sputum samples confirmed the presence of detectable amounts of MTBC from 20 out of the 68 sputum samples. Region of difference PCR, spoligotyping and gyrB long-read amplicon deep sequencing identified M. bovis (n = 10) and M. tuberculosis (n = 7). Notably, M. bovis spoligotypes SB0130 and SB1474 were identified in 4 samples, with SB0130 previously identified in local cattle and wildlife and SB1474 exclusively in African buffaloes in the adjacent park. M. bovis DNA in sputum, from people living near the park, underscores zoonotic transmission potential in SA. Identification of spoligotypes specifically associated with wildlife only and spoligotypes found in livestock as well as wildlife, highlights the complexity of TB epidemiology at wildlife-livestock-human interfaces. These findings support the need for integrated surveillance and control strategies to curb potential spillover and for the consideration of human M. bovis infection in SA patients with positive Ultra results.

Published
2024
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2. Whole genome sequencing improves the discrimination between Mycobacterium bovis strains on the southern border of Kruger National Park, South Africa

Author

Eduard O. Roos, Johannes Loubser, Tanya J. Kerr, Anzaan Dippenaar, Elizma Streicher, Francisco Olea-Popelka, Suelee Robbe-Austerman, Tod Stuber, Peter Buss, Lin-Mari de Klerk-Lorist, Robin M. Warren, Paul D. van Helden, Sven D.C. Parsons, and Michele A. Miller

Subjects
Mycobacterium bovis, Next-generation sequencing, Spoligotyping, Tuberculosis, Whole genome sequencing, Wildlife, Medicine (General), R5-920
Abstract

Background: Mycobacterium bovis forms part of the Mycobacterium tuberculosis complex and has an extensive host range and zoonotic potential. Various genotyping methods (e.g., spoligotyping) have been used to describe the molecular epidemiology of M. bovis. Advances in whole genome sequencing (WGS) have increased resolution to enable detection of genomic variants to the level of single nucleotide polymorphisms. This is especially relevant to One Health research on tuberculosis which benefits by being able to use WGS to identify epidemiologically linked cases, especially recent transmission. The use of WGS in molecular epidemiology has been extensively used in humans and cattle but is limited in wildlife. This approach appears to overcome the limitations of conventional genotyping methods due to lack of genetic diversity in M. bovis. Methods: This pilot study investigated the spoligotype and WGS of M. bovis isolates (n = 7) from wildlife in Marloth Park (MP) and compared these with WGS data from other South African M. bovis isolates. In addition, the greater resolution of WGS was used to explore the phylogenetic relatedness of M. bovis isolates in neighbouring wildlife populations. Results: The phylogenetic analyses showed the closest relatives to the seven isolates from MP were isolates from wildlife in Kruger National Park (KNP), which shares a border with MP. However, WGS data indicated that the KNP and MP isolates formed two distinct clades, even though they had similar spoligotypes and identical in silico genetic regions of difference profiles. Conclusions: Mycobacterium bovis isolates from MP were hypothesized to be directly linked to KNP wildlife, based on spoligotyping. However, WGS indicated more complex epidemiology. The presence of two distinct clades which were genetically distinct (SNP distance of 19–47) and suggested multiple transmission events. Therefore, WGS provided new insight into the molecular epidemiology of the M. bovis isolates from MP and their relationship to isolates from KNP. This approach will facilitate greater understanding of M. bovis transmission at wildlife-livestock-human interfaces and advances One Health research on tuberculosis, especially across different host species.

Published
2023
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3. Contributors

Author

Laura A. Adamovicz, Christina A. Ahlstrom, Matthew C. Allender, Neil E. Anderson, Jon M. Arnemo, Todd C. Atwood, Kay A. Backues, Eric Baitchman, Jennifer R. Ballard, Alberto Rodriguez Barbon, Laura E. Binkley, David Blyde, Deena Brenner, A. Paige Brock, Peter E. Buss, Alejandra Calderón-Hernández, James W. Carpenter, Lilian Silva Catenacci, Charlotte Causton, Norin Chai, Thomas Charpentier, Sathya K. Chinnadurai, Meredith M. Clancy, Marcus Clauss, Deana L. Clifford, Dalia A. Conde, Michael Cranfield, Andrew Cushing, Liza Dadone, Hugo David, Sharon L. Deem, Arnaud L.J. Desbiez, Mathias Dislich, Katherine Dowling, Mark L. Drew, Arne Lawrenz, Mary Duncan, Ashley N. Edes, Jonathan H. Epstein, Andrea Evlyn Reiss, Shannon T. Ferrell, Birgit Fessl, Andrea L. Fidgett, Kami Z. Fox, Steve Foxworth, Kathryn C. Gamble, Wondwossen A. Gebreyes, Jean-Yves Georges, Alexandra Goe, Frank Goeritz, Rocío González-Barrientos, Nicolas de Graaff, Alex D. Greenwood, Andrew Greenwood, Wray Grimaldi, Catherine Hadfield, Jordan O. Hampton, Christopher S. Hanley, Craig A. Harms, Tara M. Harrison, Gabriela Hernández-Mora, Robert Hermes, J. Jill Heatley, Benjamín E. Alcántar Hernández, Thomas Bernd Hildebrandt, Robert Hilsenroth, Clayton D. Hilton, Thuy Thi Thu Hoang, Dawn K. Holliday, Timothy H. Hyndman, Richard Jakob-Hoff, Donald L. Janssen, Jonathan Jennings, Trine Hammer Jensen, Gary Johnson, Szilvia Kalliopi Kalogeropoulu, Susie Kasielke, Lucy Kemp, Peter Kertesz, Matthew E. Kinney, Danilo Kluyber, Katja N. Koeppel, Lana Krol, Thijs Kuiken, Nadine Lamberski, Jennifer N. Langan, Erin E. Latimer, Kathryn S. Leach, Antoine Leclerc, Paul Ling, Nancy P. Lung, Alexis Lécu, Matt Marinkovich, Rachel E. Marschang, Nic Masters, Bryce Masuda, Vibhu Prakash Mathur, William A. McLellan, David J. McLelland, Jennifer M. Meegan, Ana Patricia Mendoza, Randi Meyerson, Michael W. Miller, Michele A. Miller, Ellie L. Milnes, Michael J. Moore, Megan E. Moriarty, Lisa Murphy, Michael J. Murray, Adrian Mutlow, Debbie Myers, Gwen Myers, Benjamin Nevitt, Dante L. Di Nucci, María Marcela Orozco, Luis R. Padilla, Johanna Painer-Gigler, An Pas, Craig A. Pelton, Nuno M. Pereira, Thierry Petit, Adriano Pinter, Tithipong Plangsangmas, Jennifer Prittie, Benoit Quintard, Jacobus P. Raath, Jan Ramer, Andrew M. Ramey, Bonnie L. Raphael, Parntep Ratanakorn, Sam Rivera, Carlos Rodriguez, Tess Rooney, Estelle Rousselet, Ilayaraja. S, Anaïs Sailler, Stephanie Sanderson, Christian Schiffmann, Peter A. Seeber, Aleksandr Semjonov, Arun A. Sha, Sarah Sharp, Michelle E. Shaw, Julie D. Sheldon, Sara Shopland, Jonathan M. Sleeman, Cynthia R. Smith, Joseph A. Smith, Lauro L. Soares-Neto, Supaphen Sripiboon, Karin Stratton, William F. Swanson, Viktória Sós-Koroknai, Endre Sós, Jennifer L. Taylor-Cousar, J. Andrew Teare, Karen A. Terio, Scott P. Terrell, Steve B. Thompson, Nikorn Thongthip, Rodrigo S. Garcés Torres, Christopher W. Tubbs, Greg A. Vicino, Fernando Javier Vilchez-Delgado, Raymund F. Wack, Sarah Wahltinez, Michael T. Walsh, Chris Walzer, Christian John Wenker, Ellen Wiedner, Barbara A. Wolfe, Lisa L. Wolfe, Tammy Culpepper Wolfe, Jeff Wyatt, Shangzhe Xie, Roy Yanong, and Enrique Yarto-Jaramillo

Published
2023

5. Contributors

Author

Michael J. Adkesson, Patricia Aguilar-Calvo, Bianca Nascimento de Alcantara, Matthew C. Allender, Leonardo Arias-Bernal, Cheryl Asa, Kay A. Backues, James E. Bailey, Karen Bauman, Katherine Belov, Mad Frost Bertelsen, Jocelyn Bezner, Ellen Bronson, Peter Buss, Kenneth Cameron, Michelle Campbell-Ward, Lilian Silva Catenacci, Norin Chai, Sathya K. Chinnadurai, Bruce Christensen, Meredith Martin Clancy, Leigh Clayton, Carmen M.H. Colitz, Galaxia Cortes-Hinojosa, José Luis Crespo-Picazo, Liza Dadone, Marietta Dindo Danforth, Sharon L. Deem, Rosalie Dench, Marion Renée Desmarchelier, Nicola Di Girolamo, Dante Luis Di Nucci, Jessica A. Emerson, Jonathan H. Epstein, Claire Erlacher-Reid, Joseph P. Flanagan, Brett Fundak, Laurie J. Gage, Kathryn C. Gamble, Daniel García-Párraga, Michael M. Garner, Timothy A. Georoff, Kirsten V.K. Gilardi, Martin Gilbert, Steven M. Goodman, Mark Greenberg, Alex David Greenwood, Carsten Grøndahl, Catherine Hadfield, Bálint Halpern, Sarah Hamer, Elizabeth E. Hammond, Robert Harman, Sonia Maria Hernandez, Carolyn Hodo, Erik Hofmeister, Carolyn J. Hogg, Lauren Lynn Howard, Marina Ivančić, Gwen Jankowski, Donald L. Janssen, Carles Juan-Sallés, Kurnia Oktavia Khairani, Matthew E. Kinney, Laura M. Kleinschmidt, Richard Anthony Kock, Corinne P. Kozlowski, Jennifer N. Langan, Alexis Lécu, Gregory A. Lewbart, Kerrie Anne T. Loyd, Imke Lüeders, Khursheed Mama, Christoph Mans, Rachel E. Marschang, Paolo R. Martelli, Gerardo Martinez, Jonna A.K. Mazet, Denise McAloose, Carol U. Meteyer, Michele A. Miller, Ellie Milnes, Christine Molter, Santiago Monsalve, Pete Morkel, Hayley Weston Murphy, Joanne Paul-Murphy, Yvonne Nadler, Julia E. Napier, Pierre Nel, Pauline Nol, Sean O'Sullivan, Francisco Olea-Popelka, Klaus Osterrieder, Annie Page-Karjian, Jean A. Paré, Adriana Pastor, Joost Philippa, Wouter Pieters, Timothy J. Portas, Robin W. Radcliffe, Jan Raines, Bonnie L. Raphael, Fidisoa Rasambainarivo, Patricia Reed, Jack C. Rhyan, Bruce Rideout, John Roberts, Sarah Robinson, Gianmarco Rojas Moreno, Laura Elizabeth Rosen, Elizabeth Marie Rush, David Sanchez-Migallon Guzman, Willem Schaftenaar, Michael R. Schirmacher, Debra A. Schmidt, Kathryn E. Seeley, Michelle E. Shaw, Christina J. Sigurdson, Kurt K. Sladky, Dale Smith, Kristine Smith, Endre Sós, Gerhard Steenkamp, Darrel K. Styles, Hui Suk-Wai, Kathleen E. Sullivan, John M. Sykes, Jessica J. Talbot, Washington Tapia, Karen A. Terio, Scott Terrell, Arshad Haroon Toosy, Dominic A. Travis, Kathryn A. Tuxbury, Eduardo V. Valdes, Caroline Van Hemert, Carrie K. Vance, Michelle L. Verant, Larry Vogelnest, Chris Walzer, Jim Wellehan, Ellen Wiedner, Peregrine L. Wolff, Enrique Yarto-Jaramillo, and Jeffery R. Zuba

Published
2019

6. Serological reactivity to MPB83 and CFP10/ESAT-6 antigens in three suid hosts of Mycobacterium bovis infection

Author

Eduard O. Roos, Christian Gortázar, María Ángeles Risalde, Michele A. Miller, Konstantin P. Lyashchenko, Archana A. Sridhara, Ashley Johnathan-Lee, South African Medical Research Council, and National Research Foundation (South Africa)

Subjects
Tuberculosis, Swine, Sus scrofa, Wild boar, Microbiology, Sensitivity and Specificity, Serology, 03 medical and health sciences, Antigen, Bacterial Proteins, biology.animal, Domestic pigs, medicine, Animals, Serologic Tests, 030304 developmental biology, 0303 health sciences, Mycobacterium bovis, Antigens, Bacterial, General Veterinary, biology, 030306 microbiology, Warthogs, Membrane Proteins, Immunodominant antigens, General Medicine, medicine.disease, biology.organism_classification, Virology, Antibodies, Bacterial, 3. Good health, Animals, Domestic, ESAT-6, Humoral immunity, biology.protein, Antibody
Abstract

Domestic pigs and wild suids are susceptible to Mycobacterium bovis (M. bovis) infection and may even serve as reservoir hosts in some situations. Therefore, detection of infected animals is important for understanding their role in the epidemiology of the disease as well as for management and control of bovine tuberculosis. Infected suids develop strong humoral responses, making serological screening a feasible approach to disease surveillance. However, to optimize sensitivity of the antibody assays, it is necessary to identify and incorporate immunodominant antigens recognized by the target species. The objective of this study was to characterize the antigen recognition by three suid species in a commercially available serological test, DPP VetTB Assay. Serum samples from naturally M. bovis-infected domestic pigs, wild boar and common warthogs were tested. MPB83 protein appeared to be the immunodominant antigen recognized by antibodies in all three species. Overall test sensitivity was increased in wild suids when seroreactivity to CFP10/ESAT-6 antigen was included. Infected animals with visible lesions showed more robust antibody responses than those without gross lesions. The high sensitivity and specificity of the DPP VetTB Assay demonstrated in the present study supports the utility of antibody tests employing these antigens in serological screening of the suid species for M. bovis infection., Financial support (MAM, EOR) was provided by the South African Medical Research Council, NRF South African Research Chair Initiative (SARChI, grant 86949) and the American Association of Zoological Medicine Wild Animal Health Fund (#7-2016).

Published
2019

7. Acknowledgments

Author

Kathryn C. Gamble, Mads Frost Bertelsen, Don Janssen, Michele A. Miller, Luis Padilla, and Larry Vogelnest

Published
2019

10. Contributors

Author

Mary Agnew, Roberto F. Aguilar, Jack L. Allen, Cheryl Asa, Kay A. Backues, Eric J. Baitchman, Ray L. Ball, Katrin Baumgautner, Hugues Beaufrère, R. Avery Bennett, Mads F. Bertelsen, Tiffany Blackett, Rosemary J. Booth, Debra Bourne, P. Walter Bravo, Elizabeth L. Buckles, Peter E. Buss, Paul P. Calle, Norin Chai, Jason Shih-Chien Chin, Leigh Ann Clayton, Darin M. Collins, Juan Cornejo, Jennifer D'Agostino, Martine de Wit, Sharon L. Deem, Gregory M. Dennis, Ryan S. DeVoe, Christopher Dold, Genevieve Dumonceaux, Mary Duncan, Jesus Fernandez-Moran, Edmund Flach, Joseph P. Flanagan, Gregory J. Fleming, Deidre K. Fontenot, Kathryn C. Gamble, Hanno Gerritsmann, Jennifer E. Graham, Zoltan S. Gyimesi, J. Jill Heatley, Timothy A. Herman, Sonia Hernandez, Thomas Bernd Hildebrandt, Clayton D. Hilton, Peter Holz, Richard M. Jakob-Hoff, Donald L. Janssen, Janis Ott Joslin, Jacques Kaandorp, Cornelia J. Ketz-Riley, George V. Kollias, Maya S. Kummrow, Claude Lacasse, Nadine Lamberski, Alex Lecu, Brad A. Lock, Linda J. Lowenstine, Robert A. MacLean, Mariano Makara, Nicholas J. Masters, Stephanie McCain, Tracey McNamara, Thomas P. Meehan, Leith C.R. Meyer, David S. Miller, Michele A. Miller, R. Eric Miller, Teresa Y. Morishita, Haylee Westin Murphy, Natalie D. Mylniczenko, Julia E. Napier, Donald L. Neiffer, Terry M. Norton, Luis R. Padilla, Romain Pizzi, Julia B. Ponder, Edward Ramsay, Sharon Redrobe, Carlos R. Sanchez, Joseph Saragusty, Joseph A. Smith, Gabrielle Stalder, Iga M. Stasiak, Hanspeter W. Steinmetz, William Kirk Suedmeyer, Mariella Superina, Meg Sutherland-Smith, John M. Sykes, J. Andrew Teare, Maryanne E. Tocidlowski, Eric Hsienshao Tsao, William George Van Bonn, Larry Vogelnest, Roberta S. Wallace, Michael T. Walsh, Chris Walzer, Martha A. Weber, Jim Wellehan, Christian J. Wenker, Douglas P. Whiteside, Ellen Wiedner, Michelle M. Willette, Cathy V. Williams, Barbara A. Wolfe, Fabia S. Wyss, Enrique Yarto-Jaramillo, and Dawn M. Zimmerman

Published
2015

11. Contributors

Author

Michael J. Adkesson, Amy Alexander, Jill Allread, Cheryl Asa, Anne E. Ballmann, Ursula Bechert, Roy G. Bengis, Rui I. Bernardino, Sally Boutelle, Elizabeth L. Buckles, Mitchell Bush, Peter E. Buss, Kenneth N. Cameron, Norin Chai, Scott B. Citino, Robert A. Cook, Graham Crawshaw, Carolyn Cray, Mark W. Cunningham, Sharon L. Deem, Ann Duncan, Gregory J. Fleming, Deidre K. Fontenot, Jeanette Fuller, Laurie J. Gage, Kathryn C. Gamble, Brett Gartrell, Martin Gilbert, Gwendolyn Griffith, Catherine Hadfield, Elizabeth E. Hammond, Jean-Michel Hatt, Michelle G. Hawkins, Gary S. Hayward, Dean A. Hendrickson, Robert Hermes, Sonia M. Hernandez, Thomas Bernd Hildebrandt, Robert Hilsenroth, Peter H. Holz, Lauren L. Howard, Ramiro Isaza, Richard Jakob-Hoff, Stephanie B. James, Donald L. Janssen, Christine K. Johnson, Randall E. Junge, Olga Martin Jurado, Jacques Kaandorp, Petra Kaczensky, William B. Karesh, Gretchen E. Kaufman, David E. Kenny, Pia Krawinkel, Andreas Kurth, Nadine Lamberski, William R. Lance, Jennifer N. Langan, Iris I. Levin, Mark Lynn Lloyd, Lesa Longley, Linda Lowenstein, Imke Lueders, Elizabeth J.B. Manning, Jonna A.K. Mazet, James F. McBain, Stephanie McCain, Rita McManamon, Thomas P. Meehan, Carol Uphoff Meteyer, James E. Miller, Michele A. Miller, Hayley Weston Murphy, Natalie D. Mylniczenko, Nicole M. Nemeth, Andreas Nitsche, Terry M. Norton, J. Lindsay Oaks, Justine O’Brien, Patricia G. Parker, Joanne Paul-Murphy, Linda M. Penfold, Allan P. Pessier, Johann 'Joost' Philippa, Shane R. Raidal, Edward C. Ramsay, Leslie Anne Reddacliff, Patricia E. Reed, Laura K. Richman, Gary Riggs, Nadia Robert, David A. Rubin, Charles E. Rupprecht, Stephanie Sanderson, Michael Schlegel, Kent J. Semmen, Jessica L. Siegal-Willott, Michelle L. Skurski, Dennis Slate, Jonathan Mark Sleeman, Andrea Brenes Soto, M. Andrew Stamper, Hanspeter W. Steinmetz, Mark Stetter, Jeffrey L. Stott, Cynthia Stringfield, Meg Sutherland Smith, Susan J. Tornquist, Eduardo V. Valdes, Michael T. Walsh, Christian Walzer, Kristen S. Warren, Martha A. Weber, Jim Wellehan, Christian J. Wenker, Ellen Wiedner, Pat Witman, Michael J. Yabsley, Nina Zimmermann, and Jeffery R. Zuba

Published
2012

12. Elephant Neonatal and Pediatric Medicine

Author

Martha A. Weber and Michele A. Miller

Subjects
medicine.medical_specialty, Pediatric Medicine, business.industry, Medicine, business, Intensive care medicine
Published
2012

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