1. Exhaled breath condensate and aerosol
- Author
-
Michael D. Davis
- Subjects
Chromatography ,Age groups ,Environmental science ,Condensed water ,Exhaled breath condensate ,Sample integrity ,complex mixtures ,Water vapor ,respiratory tract diseases ,Particle fraction ,Collection methods ,Aerosol - Abstract
Exhaled breath comprises gas-phase and aerosolized fractions of water vapor and particles. The condensed water vapor fraction is referred to as exhaled breath condensate (EBC), whereas the aerosolized particle fraction, when collected separately, is termed exhaled breath aerosols (EBA). Both of these fractions contain biomarkers relevant to pulmonary and systemic physiology. EBC is easy and safe to collect, and sampling methods have been standardized for nearly all age groups and disease states, yet the composition of EBC varies between collection method and patient population and therefore care must be taken to ensure sample integrity. This chapter provides an overview of EBC and aerosols, principles of their collection, and validated biomarkers within these matrices.
- Published
- 2020
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