1. Day-by-day symptoms following positive and negative PCR tests for SARS-CoV-2 in non-hospitalized healthcare workers: A 90-day follow-up study
- Author
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Kent J. Nielsen, Jesper Medom Vestergaard, Vivi Schlünssen, Jens Peter Bonde, Kathrine Agergård Kaspersen, Karin Biering, Ole Carstensen, Thomas Greve, Karoline Kærgaard Hansen, Annett Dalbøge, Esben Meulengracht Flachs, Sanne Jespersen, Mette Lausten Hansen, Susan Mikkelsen, Marianne Kragh Thomsen, Jacob Dvinge Redder, Else Toft Würtz, Lars Østergaard, Christian Erikstrup, and Henrik Albert Kolstad
- Subjects
Post COVID-19 ,Post-acute COVID-19 syndrome ,Long-haul COVID-19 ,Anosmia ,Ageusia ,Dyspnea ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objective: Our study aimed to compare symptoms day by day for non-hospitalized individuals testing positive and negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: In total, 210 positive-test and 630 negative-test healthcare workers in the Central Denmark Region were followed for up to 90 days after testing, between April and June, 2020. Their daily reported COVID-19-related symptoms were compared graphically and by logistic regression. Results: Thirty per cent of the positive-test and close to 0% of the negative-test participants reported a reduced sense of taste and smell during all 90 days (adjusted odds ratio [aOR] 86.07, 95% CI 22.86–323). Dyspnea was reported by an initial 20% of positive-test participants, declining to 5% after 30 days, without ever reaching the level of the negative-test participants (aOR 6.88, 95% CI 2.41–19.63). Cough, headache, sore throat, muscle pain, and fever were temporarily more prevalent among the positive-test participants; after 30 days, no increases were seen. Women and older participants were more susceptible to long-lasting COVID-19 symptoms. Conclusion: The prevalence of long-lasting reduced sense of taste and smell is highly increased in mild COVID-19 patients. This pattern is also seen for dyspnea at a low level, but not for cough, sore throat, headache, muscle pain, or fever.
- Published
- 2021
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