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Background: Missed nursing care encompasses any aspect of care that is either partially or entirely omitted, delayed, or inadequately carried out. This acknowledged concealed issue poses a serious risk to patients, potentially leading to adverse consequences. So, identifying magnitude of missed nursing care is important to enhancement of nursing care quality and patient safety. The main focus of the study was to assess the extent of missed nursing care and examine into the factors that contribute to it. Method: From June 10 to July 10, 2023, a mixed study design was implemented among nurses working in public hospitals of Wolaita Zone. Participants were randomly selected using computer-generated random numbers from each working unit and purposive sampling was used for in-depth interview. The results are presented in frequencies, means, and medians. A binary logistic regression model was utilized to evaluate the effects of independent variables on the outcome variables and content thematic analysis were done using the four-step approach of thematic analysis. Result: The level of missed nursing care was 54.9%. It was significantly associated with availability of resource, nursing teamwork, and job satisfaction. In qualitative analysis, Nurse related factor, Institution related factor, and patient related factors were emerged from the thematic analysis. Conclusion: The prevalence of missed nursing care was notably high, Nurses are encouraged to engage in effective communication and collaborate closely with fellow nurses and healthcare professionals to reduce instances of missed care.

Background: The widespread use and abuse of antibiotics has resulted in the pollution of water sources with antibiotic residues, posing a threat to human health, the environment, and the economy. Therefore, a highly sensitive and selective method is required for their detection in water samples. Herein, advanced ultrasensitive electrochemical sensor platform was developed by integrating gold-silver alloy nanocoral clusters (Au-Ag-ANCCs) with functionalized multi-walled carbon nanotube-carbon paste electrode (f-MWCNT-CPE) and choline chloride (ChCl) nanocomposites for simultaneously determining the residues of antimicrobial drugs, rifampicin (RAMP) and norfloxacin (NFX), in water samples., Results: The developed sensor (Au-Ag-ANCCs/f-MWCNTs-CPE/ChCl) was extensively characterized using several analytical (UV-Vis, FT-IR, XRD, SEM, and EDX) and electrochemical (EIS, CV, and SWV) techniques. It exhibited outstanding performance in a wide linear range, from 14 pM to 115 μM for RAMP, and from 0.9 nM to 200 μM for NFX, with a limit of detection (LOD, 3σ/m, S/N = 3, n = 5) and a limit of quantification (LOQ, 10σ/m, S/N = 3, n = 5) values of 2.7 pM and 8.85 pM for RAMP, and 0.14 nM and 0.47 nM for NFX, respectively. The sensor also exhibited exceptional reproducibility, stability, and resistance to interference., Significance: The developed sensor was effectively utilized to determine RAMP and NFX residues in hospital wastewater, river, and tap water samples, yielding recoveries within the range of 96.8-103 % and relative standard deviations below 5 %. Generally, the proposed sensor demonstrated remarkable performance in detecting the target analytes, making it an ideal tool and the first of its kind for addressing global antibiotic residue pollutants in water sources., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

A sensitive and selective method was developed for the determination of N-acetyl-p-aminophenol (APAP) and p-aminophenol (PAP) using poly(3,4-ethylenedioxythiophene) (PEDOT)-modified glassy carbon electrode (GCE). Cyclic voltammetry and differential pulse voltammetry were used to investigate the electrochemical reaction of APAP and PAP at the modified electrode. Both APAP and PAP showed quasireversible redox reactions with formal potentials of 367 mV and 101 mV (vs. Ag/AgCl), respectively, in phosphate buffer solution of pH 7.0. The significant peak potential difference (266 mV) between APAP and PAP enabled the simultaneous determination both species based on differential pulse voltammetry. The voltammetric responses gave linear ranges of 1.0×10(-6)-1.0×10(-4) mol L(-1) and 4.0×10(-6)-3.2×10(-4) mol L(-1), with detection limits of 4.0×10(-7) mol L(-1) and 1.2×10(-6) mol L(-1) for APAP and PAP, respectively. The method was successfully applied for the determination of APAP and PAP in pharmaceutical formulations and biological samples., (Copyright © 2011 Elsevier B.V. All rights reserved.)

In this paper a simple and highly sensitive electroanalytical method for the determination of caffeine content using 1,4-benzoquinone modified carbon paste electrode is presented. The method is based on suppression of 1,4-benzoquinone peak current on addition of caffeine. Square-wave and cyclic voltammetric techniques were utilised for the investigation. The 1,4-benzoquinone modified electrode exhibited a well-defined peak with reproducible peak current values for repetitive measurements; and showed a decrease in peak current value with an increase in caffeine content. The result revealed two linear range regions between 0 mmol L(-1) and 0.5 mmol L(-1) and 0.5 mmol L(-1) and 8.0 mmol L(-1), with detection limits of 0.3 micromol L(-1) and 5.1 micromol L(-1), respectively. The method was then successfully applied to the determination of caffeine content in coffee samples. The effects of pH, electrode composition, step potential, pulse amplitude and square-wave frequency on the voltammetric responses were also investigated.

The effects of acute and chronic administration of WAY100635 and WAY100135, serotonin (5-HT)1A antagonists, on 5-HT synthesis rates, calculated from the trapping of alpha-[14C]methyl-L-tryptophan (alpha-MTrp), were evaluated in the rat brain using autoradiography. In the acute treatment studies, WAY100635 (1 mg/kg) induced a significant increase in 5-HT synthesis in the median raphe nucleus and some nerve terminal structures (range between 18 and 53%), while WAY100135 (10 mg/kg) produced a significant decrease of synthesis, in the range between 16 and 33%, in the raphe magnus nucleus and several projection areas. The action of WAY100635 given acutely was likely a result of antagonist actions at the 5-HT1A somato-dendritic autoreceptors. WAY100135 probably acted acutely as a partial agonist. In the chronic treatment studies, WAY100635 (1 mg/kg/day) and WAY100135 (10 mg/kg/day) were administered for 7 days as s.c. injections once a day. Chronic treatment with both compounds significantly reduced the rate of 5-HT synthesis in the nerve terminal structures and produced a significant increase in the raphe nuclei. These treatments did not have any effect on the plasma free or total tryptophan.