1. Elucidation of anti-hyperglycemic activity of Psidium guajava L. leaves extract on streptozotocin induced neonatal diabetic Long-Evans rats
- Author
-
Md. Hafizur Rahman, Md. Asrafuzzaman, Md. Mahedi Hassan Tusher, M. Mosihuzzaman, Md Shahinul Haque Khan, Mohammad Shoeb, and Begum Rokeya
- Subjects
Psidium guajava ,Streptozotocin-induced T2DM rat ,Anti-hyperglycemia ,Insulinemia ,Dyslipidemia ,Miscellaneous systems and treatments ,RZ409.7-999 - Abstract
Background: Psidium guajava L (Guava) belongs to the Myrtaceae family and has been claimed to possess several pharmacological properties including antidiabetic. Objective: This study was designed to evaluate the anti-hyperglycemic activity of P guajava L leaves aqueous extract on neonatal streptozotocin-induced type 2 diabetic model rats. Methods: Streptozotocin was induced (90 mg/kg) intraperitoneally to 48 h old Long Evans rat pups. After three months, 18 male type-2 diabetic model rats were confirmed by OGTT (FG > 7 mmol/L). Therefore, experimental rats were divided into three groups 2) Diabetic water control (10 ml/kg), 3) Gliclazide treated (20 mg/kg), and 4) Extract treated group (1.25g/kg)] Six normal female rats comprised group 1 [Non-diabetic water control (10 ml/kg)]. All rats were treated orally with their respective treatment for 28 consecutive days. Blood samples were collected on 0 days (by tail cut method) and the end day (by cardiac puncture) of the experiment. The anti-hyperglycemic activity was evaluated by measuring fasting glucose, serum insulin, lipid profile, hepatic glycogen content, and intestinal glucose absorption by standard methods. Results: The serum glucose level of extract treated group was decreased by 16% as well as significantly (p
- Published
- 2023
- Full Text
- View/download PDF