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1. Stratified analyses refine association between TLR7 rare variants and severe COVID-19

Author: Jannik Boos, Caspar I. van der Made, Gayatri Ramakrishnan, Eamon Coughlan, Rosanna Asselta, Britt-Sabina Löscher, Luca V.C. Valenti, Rafael de Cid, Luis Bujanda, Antonio Julià, Erola Pairo-Castineira, J. Kenneth Baillie, Sandra May, Berina Zametica, Julia Heggemann, Agustín Albillos, Jesus M. Banales, Jordi Barretina, Natalia Blay, Paolo Bonfanti, Maria Buti, Javier Fernandez, Sara Marsal, Daniele Prati, Luisa Ronzoni, Nicoletta Sacchi, Joachim L. Schultze, Olaf Riess, Andre Franke, Konrad Rawlik, David Ellinghaus, Alexander Hoischen, Axel Schmidt, Kerstin U. Ludwig, Valeria Rimoldi, Elvezia M. Paraboschi, Alessandra Bandera, Flora Peyvandi, Giacomo Grasselli, Francesco Blasi, Francesco Malvestiti, Serena Pelusi, Cristiana Bianco, Lorenzo Miano, Angela Lombardi, Pietro Invernizzi, Alessio Gerussi, Giuseppe Citerio, Andrea Biondi, Maria Grazia Valsecchi, Marina Elena Cazzaniga, Giuseppe Foti, Ilaria Beretta, Mariella D'Angiò, Laura Rachele Bettini, Xavier Farré, Susana Iraola-Guzmán, Manolis Kogevinas, Gemma Castaño-Vinyals, Koldo Garcia-Etxebarria, Beatriz Nafria, Mauro D'Amato, Adriana Palom, Colin Begg, Sara Clohisey, Charles Hinds, Peter Horby, Julian Knight, Lowell Ling, David Maslove, Danny McAuley, Johnny Millar, Hugh Montgomery, Alistair Nichol, Peter J.M. Openshaw, Alexandre C. Pereira, Chris P. Ponting, Kathy Rowan, Malcolm G. Semple, Manu Shankar-Hari, Charlotte Summers, Timothy Walsh, Latha Aravindan, Ruth Armstrong, Heather Biggs, Ceilia Boz, Adam Brown, Richard Clark, Audrey Coutts, Judy Coyle, Louise Cullum, Sukamal Das, Nicky Day, Lorna Donnelly, Esther Duncan, Angie Fawkes, Paul Fineran, Max Head Fourman, Anita Furlong, James Furniss, Bernadette Gallagher, Tammy Gilchrist, Ailsa Golightly, Fiona Griffiths, Katarzyna Hafezi, Debbie Hamilton, Ross Hendry, Andy Law, Dawn Law, Rachel Law, Sarah Law, Rebecca Lidstone-Scott, Louise Macgillivray, Alan Maclean, Hanning Mal, Sarah McCafferty, Ellie Mcmaster, Jen Meikle, Shona C. Moore, Kirstie Morrice, Lee Murphy, Sheena Murphy, Mybaya Hellen, Wilna Oosthuyzen, Chenqing Zheng, Jiantao Chen, Nick Parkinson, Trevor Paterson, Katherine Schon, Andrew Stenhouse, Mihaela Das, Maaike Swets, Helen Szoor-McElhinney, Filip Taneski, Lance Turtle, Tony Wackett, Mairi Ward, Jane Weaver, Nicola Wrobel, Marie Zechner, Gill Arbane, Aneta Bociek, Sara Campos, Neus Grau, Tim Owen Jones, Rosario Lim, Martina Marotti, Marlies Ostermann, Christopher Whitton, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, David Collier, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, Peter May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, Suzanne Wood, Anne Zak, Olivier Zongo, Stephen Bonner, Keith Hugill, Jessica Jones, Steven Liggett, Evie Headlam, Nageswar Bandla, Minnie Gellamucho, Michelle Davies, Christopher Thompson, Marwa Abdelrazik, Dhanalakshmi Bakthavatsalam, Munzir Elhassan, Arunkumar Ganesan, Anne Haldeos, Jeronimo Moreno-Cuesta, Dharam Purohit, Rachel Vincent, Kugan Xavier, Kumar Rohit, Frater Alasdair, Malik Saleem, Carter David, Jenkins Samuel, Zoe Lamond, Wall Alanna, Jaime Fernandez-Roman, David O. Hamilton, Emily Johnson, Brian Johnston, Maria Lopez Martinez, Suleman Mulla, David Shaw, Alicia A.C. Waite, Victoria Waugh, Ingeborg D. Welters, Karen Williams, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Mark McPhail, Monalisa Nayak, Harriet Noble, Kevin O'Reilly, Evita Pappa, Rohit Saha, Sian Saha, John Smith, Abigail Knighton, David Antcliffe, Dorota Banach, Stephen Brett, Phoebe Coghlan, Ziortza Fernandez, Anthony Gordon, Roceld Rojo, Sonia Sousa Arias, Maie Templeton, Megan Meredith, Lucy Morris, Lucy Ryan, Amy Clark, Julia Sampson, Cecilia Peters, Martin Dent, Margaret Langley, Saima Ashraf, Shuying Wei, Angela Andrew, Archana Bashyal, Neil Davidson, Paula Hutton, Stuart McKechnie, Jean Wilson, David Baptista, Rebecca Crowe, Rita Fernandes, Rosaleen Herdman-Grant, Anna Joseph, Denise O'Connor, Meryem Allen, Adam Loveridge, India McKenley, Eriko Morino, Andres Naranjo, Richard Simms, Kathryn Sollesta, Andrew Swain, Harish Venkatesh, Jacyntha Khera, Jonathan Fox, Gillian Andrew, Lucy Barclay, Marie Callaghan, Rachael Campbell, Sarah Clark, Dave Hope, Lucy Marshall, Corrienne McCulloch, Kate Briton, Jo Singleton, Sohphie Birch, Lutece Brimfield, Zoe Daly, David Pogson, Steve Rose, Ceri Battle, Elaine Brinkworth, Rachel Harford, Carl Murphy, Luke Newey, Tabitha Rees, Marie Williams, Sophie Arnold, Petra Polgarova, Katerina Stroud, Eoghan Meaney, Megan Jones, Anthony Ng, Shruti Agrawal, Nazima Pathan, Deborah White, Esther Daubney, Kay Elston, Lina Grauslyte, Musarat Hussain, Mandeep Phull, Tatiana Pogreban, Lace Rosaroso, Erika Salciute, George Franke, Joanna Wong, Aparna George, Laura Ortiz-Ruiz de Gordoa, Emily Peasgood, Claire Phillips, Michelle Bates, Jo Dasgin, Jaspret Gill, Annette Nilsson, James Scriven, Carlos Castro Delgado, Deborah Dawson, Lijun Ding, Georgia Durrant, Obiageri Ezeobu, Sarah Farnell-Ward, Abiola Harrison, Rebecca Kanu, Susannah Leaver, Elena Maccacari, Soumendu Manna, Romina Pepermans Saluzzio, Joana Queiroz, Tinashe Samakomva, Christine Sicat, Joana Texeira, Edna Fernandes Da Gloria, Ana Lisboa, John Rawlins, Jisha Mathew, Ashley Kinch, William James Hurt, Nirav Shah, Victoria Clark, Maria Thanasi, Nikki Yun, Kamal Patel, Sara Bennett, Emma Goodwin, Matthew Jackson, Alissa Kent, Clare Tibke, Wiesia Woodyatt, Ahmed Zaki, Azmerelda Abraheem, Peter Bamford, Kathryn Cawley, Charlie Dunmore, Maria Faulkner, Rumanah Girach, Helen Jeffrey, Rhianna Jones, Emily London, Imrun Nagra, Farah Nasir, Hannah Sainsbury, Clare Smedley, Tahera Patel, Matthew Smith, Srikanth Chukkambotla, Aayesha Kazi, Janice Hartley, Joseph Dykes, Muhammad Hijazi, Sarah Keith, Meherunnisa Khan, Janet Ryan-Smith, Philippa Springle, Jacqueline Thomas, Nick Truman, Samuel Saad, Dabheoc Coleman, Christopher Fine, Roseanna Matt, Bethan Gay, Jack Dalziel, Syamlan Ali, Drew Goodchild, Rhiannan Harling, Ravi Bhatterjee, Wendy Goddard, Chloe Davison, Stephen Duberly, Jeanette Hargreaves, Rachel Bolton, Miriam Davey, David Golden, Rebecca Seaman, Shiney Cherian, Sean Cutler, Anne Emma Heron, Anna Roynon-Reed, Tamas Szakmany, Gemma Williams, Owen Richards, Yusuf Cheema, Hollie Brooke, Sarah Buckley, Jose Cebrian Suarez, Ruth Charlesworth, Karen Hansson, John Norris, Alice Poole, Alastair Rose, Rajdeep Sandhu, Brendan Sloan, Elizabeth Smithson, Muthu Thirumaran, Veronica Wagstaff, Alexandra Metcalfe, Mark Brunton, Jess Caterson, Holly Coles, Matthew Frise, Sabi Gurung Rai, Nicola Jacques, Liza Keating, Emma Tilney, Shauna Bartley, Parminder Bhuie, Sian Gibson, Amanda Lyle, Fiona McNeela, Jayachandran Radhakrishnan, Alistair Hughes, Bryan Yates, Jessica Reynolds, Helen Campbell, Maria Thompsom, Steve Dodds, Stacey Duffy, Sandra Greer, Karen Shuker, Ascanio Tridente, Reena Khade, Ashok Sundar, George Tsinaslanidis, Isobel Birkinshaw, Joseph Carter, Kate Howard, Joanne Ingham, Rosie Joy, Harriet Pearson, Samantha Roche, Zoe Scott, Hollie Bancroft, Mary Bellamy, Margaret Carmody, Jacqueline Daglish, Faye Moore, Joanne Rhodes, Mirriam Sangombe, Salma Kadiri, Maria Croft, Ian White, Victoria Frost, Maia Aquino, Rajeev Jha, Vinodh Krishnamurthy, Lai Lim, Li Lim, Edward Combes, Teishel Joefield, Sonja Monnery, Valerie Beech, Sallyanne Trotman, Christine Almaden-Boyle, Pauline Austin, Louise Cabrelli, Stephen Cole, Matt Casey, Susan Chapman, Clare Whyte, Yolanda Baird, Aaron Butler, Indra Chadbourn, Linda Folkes, Heather Fox, Amy Gardner, Raquel Gomez, Gillian Hobden, Luke Hodgson, Kirsten King, Michael Margarson, Tim Martindale, Emma Meadows, Dana Raynard, Yvette Thirlwall, David Helm, Jordi Margalef, Kristine Criste, Rebecca Cusack, Kim Golder, Hannah Golding, Oliver Jones, Samantha Leggett, Michelle Male, Martyna Marani, Kirsty Prager, Toran Williams, Belinda Roberts, Karen Salmon, Peter Anderson, Katie Archer, Karen Austin, Caroline Davis, Alison Durie, Olivia Kelsall, Jessica Thrush, Charlie Vigurs, Laura Wild, Hannah-Louise Wood, Helen Tranter, Alison Harrison, Nicholas Cowley, Michael McAlindon, Andrew Burtenshaw, Stephen Digby, Emma Low, Aled Morgan, Naiara Cother, Tobias Rankin, Sarah Clayton, Alex McCurdy, Cecilia Ahmed, Balvinder Baines, Sarah Clamp, Julie Colley, Risna Haq, Anne Hayes, Jonathan Hulme, Samia Hussain, Sibet Joseph, Rita Kumar, Zahira Maqsood, Manjit Purewal, Leonie Benham, Zena Bradshaw, Joanna Brown, Melanie Caswell, Jason Cupitt, Sarah Melling, Stephen Preston, Nicola Slawson, Emma Stoddard, Scott Warden, Bethan Deacon, Ceri Lynch, Carla Pothecary, Lisa Roche, Gwenllian Sera Howe, Jayaprakash Singh, Keri Turner, Hannah Ellis, Natalie Stroud, Jodie Hunt, Joy Dearden, Emma Dobson, Andy Drummond, Michelle Mulcahy, Sheila Munt, Grainne O'Connor, Jennifer Philbin, Chloe Rishton, Redmond Tully, Sarah Winnard, Susanne Cathcart, Katharine Duffy, Alex Puxty, Kathryn Puxty, Lynne Turner, Jane Ireland, Gary Semple, Kate Long, Simon Whiteley, Elizabeth Wilby, Bethan Ogg, Amanda Cowton, Andrea Kay, Melanie Kent, Kathryn Potts, Ami Wilkinson, Suzanne Campbell, Ellen Brown, Julie Melville, Jay Naisbitt, Rosane Joseph, Maria Lazo, Olivia Walton, Alan Neal, Peter Alexander, Schvearn Allen, Joanne Bradley-Potts, Craig Brantwood, Jasmine Egan, Timothy Felton, Grace Padden, Luke Ward, Stuart Moss, Susannah Glasgow, Lynn Abel, Michael Brett, Brian Digby, Lisa Gemmell, James Hornsby, Patrick MacGoey, Pauline O'Neil, Richard Price, Natalie Rodden, Kevin Rooney, Radha Sundaram, Nicola Thomson, Bridget Hopkins, Laura Thrasyvoulou, Heather Willis, Martyn Clark, Martina Coulding, Edward Jude, Jacqueline McCormick, Oliver Mercer, Darsh Potla, Hafiz Rehman, Heather Savill, Victoria Turner, Charlotte Downes, Kathleen Holding, Katie Riches, Mary Hilton, Mel Hayman, Deepak Subramanian, Priya Daniel, Oluronke Adanini, Nikhil Bhatia, Maines Msiska, Rebecca Collins, Ian Clement, Bijal Patel, A. Gulati, Carole Hays, K. Webster, Anne Hudson, Andrea Webster, Elaine Stephenson, Louise McCormack, Victoria Slater, Rachel Nixon, Helen Hanson, Maggie Fearby, Sinead Kelly, Victoria Bridgett, Philip Robinson, Julie Camsooksai, Charlotte Humphrey, Sarah Jenkins, Henrik Reschreiter, Beverley Wadams, Yasmin Death, Victoria Bastion, Daphene Clarke, Beena David, Harriet Kent, Rachel Lorusso, Gamu Lubimbi, Sophie Murdoch, Melchizedek Penacerrada, Alastair Thomas, Jennifer Valentine, Ana Vochin, Retno Wulandari, Brice Djeugam, Gillian Bell, Katy English, Amro Katary, Louise Wilcox, Michelle Bruce, Karen Connolly, Tracy Duncan, Helen T-Michael, Gabriella Lindergard, Samuel Hey, Claire Fox, Jordan Alfonso, Laura Jayne Durrans, Jacinta Guerin, Bethan Blackledge, Jade Harris, Martin Hruska, Ayaa Eltayeb, Thomas Lamb, Tracey Hodgkiss, Lisa Cooper, Joanne Rothwell, Angela Allan, Felicity Anderson, Callum Kaye, Jade Liew, Jasmine Medhora, Teresa Scott, Erin Trumper, Adriana Botello, Liana Lankester, Nikitas Nikitas, Colin Wells, Bethan Stowe, Kayleigh Spencer, Craig Brandwood, Lara Smith, Katie Birchall, Laurel Kolakaluri, Deborah Baines, Anila Sukumaran, Elena Apetri, Cathrine Basikolo, Laura Catlow, Bethan Charles, Paul Dark, Reece Doonan, Alice Harvey, Daniel Horner, Karen Knowles, Stephanie Lee, Diane Lomas, Chloe Lyons, Tracy Marsden, Danielle McLaughlan, Liam McMorrow, Jessica Pendlebury, Jane Perez, Maria Poulaka, Nicola Proudfoot, Melanie Slaughter, Kathryn Slevin, Vicky Thomas, Danielle Walker, Angiy Michael, Matthew Collis, Tracey Cosier, Gemma Millen, Neil Richardson, Natasha Schumacher, Heather Weston, James Rand, Nicola Baxter, Steven Henderson, Sophie Kennedy-Hay, Christopher McParland, Laura Rooney, Malcolm Sim, Gordan McCreath, Louise Akeroyd, Shereen Bano, Matt Bromley, Lucy Gurr, Tom Lawton, James Morgan, Kirsten Sellick, Deborah Warren, Brian Wilkinson, Janet McGowan, Camilla Ledgard, Amelia Stacey, Kate Pye, Ruth Bellwood, Michael Bentley, Jeremy Bewley, Zoe Garland, Lisa Grimmer, Bethany Gumbrill, Rebekah Johnson, Katie Sweet, Denise Webster, Georgia Efford, Karen Convery, Deirdre Fottrell-Gould, Lisa Hudig, Jocelyn Keshet-Price, Georgina Randell, Katie Stammers, Maria Bokhari, Vanessa Linnett, Rachael Lucas, Wendy McCormick, Jenny Ritzema, Amanda Sanderson, Helen Wild, Anthony Rostron, Alistair Roy, Lindsey Woods, Sarah Cornell, Fiona Wakinshaw, Kimberley Rogerson, Jordan Jarmain, Robert Parker, Amie Reddy, Ian Turner-Bone, Laura Wilding, Peter Harding, Caroline Abernathy, Louise Foster, Andrew Gratrix, Vicky Martinson, Priyai Parkinson, Elizabeth Stones, Llucia Carbral-Ortega, Georgia Bercades, David Brealey, Ingrid Hass, Niall MacCallum, Gladys Martir, Eamon Raith, Anna Reyes, Deborah Smyth, Letizia Zitter, Sarah Benyon, Suzie Marriott, Linda Park, Samantha Keenan, Elizabeth Gordon, Helen Quinn, Kizzy Baines, Lenka Cagova, Adama Fofano, Lucie Garner, Helen Holcombe, Sue Mepham, Alice Michael Mitchell, Lucy Mwaura, Krithivasan Praman, Alain Vuylsteke, Julie Zamikula, Bally Purewal, Vanessa Rivers, Stephanie Bell, Hayley Blakemore, Borislava Borislavova, Beverley Faulkner, Emma Gendall, Elizabeth Goff, Kati Hayes, Matt Thomas, Ruth Worner, Kerry Smith, Deanna Stephens, Louise Mew, Esther Mwaura, Richard Stewart, Felicity Williams, Lynn Wren, Sara-Beth Sutherland, Emily Bevan, Jane Martin, Dawn Trodd, Geoff Watson, Caroline Wrey Brown, Amy Collins, Waqas Khaliq, Estefania Treus Gude, Olugbenga Akinkugbe, Alasdair Bamford, Emily Beech, Holly Belfield, Michael Bell, Charlene Davies, Gareth A.L. Jones, Tara McHugh, Hamza Meghari, Lauran O'Neill, Mark J. Peters, Samiran Ray, Ana Luisa Tomas, Iona Burn, Geraldine Hambrook, Katarina Manso, Ruth Penn, Pradeep Shanmugasundaram, Julie Tebbutt, Danielle Thornton, Jade Cole, Rhys Davies, Donna Duffin, Helen Hill, Ben Player, Emma Thomas, Angharad Williams, Denise Griffin, Nycola Muchenje, Mcdonald Mupudzi, Richard Partridge, Jo-Anna Conyngham, Rachel Thomas, Mary Wright, Maria Alvarez Corral, Reni Jacob, Cathy Jones, Craig Denmade, Sarah Beavis, Katie Dale, Rachel Gascoyne, Joanne Hawes, Kelly Pritchard, Lesley Stevenson, Amanda Whileman, Patricia Doble, Joanne Hutter, Corinne Pawley, Charmaine Shovelton, Marius Vaida, Deborah Butcher, Susie O'Sullivan, Nicola Butterworth-Cowin, Norfaizan Ahmad, Joann Barker, Kris Bauchmuller, Sarah Bird, Kay Cawthron, Kate Harrington, Yvonne Jackson, Faith Kibutu, Becky Lenagh, Shamiso Masuko, Gary H. Mills, Ajay Raithatha, Matthew Wiles, Jayne Willson, Helen Newell, Alison Lye, Lorenza Nwafor, Claire Jarman, Sarah Rowland-Jones, David Foote, Joby Cole, Roger Thompson, James Watson, Lisa Hesseldon, Irene Macharia, Luke Chetam, Jacqui Smith, Amber Ford, Samantha Anderson, Kathryn Birchall, Kay Housley, Sara Walker, Leanne Milner, Helena Hanratty, Helen Trower, Patrick Phillips, Simon Oxspring, Ben Donne, Catherine Jardine, Dewi Williams, Alasdair Hay, Rebecca Flanagan, Gareth Hughes, Scott Latham, Emma McKenna, Jennifer Anderson, Robert Hull, Kat Rhead, Carina Cruz, Natalie Pattison, Rob Charnock, Denise McFarland, Denise Cosgrove, Ashar Ahmed, Anna Morris, Srinivas Jakkula, Asifa Ali, Megan Brady, Sam Dale, Annalisa Dance, Lisa Gledhill, Jill Greig, Kathryn Hanson, Kelly Holdroyd, Marie Home, Diane Kelly, Ross Kitson, Lear Matapure, Deborah Melia, Samantha Mellor, Tonicha Nortcliffe, Jez Pinnell, Matthew Robinson, Lisa Shaw, Ryan Shaw, Lesley Thomis, Alison Wilson, Tracy Wood, Lee-Ann Bayo, Ekta Merwaha, Tahira Ishaq, Sarah Hanley, Meg Hibbert, Dariusz Tetla, Chrsitopher Woodford, Latha Durga, Gareth Kennard-Holden, Debbie Branney, Jordan Frankham, Sally Pitts, Nigel White, Shondipon Laha, Mark Verlander, Alexandra Williams, Abdelhakim Altabaibeh, Ana Alvaro, Kayleigh Gilbert, Louise Ma, Loreta Mostoles, Chetan Parmar, Kathryn Simpson, Champa Jetha, Lauren Booker, Anezka Pratley, Colene Adams, Anita Agasou, Tracie Arden, Amy Bowes, Pauline Boyle, Mandy Beekes, Heather Button, Nigel Capps, Mandy Carnahan, Anne Carter, Danielle Childs, Denise Donaldson, Kelly Hard, Fran Hurford, Yasmin Hussain, Ayesha Javaid, James Jones, Sanal Jose, Michael Leigh, Terry Martin, Helen Millward, Nichola Motherwell, Rachel Rikunenko, Jo Stickley, Julie Summers, Louise Ting, Helen Tivenan, Louise Tonks, Rebecca Wilcox, Maureen Holland, Natalie Keenan, Marc Lyons, Helen Wassall, Chris Marsh, Mervin Mahenthran, Emma Carter, Thomas Kong, Helen Blackman, Ben Creagh-Brown, Sinead Donlon, Natalia Michalak-Glinska, Sheila Mtuwa, Veronika Pristopan, Armorel Salberg, Eleanor Smith, Sarah Stone, Charles Piercy, Jerik Verula, Dorota Burda, Rugia Montaser, Lesley Harden, Irving Mayangao, Cheryl Marriott, Paul Bradley, Celia Harris, Susan Anderson, Eleanor Andrews, Janine Birch, Emma Collins, Kate Hammerton, Ryan O'Leary, Michele Clark, Sarah Purvis, Russell Barber, Claire Hewitt, Annette Hilldrith, Karen Jackson-Lawrence, Sarah Shepardson, Maryanne Wills, Susan Butler, Silvia Tavares, Amy Cunningham, Julia Hindale, Sarwat Arif, Sarah Bean, Karen Burt, Michael Spivey, Carrie Demetriou, Charlotte Eckbad, Sarah Hierons, Lucy Howie, Sarah Mitchard, Lidia Ramos, Alfredo Serrano-Ruiz, Katie White, Fiona Kelly, Daniele Cristiano, Natalie Dormand, Zohreh Farzad, Mahitha Gummadi, Kamal Liyanage, Brijesh Patel, Sara Salmi, Geraldine Sloane, Vicky Thwaites, Mathew Varghese, Anelise C. Zborowski, John Allan, Tim Geary, Gordon Houston, Alistair Meikle, Peter O'Brien, Miranda Forsey, Agilan Kaliappan, Anne Nicholson, Joanne Riches, Mark Vertue, Elizabeth Allan, Kate Darlington, Ffyon Davies, Jack Easton, Sumit Kumar, Richard Lean, Daniel Menzies, Richard Pugh, Xinyi Qiu, Llinos Davies, Hannah Williams, Jeremy Scanlon, Gwyneth Davies, Callum Mackay, Joannne Lewis, Stephanie Rees, Metod Oblak, Monica Popescu, Mini Thankachen, Andrew Higham, Kerry Simpson, Jayne Craig, Rosie Baruah, Sheila Morris, Susie Ferguson, Amy Shepherd, Luke Stephen Prockter Moore, Marcela Paola Vizcaychipi, Laura Gomes de Almeida Martins, Jaime Carungcong, Inthakab Ali Mohamed Ali, Karen Beaumont, Mark Blunt, Zoe Coton, Hollie Curgenven, Mohamed Elsaadany, Kay Fernandes, Sameena Mohamed Ally, Harini Rangarajan, Varun Sarathy, Sivarupan Selvanayagam, Dave Vedage, Matthew White, Mandy Gill, Paul Paul, Valli Ratnam, Sarah Shelton, Inez Wynter, Siobhain Carmody, Valerie Joan Page, Claire Marie Beith, Karen Black, Suzanne Clements, Alan Morrison, Dominic Strachan, Margaret Taylor, Michelle Clarkson, Stuart D'Sylva, Kathryn Norman, Fiona Auld, Joanne Donnachie, Ian Edmond, Lynn Prentice, Nikole Runciman, Dario Salutous, Lesley Symon, Anne Todd, Patricia Turner, Abigail Short, Laura Sweeney, Euan Murdoch, Dhaneesha Senaratne, Michaela Hill, Thogulava Kannan, Wild Laura, Rikki Crawley, Abigail Crew, Mishell Cunningham, Allison Daniels, Laura Harrison, Susan Hope, Ken Inweregbu, Sian Jones, Nicola Lancaster, Jamie Matthews, Alice Nicholson, Gemma Wray, Helen Langton, Rachel Prout, Malcolm Watters, Catherine Novis, Anthony Barron, Ciara Collins, Sundeep Kaul, Heather Passmore, Claire Prendergast, Anna Reed, Paula Rogers, Rajvinder Shokkar, Meriel Woodruff, Hayley Middleton, Oliver Polgar, Claire Nolan, Kanta Mahay, Dawn Collier, Anil Hormis, Victoria Maynard, Cheryl Graham, Rachel Walker, Ellen Knights, Alicia Price, Alice Thomas, Chris Thorpe, Teresa Behan, Caroline Burnett, Jonathan Hatton, Elaine Heeney, Atideb Mitra, Maria Newton, Rachel Pollard, Rachael Stead, Vishal Amin, Elena Anastasescu, Vikram Anumakonda, Komala Karthik, Rizwana Kausar, Karen Reid, Jacqueline Smith, Janet Imeson-Wood, Denise Skinner, Jane Gaylard, Dee Mullan, Julie Newman, Alison Brown, Vikki Crickmore, Gabor Debreceni, Joy Wilkins, Liz Nicol, Rosie Reece-Anthony, Mark Birt, Alison Ghosh, Emma Williams, Louise Allen, Eva Beranova, Nikki Crisp, Joanne Deery, Tracy Hazelton, Alicia Knight, Carly Price, Sorrell Tilbey, Salah Turki, Sharon Turney, Joshua Cooper, Cheryl Finch, Sarah Liderth, Alison Quinn, Natalia Waddington, Tina Coventry, Susan Fowler, Michael MacMahon, Amanda McGregor, Anne Cowley, Judith Highgate, Jane Gregory, Susan O'Connell, Tim Smith, Luigi Barberis, Shameer Gopal, Nichola Harris, Victoria Lake, Stella Metherell, Elizabeth Radford, Amelia Daniel, Joanne Finn, Rajnish Saha, Nikki White, Phil Donnison, Fiona Trim, Beena Eapen, Jenny Birch, Laura Bough, Josie Goodsell, Rebecca Tutton, Patricia Williams, Sarah Williams, Barbara Winter-Goodwin, Ailstair Nichol, Kathy Brickell, Michelle Smyth, Lorna Murphy, Samantha Coetzee, Alistair Gales, Igor Otahal, Meena Raj, Craig Sell, Paula Hilltout, Jayne Evitts, Amanda Tyler, Joanne Waldron, Kate Beesley, Sarah Board, Agnieszka Kubisz-Pudelko, Alison Lewis, Jess Perry, Lucy Pippard, Di Wood, Clare Buckley, Peter Barry, Neil Flint, Patel Rekha, Dawn Hales, Lara Bunni, Claire Jennings, Monica Latif, Rebecca Marshall, Gayathri Subramanian, Peter J. McGuigan, Christopher Wasson, Stephanie Finn, Jackie Green, Erin Collins, Bernadette King, Andy Campbell, Sara Smuts, Joseph Duffield, Oliver Smith, Lewis Mallon, Watkins Claire, Liam Botfield, Joanna Butler, Catherine Dexter, Jo Fletcher, Atul Garg, Aditya Kuravi, Poonam Ranga, Emma Virgilio, Zakaula Belagodu, Bridget Fuller, Anca Gherman, Olumide Olufuwa, Remi Paramsothy, Carmel Stuart, Naomi Oakley, Charlotte Kamundi, David Tyl, Katy Collins, Pedro Silva, June Taylor, Laura King, Charlotte Coates, Maria Crowley, Phillipa Wakefield, Jane Beadle, Laura Johnson, Janet Sargeant, Madeleine Anderson, Ailbhe Brady, Rebekah Chan, Jeff Little, Shane McIvor, Helena Prady, Helen Whittle, Bijoy Mathew, Ben Attwood, Penny Parsons, Geraldine Ward, Pamela Bremmer, West Joe, Baird Tracy, Ruddy Jim, Ellie Davies, Sonia Sathe, Catherine Dennis, Alastair McGregor, Victoria Parris, Sinduya Srikaran, Anisha Sukha, Noreen Clarke, Jonathan Whiteside, Mairi Mascarenhas, Avril Donaldson, Joanna Matheson, Fiona Barrett, Marianne O'Hara, Laura Okeefe, Clare Bradley, Christine Eastgate-Jackson, Helder Filipe, Daniel Martin, Amitaa Maharajh, Sara Mingo Garcia, Glykeria Pakou, Mark De Neef, Kathy Dent, Elizabeth Horsley, Muhmmad Nauman Akhtar, Sandra Pearson, Dorota Potoczna, Sue Spencer, Melanie Clapham, Rosemary Harper, Una Poultney, Polly Rice, Rachel Mutch, Lisa Armstrong, Hayley Bates, Emma Dooks, Fiona Farquhar, Brigid Hairsine, Chantal McParland, Sophie Packham, Rehana Bi, Barney Scholefield, Lydia Ashton, Linsha George, Sophie Twiss, David Wright, Manish Chablani, Amy Kirkby, Kimberley Netherton, Kim Davies, Linda O'Brien, Zohra Omar, Emma Perkins, Tracy Lewis, Isobel Sutherland, Karen Burns, Dr Ben Chandler, Kerry Elliott, Janine Mallinson, Alison Turnbull, Prisca Gondo, Bernard Hadebe, Abdul Kayani, Bridgett Masunda, Taya Anderson, Dan Hawcutt, Laura O'Malley, Laura Rad, Naomi Rogers, Paula Saunderson, Kathryn Sian Allison, Deborah Afolabi, Jennifer Whitbread, Dawn Jones, Rachael Dore, Matthew Halkes, Pauline Mercer, Lorraine Thornton, Joy Dawson, Sweyn Garrioch, Melanie Tolson, Jonathan Aldridge, Ritoo Kapoor, David Loader, Karen Castle, Sally Humphreys, Ruth Tampsett, Katherine Mackintosh, Amanda Ayers, Wendy Harrison, Julie North, Suzanne Allibone, Roman Genetu, Vidya Kasipandian, Amit Patel, Ainhi Mac, Anthony Murphy, Parisa Mahjoob, Roonak Nazari, Lucy Worsley, Andrew Fagan, Thomas Bemand, Ethel Black, Arnold Dela Rosa, Ryan Howle, Shaman Jhanji, Ravishankar Rao Baikady, Kate Colette Tatham, Benjamin Thomas, Dina Bell, Rosalind Boyle, Katie Douglas, Lynn Glass, Emma Lee, Liz Lennon, Austin Rattray, Abigail Taylor, Rachel Anne Hughes, Helen Thomas, Alun Rees, Michaela Duskova, Janet Phipps, Suzanne Brooks, Michelle Edwards, Sheena Quaid, Ekaterina Watson, Adam Brayne, Emma Fisher, Jane Hunt, Peter Jackson, Duncan Kaye, Nicholas Love, Juliet Parkin, Victoria Tuckey, Lynne Van Koutrik, Sasha Carter, Benedict Andrew, Louise Findlay, Katie Adams, Jen Service, Alison Williams, Claire Cheyne, Anne Saunderson, Sam Moultrie, Miranda Odam, Kathryn Hall, Isheunesu Mapfunde, Charlotte Willis, Alex Lyon, Chunda Sri-Chandana, Joslan Scherewode, Lorraine Stephenson, Sarah Marsh, John Hardy, Henry Houlden, Eleanor Moncur, Ambreen Tariq, Arianna Tucci, Maria Hobrok, Ronda Loosley, Heather McGuinness, Helen Tench, Rebecca Wolf-Roberts, Val Irvine, Benjamin Shelley, Claire Gorman, Abhinav Gupta, Elizabeth Timlick, Rebecca Brady, Barry Milligan, Arianna Bellini, Jade Bryant, Anton Mayer, Amy Pickard, Nicholas Roe, Jason Sowter, Alex Howlett, Katy Fidler, Emma Tagliavini, and Kevin Donnelly
Subjects: SARS-CoV-2, host genetics, toll-like receptor 7, targeted sequencing, rare variants, variant collapsing analysis, Genetics, QH426-470
Abstract: Summary: Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.4% of young (
Published: 2024
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2. Safety and procedural success of daycase-based endovascular procedures in lower extremity arteries of patients with peripheral artery disease: a systematic review and meta-analysisResearch in context

Author: Lydia Hanna, Alexander D. Rodway, Puneet Garcha, Luci Maynard, Janane Sivayogi, Oliver Schlager, Juraj Madaric, Vinko Boc, Lucas Busch, Martin B. Whyte, Simon S. Skene, Jenny Harris, and Christian Heiss
Subjects: Daycase angioplasty, Chronic limb-threatening ischaemia, Peripheral artery disease, Endovascular, Technical success, Medicine (General), R5-920
Abstract: Summary: Background: Timely and economic provision of revascularisation procedures is a major healthcare need. We aimed to examine the safety and efficacy of daycase-based lower extremity endovascular revascularisation procedures in patients with peripheral artery disease. Methods: In this systematic review and meta-analysis, we searched MEDLINE and Embase for studies from Jan 01, 2000 through Apr 01, 2024 reporting complications of lower limb endovascular revascularisation procedures with same-day discharge. Eligibility-criteria, complications, and patient characteristics were extracted, methodological quality assessed (adapted Newcastle–Ottawa Scale), and meta-analyses of complications and technical success performed to provide pooled estimates. This study is registered with PROSPERO, CRD42022316466. Findings: Thirty observational studies (17 retrospective, 13 prospective) and 1 RCT reported 2427 minor and 653 major complications after 99,600 daycase procedures (93,344 patients). Eighteen studies reported daycase eligibility-criteria including ‘responsible adult companion’ (78%), ‘proximity to hospital’, and ‘telephone availability’ and excluding unstable and severe co-morbidities, offset coagulation, and severe chronic kidney disease. Pooled incidences of minor (4.7% [95% CI 3.8–5.6%], I2 = 96%) and major (0.64% [95% CI 0.48–0.79%], I2 = 46%) complications were low and technical success high (93% [95% CI 91–96%], I2 = 97%). Most complications were related to the puncture site. Pooled conversion-to-hospitalisation rates and re-admission after discharge were 1.6% (95% CI 1.1–2.2%, I2 = 82%) and 0.11% (95% CI 0.095–0.23%, I2 = 97%), respectively. Meta-regression identified that minor complications decreased since 2000. Male sex and coronary artery disease were associated with more frequent, and higher age and closure device use with less minor complications. Diabetes mellitus and chronic kidney disease were associated with less major complications. Six studies reported complication rates both in daycases and inpatients and there was no significant difference (−0.8% [95% CI −1.9 to 0.3%]). Interpretation: After careful evaluation of eligibility, lower limb angioplasty can be performed safely with high technical success in a daycase setting. Most complications arise from the puncture site and not the procedure itself highlighting the importance of optimal access site management. The heterogeneity between studies warrants standardised monitoring of complications and outcomes. Funding: European Partnership on Metrology, co-financed from European Union’s Horizon Europe Research and Innovation Programme and UK Research and Innovation, and Medical Research Council.
Published: 2024
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3. Titration of dietary histidine during a 15 to 35 d feeding period in male Cobb 500 broilers

Author: K.B. Nelson, S.C. Wells-Crafton, M.F. Costa, B.L. Angel, S.K. Rao, G.J. Mullenix, C.W. Maynard, and M.T. Kidd
Subjects: male broiler, breast yield, amino acid, histidine, requirement, Animal culture, SF1-1100, Food processing and manufacture, TP368-456
Abstract: SUMMARY: Dietary CP reductions in broilers can result in increased FCR when 6 or 7 feed-grade amino acids are allowed to enter formulation, and a partial explanation may be a dietary limitation of His. Histidine requirement data are sparce in the current body of literature, especially beyond 3 wk post-hatch. Therefore, a His dose-response experiment (expressed as a percentage of Lys) was conducted with male Cobb 500 broilers from 15 to 35 d post-hatch. A His deficient test diet was formulated to contain a digestible His to digestible Lys (dHis:dLys) ratio of 28.0%. Graded increments of L-His were added to the test diet to produce additional diets containing dHis:dLys ratios of 30.5, 33.0, 35.5, 38.0, 40.5, and 43.0%. A positive control (PC) diet was formulated to contain a dHis:dLys ratio of 38.0% met solely with intact protein. The PC diet outperformed the test diet in all live performance parameters and had a reduced peritoneal cavity fat yield. Linear responses to His were observed for final BW, BW gain, and FCR. In addition, a linear His response was observed for carcass yield and both linear and quadratic responses were observed for breast filet and tender yields. The 95% quadratic max method was used to derive the optimal dHis:dLys ratios of 39 and 37% for breast filet and tender yields, respectively. To accurately estimate quadratic asymptotes for live performance parameters, future His dose-response experiments may need to incorporate dHis:dLys ratios higher than 43%.
Published: 2024
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4. Influence of dietary amino acid density, crude protein level, and feed scheduling on performance and carcass traits of Ross 708 female broilers slaughtered between 1.9 and 2.0 kg

Author: C.W. Maynard, C.L. Williams, and M.T. Kidd
Subjects: amino acid density, low crude protein, feeding phase, performance, female, Animal culture, SF1-1100, Food processing and manufacture, TP368-456
Abstract: SUMMARY: Adjustments in dietary amino acid density, CP levels, and feed scheduling influence broiler performance, carcass traits, and integrator profitability. Therefore, 2 experiments were conducted to assess the former factors on the live performance and carcass traits of female Ross 708 broilers grown for a high-value bone-in market (36 d processing). Experiment 1 evaluated 4 amino acid densities while Experiment 2 was arranged as a 2 × 2 factorial evaluating dietary CP and feed scheduling. Amino acid density in Experiment 1 had no effect on any performance or processing parameter except feed conversion which was decreased for birds fed the Medium diet. The lack of substantial improvement in live performance resulted in increased feed, live BW, and carcass costs per kg. Neither feed scheduling nor dietary CP had an effect on live performance in Experiment 2. However, feeding low CP diets resulted in increased total breast meat yield, whereas increasing the number of feeding phases decreased total breast meat yield. In conclusion, dietary alterations in amino acid density in female broiler broilers warrants further attention.
Published: 2024
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5. Effectiveness of provider communication training for increasing human papillomavirus vaccine initiation at a safety-net health system

Author: Rachel J. Meadows, Aaron W. Gehr, Yan Lu, Grace Maynard, Idara N. Akpan, Tanjila Taskin, Kimberly G. Fulda, Divya Patel, Sarah Matches, Rohit P. Ojha, and Erika L. Thompson
Subjects: Papillomavirus vaccines, Papillomavirus Infections/prevention & control, Vaccination, Provider communication, Primary prevention, Medicine
Abstract: Background: Strong provider recommendation can increase uptake of human papillomavirus (HPV) vaccination. Therefore, we developed and implemented a provider education intervention on communication strategies for recommending HPV vaccination with clinic-level audit and feedback (HPV: Communicating about HPV to Adults and Teens [HPV CHAT]). We aimed to evaluate the effect of HPV CHAT on HPV vaccine uptake in seven family medicine and pediatric clinics in a large urban health system (USA). Methods: We used a quasi-experimental design, where the eligible population included people aged 9–26 years with at least one encounter in June 2020–February 2023 at one of the participating community health clinics. We used interrupted time-series analysis to assess changes in the prevalence of HPV vaccine uptake. We used segmented Poisson regression with a log link function to estimate prevalence ratios (PR) and 95% confidence limits (CL) for level (immediate) and slope (over time) changes with adjustment for seasonality using Fourier transformation. Results: Our study population comprised 60,328 observations in which the median age was 17 years (interquartile range: 13–21). A majority (58%) were female and 87% were racial/ethnic minorities. Overall, we observed no sizeable effect of the intervention on HPV vaccination uptake. Nonetheless, heterogeneity was observed by age group with modest increases in individuals aged 9–12 and 13–17 years. Conclusion: Our provider feedback intervention had minimal effect on increasing prevalence of HPV vaccination in seven family medicine and pediatric clinics. Novel strategies are needed to address provider barriers related to HPV vaccination.
Published: 2024
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6. Bridging Valleys of Death—A Roadmap for Improving Research to Practice

Author: Rebecca Shute, Jeri Ropero-Miller, Gabrielle DiEmma, Cody Sorrell, Henry Maynard, Cleveland Miles, Catherine Grgicak, Stephanie Stoiloff, and Sarah Seashols-Williams
Subjects: Criminal law and procedure, K5000-5582
Published: 2024
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7. Spark Innovation with FRC Research Tools

Author: Henry Maynard
Subjects: Criminal law and procedure, K5000-5582
Published: 2024
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8. Metronome use improves achievement of a target compression rate in out-of-hospital cardiac arrest: A retrospective analysis

Author: Jacob Kennedy, Kimberly Machado, Charles Maynard, Robert G. Walker, Michael R. Sayre, and Catherine R. Counts
Subjects: Metronome, Cardiopulmonary resuscitation, Chest compression rate, Chest compressions, Out-of-hospital cardiac arrest, Cardiac arrest, Specialties of internal medicine, RC581-951
Abstract: Aim: The aim of this study was to evaluate chest compression rates (CCR) with and without the use of a metronome during treatment of out-of-hospital cardiac arrest (OHCA). Methods: We performed a retrospective cohort investigation of non-traumatic OHCA cases treated by Seattle Fire Department from January 1, 2013, to December 31, 2019. The exposure was a metronome running during CPR at a rate of 110 beats per minute. The primary outcome was the median CCR for all periods of CPR with a metronome compared to periods without a metronome. Results: We included 2,132 OHCA cases with 32,776 minutes of CPR data; 15,667 (48%) minutes had no metronome use, and 17,109 (52%) minutes had a metronome used. Without a metronome, the median CCR was 112.8 per minute with an interquartile range of 108.4 – 119.1, and 27% of minutes were above 120 or less than 100. With a metronome, the median CCR was 110.5 per minute with an interquartile range of 110.0–112.0, and less than 4% of minutes were above 120 or less than 100. The compression rate was 109, 110, or 111 in 62% of minutes with a metronome compared to 18% of minutes with no metronome. Conclusion: The use of a metronome during CPR resulted in increased compliance to a predetermined compression rate. Metronomes are a simple tool that improves achievement of a target compression rate with little variance from that target.
Published: 2023
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9. Monitoring tacrolimus toxicity following Paxlovid administration in a liver transplant patient

Author: Robert D. Maynard, Phillip Bates, and Nichole Korpi-Steiner
Subjects: Tacrolimus, Immunosuppressant, Nirmatrelvir/ritonavir, Paxlovid, TDM, Drug-drug interaction, Medicine (General), R5-920, Chemistry, QD1-999
Abstract: Maintaining therapeutic plasma tacrolimus concentrations is essential for mitigating potential solid organ transplant rejection and preventing toxic adverse side effects. While patients can benefit greatly from tacrolimus therapy, co-administration of drugs such as Paxlovid (nirmatrelvir/ritonavir) place patients at serious risk for drug interactions and harm. Here we present a case of tacrolimus toxicity following Paxlovid administration in a liver transplant patient. Therapeutic drug monitoring was further complicated by a limited upper reportable threshold for tacrolimus testing and highlights the value of validating a higher limit to the clinical reportable range to improve tacrolimus monitoring and meet clinical needs in the setting of drug toxicity.
Published: 2023
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10. Characterization of growth patterns and carcass characteristics of male and female broilers from four commercial strains fed high or low density diets

Author: C.J. Maynard, C.W. Maynard, A.R. Jackson, M.T. Kidd, S.J. Rochell, and C.M. Owens
Subjects: broiler, amino acid density, sex, strain, yields, Animal culture, SF1-1100
Abstract: ABSTRACT: Over the last few decades, the poultry industry has seen the emergence of various market segments that are beneficial for rearing various flock sizes. Two concurrent experiments consisting of 1,200 broilers each were conducted to evaluate the effects of broiler size and diet on the performance of four commercially available broiler strains, including 2 standard yielding (SY) and 2 high yielding (HY) strains. Within each experiment (Experiment 1: males, Experiment 2: females), a small bird (38 and 40 d processing) and big bird (47 and 54 d processing) debone market were targeted to give variable carcass size. Two polyphasic diets were fed based on varying of amino acid densities. The low-density diet (L) consisted of 1.20, 1.10, 1.00, and 0.96% digestible Lys and the high-density diet (H) consisted of 1.32, 1.21, 1.10, and 1.06% across the 4-phases, respectively, with similar essential amino acid to digestible Lys ratios between the L and H diets in each phase. Weekly BW, BW gain, feed intake, and feed conversion ratio were assessed, as well as processing yields during both experiments. Broilers fed the H diets responded better than those fed the L diets, regardless of sex, with increased BW and decreased FCR (P < 0.05). Male HY strains provided the highest carcass yields (P < 0.05) compared to SY strains, with no differences observed in females (P > 0.05). High density diets (Diet H) also produced increases in carcass, breast, and tender yield (P < 0.05) for males, but that trend was not present in carcass yield for females (P < 0.05). Overall, strain impacted performance traits and carcass yields. Therefore, the use of specific strains and amino acid density for various market segments is beneficial for integrators to maximize return.
Published: 2023
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11. Assessment of meat quality attributes of four commercial broiler strains processed at various market weights

Author: A.J. Mueller, C.J. Maynard, A.R. Jackson, A. Mauromoustakos, M.T. Kidd, S.J. Rochell, J.P. Caldas-Cueva, X. Sun, A. Giampietro-Ganeco, and C.M. Owens
Subjects: meat quality, myopathy, tender myopathy, broiler strain, texture, Animal culture, SF1-1100
Abstract: ABSTRACT: As the demand for poultry meat continues to rise, industry production is constantly challenged with obtaining consumer needs. Integrators have answered this increasing demand by improving the growth rate of broilers allowing for increased production efficiently. The resulting broiler produces higher yields and a larger quantity of fresh poultry to satisfy consumer needs. However, this increase in efficiency has cost integrators as new quality issues continue to manifest through global production. Therefore, the objective of the current experiment was to evaluate the effect of genetic strain (standard and high yielding) and target weight on meat quality attributes such as pH, water holding capacity (WHC), and tenderness, alongside meat quality defects such as breast and tender myopathies. In the current study, 1,800 broilers from 4 commercial strains (2 high breast yielding (HY) and 2 standard yielding (SY) were raised sex separate to evaluate meat quality trends over time at 6 previously defined market weights. Birds were processed at weights ranging from 2,043 to 4,313 g in 454 g increments. HY strains produced higher breast and tender yields than those of SY strains (P < 0.05). There was an increase in breast and tender yield as target weight increased (P < 0.05) for both HY and SY strains. Differences were observed between strains for all fillet dimensions (P < 0.05); however, these measurements increased as target weight increased as expected. Woody breast (WB) had a higher severity (P < 0.05) in HY strains over SY strains, for both males and females. Differences were observed in white striping (WS; P < 0.05) for females in both strains, but no differences were observed in males. A main effect of target was noticed for both WB and WS (P < 0.05), expressing increased severity as target weight increased. Shear values were influenced more by target weight (P < 0.05), but inconsistent differences were observed between HY and SY groups. Meullenet-Owens Razor Shear (MORS) energy values increased slightly as target weights increased (P < 0.05) from 2,951 to 4,313 g in both males and females, but differences were minor and inconsistent with the smaller carcass weights. The MORS peak counts generally increased as target weight increased for both sexes. While strain had minimal effects on meat quality attributes, processing weight had a greater influence on quality, specifically muscle myopathies, WHC, and shear properties.
Published: 2023
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12. Meat quality attributes of male and female broilers from 4 commercial strains processed for 2 market programs

Author: C.J. Maynard, A.R. Jackson, J.P. Caldas-Cueva, A. Mauromoustakos, M.T. Kidd, S.J. Rochell, and C.M. Owens
Subjects: meat quality, myopathy, tender myopathy, tenderness, color, Animal culture, SF1-1100
Abstract: ABSTRACT: In recent times, meat quality has become a key aspect of poultry production. In the current study, 2,400 sex separate broilers from 4 commercial strains were placed in 6 replications to evaluate various meat quality characteristics when grown to 2 market weights. Broilers were fed 1 of 2 diets with varying degrees of amino acid inclusion to evaluate meat quality of broiler raised on varying planes of nutrition. Birds were processed to meet 2 specified target weights (2.5 and 3.8 kg) representing small bird and big bird debone markets in the United States, respectively. Birds were processed using commercial methods, deboned at 3-h postmortem, and meat quality was assessed. Myopathies (woody breast, white striping, spaghetti meat, along with tenderloin quality), fillet dimensions, color, water-holding capacity (e.g., drip loss, cook loss), and Meullenet Owens Razor Shear was determined. Data were analyzed using the Mixed Model platform of JMP Pro 15.2 (SAS Institute, Cary, NC). Diet had no effect (P > 0.05) on the key quality responses; data were then pooled resulting in main effects of sex, strain, and target weight (noted as carcass size). On the day of processing, high yielding (HY) strains produced higher breast and tender yields (P < 0.05) when compared to standard yielding (SY) strains. In addition, and as expected, females exhibited higher breast and tender yields (P < 0.05) than males. However, males had significantly thicker (P < 0.05) and longer (P < 0.05) fillets, higher incidences (P < 0.05) of white striping, and higher (P < 0.05) cook loss when compared to females. Differences were also observed in tenderness as SY strain A produced the lowest shear values, whereas SY strain B produced the highest shear values across parameters (P < 0.05). SY strains in the small bird (SB) market performed better than SY strains in the big bird (BB) market as indicated by lower incidences of breast and tender myopathies white striping, woody breast, spaghetti meat, woody-like tender, and tender feathering and improved quality attributes (P < 0.05). Similar trends were observed (P < 0.05) in HY strains as SB carcasses produced a better overall product than BB. Differences in carcass size directly impacted quality (P < 0.05) as SB markets showed improvements in most parameters assessed, but broilers representing BB markets had greater breast yield. Although strain had minimal impacts on quality measures, carcass size, and sex had a greater impact on muscle myopathies, water-holding capacity, and shear properties.
Published: 2023
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13. A service to help insurers understand the financial impacts of changing flood risk in Europe, based on PESETA IV

Author: Stephen Jewson, Trevor Maynard, and Francesco Dottori
Subjects: PESETA IV, Europe, Flood risk, Catastrophe modelling, Climate change, Meteorology. Climatology, QC851-999, Social sciences (General), H1-99
Abstract: The European Union PESETA IV project has produced a comprehensive dataset that quantifies the impact of climate change on river flooding and damage in Europe. This data potentially has significant application in the insurance industry, but requires some steps of post-processing, and appropriate delivery mechanisms, before it can be used in practice. The post-processing approach we apply involves statistical modelling of the simulated changes in damage to estimate rates of change of log damage versus global mean surface temperature (GMST). Under linear assumptions, these rates of change can be used to calculate the change in damage between any two time-periods for any GMST scenario. Under further assumptions, these changes can be used to adjust many of the metrics of flood risk used in the insurance industry, such as average annual losses, exceedance probabilities and year loss tables. We deliver these results in two ways to suit different users in the insurance industry. First, the rates of change, and related correlations, are provided as freely available datasets for insurers who prefer to process and apply the data themselves. Second, commercial online software is provided that performs some steps of the processing and application. Many sources of uncertainty affect our results. The results must not therefore be interpreted too literally, but hopefully give a good indication of the sign and rough magnitude of the likely changes in river flood damage due to climate change. Future studies will hopefully reduce the uncertainty.
Published: 2023
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14. Cannabis vaping among high school seniors in adult-use, medical, and prohibited legal contexts

Author: Christian P Maynard and Jennifer Schwartz
Subjects: Cannabis, Marijuana, Drug policy, Legal context, Adult-use, Legalization, Medicine
Abstract: Background: Vaping cannabis among adolescents has been increasing. Monitoring the Future (MTF) indicated in 2019 that past-month cannabis vaping among 12th graders underwent the second-highest single-year jump ever tracked by MTF for any substance in its 45-year history. These increases in adolescents who vape cannabis do not parallel declining general adolescent cannabis use trends. Nevertheless, research on cannabis consumption via vaping, especially among adolescents, has been substantially limited. Method: We examined associations between legal contexts (prohibited, medical, and adult use) and vaping cannabis in the past year among high school seniors. In addition, associations between vaping cannabis and factors such as availability and acceptability were examined using secondary data from MTF (2020), with a sub-sample size of 556 participants (overall sample size: n = 3,770), using multivariate logistic regression models. Results: We found that high school seniors in medical states had higher odds of past-year vaping cannabis, but 12th graders in adult-use states were not significantly more likely to vape cannabis than those in prohibited states. Increased availability of vaping products and decreased risk perceptions in medical states may explain this relationship. Adolescents who perceived high risks associated with regular cannabis use had decreased odds of vaping cannabis. High school seniors reporting very easy access to cannabis cartridges had increased odds of vaping cannabis, regardless of legal context. Conclusion: These results contribute knowledge about contextual factors related to adolescent cannabis vaping, a relatively new technique of cannabis consumption for which there is growing societal concern.
Published: 2023
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15. Reducing broiler breast myopathies through supplementation of guanidinoacetic acid in broiler diets

Author: C.J. Maynard, D.S. Nelson, S.J. Rochell, and C.M. Owens
Subjects: guanidinoacetic acid, broiler, woody breast, white striping, performance, Animal culture, SF1-1100, Food processing and manufacture, TP368-456
Abstract: SUMMARY: Performance and processing advantages have been noted in meat animal production when excess arginine is available in the diet. In addition, dietary inclusion of guanidinoacetic acid (GAA) has provided insight on sparing arginine for broiler chickens. Therefore, a study was conducted to assess dietary inclusion of GAA on broiler breast myopathy prevalence. Dietary treatments were established using a control basal diet fed over four feeding phases and treatments were allocated as an additional supplementation of 0.06% (GAA 0.06) and 0.12% (GAA 0.12) in the form of CreAMINO (Alzchem Group, Trostberg, Germany). Bi-weekly BW, body weight gain (BWG), feed intake (FI), and mortality corrected FCR were calculated throughout growing phase. Broilers were processed to determine part yields, with breast and tenders being scored for myopathies. Both GAA treatments improved FCR (P < 0.05) compared to the control diet at 55 d. No differences (P > 0.05) were observed for BW or BWG throughout the growout period. At day of processing, no differences were observed in yields (P > 0.05). For woody breast (WB) and woody-like tender (WT), the control produced higher mean scores (P < 0.05) when compared to GAA 0.12. For white striping (WS), the control and GAA 0.06 expressed higher mean scores (P < 0.05) than GAA 0.12. No differences were observed in tender feathering (TF; P > 0.05). The results of this experiment indicate that GAA supplementation in broiler diets may be an effective tool for improving meat quality by reducing myopathy severity, without negatively affecting growth performance.
Published: 2023
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16. Complementary and alternative medicine use among adults with eczema: A population-based study

Author: Sabrina Khan, BS, Caterina Zagona-Prizio, BS, Danielle Yee, MD, Rasika Reddy, BA, Manan Mehta, BS, Nicole Maynard, BS, Samiya Khan, BS, and April W. Armstrong, MD, MPH
Subjects: alternative medicine, atopic dermatitis, CAM, complementary alternative medicine, complementary medicine, Eczema National Health Interview Survey, Dermatology, RL1-803
Published: 2022
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17. Induction of Bdnf from promoter I following electroconvulsive seizures contributes to structural plasticity in neurons of the piriform cortex

Author: Anthony D. Ramnauth, Kristen R. Maynard, Alisha S. Kardian, BaDoi N. Phan, Madhavi Tippani, Sumita Rajpurohit, John W. Hobbs, Stephanie Cerceo Page, Andrew E. Jaffe, and Keri Martinowich
Subjects: Electroconvulsive therapy, Electroconvulsive seizures, BDNF, Plasticity, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Background: Electroconvulsive therapy (ECT) efficacy is hypothesized to depend on induction of molecular and cellular events that trigger neuronal plasticity. Investigating how electroconvulsive seizures (ECS) impact plasticity in animal models can help inform our understanding of basic mechanisms by which ECT relieves symptoms of depression. ECS-induced plasticity is associated with differential expression of unique isoforms encoding the neurotrophin, brain-derived neurotrophic factor (BDNF). Hypothesis: We hypothesized that cells expressing the Bdnf exon 1-containing isoform are important for ECS-induced structural plasticity in the piriform cortex, a highly epileptogenic region that is responsive to ECS. Methods: We selectively labeled Bdnf exon 1-expressing neurons in mouse piriform cortex using Cre recombinase dependent on GFP technology (CRE-DOG). We then quantified changes in dendrite morphology and density of Bdnf exon 1-expressing neurons. Results: Loss of promoter I-derived BDNF caused changes in spine density and morphology in Bdnf exon 1-expressing neurons following ECS. Conclusions: Promoter I-derived Bdnf is required for ECS-induced dendritic structural plasticity in Bdnf exon 1-expressing neurons.
Published: 2022
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18. Enhancing research and collaboration in forensic science: A primer on human subjects’ research protection

Author: Michael A. Marciano, Ashley Hall, Ashraf Mozayani, Tracy Cromp, and Henry P. Maynard, III
Subjects: Criminal law and procedure, K5000-5582
Published: 2023
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19. Advancing Research Within the Forensic Science Community: An Update from the ASCLD Forensic Research Committee

Author: Henry Maynard
Subjects: Criminal law and procedure, K5000-5582
Published: 2023
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20. The strategies of private higher educational institutions during the Covid-19 pandemic. A review of literature

Author: Mauricio Maynard do Lago, Elton Fernandes, and Raphael Cunha Barboza
Subjects: Covid-19, Strategy, Private university, Sustainable management, History of scholarship and learning. The humanities, AZ20-999, Social sciences (General), H1-99
Abstract: This paper sought a qualitative/quantitative bibliometric approach, using the literature review, to present the main strategies with a bias toward sustainability, used by private Higher Education Institutions, in an attempt to neutralize the effects of the lockdown caused by the Covid-19 pandemic. To meet the reliability requirements of the source of the papers used, a search was made in the Web of Science and Scopus databases, where 47 papers were selected. As a result, there was a scattering of strategic actions in several works. However, no actions were identified that orientated to deliberate planning, as a way of confrontation with the new environment that was quickly established, caused by the Covid-19 pandemic. Instead, we found fragmented or emerging strategic actions, mostly concentrated on Teaching activities as a possible response, given the circumstances, to a situation that presented itself as an emergency. This study divides the actions identified in the strategic areas of the Institutions into Teaching, Research, Extension, Business Management, and Teacher Training.
Published: 2023
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21. Humanizing dehumanization research

Author: Jonathan Leader Maynard and Aliza Luft
Subjects: Dehumanization, Violence, Atrocity, Extremism, Ideology, Identity, Psychology, BF1-990
Abstract: This essay contends that contemporary research should pay greater attention to three fundamentally human characteristics of dehumanization. First, we argue that scholars need to better consider and analyze the ideological context of dehumanization, specifically the multiple meanings that diverse cultural conceptions of the human and the dehumanized impart to dehumanizing concepts or attitudes. Second, we urge a greater emphasis on how social relationships influence dehumanization, recognizing that people are entangled in complex and intersecting social identities, relationships, and histories that affect how they respond to the dehumanizing intentions of others. Third, we argue that the institutional context of dehumanization must be investigated and theorized, as dehumanization’s effects are rarely the result of atomized individuals reacting to diffuse dehumanizing rhetoric but rather the result of collective action within more or less formal organizations. These tasks can be accomplished through increased interdisciplinarity, thereby enhancing the insights and applicability of dehumanization research to the numerous forms of conflict, brutality, and extremism that are so frequently associated with dehumanization.
Published: 2023
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22. Enhancing research and collaboration in forensic science: A primer on data sharing

Author: Michael A. Marciano and Henry P. Maynard, III
Subjects: Criminal law and procedure, K5000-5582
Published: 2023
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23. Impact of light intensity or choice of intensity on broiler performance and behavior

Author: D.J. Aldridge, C.M. Owens, C. Maynard, M.T. Kidd, and C.G. Scanes
Subjects: light intensity, production, preference, choice, Animal culture, SF1-1100, Food processing and manufacture, TP368-456
Abstract: SUMMARY: The optimal light intensities for broiler production and well-being have been investigated for some time. The use of a minimum 20 lux (lx) is mandated within the European Union (European Commission, 2000; European Union 2007). Light intensities below 20 lx are commonly used in the United States. There have been inconsistent effects of light intensities below 20 lx on broiler performance. The present study evaluated the performance of broiler chickens reared under 5, 10, and 20 lx or a choice between these intensities. The feed: gain ratio was the lowest for birds reared using 5 lx and the choice of 5, 10, and 20 lx (1.71 and 1.70) compared to 20 lx (1.81), with 10 lx being intermediate (1.74). Furthermore, there were no differences observed in carcass yield, breast yield or abdominal fat. Preference for different light intensities (5, 10, and 20 lx) was examined using a remote video system. On d 20, more birds were observed to be feeding under light intensities of 10 and 20 lx compared to 5 lx. All other (not feeding) birds preferred 20 lx on d 20. On d 31 birds feeding no longer displayed a preference while all others preferred 10 and 20 lx over 5 lx. On the final observation d 41 only those birds not feeding or drinking showed a preference for 10 lx. The results agreed with past studies in demonstrating the change of preference for light intensity. The use of choice lighting environments was able to provide the desired light intensity of broilers at a young age while maintaining production parameters of those reared using low intensity (5 lx).
Published: 2022
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24. Spirulina platensis meal inclusion effects on broilers fed a reduced protein diet

Author: G.J. Mullenix, C.J. Maynard, C.M. Owens, S.J. Rochell, W.G. Bottje, R.D. Brister, and M.T. Kidd
Subjects: broilers, algae, low crude protein, performance, processing, Animal culture, SF1-1100, Food processing and manufacture, TP368-456
Abstract: SUMMARY: Apart from soybean meal, alternative sources of protein are a long-term concern facing commercial broiler producers. These alternative protein sources must be rich in protein, have a balanced amino acid profile, be highly digestible, be nutritionally safe for the bird, and ideally contain some other intrinsic value. Spirulina platensis is a microalgae that is growing in popularity due to its high protein level, health benefits, and environmental impact. Two experiments (in female and male Ross 708 broilers) were conducted to determine the effect of Spirulina inclusion in reduced crude protein diets on broiler growth, carcass yields, breast fillet color, breast myopathy, and footpad quality. The results showed that lowering crude protein impaired carcass yield in both experiments, while hindering growth performance more in male birds than female birds. Spirulina inclusion at 10% in a reduced protein diet improved footpad score in male broilers and increased meat and skin pigmentation in all birds. The inclusion of Spirulina into a commercial setting will always be driven by costs, but this study aids in expanding fundamental research to make that possible.
Published: 2022
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25. Methods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors

Author: Neil G. Rumachik, Stacy A. Malaker, Nicole Poweleit, Lucy H. Maynard, Christopher M. Adams, Ryan D. Leib, Giana Cirolia, Dennis Thomas, Susan Stamnes, Kathleen Holt, Patrick Sinn, Andrew P. May, and Nicole K. Paulk
Subjects: AAV, adeno-associated virus, PTM, post-translational modification, potency, methylation, Genetics, QH426-470, Cytology, QH573-671
Abstract: Different approaches are used in the production of recombinant adeno-associated virus (rAAV). The two leading approaches are transiently transfected human HEK293 cells and live baculovirus infection of Spodoptera frugiperda (Sf9) insect cells. Unexplained differences in vector performance have been seen clinically and preclinically. Thus, we performed a controlled comparative production analysis varying only the host cell species but maintaining all other parameters. We characterized differences with multiple analytical approaches: proteomic profiling by mass spectrometry, isoelectric focusing, cryo-EM (transmission electron cryomicroscopy), denaturation assays, genomic and epigenomic sequencing of packaged genomes, human cytokine profiling, and functional transduction assessments in vitro and in vivo, including in humanized liver mice. Using these approaches, we have made two major discoveries: (1) rAAV capsids have post-translational modifications (PTMs), including glycosylation, acetylation, phosphorylation, and methylation, and these differ between platforms; and (2) rAAV genomes are methylated during production, and these are also differentially deposited between platforms. Our data show that host cell protein impurities differ between platforms and can have their own PTMs, including potentially immunogenic N-linked glycans. Human-produced rAAVs are more potent than baculovirus-Sf9 vectors in various cell types in vitro (p < 0.05–0.0001), in various mouse tissues in vivo (p < 0.03–0.0001), and in human liver in vivo (p < 0.005). These differences may have clinical implications for rAAV receptor binding, trafficking, expression kinetics, expression durability, vector immunogenicity, as well as cost considerations.
Published: 2020
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26. Cobb 700 response to increasing lysine by growth phase

Author: L.D. Butler, C.G. Scanes, S.J. Rochell, A. Mauromoustakos, J.V. Caldas, C.A. Keen, C.W. Maynard, S.A. Bolden, R.D. Brister, P.A. Smith, R.E. Latham, C.M. Owens, and M.T. Kidd
Subjects: broiler, lysine, protein, Cobb 700, Animal culture, SF1-1100, Food processing and manufacture, TP368-456
Abstract: Summary: The Cobb MV × Cobb 700 male broiler was evaluated for BW and feed conversion ratio (FCR) when fed diets of increasing levels of digestible lysine (Lys) and ME within each growing phase (0–12 D, 12–26 D, 26–35 D, and 35–55 D). Male BW was highest (P < 0.0001) at 12 D of age for birds fed 1.24% digestible Lys and 3,194 ME vs. birds fed 1.20% digestible Lys and 3,084 ME. Male BW were also highest (P < 0.0001) at 26 D of age for birds fed 1.23% digestible Lys and 3,194 ME. However, birds were able to compensate with increased FCR (P < 0.0001) when fed diets with lower levels of digestible Lys and ME from 26 to 55 D to achieve similar BW (P > 0.05) compared with the birds on the highest level and duration of digestible Lys and ME. The control group, that is, industry standard digestible Lys and ME levels, had the lowest levels of digestible Lys and ME for the duration of the experiment and had the highest (P < 0.0001) FCR and the lowest (P < 0.0001) BW. The results for BW and FCR suggest that the digestible Lys needs are higher than previously established. More investigations within each growing phase should be performed to better define the requirements of the Cobb MV × Cobb 700 broiler for digestible Lys.
Published: 2020
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27. Effects of Dietary Amino Acid Regimens on Live Performance and Processing Characteristics of Cobb MV × 700 Male and Female Broilers

Author: C.W. Maynard, R.E. Latham, R. Brister, C.M. Owens, and S.J. Rochell
Subjects: amino acid, regimens, broiler, performance, myopathies, Animal culture, SF1-1100, Food processing and manufacture, TP368-456
Abstract: SUMMARY: The magnitude and timing of broiler responses to dietary amino acid (AA) density can vary between sexes and among genetic lines. Two experiments (Exp) were conducted to determine the responsiveness of Cobb MV × 700 broilers to changes in dietary AA density. In Exp 1, low (L), medium (M), and high (H) AA density diets were maintained across starter and grower phases in a 28 d growth performance trial (all males). In Exp 2, combinations of L, M, and H-AA density diets were varied across 4 feeding phases to evaluate the effect of 6 AA feeding regimens (HHHH, HHHM, HHMM, HMMM, MMMM, and HHLL) on growth performance, carcass composition, and breast muscle myopathies of broilers reared sex-separately. Body weight gain, feed intake (FI), and FCR responded positively to increased AA density during the starter and grower phases (0 to 28 d) of Exp 1. In Exp 2, broiler responses to AA density from 0 to 28 d diminished by the conclusion of the finisher phase (day 35), and FCR was the only measurement influenced by dietary AA density through day 46. Carcass characteristics and breast muscle myopathies were unaffected by AA density, with the exception of fat pad percentage, which decreased with increasing AA density. These data indicate that Cobb MV × 700 broilers may be less responsive to dietary AA density than other high-yielding broiler strains and further research to establish digestible AA:Lys ratios or dietary energy concentrations that optimize responses to increased AA density are warranted.
Published: 2020
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28. The role of ibrutinib in COVID-19 hyperinflammation: A case report

Author: Suzanne Maynard, Jose Ros-Soto, Aris Chaidos, Andrew Innes, Krushika Paleja, Eitan Mirvis, Noora Buti, Harriet Sharp, Renuka Palanicawandar, and Dragana Milojkovic
Subjects: COVID-19, BTK-inhibitor, Ibrutinib, Waldenstrom macroglobulinaemia, Infectious and parasitic diseases, RC109-216
Abstract: Immune modulation in COVID-19 is emerging as an important therapeutic strategy as increasing evidence suggests that inflammatory pathways are implicated in lung damage. Bruton tyrosine kinase inhibitors (BTKi), such as ibrutinib, are commonly used to treat indolent B-cell neoplasms and chronic graft-versus-host disease (GvHD). Given their potential to suppress pulmonary inflammatory cytokines and lessen acute lung injury, this could be applicable in the context of hospitalised COVID-19 patients. We describe an 81 year-old male receiving ibrutinib for Waldenstrom macroglobulinaemia (WM) who was hospitalised with COVID-19. On stopping the BTKi due to concerns of additional immunosuppression, he required non-invasive ventilation (NIV) in the intensive care unit (ICU) and demonstrated prompt clinical recovery when ibrutinib was reinstated. Continuing ibrutinib in patients with COVID-19 may be advantageous given its immunomodulatory properties and withdrawal of ibrutinib therapy may be detrimental. Further evidence is required to explore the potential therapeutic impact of BTKis and other immunomodulatory agents on the clinical course of COVID-19 as is currently being carried out in a number of clinical trials.
Published: 2021
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29. Dying for change: A roadmap to refine the fish acute toxicity test after 40 years of applying a lethal endpoint

Author: Ioanna Katsiadaki, Tim Ellis, Linda Andersen, Philipp Antczak, Ellen Blaker, Natalie Burden, Tom Fisher, Christopher Green, Briony Labram, Audrey Pearson, Karina Petersen, Dan Pickford, Chris Ramsden, Anita Rønneseth, Kathy Ryder, Dominic Sacker, Chloe Stevens, Haruna Watanabe, Hiroshi Yamamoto, Fiona Sewell, Penny Hawkins, Hans Rufli, Richard D. Handy, Samuel K. Maynard, and Miriam N. Jacobs
Subjects: TG203, Refinement, Regulatory toxicology, Humane endpoints, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350
Abstract: The fish acute toxicity test (TG203; OECD, 2019) is frequently used and highly embedded in hazard and risk assessment globally. The test estimates the concentration of a chemical that kills 50% of the fish (LC50) over a 96 h exposure and is considered one of the most severe scientific procedures undertaken. Over the years, discussions at the Organisation for Economic Co-operation and Development (OECD) have resulted in changes to the test which reduce the number of fish used, as well as the development of a (potential) replacement test (TG236, OECD, 2013). However, refinement of the mortality endpoint with an earlier (moribundity) endpoint was not considered feasible during the Test Guideline’s (TG) last update in 2019. Several stakeholders met at a UK-based workshop to discuss how TG203 can be refined, and identified two key opportunities to reduce fish suffering: (1) application of clinical signs that predict mortality and (2) shortening the test duration. However, several aspects need to be addressed before these refinements can be adopted. TG203 has required recording of major categories of sublethal clinical signs since its conception, with the option to record more detailed signs introduced in the 2019 update. However, in the absence of guidance, differences in identification, recording and reporting of clinical signs between technicians and laboratories is likely to have generated piecemeal data of varying quality. Harmonisation of reporting templates, and training in clinical sign recognition and recording are needed to standardise clinical sign data. This is critical to enable robust data-driven detection of clinical signs that predict mortality. Discussions suggested that the 96 h duration of TG203 cannot stand up to scientific scrutiny. Feedback and data from UK contract research organisations (CROs) conducting the test were that a substantial proportion of mortalities occur in the first 24 h. Refinement of TG203 by shortening the test duration would reduce suffering (and test failure rate) but requires a mechanism to correct new results to previous 96 h LC50 data. The actions needed to implement both refinement opportunities are summarised here within a roadmap. A shift in regulatory assessment, where the 96 h LC50 is a familiar base for decisions, will also be critical.
Published: 2021
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30. Meat quality traits and Blunt Meullenet-Owens Razor Shear characteristics of broiler breast fillets affected by woody breast condition and post-cooking meat temperature

Author: Xiao Sun, Aline Giampietro-Ganeco, Ashleigh Mueller, Clay J. Maynard, Juan P. Caldas-Cueva, and Casey M. Owens
Subjects: woody breast, meat quality, cooking time, shear analysis, shear temperature, Animal culture, SF1-1100
Abstract: ABSTRACT: This study aimed to investigate meat quality attributes, cooking performance, and water properties of woody breast (WB). A total of 48 broiler breast fillets (7 wk, 3 h debone) of 24 normal (NORM) and 24 severe WB (SEV) were collected. Raw meat characteristics (L*, a*, b*, pH, compression force and energy and) along with the blunt blade of the Meullenet-Owens razor shear (BMORS) properties were determined. Cooking time and internal meat temperature were recorded for each fillet every 5 min on each fillet during cooking. Water/moisture properties and shear values of BMORS were determined at different meat temperatures (HOT [68°C], AMBIENT [22°C] and COLD [4°C]) after cooking. SEV fillets showed higher L*, a*, b*, pH, CF, CE, BMORS force, BMORS energy, and peak counts of BMORS values compared to NORM fillets in raw state (P < 0.05). Cooking time was shorter in SEV fillets than NORM fillets (P < 0.0001). Cook loss, total water loss, and moisture loss (HOT, AMBIENT) were greater in SEV fillets than NORM fillets (P < 0.01). PC-BMORS were greater in SEV fillets than NORM fillets (P < 0.05), and all BMORS shear values increased as post-cooking meat temperature decreased (P < 0.05). Positive correlations were observed between WB scores and raw meat characteristics and shear values. There were also significant relationships (P < 0.001) between WB scores and cooking performance measures except moisture loss for COLD treatment. BMORS force and energy were moderately correlated to total water loss, cook loss, and moisture loss (HOT) regardless of meat temperature (P < 0.05); however, PC-BMORS was only correlated to total water loss at COLD and moisture loss (HOT) at all meat temperatures (P < 0.05). These data corroborate the association of WB condition with impaired quality/texture characteristics in raw and cooked fillets; WB also had a significant impact on cooking time, cooking at a faster rate, along with water/moisture loss during and after thermal processing. Results demonstrate that the post-cooking meat temperature plays an important role in shear test values.
Published: 2021
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31. Applied Research Note: Development of a novel low flow water monitoring system in poultry/agriculture systems

Author: J.Z. Hiltz, S.K. Orlowski, L.N. Harrington, C.W. Maynard, T.W. Tabler, and N.B. Anthony
Subjects: broiler, water intake, water conversion ratio, nutrition, Animal culture, SF1-1100, Food processing and manufacture, TP368-456
Abstract: Summary: Water scarcity is a global reality and with the anticipated population growth, freshwater resources will be further strained to meet both human and agriculture applications. To ensure a water sustainable and food secure future, all aspects of agriculture must become more efficient. Two strategies were explored. The first strategy was to develop a more efficient and accurate method for measuring water consumption/inputs in agriculture. To date, water measuring technology has lacked the necessary sophistication to assure accuracy and repeatability of low flow water usage. The second strategy utilized the improved water measuring technology, to develop water-efficient genetics in agricultural populations (i.e., row crops, avian and mammalian species) and evaluate nutrition-related associations. Although this low flow water monitoring system has applications in many agriculture/research fields, the current research focuses on measuring water consumption in the commercial broiler.
Published: 2021
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32. Open data from the first and second observing runs of Advanced LIGO and Advanced Virgo

Author: Rich Abbott, Thomas D. Abbott, Sheelu Abraham, Fausto Acernese, Kendall Ackley, Carl Adams, Rana X. Adhikari, Vaishali B. Adya, Christoph Affeldt, Michalis Agathos, Kazuhiro Agatsuma, Nancy Aggarwal, Odylio D. Aguiar, Amit Aich, Lorenzo Aiello, Anirban Ain, Ajith Parameswaran, Gabrielle Allen, Annalisa Allocca, Paul A. Altin, Alex Amato, Shreya Anand, Alena Ananyeva, Stuart B. Anderson, Warren G. Anderson, Svetoslava V. Angelova, Stefano Ansoldi, Sarah Antier, Stephen Appert, Koji Arai, Melody C. Araya, Joseph S. Areeda, Marc Arène, Nicolas Arnaud, Scott M. Aronson, Kg G. Arun, Stefano Ascenzi, Gregory Ashton, Stuart M. Aston, Pia Astone, Florian Aubin, Peter Aufmuth, Kellie AultONeal, Corey Austin, Valerie Avendano, Stanislav Babak, Philippe Bacon, Francesca Badaracco, Maria K.M. Bader, Sangwook Bae, Anne M. Baer, Jonathon Baird, Francesca Baldaccini, Giulio Ballardin, Stefan W. Ballmer, Anna-marie Bals, Alexander Balsamo, Gregory Baltus, Sharan Banagiri, Deepak Bankar, Rameshwar S. Bankar, Juan C. Barayoga, Claudio Barbieri, Barry C. Barish, David Barker, Kevin Barkett, Pablo Barneo, Fabrizio Barone, Bryan Barr, Lisa Barsotti, Matteo Barsuglia, Daniel Barta, Jeffrey Bartlett, Imre Bartos, Riccardo Bassiri, Andrea Basti, Mateusz Bawaj, Joseph C. Bayley, Marco Bazzan, Bence Bécsy, Michal Bejger, Imene Belahcene, Angus S. Bell, Deeksha Beniwal, Michael G. Benjamin, Joe D. Bentley, Fabio Bergamin, Beverly K. Berger, Gerald Bergmann, Sebastiano Bernuzzi, Christopher P.L. Berry, Diego Bersanetti, Alessandro Bertolini, Joseph Betzwieser, Rohan Bhandare, Ankit V. Bhandari, Jeffrey Bidler, Edward Biggs, Igor A. Bilenko, Garilynn Billingsley, Ross Birney, Ofek Birnholtz, Sebastien Biscans, Matteo Bischi, Sylvia Biscoveanu, Aparna Bisht, Guldauren Bissenbayeva, Massimiliano Bitossi, Marieanne A. Bizouard, Kent K. Blackburn, Jonathan Blackman, Carl D. Blair, David G. Blair, Ryan M. Blair, Fabrizio Bobba, Nina Bode, Michel Boer, Yannick Boetzel, Gilles Bogaert, Francois Bondu, Edgard Bonilla, Romain Bonnand, Phillip Booker, Boris A. Boom, Rolf Bork, Valerio Boschi, Sukanta Bose, Vladimir Bossilkov, Joel Bosveld, Yann Bouffanais, Antonella Bozzi, Carlo Bradaschia, Patrick R. Brady, Alyssa Bramley, Marica Branchesi, Jim E. Brau, Matteo Breschi, Tristan Briant, Joseph H. Briggs, Francesco Brighenti, Alain Brillet, Marc Brinkmann, Patrick Brockill, Aidan F. Brooks, Jonathan Brooks, Daniel D. Brown, Sharon Brunett, Giacomo Bruno, Robert Bruntz, Aaron Buikema, Tomasz Bulik, Henk J. Bulten, Alessandra Buonanno, Damir Buskulic, Robert L. Byer, Miriam Cabero, Laura Cadonati, Giampietro Cagnoli, Craig Cahillane, Juan Calderón Bustillo, Jack D. Callaghan, Thomas A. Callister, Enrico Calloni, Jordan B. Camp, Maurizio Canepa, Kipp C. Cannon, Huy-tuong Cao, Junwei Cao, Giovanni Carapella, Franco Carbognani, Santiago Caride, Matthew F. Carney, Gregorio Carullo, Julia Casanueva Diaz, Claudio Casentini, Javier Castañeda, Sarah Caudill, Marco Cavaglià, Fabien Cavalier, Roberto Cavalieri, Giancarlo Cella, Pablo Cerdá-Durán, Elisabetta Cesarini, Oualid Chaibi, Kabir Chakravarti, Chiwai Chan, Manleong Chan, Shiuh Chao, Philip Charlton, Eve A. Chase, Eric Chassande-Mottin, Deep Chatterjee, Mayank Chaturvedi, Hsin-yu Y. Chen, Xu Chen, Yanbei Chen, Hai-ping Cheng, Chi-kit K. Cheong, Hanyu Y. Chia, Francesco Chiadini, Roberto Chierici, Andrea Chincarini, Antonino Chiummo, Gihyuk Cho, Heesuk S. Cho, Min-a Cho, Nelson Christensen, Qi Chu, Sheon Chua, Ka-wai W. Chung, Shinkee Chung, Giacomo Ciani, Pawel Ciecielag, Marek Cieślar, Alexei A. Ciobanu, Riccardo Ciolfi, Francesco Cipriano, Alessio Cirone, Filiberto Clara, James A. Clark, Patrick Clearwater, Sebastien Clesse, Frederic Cleva, Eugenio Coccia, Pierre-francois Cohadon, David Cohen, Marta Colleoni, Christophe G. Collette, Christopher Collins, Monica Colpi, Marcio Constancio Jr., Livia Conti, Sam J. Cooper, Paul Corban, Thomas R. Corbitt, Isabel Cordero-Carrión, Silvia Corezzi, Kenneth R. Corley, Neil Cornish, David Corre, Alessandra Corsi, Stefano Cortese, Cesar A. Costa, Roberto Cotesta, Michael W. Coughlin, Scott B. Coughlin, Jeanpierre Coulon, Stefan T. Countryman, Peter Couvares, Pep B. Covas, David M. Coward, Matthew J. Cowart, Dennis C. Coyne, Robert Coyne, Jolien D. E. Creighton, Teviet D. Creighton, Jonathan Cripe, Michael Croquette, Sgwynne G. Crowder, Jean-rene Cudell, Torrey J. Cullen, Alan Cumming, Rebecca Cummings, Liam Cunningham, Elena Cuoco, Malgorzata Curylo, Tito Dal Canton, Gergely Dálya, Aykutlu Dana, Lara M. Daneshgaran-Bajastani, Beatrice D’Angelo, Stefan L. Danilishin, Sabrina D’Antonio, Karsten Danzmann, Christian Darsow-Fromm, Arnab Dasgupta, Laurence E. H. Datrier, Vincenzo Dattilo, Ishant Dave, Michel Davier, Gareth S. Davies, Derek Davis, Edward J. Daw, Dan DeBra, Malathi Deenadayalan, Jerome Degallaix, Martina De Laurentis, Samuel Deléglise, Matthew Delfavero, Nicola De Lillo, Walter Del Pozzo, Lindsay M. DeMarchi, Virginia D’Emilio, Nicholas Demos, Thomas Dent, Roberto De Pietri, Rosario De Rosa, Camilla De Rossi, Riccardo DeSalvo, Omar de Varona, Sanjeev Dhurandhar, Mario C. Díaz, Mauricio Diaz-Ortiz Jr., Tim Dietrich, Luciano Di Fiore, Chiara Di Fronzo, Cinzia Di Giorgio, Fabrizio Di Giovanni, Matteo Di Giovanni, Tristano Di Girolamo, Alberto Di Lieto, Binlei Ding, Sibilla Di Pace, Irene Di Palma, Francesco Di Renzo, Atul K. Divakarla, Artemiy Dmitriev, Zoheyr Doctor, Fred Donovan, Katherine L. Dooley, Suresh Doravari, Iain Dorrington, Thomas P. Downes, Marco Drago, Jenne C. Driggers, Zhihui Du, Jean-gregoire Ducoin, Peter Dupej, Ofelia Durante, Domenico D’Urso, Sheila E. Dwyer, Paul J. Easter, Graeme Eddolls, Bruce Edelman, Tega B. Edo, Oliver Edy, Anamaria Effler, Phil Ehrens, Johannes Eichholz, Stephen S. Eikenberry, Marc Eisenmann, Robert A. Eisenstein, Aldo Ejlli, Lucianolucianikerrico Errico, Reed C. Essick, Hector Estelles, Dimitri Estevez, Zachariah B. Etienne, Todd Etzel, Matthew Evans, Tom M. Evans, Rebecca E. Ewing, Viviana Fafone, Stephen Fairhurst, Xilong Fan, Stefania Farinon, Benjamin Farr, Will M. Farr, Edward J. Fauchon-Jones, Marc Favata, Maxime Fays, Mariana Fazio, Jon Feicht, Martin M. Fejer, Fangchen Feng, Edit Fenyvesi, Deborah L. Ferguson, Alvaro Fernandez-Galiana, Isidoro Ferrante, Elvis C. Ferreira, Tabata A. Ferreira, Francesco Fidecaro, Irene Fiori, Donatella Fiorucci, Maya Fishbach, Ryan P. Fisher, Rosalba Fittipaldi, Margot Fitz-Axen, Vincenzo Fiumara, Raffaele Flaminio, Erik Floden, Eric Flynn, Heather Fong, Antonio A. Font, Perry Forsyth, Jean-daniel Fournier, Sergio Frasca, Franco Frasconi, Zsolt Frei, Andreas Freise, Raymond Frey, Valentin Frey, Peter Fritschel, Valery V. Frolov, Gabriele Fronzè, Paul Fulda, Michael Fyffe, Hunter A. Gabbard, Bhooshan U. Gadre, Sebastian M. Gaebel, Jonathan R. Gair, Shanika Galaudage, Dhruva Ganapathy, Sharad G. Gaonkar, Cecilio García-Quirós, Fabio Garufi, Bubba Gateley, Sergio Gaudio, Gayathri Gayathri, Gianluca Gemme, Eric Genin, Alberto Gennai, Daniel George, Jogy George, Laszlo Gergely, Sudarshan Ghonge, Abhirup Ghosh, Archisman Ghosh, Shaon Ghosh, Bruno Giacomazzo, Joe A. Giaime, Dwayne D. Giardina, Des R. Gibson, Chalisa Gier, Kiranjyot Gill, Jane Glanzer, Jan Gniesmer, Patrick Godwin, Evan Goetz, Ryan Goetz, Niklas Gohlke, Boris Goncharov, Gabriela González, Gopakumar Gopakumar, Sarah E. Gossan, Matthieu Gosselin, Romain Gouaty, Benjamin Grace, Aniello Grado, Massimo Granata, Alastair Grant, Slawomir Gras, Philippe Grassia, Corey Gray, Rachel Gray, Giuseppe Greco, Anna C. Green, Rhys Green, Elizabeth M. Gretarsson, Hannah L. Griggs, G. Grignani, Andrea Grimaldi, Stefan J. Grimm, Hartmut Grote, Steffen Grunewald, Pierre Gruning, Gianluca M. Guidi, Andre R. Guimaraes, Gerard Guixé, Hitesh K. Gulati, Yuefan Guo, Anuradha Gupta, Anchal Gupta, Pawan Gupta, Eric K. Gustafson, Dick Gustafson, Leila Haegel, Odysse Halim, Evan D. Hall, Eleanor Z. Hamilton, Giles Hammond, Maria Haney, Manuela M. Hanke, Jonathan Hanks, Chad Hanna, Mark D. Hannam, Otto A. Hannuksela, Travis J. Hansen, Joe Hanson, Thomas Harder, Terra Hardwick, Haris Haris, Jan Harms, Gregg M. Harry, Ian W. Harry, Raine K. Hasskew, Carl-johan Haster, Karen Haughian, Fergus J. Hayes, James Healy, Antoine Heidmann, Matthew C. Heintze, Joscha Heinze, Henrich Heitmann, Frances Hellman, Patrice Hello, Gary Hemming, Martin Hendry, Siong S. Heng, Eric Hennes, Jan-simon Hennig, Michele Heurs, Stefan Hild, Tanja Hinderer, Sarah Y. Hoback, Sven Hochheim, Elyssa Hofgard, David Hofman, Aaron M. Holgado, Nathan A. Holland, Kathy Holt, Daniel E. Holz, Paul Hopkins, Christian Horst, James Hough, Eric J. Howell, Charlie G. Hoy, Yiwen Huang, Moritz T. Hübner, Eliu A. Huerta, Dominique Huet, Brennan Hughey, Victor Hui, Sascha Husa, Sabina H. Huttner, Rachael Huxford, Tien Huynh-Dinh, Bartosz Idzkowski, Alberto Iess, Henri Inchauspe, Craig Ingram, Giuseppe Intini, Jean M. Isac, Max Isi, Bala R. Iyer, Thibaut Jacqmin, Sameer J. Jadhav, Shreejit P. Jadhav, Alasdair L. James, Karan Jani, Nagaraj N. Janthalur, Piotr Jaranowski, Deep Jariwala, Rafel Jaume, Alex C. Jenkins, Jun Jiang, Grace R. Johns, Aaron W. Jones, Ian I. Jones, Jeff D. Jones, Philip Jones, Russell Jones, Reinier J. G. Jonker, Ju Ju, Jonas Junker, Chinmay V. Kalaghatgi, Vassiliki Kalogera, Brittany Kamai, Shivaraj Kandhasamy, Gungwon Kang, Jonah B. Kanner, Shasvath J. Kapadia, Sudarshan Karki, Rahul Kashyap, Marie Kasprzack, Wolfgang Kastaun, Stavros Katsanevas, Erik Katsavounidis, William Katzman, Steffen Kaufer, Keita Kawabe, Fabien Kéfélian, David Keitel, Azadeh Keivani, Ross Kennedy, Joey S. Key, Sudiksha Khadka, Farit Y. Khalili, Imran Khan, Sebastian Khan, Zaki A. Khan, Efim A. Khazanov, Nandita Khetan, Mohammad Khursheed, Nutsinee Kijbunchoo, Chunglee Kim, Grace J. Kim, Jeongcho C. Kim, Kyungmin Kim, Won Kim, Whansun S. Kim, Young-min Kim, Charles Kimball, Peter J. King, Maya Kinley-Hanlon, Robin Kirchhoff, Jeffrey S. Kissel, Lisa Kleybolte, Sergei Klimenko, Tyler D. Knowles, Philip Koch, Sina M. Koehlenbeck, Gideon Koekoek, Soumen Koley, Veronica Kondrashov, Antonios Kontos, Nico Koper, Mikhail Korobko, William Z. Korth, Manoj Kovalam, Dan B. Kozak, Volker Kringel, Nv V. Krishnendu, Andrzej Królak, Natalie Krupinski, Gerrit Kuehn, Anil Kumar, Prayush Kumar, Rahul Kumar, Rakesh Kumar, Sumit Kumar, Ling-chi Kuo, Adam Kutynia, Benjamin D. Lackey, Danny Laghi, Emile Lalande, Lam L. Lam, Astrid Lamberts, Michael Landry, Benjamin B. Lane, Ryan N. Lang, Jacob Lange, Brian Lantz, Robert K. Lanza, Iuri La Rosa, Angelique Lartaux-Vollard, Paul D. Lasky, Michael Laxen, Albert Lazzarini, Claudia Lazzaro, Paola Leaci, Sean Leavey, Yannick K. Lecoeuche, Chang-hwan H. Lee, Hyung-mok M. Lee, Hyungwon W. Lee, Joongoo Lee, Kyung-ha Lee, Johannes Lehmann, Nicolas Leroy, Nicolas Letendre, Yuri Levin, Alvin K. Y. Li, Jin Li, Kaye li, Tjonnie G. F. Li, Xiang Li, Frank Linde, Seth D. Linker, Jethro N. Linley, Tyson B. Littenberg, Liu Liu, Xiaoshu Liu, Miquel Llorens-Monteagudo, Ka-lok Lo, Alexandra Lockwood, Lionel T. London, Alessandro Longo, Matteo Lorenzini, Vincent Loriette, Marc Lormand, Giovanni Losurdo, James D. Lough, Carlos O. Lousto, Geoffrey Lovelace, Harald Lück, Diana Lumaca, Andrew P. Lundgren, Ma Yiqiu, Ronaldas Macas, Sean Macfoy, Myron MacInnis, Duncan M. Macleod, Ian O. MacMillan, Adrian Macquet, Ignacio Magaña Hernandez, Fabian Magaña-Sandoval, Ryan M. Magee, Ettore Majorana, Ivan Maksimovic, Asmita Malik, Catherine Man, Vuk Mandic, Valentina Mangano, Georgia L. Mansell, Michael Manske, Maddalena Mantovani, Michela Mapelli, Fabio Marchesoni, Frederique Marion, Szabolcs Márka, Zsuzsanna Márka, Charalampos Markakis, Ashot S. Markosyan, Aaron Markowitz, Ed Maros, Antonio Marquina, Sylvain Marsat, Filippo Martelli, Ian W. Martin, Rodica M. Martin, Valerie Martinez, Denis V. Martynov, Hossein Masalehdan, Ken Mason, Elena Massera, Alain Masserot, Thomas J. Massinger, Mariela Masso-Reid, Simone Mastrogiovanni, Andrew Matas, Fabrice Matichard, Nergis Mavalvala, Emily Maynard, Joshua J. McCann, Richard McCarthy, David E. McClelland, Scott McCormick, Lee McCuller, Stephen C. McGuire, Connor McIsaac, Jessica McIver, David J. McManus, Terry McRae, Sean T. McWilliams, Duncan Meacher, Grant D. Meadors, Moritz Mehmet, Ajit K. Mehta, Elena Mejuto Villa, Andrew Melatos, Gregory Mendell, Adam A. Mercer, Lorenzo Mereni, Kara Merfeld, Edmond L. Merilh, Jonathan D. Merritt, Mourad Merzougui, Syd Meshkov, Chris Messenger, Cody Messick, Remi Metzdorff, Patrick M. Meyers, Fabian Meylahn, Ashish Mhaske, Andrea Miani, Haixing Miao, Ioannis Michaloliakos, Christophe Michel, Hannah Middleton, Leopoldo Milano, Andrewlawrence L. Miller, Meg Millhouse, Joseph C. Mills, Edoardo Milotti, Michael C. Milovich-Goff, Olivier Minazzoli, Yuri Minenkov, Alec Mishkin, Chandra Mishra, Timesh Mistry, Sanjit Mitra, Valery P. Mitrofanov, Guenakh Mitselmakher, Richard Mittleman, Geoffrey Mo, Kentaro Mogushi, Satyanarayan R. P. Mohapatra, Siddharth R. Mohite, Manel Molina-Ruiz, Marina Mondin, Matteo Montani, Christopher J. Moore, Dan Moraru, Filip Morawski, Gerardo Moreno, Soichiro Morisaki, Benoit Mours, Conor M. Mow-Lowry, Simone Mozzon, Federico Muciaccia, Arunava Mukherjee, Debnandini Mukherjee, Soma Mukherjee, Subroto Mukherjee, Nikhil Mukund, Adam Mullavey, Jesper Munch, Erik A. Muñiz, Peter G. Murray, Alessandro Nagar, Ilaria Nardecchia, Luca Naticchioni, Rajesh K. Nayak, Benjamin F. Neil, Joshua Neilson, Gijs Nelemans, Timothy J. N. Nelson, Marina Nery, Ansel Neunzert, Kwan-yeung Y. Ng, Sebastian Ng, Catherine Nguyen, Philippe Nguyen, David Nichols, Shania A. Nichols, Samaya Nissanke, Flavio Nocera, Minkyun Noh, Chris North, Devon Nothard, Laura K. Nuttall, Jason Oberling, Brendan D. O’Brien, Gor Oganesyan, Greg H. Ogin, John J. Oh, Sanghoon H. Oh, Frank Ohme, Hiroaki Ohta, Marcos A. Okada, Miquel Oliver, Christian Olivetto, Patrick Oppermann, Richard Oram, Brian O’Reilly, Rich G. Ormiston, Luis F. Ortega, Richard O’Shaughnessy, Serguei Ossokine, Charles Osthelder, David J. Ottaway, Harry Overmier, Ben J. Owen, Alexander E. Pace, Giulia Pagano, Michael A. Page, Giulia Pagliaroli, Archana Pai, Siddhesh A. Pai, Jordan R. Palamos, Oleg Palashov, Cristiano Palomba, Howard Pan, Pratap K. Panda, Tsun-ho Pang, Chris Pankow, Francesco Pannarale, Brijesh C. Pant, Federico Paoletti, Andrea Paoli, Abhishek Parida, William Parker, Daniela Pascucci, Antonio Pasqualetti, Roberto Passaquieti, Diego Passuello, Barbara Patricelli, Ethan Payne, Brynley L. Pearlstone, Thida C. Pechsiri, Ari J. Pedersen, Mike Pedraza, Arnaud Pele, Steven Penn, Albino Perego, Carlos J. Perez, Perigois Périgois, Antonio Perreca, Stephane Perriès, Jan Petermann, Harald P. Pfeiffer, Margot Phelps, Khun S. Phukon, Ornella J. Piccinni, Mikhael Pichot, Marco Piendibene, Francesco Piergiovanni, Vincenzo Pierro, Gabriel Pillant, Laurent Pinard, Innocenzo M. Pinto, Krzysztof Piotrzkowski, Marc Pirello, Matthew Pitkin, Wolfango Plastino, Rosa Poggiani, Yat-tung T. Pong, Sarah Ponrathnam, Pasquale Popolizio, Ed K. Porter, Jade Powell, Atul K. Prajapati, Kiran Prasai, Raghurama Prasanna, Geraint Pratten, Tanner Prestegard, Maria Principe, Giovanni A. Prodi, Leonid Prokhorov, Michele Punturo, Paola Puppo, Michael Pürrer, Hong Qi, Volker Quetschke, Pedro J. Quinonez, Fred J. Raab, Geert Raaijmakers, Hugh Radkins, Nicholas Radulesco, Peter Raffai, Hanna Rafferty, Sendhil Raja, Rajan Rajan, Binod Rajbhandari, Malik Rakhmanov, Karla E. Ramirez, Antoni Ramos-Buades, Javed Rana, Kaushik Rao, Piero Rapagnani, Vivien Raymond, Massimiliano Razzano, Jocelyn Read, Tania Regimbau, Luca Rei, Stuart Reid, David H. Reitze, Piero Rettegno, Fulvio Ricci, Colter J. Richardson, Jonathan W. Richardson, Paul M. Ricker, Gunnar Riemenschneider, Keith Riles, Monica Rizzo, Norna A. Robertson, Florent Robinet, Alessio Rocchi, Ramon D. Rodriguez-Soto, Loic Rolland, Jameson G. Rollins, Vincent J. Roma, Marco Romanelli, Rocco Romano, Chandra L. Romel, Isobel M. Romero-Shaw, Janeen H. Romie, Caitlin A. Rose, Dakota Rose, Kyle Rose, Dorota Rosińska, Shawn G. Rosofsky, Michael P. Ross, Sheila Rowan, Samuel J. Rowlinson, Palash K. Roy, Santosh Roy, Soumen Roy, Paolo Ruggi, Guntis Rutins, Kyle Ryan, Surabhi Sachdev, Travis Sadecki, Mairi Sakellariadou, Om S. Salafia, Livio Salconi, Muhammed Saleem, Anuradha Samajdar, Eduardo J. Sanchez, Luis E. Sanchez, Nicolas Sanchis-Gual, Jaclyn R. Sanders, Kevin A. Santiago, Edison Santos, Nikhil Sarin, Benoit Sassolas, B S. Sathyaprakash, Orion Sauter, Richard L. Savage, Vaibhav Savant, Disha Sawant, Sihem Sayah, Dean Schaetzl, Paul Schale, Mark Scheel, Jacob Scheuer, Patricia Schmidt, Roman Schnabel, Robert M. S. Schofield, Axel Schönbeck, Emil Schreiber, Bernd W. Schulte, Bernard F. Schutz, Otto Schwarm, Eyal Schwartz, Jamie Scott, Susan M. Scott, Ed Seidel, Danny Sellers, Anand S. Sengupta, Noah Sennett, Daniel Sentenac, Valeria Sequino, Alexander Sergeev, Yoshinta Setyawati, Daniel A. Shaddock, Thomas Shaffer, Selim S. Shahriar, A. Sharma, Priyanka Sharma, Peter Shawhan, Hongyu Shen, Minori Shikauchi, Rosalie Shink, David H. Shoemaker, Deirdre M. Shoemaker, Keerti Shukla, Shyamsundar ShyamSundar, Karelle Siellez, Magdalena Sieniawska, Daniel Sigg, Leo P. Singer, Divya Singh, Neha Singh, Ayatri Singha, Akshat Singhal, Alicia M. Sintes, Valeria Sipala, Vasileios Skliris, Bram J. J. Slagmolen, Teresa J. Slaven-Blair, Jiri Smetana, Joshua R. Smith, Rory J. E. Smith, Surendranadh Somala, Edwin J. Son, Siddharth Soni, Borja Sorazu, Viola Sordini, Fiodor Sorrentino, Tarun Souradeep, Eric Sowell, Andrew P. Spencer, Mario Spera, Amit K. Srivastava, Varun Srivastava, Kai Staats, Cosmin Stachie, Mark Standke, Daniele A. Steer, Michael Steinke, Jessica Steinlechner, Sebastian Steinlechner, Daniel Steinmeyer, Dane Stocks, David J. Stops, Madeline Stover, Ken A. Strain, Giulia Stratta, Amber Strunk, Riccardo Sturani, Amber L. Stuver, Sudhagar Sudhagar, Vivishek Sudhir, Tiffany Z. Summerscales, Ling Sun, Sunil Sunil, Ankan Sur, Jishnu Suresh, Patrick J. Sutton, Bas L. Swinkels, Marek J. Szczepańczyk, Matteo Tacca, Simon C. Tait, Colm Talbot, Andres J. Tanasijczuk, David B. Tanner, Duo Tao, Marton Tápai, Amauri Tapia, Enzo N. Tapia San Martin, Jay D. Tasson, Robert Taylor, Rodrigo Tenorio, Lukas Terkowski, Manasadevi P. Thirugnanasambandam, Michael Thomas, Patrick Thomas, Jonathan E. Thompson, Sivananda R. Thondapu, Keith A. Thorne, Eric Thrane, Calley L. Tinsman, Saravanan R. Saravanan, Shubhanshu Tiwari, Srishti Tiwari, Vaibhav Tiwari, Karl Toland, Mauro Tonelli, Zeno Tornasi, Alejandro Torres-Forné, Calum I. Torrie, Iara Tosta e Melo, Daniel Töyrä, Emily A. Trail, Flavio Travasso, Gary Traylor, Maria C. Tringali, Aashish Tripathee, Agata Trovato, Randy J. Trudeau, Ka-wa W. Tsang, Maggie Tse, Rhondale Tso, Leo Tsukada, Daichi Tsuna, Takuya Tsutsui, Margherita Turconi, Amit S. Ubhi, Koh Ueno, Dennis Ugolini, Cs S. Unnikrishnan, Alexander L. Urban, Samantha A. Usman, Andrei C. Utina, Henning Vahlbruch, Gabriele Vajente, Guillermo Valdes, Michele Valentini, M. Vallisneri, Niels van Bakel, Martin van Beuzekom, Jo F. J. van den Brand, Chris Van Den Broeck, Daniel C. Vander-Hyde, Laura van der Schaaf, Joris V. Van Heijningen, Marielle A. van Veggel, Marco Vardaro, Vijay Varma, Steve Vass, Matyas Vasúth, Alberto Vecchio, Gabriele Vedovato, John Veitch, Peter J. Veitch, Krishna Venkateswara, Gautam Venugopalan, Didier Verkindt, Doga Veske, Flavio Vetrano, Andrea Viceré, Aaron D. Viets, Serena Vinciguerra, David J. Vine, Jeanyves Vinet, Salvatore Vitale, Francisco Hernandez Vivanco, Thomas Vo, Helios Vocca, Cheryl Vorvick, Sergey P. Vyatchanin, Andrew R. Wade, Leslie E. Wade, Madeline Wade, Rob Walet, Marissa Walker, Gavin S. Wallace, Larry Wallace, Sinead Walsh, Jonathan Z. Wang, Sibo Wang, Wenhui H. Wang, Yifan F. Wang, Robert L. Ward, Zane A. Warden, Jim Warner, Michal Was, Jennifer Watchi, Betsy Weaver, Li-wei Wei, Michael Weinert, Alan J. Weinstein, Rainer Weiss, Felix Wellmann, Linqing Wen, Peter Weßels, Jonathan W. Westhouse, Karl Wette, John T. Whelan, Bernard F. Whiting, Chris Whittle, Dennis M. Wilken, Daniel Williams, Roy D. Williams, Andrew R. Williamson, Joshua L. Willis, Benno Willke, Walter Winkler, Christopher C. Wipf, Holger Wittel, Graham Woan, Janis Woehler, Jared K. Wofford, Chun-fung Wong, Jennifer L. Wright, David S. Wu, Daniel M. Wysocki, Liting Xiao, Hiro Yamamoto, Le Yang, Yang Yang, Ziyan Yang, Min-jet J. Yap, Maher Yazback, David W. Yeeles, Hang Yu, Haocun Yu, Shingheirobin Yuen, Adam K. Zadrożny, Adam Zadrożny, Michele Zanolin, Tatiana Zelenova, Jean-pierre Zendri, Michael Zevin, Jue Zhang, Liyuan Zhang, Teng Zhang, Chunnong Zhao, Guoying Zhao, Minchuan Zhou, Zifan Zhou, Xingjiang J. Zhu, Aaron B. Zimmerman, Michael E. Zucker, and John Zweizig
Subjects: GWOSC, Scientific databases, Data representation and management, Gravitational Waves, Computer software, QA76.75-76.765
Abstract: Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and second observing runs. The main data products are gravitational-wave strain time series sampled at 16384 Hz. The datasets that include this strain measurement can be freely accessed through the Gravitational Wave Open Science Center at http://gw-openscience.org, together with data-quality information essential for the analysis of LIGO and Virgo data, documentation, tutorials, and supporting software.
Published: 2021
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33. Which men should undergo non-targeted systematic sampling in an mpMRI-targeted pathway – an analysis from 1,719 pre-biopsy mpMRI cases?

Author: M.J. Connor, D. Eldred-Evans, F. Hosking-Jervis, E. Bass, D. Reddy, M. Bertoncelli Tanaka, H. Bhola-Stewart, W. Maynard, C. Khoo, T.T. Shah, J. Lee, D. Sri, L. Powell, S. Ahmad, M. Noureldin, S. Joshi, E. Pegers, K. Wong, H. Tam, D. Hrouda, M. Winkler, S. Gordon, H. Qazi, and H.U. Ahmed
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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34. The impact of total motile sperm count on IVF/ICSI outcomes: Is total motile sperm count a better parameter than sperm morphology?

Author: T. Tharakan, D. Dodia, T Attra, M. Smith, L. Vyas, W. Maynard, T. Bracewell-Milnes, M. Thum, T. Yap, C. Jayasena, J. Ramsay, and S. Minhas
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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35. Indeterminate mpMRI lesions: Evaluating the optimal PSA density threshold for prostate biopsy

Author: D.T. Reddy, D. Eldred-Evans, M.J. Connor, F. Hosking-Jervis, M. Bertoncelli-Tanaka, H. Bhola-Stewart, W. Maynard, C. Khoo, T.T. Shah, E. Bass, J. Lee, D. Sri, L. Powell, S. Ahmad, M. Noureldin, S. Joshi, E. Pegers, K. Wong, H. Tam, D. Hrouda, M. Winkler, S. Gordon, H. Qazi, and H.U. Ahmed
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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36. The RAPID risk model: A novel risk score to predict significant prostate cancer in men with an mpMRI lesion

Author: D. Eldred-Evans, M. Peters, M. Bertoncelli Tanaka, F. Hosking-Jervis, M.J Connor, D. Reddy, T.T Shah, C. Khoo, W. Maynard, E. Bass, J. Lee, D. Sri, H. Bhola-Stewart, L. Powell, S. Ahmad, S. Joshi, E. Pegers, K. Wong, H. Tam, D. Hrouda, M. Winkler, H. Qazi, S. Gordon, and H.U Ahmed
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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37. A contemporary analysis of radical orchidectomy for testis cancer

Author: C.C. Khoo, A. Scott, M. Peters, W. Maynard, G. Chamberlain, P. Fooks, D. Hrouda, and S. Minhas
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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38. Man vs machine: Comparative effectiveness of cognitive targeted and image-fusion targeted transperineal prostate biopsy

Author: C.C. Khoo, D. Eldred-Evans, M. Peters, F. Hosking-Jervis, M.J. Connor, D. Reddy, M. Bertoncelli Tanaka, H. Bhola-Stewart, W. Maynard, E. Bass, T.T. Shah, J. Lee, D. Sri, L. Powell, S. Ahmad, M. Noureldin, S. Joshi, E. Pegers, K. Wong, H. Tam, D. Hrouda, M. Winkler, S. Gordon, H. Qazi, and H.U. Ahmed
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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39. Direct and marginal cost analysis of not aiming for the target in a MRI-targeted prostate biopsy pathway

Author: M.J. Connor, D. Eldred-Evans, F. Hosking-Jervis, E. Bass, D. Reddy, M. Bertoncelli Tanaka, H. Bhola-Stewart, C. Khoo, W. Maynard, T.T. Shah, J. Lee, D. Sri, L. Powell, S. Ahmad, S. Joshi, E. Pegers, W. Kathie, H. Tam, D. Hrouda, M. Winkler, S. Gordon, H. Qazi, J. Carton, and H.U. Ahmed
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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40. Local anaesthetic transperineal prostate biopsy: Optimising patient selection

Author: W. Maynard, D. Eldred-Evans, M. Connor, D. Reddy, M. Bertoncelli Tanaka, H. Bhola-Stewart, C. Khoo, E. Bass, T. Shah, J. Lee, D. Sri, L. Powell, S. Ahmad, M. Noureldin, S. Joshi, E. Pegers, K. Wong, H. Tam, D. Hrouda, M. Winkler, S. Gordon, H. Qazi, and H. Ahmed
Subjects: Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Published: 2020
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41. Nitrite elicits divergent NO-dependent signaling that associates with outcome in out of hospital cardiac arrest

Author: Dario A. Vitturi, Charles Maynard, Michele Olsufka, Adam C. Straub, Nick Krehel, Peter J. Kudenchuk, Graham Nichol, Michael Sayre, Francis Kim, and Cameron Dezfulian
Subjects: Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract: Brain and heart injury cause most out-of-hospital cardiac arrest deaths but limited pharmacotherapy exists to protect these tissues. Nitrite is a nitric oxide precursor that is protective in pre-clinical models of ischemic injury and safe in Phase I testing. Protection may occur by cGMP generation via the sGC pathway or through S-nitrosothiol and nitrated conjugated linoleic acid (NO2-CLA) formation. We hypothesized that nitrite provided during CPR signals through multiple pathways and that activation of signals is associated with OHCA outcome. To this end, we performed a secondary analysis of a phase 1 study of intravenous nitrite administration during resuscitation in adult out-of-hospital cardiac arrest. Associations between whole blood nitrite and derived plasma signals (cGMP and NO2-CLA) with patient characteristics and outcomes were defined using Chi-square or t-tests and multiple logistic regression. Whole blood nitrite levels correlated inversely with plasma NO2-CLA (p = 0.039) but not with cGMP. Patients with shockable rhythms had higher cGMP (p = 0.027), NO2-CLA (p
Published: 2020
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42. Midlife mortality in White non-Hispanic male veterans enrolled in Department of Veterans Affairs primary care, 2003–2014

Author: Chuan-Fen Liu, Paul Hebert, Edwin S. Wong, Karin Nelson, and Charles Maynard
Subjects: Epidemiology, Health sciences, Internal medicine, Clinical research, Social sciences, Sociology, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Background: After years of decline in mortality rates in the United States, there have been increases in mortality rates in White non-Hispanic Americans ages 45–54, due to increases in deaths from suicide, poisoning, and alcoholic liver disease. Objectives: To determine whether White non-Hispanic middle age male Veterans enrolled in Department of Veterans Affairs (VA) primary care had increased mortality, as found in the general population. Research design: Repeated cross-sectional analysis over 12 years to describe trends in death rates for men across 3 race/ethnicity groups (White non-Hispanic, Black non-Hispanic, Hispanic) and 2 age groups (45–54, 55–64) for the Veteran and general US male populations. Subjects: 60 million patient-years for Veterans enrolled in VA primary care from 2003 to 2014 and 1.8 million who died during the study period. Measures: All-cause and cause specific death rates for alcoholic liver disease, poisoning, and suicide. Results: For White non-Hispanic male Veterans ages 55–64, the increase in all-cause mortality from 2003 to 2014 (+309 deaths/100,000) was accompanied by significant changes in deaths due to poisoning (+30/100,000), alcoholic liver disease (+23/100,000), and suicide (+17/100,000). For US men ages 55–64, all-cause mortality decreased slightly from 2003-2014 (-22 deaths/100,000). However, there were increases in death rates due to poisoning (+17/100,000), alcoholic liver disease (+14/100,000) and suicide (+11/100,000). Conclusions: These disturbing findings for White non-Hispanic Veteran men ages 55–64 suggest the critical importance of suicide prevention programs as well as the importance of high quality integrated health care for both Veteran and non-Veteran men.
Published: 2020
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43. Ecosystem‐based translation of health research: expanding frameworks for environmental health

Author: Rosemary McFarlane, Colin David Butler, Simone Maynard, Steve Cork, and Phillip Weinstein
Subjects: Public aspects of medicine, RA1-1270
Published: 2018
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44. Exploring childhood obesity prevention among diverse ethnic groups in schools and places of worship: Recruitment, acceptability and feasibility of data collection and intervention components

Author: Maria Maynard, Graham Baker, and Seeromanie Harding
Subjects: Ethnicity, Intervention, Obesity, Child, Diet, Physical activity, Medicine
Abstract: Small-scale, detailed exploration of the recruitment, assessment, and evaluation processes of obesity intervention among minority ethnic children. The study took place in schools and places of worship during 2008–2010 in London, UK. Measures included 3-day food diaries, 24 h dietary recalls, the Youth Physical Activity Questionnaire, accelerometry, and diet and physical activity self-efficacy questionnaires. Potential intervention components were evaluated via observation, questionnaires, and focus group discussions. Schools and places of worship that reflected the ethnic and religious diversity of inner city London populations (Hindus, Muslims and Christians) were targeted. Telephone invitations to 12 schools achieved recruitment of five schools (42% response); 181 invitations to 94 places of worship, recruited eight organisations (9%). Multi-strategy approaches were required to build relationships with faith organisations. Sixty-five children aged 8–13 years participated in the testing of measures. High completion rates were achieved for 24 h recalls, diet and PA self-efficacy questionnaires (ranging from 89% to 100%), with more consistent quality in schools. Dietary assessment highlighted inadequacies in composition data for minority ethnic foods. Intervention sessions were tested among 155 children in all five schools, and 33 children in a church, temple and mosque. Evaluation coverage was more consistent in these places of worship than in schools. Schools may logistically be more straightforward settings for delivery of interventions but, despite complex issues (engagement strategies; cultural foodways), places of worship provide opportunities for effective reach of children, families and communities. We suggest community based participatory research between researchers, schools and community organisations to harness culturally-specific support.
Published: 2017
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45. The air pollution pendulum begins to swing, again

Author: R.L. Maynard
Subjects: Environmental sciences, GE1-350, Urban groups. The city. Urban sociology, HT101-395
Published: 2019
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46. Sodium sulfide selectively induces oxidative stress, DNA damage, and mitochondrial dysfunction and radiosensitizes glioblastoma (GBM) cells.

Author: Adam Y. Xiao, Matthew R. Maynard, Cortt G. Piett, Zachary D. Nagel, J. Steven Alexander, Christopher G. Kevil, Michael V. Berridge, Christopher B. Pattillo, Lane R. Rosen, Sumitra Miriyala, and Lynn Harrison
Subjects: Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract: Glioblastoma (GBM) has a poor prognosis despite intensive treatment with surgery and chemoradiotherapy. Previous studies using dose-escalated radiotherapy have demonstrated improved survival; however, increased rates of radionecrosis have limited its use. Development of radiosensitizers could improve patient outcome. In the present study, we report the use of sodium sulfide (Na2S), a hydrogen sulfide (H2S) donor, to selectively kill GBM cells (T98G and U87) while sparing normal human cerebral microvascular endothelial cells (hCMEC/D3). Na2S also decreased mitochondrial respiration, increased oxidative stress and induced γH2AX foci and oxidative base damage in GBM cells. Since Na2S did not significantly alter T98G capacity to perform non-homologous end-joining or base excision repair, it is possible that GBM cell killing could be attributed to increased damage induction due to enhanced reactive oxygen species production. Interestingly, Na2S enhanced mitochondrial respiration, produced a more reducing environment and did not induce high levels of DNA damage in hCMEC/D3. Taken together, this data suggests involvement of mitochondrial respiration in Na2S toxicity in GBM cells. The fact that survival of LN-18 GBM cells lacking mitochondrial DNA (ρ0) was not altered by Na2S whereas the survival of LN-18 ρ+ cells was compromised supports this conclusion. When cells were treated with Na2S and photon or proton radiation, GBM cell killing was enhanced, which opens the possibility of H2S being a radiosensitizer. Therefore, this study provides the first evidence that H2S donors could be used in GBM therapy to potentiate radiation-induced killing. Keywords: Hydrogen sulfide, Glioblastoma, Ionizing radiation, DNA damage, DNA repair, Mitochondria, Reactive oxygen species
Published: 2019
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47. Characteristics of younger women Veterans with service connected disabilities

Author: Charles Maynard, Karin Nelson, and Stephan D. Fihn
Subjects: Public health, Science (General), Q1-390, Social sciences (General), H1-99
Abstract: Objectives: There has been an increase in the number of women Veterans with service connected disabilities, which are illnesses or injuries incurred or aggravated during military service. We compared military service and disability characteristics in women and men ≤50 years of age. Methods: This study included 4,029,672 living Veterans who had at least 1 service connected condition and an active award status as of October 1, 2016. The date of last award as well as demographic, military service, and disability characteristics were obtained from the Veterans Benefits Administration (VBA) VETSNET file. Results: Among 388,947 women Veterans with service connected conditions, almost 60% (n = 231,364) were ≤50 years of age. Roughly 55% of both women and men ≤50 years had a ≥50% combined rating, although there were differences with respect to individual service connected conditions. Women less often had service connected post traumatic stress disorder (23% vs 32%), but more often had major depression (15% vs 7%). While traumatic brain disease was more common in men, migraine headache was much more common in women (32% vs 18%). Less than half had a VA outpatient visit in the previous year. Conclusions: The findings of significant numbers of younger women with service connected PTSD, depression, or migraine headache should be considered within the context of post deployment health. These findings raise questions regarding outreach to women Veterans who have these conditions, but do not use VA health care.
Published: 2019
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48. Calculating the mean time to capture for tethered ligands and its effect on the chemical equilibrium of bound ligand pairs

Author: Lu Shen, Caitlin G. Decker, Heather D. Maynard, and Alex J. Levine
Subjects: Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390
Abstract: We present here the calculation of the mean time to capture of a tethered ligand to the receptor. This calculation is then used to determine the shift in the partitioning between (1) free, (2) singly bound, and (3) doubly bound ligands in chemical equilibrium as a function of the length of the tether. These calculations are used in the research article Fibroblast Growth Factor 2 Dimer with Superagonist in vitro Activity Improves Granulation Tissue Formation During Wound Healing (Decker et al., in press [1]) to explain quantitatively how changes in polymeric linker length in the ligand dimers modifies the efficacy of these molecules relative to that of free ligands. Keywords: Ligand binding
Published: 2016
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49. Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

Author: Evelyne Beerling, Daniëlle Seinstra, Elzo de Wit, Lennart Kester, Daphne van der Velden, Carrie Maynard, Ronny Schäfer, Paul van Diest, Emile Voest, Alexander van Oudenaarden, Nienke Vrisekoop, and Jacco van Rheenen
Subjects: cancer, epithelial-to-mesenchymal transition (EMT), intravital microscopy, Biology (General), QH301-705.5
Abstract: Forced overexpression and/or downregulation of proteins regulating epithelial-to-mesenchymal transition (EMT) has been reported to alter metastasis by changing migration and stem cell capacity of tumor cells. However, these manipulations artificially keep cells in fixed states, while in vivo cells may adapt transient and reversible states. Here, we have tested the existence and role of epithelial-mesenchymal plasticity in metastasis of mammary tumors without artificially modifying EMT regulators. In these tumors, we found by intravital microscopy that the motile tumor cells have undergone EMT, while their epithelial counterparts were not migratory. Moreover, we found that epithelial-mesenchymal plasticity renders any EMT-induced stemness differences, as reported previously, irrelevant for metastatic outgrowth, because mesenchymal cells that arrive at secondary sites convert to the epithelial state within one or two divisions, thereby obtaining the same stem cell potential as their arrived epithelial counterparts. We conclude that epithelial-mesenchymal plasticity supports migration but additionally eliminates stemness-enhanced metastatic outgrowth differences.
Published: 2016
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50. Noninvasive skin fluorescence spectroscopy for detection of abnormal glucose tolerance

Author: Edward L. Hull, PhD, Nathaniel I. Matter, PhD, Byron P. Olson, PhD, Marwood N. Ediger, PhD, Andrea J. Magee, MS, Jeff F. Way, MS, Kay E. Vugrin, PhD, and John D. Maynard, MS
Subjects: Abnormal glucose tolerance, Diabetes screening, Fluorescence, Noninvasive, Scout DS, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: The ENGINE study evaluated noninvasive skin fluorescence spectroscopy (SFS) for detection of abnormal glucose tolerance (AGT). The AGT detection performance of SFS was compared to fasting plasma glucose (FPG) and hemoglobin A1C (A1C). The study was a head-to-head comparison of SFS to FPG and A1C in an at-risk population of 507 subjects, with no prior diagnosis of diabetes, each of whom received a 75 g, two-hour oral glucose tolerance test (OGTT). Subjects were measured by SFS on multiple days in fasting and non-fasting states. SFS data were acquired and analyzed with the SCOUT DS® device (VeraLight, Albuquerque, NM, USA). Disease truth was AGT, defined as OGTT ≥ 7.8 mmol/L. Sensitivity, false positive rate (FPR), ROC area, and equal error rate (EER) for detection of AGT were computed. The reproducibility of SFS and FPG was assessed. The AGT sensitivity of SFS at the device's recommended screening threshold of 50 was 75.2%, higher than that of FPG (thresholds of 5.6 mmol/L or 6.1 mmol/L) and A1C (thresholds of 5.7% or 6.0%). The SFS FPR was 42.1%, comparable to an A1C threshold of 5.7% (FPR = 43.5%). The EERs of SFS, FPG and A1C were similar, as were the partial ROC areas for FPRs of 20–50%. The reproducibility of SFS was 7.7% versus 8.1% for FPG. SFS had similar AGT detection performance to FPG and A1C and is a viable alternative to screening individuals for AGT.
Published: 2014
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