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6 results on '"Marlene Fischer"'

1. Personalised blood pressure management during major noncardiac surgery and postoperative neurocognitive disorders: a randomised trial

Author

Julia Y. Nicklas, Alina Bergholz, Francesco Däke, Hanh H.D. Pham, Marie-Christin Rabe, Hanna Schlichting, Sophia Skrovanek, Moritz Flick, Karim Kouz, Marlene Fischer, Cynthia Olotu, Jakob R. Izbicki, Oliver Mann, Margit Fisch, Barbara Schmalfeldt, Karl-Heinz Frosch, Thomas Renné, Linda Krause, Christian Zöllner, and Bernd Saugel

Subjects
anaesthesia, cardiovascular dynamics, haemodynamic monitoring, individualised, morbidity, mortality, Anesthesiology, RD78.3-87.3
Abstract

Background: It remains unknown whether there is a causal relationship between intraoperative hypotension and postoperative neurocognitive disorders. We tested the hypothesis that personalised—compared to routine—intraoperative blood pressure management reduces the incidence of postoperative neurocognitive disorders in patients having major noncardiac surgery. Methods: In this single-centre trial, 328 elective major noncardiac surgery patients were randomly allocated to receive personalised blood pressure management (i.e. maintaining intraoperative mean arterial pressure [MAP] above preoperative baseline MAP from automated 24-h blood pressure monitoring) or routine blood pressure management (i.e. maintaining MAP above 65 mm Hg). The primary outcome was the incidence of neurocognitive disorders (composite of delayed neurocognitive recovery and delirium) between postoperative days 3 and 7. Results: The primary outcome, neurocognitive disorders, occurred in 18 of 147 patients (12%) assigned to personalised and 21 of 148 patients (14%) assigned to routine blood pressure management (odds ratio [OR]=0.84, 95% confidence interval [CI]: 0.40–1.75, P=0.622). Delayed neurocognitive recovery occurred in 17 of 146 patients (12%) assigned to personalised and 17 of 145 patients (12%) assigned to routine blood pressure management (OR=0.99, 95% CI: 0.45–2.17, P=0.983). Delirium occurred in 2 of 157 patients (1%) assigned to personalised and 4 of 158 patients (3%) assigned to routine blood pressure management (OR=0.50, 95% CI: 0.04–3.53, P=0.684). Conclusions: Personalised intraoperative blood pressure management maintaining preoperative baseline MAP neither reduced the incidence of the composite primary outcome neurocognitive disorders between postoperative days 3 and 7 nor the incidences of the components of the composite primary outcome—delayed neurocognitive recovery and delirium—compared to routine blood pressure management in patients having major noncardiac surgery. Clinical trial registration: ClinicalTrials.gov (NCT03442907).

Published
2024
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2. Comparative analysis of characteristics and outcomes in hospitalized COVID-19 patients infected with different SARS-CoV-2 variants between January 2020 and April 2022 – A retrospective single-center cohort study

Author

Thomas Theo Brehm, Andreas Heyer, Marcel S. Woo, Marlene Fischer, Marc van der Meirschen, Dominic Wichmann, Dominik Jarczak, Kevin Roedl, Stefan Schmiedel, Marylyn M. Addo, Marc Lütgehetmann, Martin Christner, Samuel Huber, Ansgar W. Lohse, Stefan Kluge, and Julian Schulze zur Wiesch

Subjects
SARS-CoV-2, COVID-19, Alpha variant, Delta variant, Omicron variant, Mortality, Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270
Abstract

Background: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, the roll-out of vaccines and therapeutic agents, as well as the emergence of novel SARS-CoV-2 variants, have shown significant effects on disease severity. Methods: Patients hospitalized at our center between January 2020 and April 2022 were attributed to subgroups depending on which SARS-CoV-2 variant was predominantly circulating in Germany: (i) Wild-type: January 1, 2020, to March 7, 2021, (ii) Alpha variant: August 3, 2021, to June 27, 2021, (iii) Delta variant: June 28, 2021, to December 26, 2021, and (iv) Omicron variant: December 27, 2021, to April 30, 2022. Results: Between January 2020 and April 2022, 1500 patients with SARS-CoV-2 infections were admitted to the University Medical Center Hamburg-Eppendorf. The rate of patients who were admitted to the intensive care unit (ICU) decreased from 31.2% (n = 223) in the wild-type group, 28.5% (n = 72) in the Alpha variant group, 18.8% (n = 67) in the Delta variant group, and 13.4% (n = 135) in the Omicron variant group. Also, in-hospital mortality decreased from 20.6% (n = 111) in the wild-type group, 17.5% (n = 30) in the Alpha variant group, 16.8% (n = 33) in the Delta variant group, and 6.6% (n = 39) in the Omicron variant group. The median duration of hospitalization was similar in all subgroups and ranged between 11 and 15 days throughout the pandemic. Conclusions: In-hospital mortality and rate of ICU admission among hospitalized COVID-19 patients steadily decreased throughout the pandemic. However, the practically unchanged duration of hospitalization demonstrates the persistent burden of COVID-19 on the healthcare system.

Published
2023
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4. Contributors

Author

Harold P. Adams, Opeolu Adeoye, Gregory W. Albers, Andrei V. Alexandrov, Sepideh Amin-Hanjani, Hongyu An, Craig S. Anderson, Josef Anrather, Hugo J. Aparicio, Ken Arai, Jaroslaw Aronowski, Kunakorn Atchaneeyasakul, Heinrich Audebert, Roland N. Auer, Issam A. Awad, Hakan Ay, Selva Baltan, Ramani Balu, Mandana Behbahani, Oscar R. Benavente, Eric M. Bershad, Jimmy V. Berthaud, Spiros L. Blackburn, Leo H. Bonati, Julian Bösel, Marie Germaine Bousser, Joseph P. Broderick, Martin M. Brown, Wendy Brown, John C.M. Brust, Cheryl Bushnell, Patrícia Canhão, Louis R. Caplan, Julián Carrión-Penagos, Mar Castellanos, Michelle R. Caunca, Hugues Chabriat, Angel Chamorro, Jieli Chen, Jun Chen, Michael Chopp, Greg Christorforids, E. Sander Connolly, Steven C. Cramer, Brett L. Cucchiara, Alexandra L. Czap, Mark J. Dannenbaum, Patricia H. Davis, Ted M. Dawson, Valina L. Dawson, Arthur L. Day, T. Michael De Silva, Diana Aguiar de Sousa, Victor J. Del Brutto, Gregory J. del Zoppo, Colin P. Derdeyn, Marco R. Di Tullio, Hans Christoph Diener, Michael N. Diringer, Bruce H. Dobkin, Imanuel Dzialowski, Mitchell S.V. Elkind, Jordan Elm, Valery L. Feigin, José Manuel Ferro, Thalia S. Field, Marlene Fischer, Myriam Fornage, Karen L. Furie, Lidia Garcia-Bonilla, Steven L. Giannotta, Y. Pierre Gobin, Mark P. Goldberg, Larry B. Goldstein, Nicole R. Gonzales, David M. Greer, James C. Grotta, Ruiming Guo, Jose Gutierrez, Peter Harmel, George Howard, Virginia J. Howard, Jee-Yeon Hwang, Costantino Iadecola, Reza Jahan, Glen C. Jickling, Anne Joutel, Scott E. Kasner, Mira Katan, Christopher P. Kellner, Muhib Khan, Chelsea S. Kidwell, Helen Kim, Jong S. Kim, Charles E. Kircher, Timo Krings, Rita V. Krishnamurthi, Tobias Kurth, Maarten G. Lansberg, Elad I. Levy, David S. Liebeskind, Sook-Lei Liew, David J. Lin, Benjamin Lisle, Eng H. Lo, Patrick D. Lyden, Takakuni Maki, Georgios A. Maragkos, Miklos Marosfoi, Louise D. McCullough, Jason M. Meckler, James Frederick Meschia, Steven R. Messé, J Mocco, Maxim Mokin, Michael A. Mooney, Lewis B. Morgenstern, Michael A. Moskowitz, Michael T. Mullen, Steffen Nägel, Maiken Nedergaard, Justin A. Neira, Sarah Newman, Patrick J. Nicholson, Bo Norrving, Martin O’Donnell, Dimitry Ofengeim, Jun Ogata, Christopher S. Ogilvy, Emanuele Orrù, Santiago Ortega-Gutiérrez, Matthew Maximillian Padrick, Kaushik Parsha, Mark Parsons, Neil V. Patel, Virendra I. Patel, Ludmila Pawlikowska, Adriana Pérez, Miguel A. Perez-Pinzon, John M. Picard, Sean P. Polster, William J. Powers, Volker Puetz, Jukka Putaala, Margarita Rabinovich, Bruce R. Ransom, Jorge A. Roa, Gary A. Rosenberg, Christina P. Rossitto, Tatjana Rundek, Jonathan J. Russin, Ralph L. Sacco, Apostolos Safouris, Edgar A. Samaniego, Lauren H. Sansing, Nikunj Satani, Ronald J. Sattenberg, Jeffrey L. Saver, Sean I. Savitz, Christian Schmidt, Sudha Seshadri, Vijay K. Sharma, Frank R. Sharp, Kevin N. Sheth, Omar K. Siddiqi, Aneesh B. Singhal, Christopher G. Sobey, Clemens J. Sommer, Robert F. Spetzler, Christopher J. Stapleton, Ben A. Strickland, Hua Su, José I. Suarez, Hiroo Takayama, Joseph Tarsia, Turgut Tatlisumak, Ajith J. Thomas, John W. Thompson, Georgios Tsivgoulis, Elizabeth Tournier-Lasserve, Gabriel Vidal, Ajay K. Wakhloo, Babette B. Weksler, Joshua Z. Willey, Max Wintermark, Lawrence K.S. Wong, Guohua Xi, Jinchong Xu, Shadi Yaghi, Takenori Yamaguchi, Tuo Yang, Masahiro Yasaka, Darin B. Zahuranec, Feng Zhang, John H. Zhang, Zhitong Zheng, R. Suzanne Zukin, and Richard M. Zweifler

Published
2022
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5. Thallium sorption and speciation in soils: Role of micaceous clay minerals and manganese oxides

Author

Silvan Wick, Bart Baeyens, Michael Plötze, Numa Pfenninger, Maria Marques Fernandes, Andreas Voegelin, Jörg Göttlicher, and Marlene Fischer

Subjects
Technology, 010504 meteorology & atmospheric sciences, chemistry.chemical_element, Manganese, engineering.material, 010502 geochemistry & geophysics, 01 natural sciences, complex mixtures, Soil, Adsorption, Geochemistry and Petrology, Leaching (agriculture), Thallium, 0105 earth and related environmental sciences, Topsoil, Minerals, Manganese oxides, Sorption, chemistry, Environmental chemistry, Soil water, Illite, engineering, Clay, Clay minerals, ddc:600
Abstract

Sorption processes control the solubility of toxic thallium (Tl) in soils and thereby its potential leaching into groundwater or uptake by plants. Micaceous clay minerals and Mn oxides are considered to be key sorbents for Tl in soils. We studied the sorption and speciation of Tl in 36 geogenically Tl-rich topsoil materials from the Swiss Jura Mountains by combining chem-ical extractions, isotope exchange experiments, adsorption experiments, X-ray absorption spectroscopy (XAS), and sorption modelling. We demonstrate that the relation between exchangeable and soluble Tl determined in batch extractions of soils with only geogenic and with freshly spiked Tl matches adsorption isotherms of freshly spiked Tl, and that this relation can be described with a published 3-site cation exchange model for Tl adsorption onto illite. Complemented with XAS data, the results show that micaceous clay minerals control the short-term solubility of Tl via cation exchange, but also the long-term sequestration of most geogenic soil Tl (>90%) via structural fixation. Adsorption competition with K+ and NH4+ at the frayed edges of micaceous clay minerals greatly affects Tl solubility. Increases in the dissolved concentrations of K and NH4 in soil pore water may therefore lead to the release of Tl into solution. The fractions of geogenic Tl associated with Mn oxides were about half as high as the fractions of exchangeable Tl. This Mn-associated Tl is not readily mobilized by cation exchange, but could be released during periodic water logging and soil reduction. In (periodically) reducing environments, the potential of Mn oxides for long-term Tl sequestration is therefore limited. In conclusion, the results from this study high-light the importance of micaceous clay minerals for Tl cycling in soils and sediments, and suggest that concepts developed to assess the sorption of (radio)caesium onto micaceous clay minerals in soils and sediments are transferable to Tl., Geochimica et Cosmochimica Acta, 288, ISSN:0016-7037, ISSN:1872-9533

Published
2020

6. Comparison of cognitive function after robot-assisted prostatectomy and open retropubic radical prostatectomy: A prospective observational single-center study

Author

Pierre Tennstedt, Alexander Haese, F. Von Breunig, Marlene Fischer, Christian Zöllner, L. Zins, Sophie Knipper, Stefanie Beck, C. Holthusen, Markus Graefen, and Cornelius Rademacher

Subjects
medicine.medical_specialty, business.industry, Urology, Cognition, Robot assisted prostatectomy, Single Center, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, medicine, Retropubic radical prostatectomy, Observational study, business
Published
2020

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