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6 results on '"Mark T. Langhans"'

1. Stem Cell Therapy for Musculoskeletal Diseases

Author

Benjamin B. Rothrauff, Hang Lin, Rocky S. Tuan, Alessandro Pirosa, Mark T. Langhans, and Jihee Sohn

Subjects
business.industry, medicine.medical_treatment, Intervertebral disc, Stem-cell therapy, Meniscus (anatomy), musculoskeletal system, Bioinformatics, Regenerative medicine, Bench to bedside, Tendon, medicine.anatomical_structure, medicine, Ligament, Stem cell, business
Abstract

Musculoskeletal disorders constitute a substantial disease burden. Neither conservative management nor surgical intervention provides adequate treatment for several pathologies. As an element of regenerative medicine, stem cell therapies may overcome the poor innate healing capacity of several musculoskeletal tissues. This review highlights promising results of preclinical studies in which stem cell therapies have been applied to individual tissues of the musculoskeletal system (bone, articular cartilage, tendon and ligament, meniscus, intervertebral disc, and skeletal muscle) as well as transitions between tissues (osteochondral interfaces and tendon–bone interfaces). Clinical studies, although limited in number, are also reviewed. Challenges to the translation of stem cell therapies from bench to bedside are discussed and possible solutions are highlighted.

Published
2019
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2. Contributors

Author

Rachit Agarwal, Jon D. Ahlstrom, Rafiq Ahmad, Emilio I. Alarcon, Alejandro J. Almarza, Graça Almeida-Porada, Manuel Almeida, Melissa Alvarado-Velez, James M. Anderson, Judith Arcidiacono, Anthony Atala, Stephen F. Badylak, Wayne Balkan, Brian G. Ballios, Pedro M. Baptista, M. Douglas Baumann, Supinder S. Bedi, Ravi V. Bellamkonda, Nicole M. Bergmann, Helen M. Blau, Joel D. Boerckel, Andres M. Bratt-Leal, James C. Brown, Scott Brubaker, Isabelle Brunette, Gisele A. Calderon, Arnold I. Caplan, David G. Castner, Cynthia Chang, Aditya Chawla, Xuguang Chen, Paul Cohen, Michael J. Cooke, Joshua S. Copus, Vitor M. Correlo, Charles S. Cox, Abritee Dahl, Richard M. Day, Paolo De Coppi, Mahesh C. Dodla, Jennifer H. Elisseeff, Juliet A. Emamaullee, Adam Esa, Yunlan Fang, Heather J. Faust, John P. Fisher, Matthew B. Fisher, Elvis L. Francois, Andrés J. García, Svetlana Gavrilov, Dan Gazit, Zulma Gazit, Christopher V. Gemmiti, Gregory J. Gillispie, Sarah E. Gilpin, W.T. Godbey, Andrea Gray, Ronald M. Green, May Griffith, Robert E. Guldberg, Qiongyu Guo, Geoffrey C. Gurtner, Michael C. Hacker, Issa A. Hanna, Joshua M. Hare, Konstantinos E. Hatzistergos, Ralf-Peter Herber, Jöns Hilborn, H. David Humes, Joshua G. Hunsberger, Kenjiro Iwasa, John D. Jackson, Margaret L. Jackson, Hae Lin Jang, John A. Jansen, Josephine Johnston, Carl Jorns, Huijun Kang, David L. Kaplan, David S. Kaplan, Adam J. Katz, Matthew W. Kelley, Kelsey Kennedy, Ali Khademhosseini, Gilson Khang, Jinho Kim, Rachel H. Klein, Irina Klimanskaya, Paul S. Knoepfler, In Kap Ko, Yash M. Kolambkar, Jan Krieghoff, Nathan W. Kucko, Manoj Kumar, Joanne Kurtzberg, Anna Kwilas, Donald W. Landry, Mark T. Langhans, Robert Lanza, Giacomo Lanzoni, Sang Jin Lee, Sander C.G. Leeuwenburgh, Kam W. Leong, Rui Liang, Volha Liaudanskaya, Hang Lin, Michael T. Longaker, Hermann P. Lorenz, Jeanne F. Loring, Shi-Jiang Lu, Alberto Lue, Peter X. Ma, Renata S. Magalhaes, Serena Mandla, Clement D. Marshall, Manuela Martins-Green, Devon E. Mason, Jonquil R. Mau, Richard McFarland, Melissa K. McHale, James C. Melville, Jason R. Meyers, Antonios G. Mikos, Jordan S. Miller, Paul A. Mittermiller, Hideki Miyachi, Shinka Miyamoto, Nelson Monteiro, Alessandra L. Moore, Sara Morini, Philipp T. Moser, Vivek J. Mukhatyar, Mark Murdock, Aaron Nagiel, Gail K. Naughton, Allison Nauta, Javier Navarro, Jared M. Newton, Aparna Nori, Teruo Okano, Joaquim M. Oliveira, Harald C. Ott, Jagannath Padmanabhan, Kristin M. Page, Anil Kumar Pallickaveedu Rajan Asari, Virginia E. Papaioannou, Jihoon Park, Samantha L. Payne, Gadi Pelled, Andrew Pepper, Elumalai Perumal, Melissa Petreaca, Christopher J. Pino, Alessandro Pirosa, Iris Pla-Palacín, Marta Pokrywczynska, Christopher D. Porada, Blaise D. Porter, Milica Radisic, Kunal J. Rambhia, F. Raquel Maia, Buddy D. Ratner, A.H. Reddi, Rui L. Reis, Laura Ricles, Camillo Ricordi, Muhammad Rizwan, Rebecca Robinson, Melanie Rodrigues, Benjamin B. Rothrauff, Hooman Sadri-Ardekani, Pilar Sainz-Arnal, Rangarajan Sambathkumar, Natalia Sánchez-Romero, Michelle Scarritt, Christopher M. Schneider, Steven D. Schwartz, Sarah Selem, Trinidad Serrano-Aulló, A.M. James Shapiro, Dmitriy Sheyn, Tatsuya Shimizu, Toshiharu Shinoka, Molly S. Shoichet, Toshihiro Shoji, Thomas Shupe, Andrew G. Sikora, Fiona Simpson, Aleksander Skardal, Daniel Skuk, Brandon T. Smith, Jihee Sohn, Shay Soker, Estela Solanas, Jeong Eun Song, Disha Sood, David L. Stocum, Stephen C. Strom, Jessica M. Sun, Hironobu Takahashi, Jacques P. Tremblay, Nirmalya Tripathy, John W. Tse, Rocky S. Tuan, Catherine M. Verfaillie, Gordana Vunjak-Novakovic, William R. Wagner, Yanling Wang, Emma Watson, Jennifer L. West, David F. Williams, James K. Williams, Mark E. Wong, Savio L-Y. Woo, Fiona M. Wood, Lei Xu, Doron C. Yakubovich, Yafeng Yang, Michael J. Yaszemski, Pamela C. Yelick, Evelyn K.F. Yim, Carolyn Yong, James J. Yoo, Simon Young, Nora Yucel, Rachel L. Zacharias, Yuanyuan Zhang, Ai Zhang, Jin Zhang, and Yang Zhu

Published
2018
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3. Contributors

Author

Graça Almeida-Porada, Greg Asatrian, Anthony Atala, Stephen F. Badylak, Pedro M. Baptista, Cameron Best, Khalil N. Bitar, Christopher K. Breuer, Bryan N. Brown, Raphaël F. Canadas, Arnold I. Caplan, Irene Cervelló, William C.W. Chen, Dong F. Chen, Martin K. Childers, Kin-Sang Cho, Claudio J. Conti, A. Crespo-Barreda, Marcela Del Río, Giacomo Della Verde, Abritee Dhal, Albert Donnenberg, M.M. Encabo-Berzosa, Ignacio Giménez, Melissa A. Goddard, R. González-Pastor, Riccardo Gottardi, Xuan Guan, Sara Guerrero-Aspizua, Chenying Guo, Winters Hardy, Ira M. Herman, Catalina K. Hwang, M. Iglesias, Glicerio Ignacio, Aaron W. James, Thi H. Khanh Vu, Nobuaki Kikyo, Joanne Kurtzberg, Gabriela M. Kuster, Angel Lanas, Mark T. Langhans, Fernando Larcher, Avione Y. Lee, Yong-Ung Lee, Ronglih Liao, Jr-Jiun Liou, David L. Mack, Nathan Mahler, Alexandra P. Marques, Kacey G. Marra, P. Martin-Duque, Patricia Meade, Jose Vicente Medrano, Emma Moran, Joaquim M. Oliveira, P. Ortíz-Teba, Bruno Péault, Otmar Pfister, Sandra Pina, Christopher D. Porada, Rui L. Reis, J. Peter Rubin, Keith Sabin, Natalia Sánchez-Romero, Alvaro Santamaria, J.L. Serrano, Anthony R. Sheets, Carlos Simón, Shay Soker, Chia Soo, Jessica M. Sun, Mays Talib, Shuhei Tara, Kang Ting, Rocky S. Tuan, Jolene E. Valentin, Dipen Vyas, Bo Wang, Jason A. Wertheim, Honghua Yu, Elie Zakhem, Elisabeth Zapatero-Solana, Nan Zhang, and Yuanyuan Zhang

Published
2016
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4. Injury and Repair of Tendon, Ligament, and Meniscus

Author

Rocky S. Tuan, Riccardo Gottardi, Mark T. Langhans, and Jr-Jiun Liou

Subjects
medicine.medical_specialty, business.industry, Mesenchymal stem cell, Meniscus (anatomy), musculoskeletal system, Regenerative medicine, Surgery, medicine.anatomical_structure, Tissue engineering, medicine, Ligament, Progenitor cell, business, Adult stem cell, Stem cell transplantation for articular cartilage repair
Abstract

Injuries of tendon, ligament, and meniscus affect more than 10 million people in the United States annually. Unfortunately, most of the current clinical reparative interventions do not adequately address the requirements of the tissue junction sites, resulting in high failure rates of surgery and readmission upon overuse. This chapter reviews the nature and current treatments for such injuries and summarizes selected clinical trials in specific categories. Adult stem cells, or mesenchymal stem cells, are of particular therapeutic interest for these skeletal soft tissues in part because of the relative ease of isolation and enrichment, and freedom from ethical issues. Successful cell-based therapies will require the use of biomimetic biomaterial scaffolds to support and promote cell differentiation and tissue regeneration. The challenges and promises of combining stem/progenitor cells, scaffolds, and bioactive factors, for ligament, tendon, and meniscus tissue engineering and regenerative medicine approaches are highlighted in this review.

Published
2016
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5. Skeletal Development

Author

Peter G. Alexander, Mark T. Langhans, and Rocky S. Tuan

Subjects
Mesoderm, Ossification, Chemistry, Lateral plate mesoderm, Cell biology, Somite, medicine.anatomical_structure, embryonic structures, Intramembranous ossification, Notochord, Paraxial mesoderm, medicine, medicine.symptom, Endochondral ossification
Abstract

The bones and connective tissues of the body are derived from two embryonic origins, the mesoderm and neural crest. The appendicular skeleton arises from the lateral plate mesoderm, the axial skeleton from the paraxial mesoderm, and the craniofacial skeleton from a combination of cephalic paraxial mesoderm and neural crest cells. Bones are formed through one of two processes: Endochondral ossification involves the formation of primordial cartilaginous anlagen that are subsequently replaced by bone via the growth plates. Intramembranous ossification is characterized by the direct differentiation of mesenchymal cells to osteogenic tissue. The growth plate can be divided into a resting zone, a proliferating zone, a pre-hypertrophic zone, and a hypertrophic zone, reflecting a gradient of chondrocyte differentiation that is regulated by antagonism between bone morphogenetic protein (BMP) and fibroblast growth factor (FGF) signaling pathways and gradients of IHH and PTHrP. Replacement of cartilage by osteoblasts is dependent upon prior mineralization of the cartilage matrix and vascular invasion. The activities of the hypertrophic chondrocytes and of the osteoblasts are regulated by RUNX2. Osteoclasts are of hematopoietic origin (monocyte), and with osteoblasts, they remodel bone throughout an individual’s lifetime to adapt to mechanical demands. Joints and intra-articular structures arise from a cohort of progenitor cells distinct from those of the bones and are labeled by GDF5 and TGFBRII expression. Somites are formed from the segmental plate through the interaction of a cell-autonomous oscillator and a morphogenetic wave that coordinates somite boundary formation via the Notch-Delta juxtacrine system and epithelialization via WNT paracrine system and cadherin activity. Dysregulation of this developmental process leads to congenital scoliosis. The axial skeleton is derived from the ventro-medial sclerotome of somites. Differentiation of the somite is regulated by paracrine factors from surrounding tissues and the sclerotome in particular is induced by SHH. Tendons and ligaments develop from the interaction of mesodermal mesenchyme with myoblasts. The nucleus pulposus of the intervertebral disc is initially derived from the notochord. The gradual loss of “embryonic cells” from the disc may be related to disc degeneration and back pain.

Published
2015
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6. Contributors

Author

Kate G. Ackerman, Peter G. Alexander, Xiaoying Bai, Jennifer L. Baker, David R. Beier, John W. Belmont, David A. Billmire, Ira L. Blitz, Samantha A. Brugmann, Matthew G. Butler, Ching-Fang Chang, Ajay B. Chitnis, William T.Y. Chiu, Ken W.Y. Cho, Albert J. Courey, Damian Dalle Nogare, Jamie Davies, Sheng Ding, Darin Dolezal, Nataki C. Douglas, Hongling Du, Benjamin Feldman, Alejandra Fernandez, Maureen Gannon, Mor Grinstein, Yanli Guo, Renée V. Hoch, Keiji Itoh, Beverly A. Karpinski, Matthew W. Kelley, Kristy L. Kenyon, Paul A. Krieg, Anthony-Samuel LaMantia, Mark T. Langhans, Ke Li, Frederick J. Livesey, Mui Luong, Shawn M. Luttrell, Nasir Malik, Zoë F. Mann, Nathan Martin, Thomas M. Maynard, Roberto Mayor, Daniel Meechan, Sigolène M. Meilhac, Anna M. Method, Sally A. Moody, Steven Moore, Timothy S. Mulligan, L.A. Naiche, Virginia E. Papaioannou, Aitana Perea-Gomez, Francesca Pignoni, Mahendra S. Rao, Girish S. Ratnaparkhi, Kimberly G. Riley, Jean-Pierre Saint-Jeannet, Eric T. Sause, Elizabeth N. Schock, Thomas M. Schultheiss, Soojung Shin, Sergei Y. Sokol, Philippe Soriano, Amber N. Stratman, Billie J. Swalla, Hugh S. Taylor, Irma Thesleff, Eric Theveneau, Rocky S. Tuan, Andrea S. Viczian, Andrew S. Warkman, Andrew J. Washkowitz, Brant M. Weinstein, James M. Wells, Marcin Wlizla, Min Xie, Yingzi Yang, Jianxin A. Yu, Mingliang Zhang, Irene E. Zohn, Leonard I. Zon, Aaron M. Zorn, and Michael E. Zuber

Published
2015
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