Search

Your search keyword '"Mark P. Gorman"' showing total 4 results
Start Over Author "Mark P. Gorman" Publisher elsevier
4 results on '"Mark P. Gorman"'

1. Posterior-onset Rasmussen's encephalitis with ipsilateral cerebellar atrophy and uveitis resistant to rituximab

Author

Arnold J. Sansevere, Lauren A. Henderson, Coral M. Stredny, Sanjay P. Prabhu, Ankoor Shah, Robert Sundel, Joseph Madsen, Chantal Dufreney, Annapurna Poduri, and Mark P. Gorman

Subjects
Rasmussen encephalitis, atypical Rasmussen encephalitis, Bien criteria, Drug resistant epilepsy, Neurology. Diseases of the nervous system, RC346-429, Neurophysiology and neuropsychology, QP351-495
Abstract

Rasmussen encephalitis (RE) is a disorder characterized by drug-resistant seizures and progressive unihemispheric atrophy, hemiparesis, and varying degrees of cognitive decline. The pathophysiology of RE remains elusive, with hypotheses suggesting underlying autoimmune- and T cell-mediated processes. In this case report, we describe a single patient's clinical course from the first day of presentation until definitive treatment for atypical Rasmussen encephalitis at a tertiary care pediatric center. The patient exhibited several atypical features of Rasmussen encephalitis, including a posterior predominance of initial seizure onset with the development of severe choreoathetosis and ipsilateral cerebellar atrophy. He subsequently developed coexistent autoimmune disorders in the form of psoriasis and uveitis, and underwent multiple forms of immunotherapy with limited benefit.This patient shows an association of RE with other autoimmune conditions supporting an autoimmune mechanism of disease while exhibiting several atypical features of RE. Rarely, occipital lobe seizures have been documented as the presenting semiology of this syndrome. This case highlights the need to be mindful of atypical features that may delay hemispherectomy, which remains the definitive treatment. It also suggests that children may be predisposed to the development of autoimmune disorders in later stages of the disease.

Published
2020
Full Text
View/download PDF

2. Pain and spinal cord imaging measures in children with demyelinating disease

Author

Nadia Barakat, Mark P. Gorman, Leslie Benson, Lino Becerra, and David Borsook

Subjects
Inflammation, Chronic pain, MRI, DTI, MTI, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
Abstract

Pain is a significant problem in diseases affecting the spinal cord, including demyelinating disease. To date, studies have examined the reliability of clinical measures for assessing and classifying the severity of spinal cord injury (SCI) and also to evaluate SCI-related pain. Most of this research has focused on adult populations and patients with traumatic injuries. Little research exists regarding pediatric spinal cord demyelinating disease. One reason for this is the lack of reliable and useful approaches to measuring spinal cord changes since currently used diagnostic imaging has limited specificity for quantitative measures of demyelination. No single imaging technique demonstrates sufficiently high sensitivity or specificity to myelin, and strong correlation with clinical measures. However, recent advances in diffusion tensor imaging (DTI) and magnetization transfer imaging (MTI) measures are considered promising in providing increasingly useful and specific information on spinal cord damage. Findings from these quantitative imaging modalities correlate with the extent of demyelination and remyelination. These techniques may be of potential use for defining the evolution of the disease state, how it may affect specific spinal cord pathways, and contribute to the management of pediatric demyelination syndromes. Since pain is a major presenting symptom in patients with transverse myelitis, the disease is an ideal model to evaluate imaging methods to define these regional changes within the spinal cord. In this review we summarize (1) pediatric demyelinating conditions affecting the spinal cord; (2) their distinguishing features; and (3) current diagnostic and classification methods with particular focus on pain pathways. We also focus on concepts that are essential in developing strategies for the detection, monitoring, treatment and repair of pediatric myelitis.

Published
2015
Full Text
View/download PDF

3. Posterior-onset Rasmussen's encephalitis with ipsilateral cerebellar atrophy and uveitis resistant to rituximab

Author

Joseph R. Madsen, Lauren A. Henderson, Annapurna Poduri, Mark P. Gorman, Coral M. Stredny, Robert P. Sundel, Sanjay P. Prabhu, Chantal Dufreney, Arnold J. Sansevere, and Ankoor S. Shah

Subjects
Rasmussen's encephalitis, Pediatrics, medicine.medical_specialty, Rasmussen encephalitis, medicine.medical_treatment, Choreoathetosis, lcsh:RC346-429, Article, Behavioral Neuroscience, Atrophy, Bien criteria, medicine, Cognitive decline, atypical Rasmussen encephalitis, lcsh:Neurology. Diseases of the nervous system, Drug resistant epilepsy, business.industry, lcsh:QP351-495, medicine.disease, Hemispherectomy, lcsh:Neurophysiology and neuropsychology, Neurology, Cerebellar atrophy, Rituximab, Neurology (clinical), medicine.symptom, business, Uveitis, medicine.drug
Abstract

Rasmussen encephalitis (RE) is a disorder characterized by drug-resistant seizures and progressive unihemispheric atrophy, hemiparesis, and varying degrees of cognitive decline. The pathophysiology of RE remains elusive, with hypotheses suggesting underlying autoimmune- and T cell-mediated processes. In this case report, we describe a single patient's clinical course from the first day of presentation until definitive treatment for atypical Rasmussen encephalitis at a tertiary care pediatric center. The patient exhibited several atypical features of Rasmussen encephalitis, including a posterior predominance of initial seizure onset with the development of severe choreoathetosis and ipsilateral cerebellar atrophy. He subsequently developed coexistent autoimmune disorders in the form of psoriasis and uveitis, and underwent multiple forms of immunotherapy with limited benefit. This patient shows an association of RE with other autoimmune conditions supporting an autoimmune mechanism of disease while exhibiting several atypical features of RE. Rarely, occipital lobe seizures have been documented as the presenting semiology of this syndrome. This case highlights the need to be mindful of atypical features that may delay hemispherectomy, which remains the definitive treatment. It also suggests that children may be predisposed to the development of autoimmune disorders in later stages of the disease., Highlights • Occipital seizure localization and semiology should not dissuade the diagnosis of Rasmussen's encephalitis • Movement disorders, can accompany Rasmussen's encephalitis • Ipsilateral cerebellar atrophy has been described in Rasmussen's encephalitis • Children with Rasmussen's encephalitis may be predisposed to autoimmune disorders in the later stages of the disease

Published
2020

4. CONTRIBUTORS

Author

John G. Aaskov, Susan M. Abdel-Rahman, Christoph Aebi, Marvin E. Ament, Marsha S. Anderson, Stephen S. Arnon, Ann M. Arvin, Jane T. Atkins, Robert L. Atmar, Carol J. Baker, Robert S. Baltimore, Stephen J. Barenkamp, Elizabeth D. Barnett, Robert D. Basow, William R. Beisel, Beth P. Bell, Gil Benard, David I. Bernstein, Kathrin M. Bernt, Andrea A. Berry, Charles D. Bluestone, Jeffrey L. Blumer, Robert Bortolussi, Bobby L. Boyanton, Kenneth M. Boyer, John S. Bradley, Michael T. Brady, William J. Britt, Annemarie Broderick, David E. Bronstein, David A. Bruckner, Steven C. Buckingham, Ana Burgos, Carrie L. Byington, Judith R. Campbell, Samson Cantu, Mariam R. Chacko, Louisa E. Chapman, Rémi N. Charrel, Tempe K. Chen, James D. Cherry, P. Joan Chesney, Madhuri C. Chilakapati, Javier Chinen, Natascha Ching, H. Fred Clark, Thomas G. Cleary, David K. Coats, Armando G. Correa, J. Thomas Cross, William B. Cutrer, Ronald Dagan, David E. Dassey, Jeffrey P. Davis, Gail J. Demmler-Harrison, Penelope H. Dennehy, Minh L. Doan, Simon R. Dobson, Jan E. Drutz, Paul H. Edelstein, Kathryn M. Edwards, Morven S. Edwards, B. Keith English, Dora Estripeaut, Leland L. Fan, Ralph D. Feigin, George D. Ferry, Anthony E. Fiore, Philip R. Fischer, Randall G. Fisher, Patricia M. Flynn, Thomas R. Flynn, Lisa M. Frenkel, Ellen M. Friedman, Richard A. Friedman, Lynne S. Garcia, Patrick J. Gavin, Michael A. Gerber, Anne A. Gershon, Mark A. Gilger, Susan L. Gillespie, Daniel G. Glaze, W. Paul Glezen, Mary P. Glodé, Donald A. Goldmann, Ellie J.C. Goldstein, Nira A. Goldstein, Edmond T. Gonzales, Mark P. Gorman, Michael D. Green, David Greenberg, Andreas H. Groll, Charles Grose, Duane J. Gubler, Roberto A. Guerrero, Javier Nieto Guevara, Kathleen M. Gutierrez, Caroline Breese Hall, Scott B. Halstead, Shinjiro Hamano, Richard J. Hamill, Margaret R. Hammerschlag, I. Celine Hanson, Nada Harik, Rick E. Harrison, C. Mary Healy, Ulrich Heininger, Gloria P. Heresi, Peter W. Hiatt, Harry R. Hill, David C. Hilmers, Jill A. Hoffman, Ellis K.L. Hon, Margaret K. Hostetter, Peter J. Hotez, Walter T. Hughes, Kristina G. Hulten, David A. Hunstad, Eugene S. Hurwitz, W. Charles Huskins, David Y. Hyun, Mary Anne Jackson, Michael R. Jacobs, Richard F. Jacobs, Jenifer L. Jaeger, Ravi R. Jhaveri, Samantha Johnston, Maureen M. Jonas, Meena R. Julapalli, Edward L. Kaplan, Sheldon L. Kaplan, Saul J. Karpen, Gregory L. Kearns, Margaret A. Keller, Chaouki K. Khoury, Martin B. Kleiman, Jerome O. Klein, Mark W. Kline, Katherine M. Knapp, Heidi M. Kokkinos, Peter J. Krause, Leonard R. Krilov, Paul Krogstad, Thomas L. Kuhls, Xavier de Lamballerie, Timothy R. La Pine, Matthew B. Laurens, Charles T. Leach, Robert J. Leggiadro, Diana R. Lennon, Carolyn Lentzsch-Parcells, Eric Leroy, Chi Wai Leung, Moise L. Levy, Karen Lewis, Phyllis T. Losikoff, Timothy Edward Lotze, Adam W. Lowry, Timothy Mailman, Susan A. Maloney, Laurene Mascola, Edward O. Mason, David O. Matson, Alan N. Mayer, Marc A. Mazade, James B. McAuley, George H. McCracken, Kenneth McIntosh, James E. McJunkin, Kelly T. McKee, Rima L. McLeod, Valérie A. McLin, Maria José Soares Mendes-Giannini, Wayne M. Meyers, Marian G. Michaels, Ian C. Michelow, Vladana Milisavljevic, Aaron M. Miller, James N. Miller, Marjorie J. Miller, James N. Mills, Linda L. Minnich, Ann Moran, James R. Murphy, Pratip K. Nag, Joseph J. Nania, James P. Nataro, Roger K. Nicome, Karin Nielsen-Saines, Delma J. Nieves, Richard A. Oberhelman, Theresa J. Ochoa, Christopher M. Oermann, Alina Olteanu, Gary D. Overturf, Debra L. Palazzi, Pia S. Pannaraj, Janak A. Patel, Christian C. Patrick, Evelyn A. Paysse, Norma Pérez, C.J. Peters, William A. Petri, Brandon Lane Phillips, Larry K. Pickering, Joseph F. Piecuch, Francisco P. Pinheiro, Stanley A. Plotkin, Scott L. Pomeroy, Alice Pong, David L. Pugatch, Joan S. Purcell, Ramya Ramraj, Jack S. Remington, Carina A. Rodriguez, José R. Romero, Benjamin A. Ross, Lawrence A. Ross, Judith L. Rowen, Charles E. Rupprecht, Xavier Sáez-Llorens, Lisa Saiman, Joseph W. St. Geme, Pablo J. Sánchez, Laura A. Sass, Carlos A. Sattler, Danica J. Schulte, Gordon E. Schutze, Filiz O. Seeborg, Eugene D. Shapiro, Nina L. Shapiro, William T. Shearer, Ziad M. Shehab, Jerry L. Shenep, W. Donald Shields, Robyn Shimizu-Cohen, Stanford T. Shulman, Constantine Simos, Arnold L. Smith, Jason S. Soden, Mary Allen Staat, Jeffrey R. Starke, Barbara W. Stechenberg, William J. Steinbach, Paul G. Steinkuller, E. Richard Stiehm, Stephanie H. Stovall, Jeffrey Suen, Ciro V. Sumaya, Andrea P. Summer, Douglas S. Swanson, Tina Q. Tan, Herbert B. Tanowitz, Robert B. Tesh, Philip Toltzis, Richard G. Topazian, Michael F. Tosi, Amelia P.A. Travassos da Rosa, Theodore F. Tsai, Tulio A. Valdez, Jesus G. Vallejo, John A. Vanchiere, Pedro Fernando da C. Vasconcelos, Jorge J. Velarde, James Versalovic, Ellen R. Wald, Douglas S. Walsh, Edward E. Walsh, Thomas J. Walsh, Mark A. Ward, Richard L. Ward, Michelle Weinberg, Robert C. Welliver, J. Gary Wheeler, A. Clinton White, Suzanne Whitworth, Bernhard L. Wiedermann, Natalie Williams-Bouyer, Murray Wittner, Charles R. Woods, Kimberly G. Yen, Ram Yogev, Edward J. Young, and Theoklis E. Zaoutis

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results