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Your search keyword '"Marco Giampà"' showing total 3 results
Start Over Author "Marco Giampà" Publisher elsevier
3 results on '"Marco Giampà"'

1. Contributors

Author

Murali Aarthy, Bidisha Acharya, Priyanka Aggarwal, Nabeel Ahmad, Natarajan Aiswarya, Hakan Alici, Khattab Al-Khafaji, Anshul Assaiya, Saurabh Bansal, Suparna Bhar, Aparna Bhardwaj, Dhiraj Bhatia, Neel Sarovar Bhavesh, Joanna Bons, Krishnananda Chattopadhyay, Purna Bahadur Chetri, Orkid Coskuner-Weber, Soumya De, Veronica Isabel Dodero, Jack A. Elias, Agusti Emperador, Roberto Giambruno, Marco Giampà, Rajanish Giri, Steffen P. Graether, Akshita Gupta, Smita Gupta, Md Anzarul Haque, Orkun Hasekioglu, Md Imtaiyaz Hassan, Prajna N. Hebbar, A. Hema Naveena, Maria Georgina Herrera, Alexander-Maurice Illig, Asimul Islam, Matej Janežič, Jeyaraman Jeyakanthan, Suchitra Kamle, Kota Kasahara, Punit Kaur, Heena Khan, Janesh Kumar, Prateek Kumar, Ritesh Kumar, Saravanan Kumar, Vijay Kumar, Pooja Kumari, Varsha Kumari, Bishwajit Kundu, Chun Geun Lee, Dawei Li, Xubo Lin, Snigdha Maiti, Narattam Mandal, Anil Mhashal, Parul Mishra, Ajitha Mohan, Sandip Mukherjee, Sunandan Mukherjee, Niharika Nag, Koomity V. Nageswar, Fouzia Nasim, Santoshi Nayak, Siddharth Neog, Chandran Nithin, Amy O’Broin, Olujide O. Olubiyi, Laura Orellana, Aditya K. Padhi, Amrita Arpita Padhy, Dipak N. Patil, Vijay Kumar Prajapati, Insaf Ahmed Qureshi, Chandrashekar Narayanan Rahul, Anjali Rajwar, Kristijan Ramadan, S. Rashmi, Tadi Sai Ratnakar, Arun Kumar Rawat, Jacob Rose, Anwesha Roy, Jakob Rupert, Subhashree Sahoo, Nikita V. Saibo, Suman Samantray, Nikhil H. Samarth, Madhumathi Sanjeevi, Achinta Sannigrahi, Santanu Sasidharan, Prakash Saudagar, Birgit Schilling, Kanagaraj Sekar, Mansi Sharma, Pradeep Sharma, Sujata Sharma, Vinita Sharma, Kummari Shivani, Abhay Narayan Singh, Anamika Singh, Appu K. Singh, Meenakshi Singh, Sanjeev Kumar Singh, Satyendra Singh, Shailza Singh, Shalini Singh, Sudhir Kumar Singh, Tej P. Singh, Tugba Taskin-Tok, Arianne L. Theiss, Nicolo Tonali, Timir Tripathi, Vishal Trivedi, Vladimir N. Uversky, Payal Vaswani, K. Venuprasad, Elsa Zacco, and Kam Y.J. Zhang

Published
2022

3. Mass spectrometry imaging reveals lipid upregulation and bile acid changes indicating amitriptyline induced steatosis in a rat model

Author

M. Slopianka, Hanna Bednarz, Marco Giampà, Mikail Sahin, Rainer Ernst, Karsten Niehaus, Judith M. Kampa, Bjoern Riefke, and Amol Fatangare

Subjects
Male, 0301 basic medicine, medicine.drug_class, Amitriptyline, Antidepressive Agents, Tricyclic, Pharmacology, Toxicology, Mass Spectrometry, Bile Acids and Salts, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, Oil Red O, Liver injury, Bile acid, Chemistry, Organ Size, General Medicine, Metabolism, Lipid Metabolism, medicine.disease, Rats, Up-Regulation, 030104 developmental biology, Liver, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Toxicity, Phosphatidylcholines, Chemical and Drug Induced Liver Injury, Steatosis, 030217 neurology & neurosurgery, Drug metabolism, medicine.drug
Abstract

As a consequence of the detoxification process, drugs and drug related metabolites can accumulate in the liver, resulting in drug induced liver injury (DILI), which is the major cause for dose limitation. Amitriptyline, a commonly used tricyclic anti-depressant, is known to cause DILI. The mechanism of Amitriptyline induced liver injury is not yet completely understood. However, as it undergoes extensive hepatic metabolism, unraveling the molecular changes in the liver upon Amitriptyline treatment can help understand Amitriptyline's mode of toxicity. In this study, Amitriptyline treated male rat liver tissue was analyzed using Matrix Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging (MALDI-MSI) to investigate the spatial abundances of Amitriptyline, lipids, and bile acids. The metabolism of Amitriptyline in liver tissue was successfully demonstrated, as the spatial distribution of Amitriptyline and its metabolites localize throughout treatment group liver samples. Several lipids appear upregulated, from which nine were identified as distinct phosphatidylcholine (PC) species. The detected bile acids were found to be lower in Amitriptyline treatment group. The combined results from histological findings, Oil Red O staining, and lipid zonation by MSI reveal lipid upregulation in the periportal area indicating drug induced macrovesicular steatosis (DIS). Copyright © 2020. Published by Elsevier B.V.

Published
2020

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