31 results on '"Manickam, Sivakumar"'
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2. Use of alternative energy sources for the initiation and execution of chemical reactions and processes
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Malkapuram, Surya Teja, primary, Patil, Yogesh, additional, Sivaprakash, S., additional, Manickam, Sivakumar, additional, Kale, Manoj, additional, and Sonawane, Shirish Hari, additional
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- 2024
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3. Semisynthesis of antibiotics
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Majhi, Sasadhar, primary and Manickam, Sivakumar, additional
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- 2024
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4. New derivatives as nutraceuticals: regulatory considerations
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Majhi, Sasadhar, primary and Manickam, Sivakumar, additional
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- 2024
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5. Preliminary concept of semisynthesis and its importance
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Majhi, Sasadhar, primary and Manickam, Sivakumar, additional
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- 2024
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6. Semisynthesis of natural products at room temperature
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Majhi, Sasadhar, primary and Manickam, Sivakumar, additional
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- 2024
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7. List of contributors
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Barai, Divya P., primary, Bhanvase, Bharat A., additional, Boravelli, Joseph Abhisheka Rao, additional, Gayen, Neelabja, additional, Gumfekar, Sarang P., additional, Hakke, Vikas S., additional, Kale, Manoj, additional, Maddirala, Shivani, additional, Malkapuram, Surya Teja, additional, Mangal, Nishita, additional, Manickam, Sivakumar, additional, Mekala, Mallaiah, additional, Murse, Vrushabh S., additional, Patankar, Saurabh C., additional, Patel, Sanjaykumar R., additional, Patel, Yash, additional, Patil, Yogesh, additional, Sevda, Surajbhan, additional, Shirsat, Sanjay P., additional, Shrimal, Preena, additional, Singh, Siddharth Arvind, additional, Sivaprakash, S., additional, Sonawane, Shirish Hari, additional, Suranani, Srinath, additional, and Vir, Anil B., additional
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- 2024
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8. Semisynthesis of natural products through the insertion of oxygen atom under metal-free conditions
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Majhi, Sasadhar, primary and Manickam, Sivakumar, additional
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- 2024
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9. Computational chemistry of natural product analogues
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Majhi, Sasadhar, primary and Manickam, Sivakumar, additional
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- 2024
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10. List of contributors
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Ahmadi, Seyedeh Melika, primary, Alamdari, Sania Ghobadi, additional, Almalki, Waleed H., additional, Amini, Mohammad, additional, Amirkhanloo, Shervin, additional, Arora, Swati, additional, Asadi, Peyman, additional, Avan, Amir, additional, Azari, Hanieh, additional, Baradaran, Behzad, additional, Bercoff, Paula Gabriela, additional, Biswas, Swati, additional, Ch, Sanjay, additional, Chakrabarti, Gopal, additional, Chamanara, Mohsen, additional, Chatterjee, Arindam, additional, Daboin, Viviana Beatriz, additional, Dandela, Rambabu, additional, Dash, Shwetapadma, additional, Dehghani, Sadegh, additional, Demirkaya, Durmus Burak, additional, Donyadideh, Ghazaleh, additional, Dutta, Gouranga, additional, Ebrahimnejad, Pedram, additional, Ferns, Gordon A., additional, Ghosh, Balaram, additional, Ghosh, Dipanjan, additional, Ghosh, Jyotirmoy, additional, Giri, Lopamudra, additional, Gupta, Neelima, additional, Hamid, Fiuji, additional, Hassanian, Seyed Mahdi, additional, Jamialahmadi, Hamid, additional, Kar, Ananya, additional, Kaur, Gurleen, additional, Kesharwani, Prashant, additional, Khalili-Tanha, Ghazaleh, additional, Khazaei, Majid, additional, Maftooh, Mina, additional, Manickam, Sivakumar, additional, Mansouri, Atena, additional, Manu, K.R., additional, Mavandadnejad, Faranak, additional, Mehrabadi, Shima, additional, Misra, Ranjita, additional, Mogharabi-Manzari, Mehdi, additional, Mohammadi, Hamidreza, additional, Mohammadzadeh, Reza, additional, Mokhtarzadeh, Ahad, additional, Moya Betancourt, Sara Natalia, additional, Nazari, Elham, additional, Oroojalian, Fatemeh, additional, Palani, Geetha, additional, Patel, Tarun Kumar, additional, Pawar, Smita C., additional, Perumal, Venkatesan, additional, Pourali, Ghazaleh, additional, P., Shalini Preethi, additional, Rahimnia, Seyyed Mobin, additional, Rahmani, Farzad, additional, Ravula, Arun Reddy, additional, Riva, Julieta Soledad, additional, Saberi-Hasanabadi, Parisa, additional, Saeedi, Majid, additional, Sahebkar, Amirhossein, additional, Sahoo, Sanjeeb Kumar, additional, Sahoo, Sonali, additional, Salmasi, Zahra, additional, Sambath, Karthik, additional, Shad, Amin, additional, Sharath, Naomi Sanjana, additional, Sheoran, Sumit, additional, V., Sindhu, additional, Sugumaran, Abimanyu, additional, I., Shanmuga Sundari, additional, Uranga, Jorge Gustavo, additional, Velingkar, Aayushi, additional, Vijayaraghavalu, Sivakumar, additional, Vuree, Sugunakar, additional, Yalcin, Serap, additional, Yazdian-Robati, Rezvan, additional, and Yıldırım, Mehmethan, additional
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- 2024
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11. Semisynthesis of natural products under greener conditions
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Majhi, Sasadhar, primary and Manickam, Sivakumar, additional
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- 2024
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12. Ultrasonic liquid exfoliation for producing graphene materials from rice stem: Investigating cellular components and functionalities
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Xinyun Wu, Manickam Sivakumar, Siew Shee Lim, Tao Wu, and Pang Cheng Heng
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Graphene ,Ultrasonication ,Biomass conversion ,Cell structure ,Solvent system ,And Nanopore formation ,Chemistry ,QD1-999 ,Acoustics. Sound ,QC221-246 - Abstract
This study investigates a prospective and straightforward method for producing graphene material derived from biomass, examining the influence of plant cell composition and functions. The experimental outcomes highlight ultrasound's crucial role in synthesizing graphene material sourced from biomass. Ultrasound, a pivotal element in the experiment, significantly affects graphene production from biomass by working synergistically with the liquid components in the solvent system. Notably, the ethanol content reduces the solution’s surface tension, facilitating the effective dispersion of biochar and graphene oxide sheets throughout the process. Simultaneously, the water content maintains the solution’s polarity, enhancing the cavitation effect induced by ultrasound. Biomass-derived graphene is exfoliated utilizing an ultrasonic bath system (134.4 W, 40 kHz, 0.5 W/cm2) from biochar. The as-synthesized graphene oxide exhibits a structure comprising a few layers while remaining intact, featuring abundant functional groups. Interestingly, the resulting product displays nanopores with an approximate diameter of 100 nm. These nanopores are attributed to preserving specific cell structures, particularly those with specialized cell wall structures or secondary metabolite deposits from biomass resources. The study's findings shed light on the impact of cellular structure on synthesizing graphene material sourced from biomass, emphasizing the potential application of ultrasound as a promising approach in graphene production.
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- 2024
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13. Contributors
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Al-Mayouf, Abdullah M., primary, Ambapuram, Meenakshamma, additional, Amer, Mabrook S., additional, Aruna Kumari, M.L., additional, Arunachalam, Prabhakarn, additional, Balaji, Dhandapani, additional, Bathula, Chinna, additional, Battula, Ramya Krishna, additional, Bezerra, Leticia S., additional, Bhyrappa, P., additional, Cardoso, Eduardo S.F., additional, Chinnakutti, Karthik Kumar, additional, Choi, Myong Yong, additional, Chul Kim, Byung, additional, Elumalai, Ganesan, additional, Fortunato, Guilherme V., additional, Govindarajan, Durai, additional, Grace, Andrews Nirmala, additional, Haidyrah, Ahmed S., additional, Jagannathan, Madhavan, additional, Jaihindh, Dhayanantha Prabu, additional, Jung, Hyun, additional, Justin Raj, C., additional, Kaliamurthy, Ashok Kumar, additional, Karuppasamy, K., additional, Karuppiah, Chelladurai, additional, Kumar, Subalakshmi, additional, Lee, Kiyoung, additional, Lee, Sejoon, additional, Lee, Seung Jun, additional, Maddala, Gurulakshmi, additional, Madhavan, Bradha, additional, Maia, Gilberto, additional, Manickam, Sivakumar, additional, Martini, Bibiana K., additional, Mitty, Raghavender, additional, Murthy, Arun Prasad, additional, Murugadoss, Govindhasamy, additional, Muthu, Senthilkumar, additional, Muthukonda Venkatakrishnan, Shankar, additional, Nagappagari, Lakshmana Reddy, additional, Nichelson, A., additional, Pasha, S.K. Khadheer, additional, Patil, Santosh S., additional, Premnath, Kumar, additional, Ramasamy, Easwaramoorthi, additional, Ramesh, Pugalenthi, additional, Ramu, A.G., additional, Salla, Sunitha, additional, Sekar, Sankar, additional, Senthil, Chenrayan, additional, Senthil, Raja Arumugam, additional, Sudakar, C., additional, Tanveer, Waqas Hassan, additional, Theerthagiri, Jayaraman, additional, Thirumalraj, Balamurugan, additional, Veerappan, Ganapathy, additional, Veerasubramani, Ganesh Kumar, additional, Vikraman, Dhanasekaran, additional, Yang, Chun-Chen, additional, and Yi, Sung-Chul, additional
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- 2022
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14. Multijunction solar cells based on III–V and II–VI semiconductors
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Senthil, Raja Arumugam, primary, Theerthagiri, Jayaraman, additional, Pasha, S.K. Khadheer, additional, Jagannathan, Madhavan, additional, Grace, Andrews Nirmala, additional, and Manickam, Sivakumar, additional
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- 2022
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15. List of Contributors
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Abu-Thabit, Nedal Y., primary, Awad Abouelata, Ahmed M., additional, Bagale, Uday B., additional, Bhanvase, Bharat, additional, Bouali, Anissa C., additional, Elkholy, Ayman E., additional, Ellinas, Kosmas, additional, Fathona, Indra W., additional, Ferretiz, Daisy, additional, Figueira, Rita B., additional, Gajarla, Yashwanth, additional, Galvão, Tiago L.P., additional, Ghosh, Sreyan, additional, Guerrero, Edgar, additional, Hakke, Vikas S., additional, Haldar, Jayanta, additional, Heakal, Fakiha El-Taib, additional, Kakunuri, Manohar, additional, Kang, En-Tang, additional, Makhlouf, Abdel Salam Hamdy, additional, Manickam, Sivakumar, additional, Meng, Xiangkang, additional, Mitra, Debirupa, additional, Neoh, Koon Gee, additional, Perez, Adrian, additional, Prado, Jose, additional, Rodriguez, Rocio, additional, Serdechnova, Maria, additional, Sharafudeen, Riyas, additional, Silva, Carlos J.R., additional, Sonawane, Shirish H., additional, Sonawane, Shriram S., additional, Sousa, Rui, additional, Syed, Junaid Ali, additional, Tedim, João, additional, Telegdi, Judit, additional, Yabuki, Akihiro, additional, Yasakau, Kiryl A., additional, Zheludkevich, Mikhail L., additional, and Zia, Abdul Wasy, additional
- Published
- 2020
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16. Multifunctional coatings based on smart nanocontainers
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Bagale, Uday B., primary, Sonawane, Shirish H., additional, Bhanvase, Bharat, additional, Hakke, Vikas S., additional, Kakunuri, Manohar, additional, Manickam, Sivakumar, additional, and Sonawane, Shriram S., additional
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- 2020
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17. The contribution of microbial biotechnology to sustainable development in agriculture and allied sectors
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Pratheesh, P.T., primary, Lal, Sunaina, additional, Tuvikene, Rando, additional, Manickam, Sivakumar, additional, and Sudheer, Surya, additional
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- 2020
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18. Nanomedicine in Theranostics
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Bai, Renu Geetha, primary, Muthoosamy, Kasturi, additional, and Manickam, Sivakumar, additional
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- 2015
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19. List of Contributors
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Almeida, António J., primary, Arathyram, R.S., additional, Bai, Renu Geetha, additional, Bettencourt, Ana, additional, Bose, Anirbandeep, additional, Chandran, Parvathy R., additional, Narayana Charyulu, R., additional, Detamore, Michael S., additional, Gonçalves, Lídia M., additional, Grohens, Yves, additional, Gupta, Prem N., additional, Jain, Ankush, additional, Jain, Sanjay, additional, Jayaramudu, Tippabattini, additional, Khare, Vaibhav, additional, Kim, Cheol Sang, additional, Kim, Se-Kwon, additional, Louro, Henriqueta, additional, Manickam, Sivakumar, additional, Mohan, Neethu, additional, Muthoosamy, Kasturi, additional, Ninan, Neethu, additional, Raghavendra, Gownolla Malegowd, additional, Ramam, K., additional, Sadiku, E.R., additional, Saxena, Ajit K., additional, Shajkumar, Aruni, additional, Silva, Maria João, additional, Simonkutty, Pradeep Manaloor, additional, Sudhakar, C.K., additional, Thomas, Reny Thankam, additional, Thomas, Sabu, additional, Unnithan, Afeesh Rajan, additional, Upadhyay, Nitish, additional, Varaprasad, Kokkarachedu, additional, Venkatesan, Jayachandran, additional, Verma, Arpit, additional, Vimala, K., additional, and Wong, Tin Wui, additional
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- 2015
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20. Current overview of encapsulation
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Shirish H. Sonawane, Manickam Sivakumar, Bharat A. Bhanvase, and Shital B. Potdar
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Materials science ,Carrier material ,Chemical engineering ,Biological property ,Shell (structure) ,Encapsulation (networking) - Abstract
Encapsulation is the process of stabilization of active compounds through the structuring of systems capable of preserving their chemical, physical, and biological properties, x their release or delivery under established or desired conditions In the process of encapsulation, either one or the mixture of bioactive material is coated with another single material or combination of materials. In encapsulation, two main terminologies are frequently used. One is the material that is being coated is termed active material or core material, and the other is the shell material that is also termed carrier material (shell). The shell material can be in solid, liquid droplets, and gas bubbles to encapsulate liquid or gas inside as a core. The core and shell structure can be in various shapes such as the sphere, microcapsules, microbeads, monocore, multicore, matrix, and multishell.
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- 2020
21. List of contributors
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Uday Bagale, Divya P. Barai, Shrikant S. Barkade, Bharat A. Bhanvase, Mayuri Bhatia, Bhaskar Birru, Pallab Kumar Borah, Jitendra Carpenter, Raj Kumar Duary, Vikash Kumar Dubey, Suja George, Shailesh A. Ghodke, M. Clara Gonçalves, Sarang P. Gumfekar, Kalpana Joshi, Irina Kalinina, Trupti Khatal, Vividha K. Landge, Joana C. Matos, Vinod Mokale, D.N. Mokat, Shivraj Naik, Sreenivasa Rao Parcha, Laura C.J. Pereira, Dipak Pinjari, Shital B. Potdar, Irina Potoroko, Ashish P. Pradhane, Gundappa Saha, Virendra Kumar Saharan, Santanu Sasidharan, Prakash Saudagar, P. Shalini, Manickam Sivakumar, Shirish H. Sonawane, Shriram S. Sonawane, Y.C. Suryawanshi, Parag Thakur, S.D. Torawane, and João Carlos Waerenborgh
- Published
- 2020
22. A starch/gelatin-based Halochromic film with black currant anthocyanin and Nanocellulose-stabilized cinnamon essential oil Pickering emulsion: Towards real-time Salmon freshness assessment.
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Lim HJ, Tang SY, Chan KW, Manickam S, Yu LJ, and Tan KW
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- Animals, Antioxidants chemistry, Antioxidants pharmacology, Escherichia coli drug effects, Staphylococcus aureus drug effects, Anthocyanins chemistry, Gelatin chemistry, Oils, Volatile chemistry, Oils, Volatile pharmacology, Cinnamomum zeylanicum chemistry, Food Packaging methods, Starch chemistry, Emulsions chemistry, Cellulose chemistry
- Abstract
Neoterically, food packaging systems designed solely for prolonging shelf life or monitoring freshness could not fulfil the dynamic demands of consumers. In this current investigation, using the solvent casting method, a versatile halochromic indicator was created by integrating black currant anthocyanin and cinnamon essential oil-loaded Pickering emulsion into a starch/gelatin matrix. The resulting indicator film underwent scrutiny for its structural, pH-sensitive, antioxidant, and antimicrobial attributes. Unexpectedly, the amalgamation of anthocyanin and essential oil led to decreased antioxidant activity, dropping from 73.23 ± 2.17 to 28.87 ± 2.50 mg Trolox equivalent/g sample. Additionally, no discernible antimicrobial properties were detected in the composite film sample against both Staphylococcus aureus and Escherichia coli. Fourier transform infrared analyses unveiled robust intermolecular interactions among the film-forming components, providing insights into the observed antagonistic effect. The indicator film displayed distinctive colour changes corresponding to the fresh (greyish-brown), onset of decomposition (khaki), and spoiled (dark green) stages of the stored fish sample. This highlights its promising potential for providing real-time indications of food spoilage. These findings are important for the efficient design of composite films incorporating anthocyanins and essential oils. They serve as a guide towards their potential use as multifunctional packaging materials in the food industry., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
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- 2024
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23. Electrochemical detection of arsenic (III) hazardous chemicals using cubic CsPbBr 3 single crystals: Structural insights from DFT study.
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Chinnakutti KK, C Maridevaru M, Kaimal R, Paramasivam N, Kirubaharan AMK, Theerthagiri J, M L AK, Manickam S, Anandan S, and Choi MY
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- Humans, Limit of Detection, Hazardous Substances, Electrochemical Techniques methods, Water, Carbon chemistry, Arsenic analysis
- Abstract
Long-term exposure to the highly toxic heavy metal arsenic can harm ecological systems and pose serious health risks to humans. Arsenic pollutant in water and the food chain must be addressed, and active prompt detection of As(III) is essential. The development of an effective detection method for As(III) ions is urgently needed to slow the alarming growth of arsenic pollution in the environment and safeguard the well-being of future generations. This study presents the results of our exhaustive investigation into cubic CsPbBr
3 single crystals, the glassy carbon (GC) electrode modification with CsPbBr3 single crystals prepared by direct solvent evaporation, as well as our observations of the material's remarkable electrocatalytic properties and exceptional anti-interference sensing of As(III) ions in neutral pH media. The developed CsPbBr3 /GC is exceptionally useful for the ultra-sensitive and specific identification of arsenic in water, exhibiting a detection limit of 0.381 μmol/L, a rapid response across a defined range of 0.1-25 μmol/L, and an ultra-sensitivity of 0.296 μA/μmolL-1 . CsPbBr3 /GCE (prepared without a specific reagent) is superior to other modified electrodes used as sensors in electrocatalytic activity, detection limit, analytical sensitivity, and stability response., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)- Published
- 2023
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24. Architecture of visible-light induced Z-scheme MoS 2 /g-C 3 N 4 /ZnO ternary photocatalysts for malachite green dye degradation.
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R M, Jaleel Uc JR, Pinheiro D, Nk R, Devi Kr S, Park J, Manickam S, and Choi MY
- Abstract
The synthesis of bilayer heterojunctions has received considerable attention recently. Fabrication of novel bilayer composites is of significant interest to improve their photocatalytic efficiency. In this study, molybdenum disulfide (MoS
2 ), a layered dichalcogenide material exhibiting unique properties, in combination with graphitic carbon nitride (g-C3 N4 ), a carbon-based layered material, was fabricated with small amounts of zinc oxide (ZnO). Three composites, MoS2 /g-C3 N4 , MoS2 /ZnO, and MoS2 /g-C3 N4 /ZnO were prepared via a simple exfoliation method and characterized by various physicochemical methods. The Z-scheme charge transfer mechanism in the prepared ternary composite improves efficiency by inhibiting the recombination rate of electron-hole pairs. It has shown excellent performance in degrading a major water contaminant, malachite green (MG) dye, under visible light irradiation., (Copyright © 2022 Elsevier Inc. All rights reserved.)- Published
- 2022
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25. Biosustainable production of nanoparticles via mycogenesis for biotechnological applications: A critical review.
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Sudheer S, Bai RG, Muthoosamy K, Tuvikene R, Gupta VK, and Manickam S
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- Fungi, Green Chemistry Technology, Plants, Metal Nanoparticles, Nanostructures
- Abstract
The demand for the green synthesis of nanoparticles has gained prominence over the conventional chemical and physical syntheses, which often entails toxic chemicals, energy consumption and ultimately lead to negative environmental impact. In the green synthesis approach, naturally available bio-compounds found in plants and fungi can be effective and have been proven to be alternative reducing agents. Fungi or mushrooms are particularly interesting due to their high content of bioactive compounds, which can serve as excellent reducing agents in the synthesis of nanoparticles. Apart from the economic and environmental benefits, such as ease of availability, low synthesis/production cost, safe and no toxicity, the nanoparticles synthesized from this green method have unique physical and chemical properties. Stabilisation of the nanoparticles in an aqueous solution is exceedingly high, even after prolonged storage with unperturbed size uniformity. Biological properties were significantly improved with higher biocompatibility, anti-microbial, anti-oxidant and anti-cancer properties. These remarkable properties allow further exploration in their applications both in the medical and agricultural fields. This review aims to explore the mushroom-mediated biosynthesis of nanomaterials, specifically the mechanism and bio-compounds involved in the synthesis and their interactions for the stabilisation of nanoparticles. Various metal and non-metal nanoparticles have been discussed along with their synthesis techniques and parameters, making them ideal for specific industrial, agricultural, and medical applications. Only recent developments have been explored in this review., (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Published
- 2022
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26. Apoferritin and Dps as drug delivery vehicles: Some selected examples in oncology.
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Kuruppu AI, Turyanska L, Bradshaw TD, Manickam S, Galhena BP, Paranagama P, and De Silva R
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- Humans, Animals, Drug Carriers chemistry, Nanoparticles chemistry, Antineoplastic Agents administration & dosage, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Iron-Binding Proteins metabolism, Iron-Binding Proteins chemistry, Iron metabolism, Iron chemistry, Apoferritins chemistry, Apoferritins metabolism, Neoplasms drug therapy, Neoplasms metabolism, Drug Delivery Systems methods
- Abstract
Background: The ideal nanoparticle should be able to encapsulate either pharmaceutical agents or imaging probes so that it could treat or image clinical tumours by targeting the cancer site efficiently. Further, it would be an added advantage if it demonstrates: small size, built in targeting, biocompatibility and biodegradability. Ferritin, which is an endogenous self-assembling protein, stores iron and plays a role in iron homeostasis. When iron atoms are removed apoferritin (AFt) is formed which consists of a hollow shell where it can be used to load guest molecules. Due to its unique architecture, AFt has been investigated as a versatile carrier for tumour theranostic applications. DNA-binding protein from starved cells (Dps), which also belongs to the ferritin family, is a protein found only in prokaryotes. It is used to store iron and protect chromosomes from oxidative damage; because of its architecture, Dps could also be used as a delivery vehicle., Conclusions: Both these nano particles are promising in the field of oncology, especially due to their stability, solubility and biocompatibility features. Further their exterior surface can be modified for better tumour-targeting ability. More studies, are warranted to determine the immunogenicity, biodistribution, and clearance from the body., General Perspective: This review discusses a few selected examples of the remarkable in vitro and in vivo studies that have been carried out in the recent past with the use of AFt and Dps in targeting and delivery of various pharmaceutical agents, natural products and imaging probes in the field of oncology., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2022
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27. Development of an extended model for the permeation of environmentally hazardous CO 2 gas across asymmetric hollow fiber composite membranes.
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Jamil A, Ching OP, Iqbal T, Rafiq S, Zia-Ul-Haq M, Shahid MZ, Mubashir M, Manickam S, and Show PL
- Abstract
This study presents an extended thermodynamic and phenomenological combined model to mitigate the environmental hazardous acid gas over composite membranes. The model has been applied to an acid gas such as carbon dioxide (CO
2 ) for its permeation through polyetherimide incorporated montmorillonite (Mt) nanoparticles hollow fiber asymmetric composite membranes. The well-established non-equilibrium lattice fluid (NELF) model for penetrating low molecular weight penetrant in a glassy polyetherimide (PEI) was extended to incorporate the other important polymer/filler system features such as tortuosity in acid gas diffusion pathways resulted from layered filler aspect ratio and concentration. The model mentioned above predicts the behavior of acid gas in PEI-Mt composite membranes based on thermodynamic characteristics of CO2 and PEI and tortuosity due to Mt. The calculated results are compared to experimentally determined values of CO2 permeability through PEI-Mt composite asymmetric hollow fiber membranes at varying transmembrane pressures and Mt concentrations. A reasonable agreement was found between the model predicted behavior and experimentally determined data in terms of CO2 solubility, Mt concentration and aspect ratio were calculated based on average absolute relative error (%AARE). The proposed modified model efficiently predicts the CO2 permeance across MMMs up to 3 wt% Mt loadings and 6 bar pressure with ± 10%AARE., (Copyright © 2021 Elsevier B.V. All rights reserved.)- Published
- 2021
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28. Fluorescence "turn-off/turn-on" biosensing of metal ions by gold nanoclusters, folic acid and reduced graphene oxide.
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Wong XY, Quesada-González D, Manickam S, and Muthoosamy K
- Subjects
- Folic Acid, Gold, Graphite, Ions, Spectrometry, Fluorescence, Biosensing Techniques, Metal Nanoparticles
- Abstract
Metal ions homeostasis plays an important role in biological processes. The ability to detect the concentration of metal ions in biological fluids is often challenged by the obvious interference or competitive binding nature of other alkaline metals ions. Common analytical techniques employed for metal ions detection are electrochemical, fluorescence and colorimetric methods. However, most reported metal ions sensors are complicated, time-consuming and involve costly procedures with limited effectiveness. Herein, a nanobiosensor for detecting sodium and potassium ions using folic acid-functionalised reduced graphene oxide-modified RNase A gold nanoclusters (FA-rGO-RNase A/AuNCs) based on fluorescence "turn-off/turn-on" is presented. Firstly, a facile and optimised protocol for the fabrication of RNase A/AuNCs is developed. The activity of RNase A protein after the formation of RNase A/AuNCs is studied. RNase A/AuNCs is then loaded onto FA-rGO, in which FA-rGO is used as a potential carrier and fluorescence quencher for RNase A/AuNCs. Finally, a fluorescence "turn-on" sensing strategy is developed using the as-synthesised FA-rGO-RNase A/AuNCs to detect sodium and potassium ions. The developed nanobiosensor revealed an excellent sensing performance and meets the sensitivity required to detect both sodium and potassium ions. To the best of our knowledge, this is the first work done on determining the RNase A protein activity in RNase A/AuNCs and exploring the potential application of RNase A/AuNCs as a metal ion sensor. This work serves as a proof-of-concept for combining the potential of drug delivery, active targeting and therapy on cancer cells, as well as biosensing of metal ions into a single platform., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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29. Stable W/O/W multiple nanoemulsion encapsulating natural tocotrienols and caffeic acid with cisplatin synergistically treated cancer cell lines (A549 and HEP G2) and reduced toxicity on normal cell line (HEK 293).
- Author
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Raviadaran R, Ng MH, Chandran D, Ooi KK, and Manickam S
- Subjects
- Apoptosis, Caffeic Acids, Cell Line, Tumor, Cisplatin pharmacology, HEK293 Cells, Humans, Antineoplastic Agents pharmacology, Neoplasms, Tocotrienols pharmacology
- Abstract
This work aimed to evaluate the effects of encapsulated tocotrienols (TRF) and caffeic acid (CA) in water-in-oil-in-water (W/O/W) multiple nanoemulsion with cisplatin towards cancer cells. This work is important considering the limited efficacy of cisplatin due to tumour resistance, as well as its severe side effects. A549 and HEP G2 cancer cell lines were utilised for evaluating the efficacy of the encapsulated W/O/W while HEK 293 normal cell line was used for evaluating the toxicity. TRF, CA and CIS synergistically improved apoptosis in the late apoptotic phase in A549 and HEP G2 by 23.1% and 24.9%, respectively. The generation of ROS was enhanced using TRF:CA:CIS by 16.9% and 30.2% for A549 and HEP G2, respectively. Cell cycle analysis showed an enhanced cell arrest in the G0/G1 phase for both A549 and HEP G2. TRF, CA and CIS led to cell death in A549 and HEP G2. For HEK 293, ~33% cell viability was found when only CIS was used while >95% cell viability was observed when TRF, CA and CIS were used. This study demonstrates that the encapsulated TRF and CA in W/O/W with CIS synergistically improved therapeutic efficacy towards cancer cells, as well as lowered the toxicity effects towards normal cells., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
30. Enzymatic pretreatment to enhance anaerobic bioconversion of high strength wastewater to biogas: A review.
- Author
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Liew YX, Chan YJ, Manickam S, Chong MF, Chong S, Tiong TJ, Lim JW, and Pan GT
- Subjects
- Anaerobiosis, Bioreactors, Hydrolysis, Methane, Wastewater, Biofuels
- Abstract
Oil and grease, carbohydrate, protein, and lignin are the main constituents of high strength wastewaters such as dairy wastewater, cheese whey wastewater, distillery wastewater, pulp and paper mill wastewater, and slaughterhouse wastewaters. These constituents have contributed to various operational problems faced by the high-rate anaerobic bioreactor (HRAB). During the hydrolysis stage of anaerobic digestion (AD), these constituents can be hydrolyzed. Since hydrolysis is known to be the rate-limiting step of AD, the overall AD can be enhanced by improving the hydrolysis stage. This can be done by introducing pretreatment that targets the degradation of these constituents. This review mainly focuses on the biological pretreatment on various high-strength wastewaters by using different types of enzymes namely lipase, amylase, protease, and ligninolytic enzymes which are responsible for catalyzing the degradation of oil and grease, carbohydrate, protein, and lignin respectively. This review provides a summary of enzymatic systems involved in enhancing the hydrolysis stage and consequently improve biogas production. The results show that the use of enzymes improves the biogas production in the range of 7 to 76%. Though these improvements are highly dependent on the operating conditions of pretreatment and the types of substrates. Therefore, the critical parameters that would affect the effectiveness of pretreatment are also discussed. This review paper will serve as a useful piece of information to those industries that face difficulties in treating their high-strength wastewaters for the appropriate process, equipment selection, and design of an anaerobic enzymatic system. However, more intensive studies on the optimum operating conditions of pretreatment in a larger-scale and synergistic effects between enzymes are necessary to make the enzymatic pretreatment economically feasible., Competing Interests: Declaration of competing interest All authors have participated in (a) conception and design, or analysis and interpretation of the data; (b) drafting the article or revising it critically for important intellectual content; and (c) approval of the final version. This manuscript has not been submitted to, nor is under review at, another journal or other publishing venue. The authors have no affiliation with any organization with a direct or indirect financial interest in the subject matter discussed in the manuscript., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
31. Tamoxifen-loaded nanostructured lipid carrier as a drug delivery system: characterization, stability assessment and cytotoxicity.
- Author
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How CW, Rasedee A, Manickam S, and Rosli R
- Subjects
- Adenocarcinoma drug therapy, Adenocarcinoma metabolism, Adenocarcinoma pathology, Animals, Antineoplastic Agents, Hormonal administration & dosage, Antineoplastic Agents, Hormonal pharmacokinetics, Breast Neoplasms metabolism, Breast Neoplasms pathology, Cell Line, Tumor, Cell Survival drug effects, Chemistry, Pharmaceutical, Drug Stability, Female, Humans, Lipids chemistry, MCF-7 Cells, Mammary Neoplasms, Experimental drug therapy, Mammary Neoplasms, Experimental metabolism, Mammary Neoplasms, Experimental pathology, Mice, Microscopy, Electron, Transmission, Nanomedicine, Nanoparticles ultrastructure, Particle Size, Tamoxifen pharmacokinetics, Breast Neoplasms drug therapy, Drug Carriers chemistry, Drug Delivery Systems, Nanoparticles chemistry, Tamoxifen administration & dosage
- Abstract
Cancer nanotherapeutics is beginning to overwhelm the global research and viewed to be the revolutionary treatment regime in the medical field. This investigation describes the development of a stable nanostructured lipid carrier (NLC) system as carrier for Tamoxifen (TAM). The TAM-loaded NLC (TAM-NLC) developed with 200mg of TAM showed a spherical particle with the size of 46.6nm, polydispersity index of 0.267, entrapment efficiency of 99.74% and with the zeta potential of -23.78mV. Besides, the equivalent cytotoxicity of TAM and TAM-NLC to human (MCF-7) and mice (4T1) mammary breast cancer cell lines were observed. Incubating the formulation at the physiological pH resulted into reduced Ostwald ripening rate but without any significant change in the absorptivity. When coupled with the measurements of zeta potential and Ostwald ripening rate, the absorbance assay may be used to predict the long-term stability of drug-loaded nanoparticle formulations. The results of the study also suggest that TAM-NLC is a promising drug delivery system for breast cancer therapy. This is the first encouraging report on the in vitro effect of TAM-NLC against human and mouse mammary adenocarcinoma cell lines., (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
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