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4 results on '"Makoto Nagashima"'

1. Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements

Author

Yoshinori Aoki, Daisuke Nishizawa, Junko Hasegawa, Shinya Kasai, Kaori Yoshida, Yoshihiko Koukita, Tatsuya Ichinohe, Makoto Nagashima, Ryoji Katoh, Yasuo Satoh, Megumi Tagami, Masakazu Hayashida, Ken-ichi Fukuda, and Kazutaka Ikeda

Subjects
TRPC3, Analgesics, Polymorphism, Therapeutics. Pharmacology, RM1-950
Abstract

An association between postoperative analgesic requirements in subjects who underwent orthognathic surgery and the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene was suggested by our previous genome-wide association study. To verify this association, we analyzed the association between the rs1465040 SNP and analgesic requirements, including opioid requirements, after open abdominal surgery. The association between the rs1465040 SNP and postoperative analgesic requirements was confirmed in the open abdominal surgery group (P = 0.036), suggesting that the TRPC3 SNP may contribute to predicting postoperative analgesic requirements.

Published
2015
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2. Association Between Genetic Polymorphisms of the β1-Adrenergic Receptor and Sensitivity to Pain and Fentanyl in Patients Undergoing Painful Cosmetic Surgery

Author

Ayako Moriyama, Daisuke Nishizawa, Shinya Kasai, Junko Hasegawa, Ken-ichi Fukuda, Makoto Nagashima, Ryoji Katoh, and Kazutaka Ikeda

Subjects
Therapeutics. Pharmacology, RM1-950
Abstract

Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. The adrenergic system is reportedly involved in the mechanisms of pain and analgesia. Here, we focused on one of the adrenergic receptor genes, ADRB1, and analyzed the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain and analgesic sensitivity. We examined associations between pain and fentanyl sensitivity and the two SNPs, A145G and G1165C, in the human ADRB1 gene in 216 Japanese patients who underwent painful orofacial cosmetic surgery, including bone dissection. The patients who carried the A-allele of the A145G SNP were more sensitive to cold pressor–induced pain than those who did not carry this allele, especially in male patients. The analgesic effect was significantly less in females who carried the G-allele of the G1165C SNP than the females who did not carry the G-allele. The haplotype analysis revealed a significant decrease in 24-h postoperative fentanyl use in female 145A/1165C haplotype carriers. These results suggest that SNPs in the ADRB1 gene are associated with individual differences in pain and analgesic sensitivity, and analyzing these SNPs may promote personalized pain treatment in the future. Keywords:: β1-adrenergic receptor, gene polymorphism, opioid, pain, individual difference

Published
2013
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3. Association Between Genetic Polymorphisms of the β1-Adrenergic Receptor and Sensitivity to Pain and Fentanyl in Patients Undergoing Painful Cosmetic Surgery

Author

Ryoji Katoh, Ken-ichi Fukuda, Ayako Moriyama, Kazutaka Ikeda, Daisuke Nishizawa, Makoto Nagashima, Shinya Kasai, and Junko Hasegawa

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Analgesic, Adrenergic, Single-nucleotide polymorphism, Fentanyl, Young Adult, SNP, Medicine, Humans, Precision Medicine, Alleles, Pharmacology, Postoperative Care, Pain, Postoperative, Polymorphism, Genetic, business.industry, Orthognathic Surgical Procedures, Haplotype, lcsh:RM1-950, Middle Aged, Plastic Surgery Procedures, Surgery, Analgesics, Opioid, lcsh:Therapeutics. Pharmacology, Opioid, Molecular Medicine, Female, Gene polymorphism, Receptors, Adrenergic, beta-1, business, medicine.drug
Abstract

Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. The adrenergic system is reportedly involved in the mechanisms of pain and analgesia. Here, we focused on one of the adrenergic receptor genes, ADRB1, and analyzed the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain and analgesic sensitivity. We examined associations between pain and fentanyl sensitivity and the two SNPs, A145G and G1165C, in the human ADRB1 gene in 216 Japanese patients who underwent painful orofacial cosmetic surgery, including bone dissection. The patients who carried the A-allele of the A145G SNP were more sensitive to cold pressor–induced pain than those who did not carry this allele, especially in male patients. The analgesic effect was significantly less in females who carried the G-allele of the G1165C SNP than the females who did not carry the G-allele. The haplotype analysis revealed a significant decrease in 24-h postoperative fentanyl use in female 145A/1165C haplotype carriers. These results suggest that SNPs in the ADRB1 gene are associated with individual differences in pain and analgesic sensitivity, and analyzing these SNPs may promote personalized pain treatment in the future. Keywords:: β1-adrenergic receptor, gene polymorphism, opioid, pain, individual difference

Published
2013

4. Controlled-potential electrosynthesis of glucosaminic acid from glucosamine at a gold electrode

Author

Isao Taniguchi, Masato Tominaga, and Makoto Nagashima

Subjects
Electrolysis, Working electrode, Chemistry, Inorganic chemistry, Buffer solution, Electrochemistry, Electrosynthesis, law.invention, lcsh:Chemistry, chemistry.chemical_compound, Plate electrode, lcsh:Industrial electrochemistry, lcsh:QD1-999, law, Aldonic acid, Gluconic acid, lcsh:TP250-261
Abstract

The electrocatalytic oxidation of d-glucosamine (2-amino-2-deoxy-d-glucose) in alkaline and neutral solutions was examined using a carbon felt electrode modified with 2 nm core sized gold nanoparticles (Au2 nm nanoparticles) and a gold plate electrode. The electrocatalytic voltammetric oxidation curves of d-glucosamine were obtained in both solutions. The voltammetric responses for the electrocatalytic oxidation at a Au2 nm nanoparticle-modified electrode in both alkaline and neutral solutions were almost the same to those at a gold plate electrode. The oxidized product was identified to be d-glucosaminic acid (2-amino-2-deoxy- d-gluconic acid) generated by the 2-electron oxidation product of d-glucosamine by electrospray ionization time-of-flight mass spectra (ESI TOF-MS). The HPLC results also indicated that the oxidation product was d-glucosaminic acid.The controlled-potential electrolysis of d-glucosamine was performed at the Au2 nm nanoparticle-modified carbon felt electrodes in both alkaline and neutral solutions. In the alkaline solution, at a potential of −0.2 V, d-glucosaminic acid was formed with a current efficiency of 100%. In the neutral solution, electrolysis at 0.4 V on d-glucosaminic acid was obtained with current efficiencies of 70%. Keywords: Electrochemistry, Gold, Oxidation, Glucosamine, Glucosaminic acid, Electrolysis

Published
2007

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