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Your search keyword '"MASSIMO BOVENZI"' showing total 3 results
Start Over Author "MASSIMO BOVENZI" Publisher elsevier
3 results on '"MASSIMO BOVENZI"'

1. Force-feeding malignant mesothelioma stem-cell like with exosome-delivered miR-126 induces tumour cell killing

Author

Federica Monaco, Laura De Conti, Simone Vodret, Nunzia Zanotta, Manola Comar, Sandra Manzotti, Corrado Rubini, Laura Graciotti, Gianluca Fulgenzi, Massimo Bovenzi, Marco Baralle, Marco Tomasetti, and Lory Santarelli

Subjects
Mesothelioma, miR-126, exosome, spheroids, miRNA-based therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Malignant pleural mesothelioma (MPM) is an aggressive tumour resistant to treatments. It has been postulated that cancer stem cells (CSCs) persist in tumours causing relapse after multimodality treatment. In the present study, a novel miRNA-based therapy approach is proposed. MPM-derived spheroids have been treated with exosome-delivered miR-126 (exo-miR) and evaluated for their anticancer effect. The exo-miR treatment increased MPM stem-cell like stemness and inhibited cell proliferation. However, at a prolonged time, the up taken miR-126 was released by the cells themselves through exosomes; the inhibition of exosome release by an exosome release inhibitor GW4869 induced miR-126 intracellular accumulation leading to massive cell death and in vivo tumour growth arrest. Autophagy is involved in these processes; miR-126 accumulation induced a protective autophagy and the inhibition of this process by GW4869 generates a metabolic crisis that promotes necroptosis, which was associated with PARP-1 over-expression and cyt-c and AIF release. Here, for the first time, we proposed a therapy against CSCs, a heterogeneous cell population involved in cancer development and relapse.

Published
2022
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3. Hand-Arm Vibration in Shipyard Caulkers

Author

F. Di Marino, Massimo Bovenzi, Lorenzo Petronio, BIANCHI G, FROLOV KV, OLEDZKI A, Bovenzi, Massimo, Petronio, L, and DI MARINO, F.

Subjects
Orthodontics, business.industry, Olecranon, Significant difference, Structural engineering, medicine.disease, Frequency spectrum, law.invention, Vibration, medicine.anatomical_structure, Cold test, law, Vibration white finger, Medicine, Hammer, business, Hand arm
Abstract

Summary The results of a survey performed on shipyard caulkers exposed to hand-arm vibration are reported.Percussive(chipping hammer)and rotatory(grinders)hand held tools have been examined, Frequency spectrum of the chipping hammer shows high acceleration levels which exceed ISO acceptable boundaries for the exposure time of caulkers. Acceleration levels of the grinders, on the contrary, exceed ISO limits only in a few third octave bands. Medical investigations included 169 caulkers and 60 controls. The results of medical examinations demonstrate:1)a high prevalence (78.7%)of neurovascular complaints in the upper limbs of the caulkers; 2)among 169 caulkers, 53 (31.3%)are suffering from vibration white finger, while a prevalence of 6.6% is found in the control group; 3)X-ray of the right upper limbs of the caulkers show a moderate prevalence of typical carpal cysts(31.3%) and olecranon exostoses (10.0%);4)the measurement of basal skin temperature of the hands and the recovery time of basal skin temperature after cold test reveal a statistically significant difference between caulkers and controls. At conclusion, some preventive considerations are reported.

Published
1981

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