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3 results on '"Luleci G"'

2. A somatic origin of homologous Robertsonian translocations and isochromosomes

Author

Robinson, Wendy P, Bernasconi, Fabiana, Basaran, S, Yüksel-Apak, M, Neri, Giovanni, Serville, F, Balicek, P, Haluza, R, Farah, L M S, Luleci, G, Schinzel, Albert, Robinson, Wendy P, Bernasconi, Fabiana, Basaran, S, Yüksel-Apak, M, Neri, Giovanni, Serville, F, Balicek, P, Haluza, R, Farah, L M S, Luleci, G, and Schinzel, Albert

Abstract

One t(14q14q), three t(15q15q), two t(21q21q), and two t(22q22q) nonmosaic, apparently balanced, de novo Robertsonian translocation cases were investigated with polymorphic markers to establish the origin of the translocated chromosomes. Four cases had results indicative of an isochromosome: one t(14q14q) case with mild mental retardation and maternal uniparental disomy (UPD) for chromosome 14, one t(15q15q) case with the Prader-Willi syndrome and UPD(15), a phenotypically normal carrier of t(22q22q) with maternal UPD(22), and a phenotypically normal t(21q21q) case of paternal UPD(21). All UPD cases showed complete homozygosity throughout the involved chromosome, which is supportive of a postmeiotic origin. In the remaining four cases, maternal and paternal inheritance of the involved chromosome was found, which unambiguously implies a somatic origin. One t(15q15q) female had a child with a ring chromosome 15, which was also of probable postmeiotic origin as recombination between grandparental haplotypes had occurred prior to ring formation. UPD might be expected to result from de novo Robertsonian translocations of meiotic origin; however, all de novo homologous translocation cases, so far reported, with UPD of chromosomes 14, 15, 21, or 22 have been isochromosomes. These data provide the first direct evidence that nonmosaic Robertsonian translocations, as well as isochromosomes, are commonly the result of a mitotic exchange.

Published
1994

3. The assessment of PTEN tumor suppressor gene in combination with Gleason scoring and serum PSA to evaluate progression of prostate carcinoma.

Author

Koksal IT, Dirice E, Yasar D, Sanlioglu AD, Ciftcioglu A, Gulkesen KH, Ozes NO, Baykara M, Luleci G, and Sanlioglu S

Subjects
Blotting, Western, Disease Progression, Genes, Tumor Suppressor, Humans, Male, PTEN Phosphohydrolase, Predictive Value of Tests, Prognosis, Prostatic Hyperplasia genetics, Prostatic Hyperplasia pathology, Sensitivity and Specificity, Neoplasm Staging methods, Phosphoric Monoester Hydrolases genetics, Prostate-Specific Antigen analysis, Prostatic Neoplasms genetics, Prostatic Neoplasms pathology, Tumor Suppressor Proteins genetics
Abstract

Objective: The purpose of the study was to determine if the tumor suppressor gene phosphate and tensin homolog (PTEN) (mutated in multiple advanced cancers 1) in combination with Gleason scoring and serum prostate specific antigen (PSA) could be employed to better predict the progression of prostate carcinoma., Materials and Methods: The study group consisted of 43 patients with benign prostate hyperplasia (BPH), 15 with organ confined prostate carcinoma (OCPCa), and 18 with advanced prostate carcinoma (APCa). Prostate tissue samples were obtained from radical prostatectomy, transurethral resection, and TRUS guided trans-rectal needle biopsy and then evaluated for biomarker expression. The clinical stage was assessed according to tumor node metastasis classification and grade according to Gleason system. Serum PSA was measured by conventional techniques and Western blotting analysis was used to determine PTEN expression in the primary tissue. Multivariate analysis was performed to analyze whether these markers could individually predict the progression of prostate carcinoma., Results: APCa patients displayed higher Gleason scores and serum PSA levels. But much lower PTEN expression was detected in prostate of APCa patients compared to patients with BPH or OCPCa. Hormone refractory (HR) and hormone sensitive (HS) APCa cases did not yield any significant differences in terms of Gleason scoring, serum PSA and PTEN expression. PSA levels were significantly higher in patients with OCPCa or APCa compared to patients with BPH., Conclusion: Our results suggested that both PTEN and serum PSA appeared to be useful as independent markers to depict the nature of tumor behavior as benign or malign. In addition, PTEN also appeared to be useful as an independent marker to predict the progression of prostate carcinoma., (Copyright 2004 Elsevier Inc.)

Published
2004
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