1. Functional reconstruction of the impaired cortex and motor function by hMGEOs transplantation in stroke.
- Author
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Cao SY, Tao MD, Lou SN, Yang D, Lin YH, Wu HY, Chang L, Luo CX, Xu Y, Liu Y, and Zhu DY
- Subjects
- Humans, Mice, Animals, Brain, Interneurons, Cell Differentiation, Induced Pluripotent Stem Cells physiology, Stroke therapy
- Abstract
Stroke is the leading cause of death and long-term disability worldwide. But treatments are not available to promote functional recovery, and efficient therapies need to be investigated. Stem cell-based therapies hold great promise as potential technologies to restore function in brain disorders. Loss of GABAergic interneurons after stroke may result in sensorimotor defects. Here, by transplanting human brain organoids resembling the MGE domain (human MGE organoids, hMGEOs) derived from human induced pluripotent stem cells (hiPSCs) into the infarcted cortex of stroke mice, we found that grafted hMGEOs survived well and primarily differentiated into GABAergic interneurons and significantly restored the sensorimotor deficits of stroke mice for a long time. Our study offers the feasibility of stem cell replacement therapeutics strategy for stroke., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
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