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1. Diterpene from Baccharis trimera with a relaxant effect on rat vascular smooth muscle.

Author

Torres LM, Gamberini MT, Roque NF, Lima-Landman MT, Souccar C, and Lapa AJ

Subjects
Animals, Diterpenes chemistry, Diterpenes isolation & purification, Female, Muscle, Smooth, Vascular physiology, Rats, Rats, Wistar, Asteraceae chemistry, Diterpenes pharmacology, Muscle Relaxation drug effects, Muscle, Smooth, Vascular drug effects
Abstract

A bioassay monitored fractionation of a chloroform extract from the aerial parts of Baccharis trimera yielded a mixture that blocked the Ca2+-induced contractions of KCl- depolarized rat portal vein preparations. Pharmacological tests of two pure compounds isolated from the mixture revealed the dilactonic clerodane diterpene as the active compound.

Published
2000
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