1. Galectin-9 as an important marker in the differential diagnosis between oral squamous cell carcinoma, oral leukoplakia and oral lichen planus.
- Author
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Muniz JM, Bibiano Borges CR, Beghini M, de Araújo MS, Miranda Alves P, de Lima LM, Pereira SA, Nogueira RD, Napimoga MH, Rodrigues V Jr, and Rodrigues DB
- Subjects
- Benzamides metabolism, Carcinoma, Squamous Cell pathology, Diagnosis, Differential, Galectin 3 metabolism, Humans, Immunohistochemistry, Mouth Neoplasms pathology, Tyrosine analogs & derivatives, Tyrosine metabolism, Biomarkers, Tumor metabolism, Carcinoma, Squamous Cell diagnosis, Galectins metabolism, Leukoplakia diagnosis, Lichen Planus diagnosis, Mast Cells immunology, Matrix Metalloproteinase 3 metabolism, Mouth Neoplasms diagnosis
- Abstract
Objectives: To evaluate the expression of Galectins (Gal) 1, 3 and 9, Metalloproteinase 3 (MMP-3) and mast cell density in oral lesions of patients with potentially malignant disorders (PMD) and oral squamous cell carcinomas (OSCC) by comparison with the controls., Study Design: We selected 40 cases of PMD, 40 OSCC and 13 with normal histopathological profile. Immunohistochemistry was performed for Gal-1, Gal-3, Gal-9 and MMP-3., Results: Gal-9 was significantly higher in patients with OSCC than in others groups (p < 0.001). Gal-1 expression was significantly lower in patients with leukoplakia than those with OSCC and controls (p = 0.0001). Gal-3 was significantly lower in patients with OSCC than those with leukoplakia (p = 0.03). MMP-3 was lower in patients with leukoplakia in comparison with the lichen planus group (p = 0.013)., Conclusion: The increased expression of Gal-9 may be helpful to differentiate of OSCC from other oral cavity lesions., (Copyright © 2015 Elsevier GmbH. All rights reserved.)
- Published
- 2015
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