1. Early protein energy malnutrition impacts life-long developmental trajectories of the sources of EEG rhythmic activity
- Author
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Jorge Bosch-Bayard, Fuleah Abdul Razzaq, Carlos Lopez-Naranjo, Ying Wang, Min Li, Lidice Galan-Garcia, Ana Calzada-Reyes, Trinidad Virues-Alba, Arielle G. Rabinowitz, Carlos Suarez-Murias, Yanbo Guo, Manuel Sanchez-Castillo, Kassandra Roger, Anne Gallagher, Leslie Prichep, Simon G. Anderson, Christoph M. Michel, Alan C. Evans, Maria L. Bringas-Vega, Janina R. Galler, and Pedro A. Valdes-Sosa
- Subjects
EEG ,qEEG ,Source analysis ,Malnutrition ,Tomography ,Longitudinal study ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Protein Energy Malnutrition (PEM) has lifelong consequences on brain development and cognitive function. We studied the lifelong developmental trajectories of resting-state EEG source activity in 66 individuals with histories of Protein Energy Malnutrition (PEM) limited to the first year of life and in 83 matched classmate controls (CON) who are all participants of the 49 years longitudinal Barbados Nutrition Study (BNS). qEEGt source z-spectra measured deviation from normative values of EEG rhythmic activity sources at 5–11 years of age and 40 years later at 45–51 years of age. The PEM group showed qEEGt abnormalities in childhood, including a developmental delay in alpha rhythm maturation and an insufficient decrease in beta activity. These profiles may be correlated with accelerated cognitive decline.
- Published
- 2022
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