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Clostridium subterminale is an anaerobic spore-forming bacterium usually associated with infections in patients who are immunocompromised. This case report focuses on a rare presentation of a multifascial space odontogenic infection associated with the bacterial isolate Clostridium subterminale. The management of an odontogenic infection associated with an isolate of Clostridium subterminale in an immunocompetent female is described, as well as a review of the literature. Keywords: Clostridium subterminale, Oral/maxillofacial infections, Masticator space, Anaerobic resistance, Immunocompetence