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2 results on '"Leema George"'

1. List of Contributors

Author

Padma Ambalam, Frank Antonicelli, Syed Asrafuzzaman, Debasis Bagchi, Philippe Bernard, Elango Bhakkiyalakshmi, Chhanda Biswas, Marco Bonesi, Nabil Bosco, Olivier Cexus, Scott Chaffee, Shampa Chatterjee, Dorothy H.J. Cheong, Sung J. Choe, Amitava Das, Ingrid De Meester, Fernando Del Rosario, Neeraj Dholia, Mukesh Doble, Katia Falasca, Koustav Ganguly, Leema George, Nandini Ghosh, Catherine L. Grimes, Zhaoping He, Elizabeth D. Hood, Melanie-Jayne R. Howes, Shaik Abdul Hussain, Se K. Jeong, Wolfgang Jungraithmayr, Toshihide Kabuki, Yoshihiro Kawasaki, Charmy Kothari, Anis Larbi, Sébastien Le Jan, Eun-Ji Lee, Jeong-Sang Lee, Robert J. Lee, Chae J. Lim, Monica R. Loizzo, Francesco Menichini, Karthik B. Mallilankaraman, Selvaraj Manoj Kumar Kingsley, Derek B. McMahon, James E. Melnyk, Tomohiro Moriya, David L. Moyes, Hye-Kyung Na, Pradeep M.K. Nair, Jun Nishihira, Mie Nishimura, Keedon Park, Kyungho Park, Priyal Patel, Bela Peethambaran, Sheetal Pithva, Julie Plée, Ramesh Pothuraju, Nupoor Prasad, Ravi Kiran Purama, Yongkang Qiao, Maya Raman, Kunka M. Ramkumar, Prerna Ramteke, Marcella Reale, Sashwati Roy, Fumihiko Sakai, Hyndavi Salwa, Venkatesh Sampath, Amy K. Schaefer, Chandan K. Sen, Rahul Shah, Ashish K. Sharma, Minaxi Sharma, Travis M. Sifers, Dina C. Simes, Dornadula Sireesh, Young-Joon Surh, Tania A. Thimraj, Thai Tran, Rosa Tundis, Swapna Upadhyay, Jose P. Vazquez-Medina, Carla S.B. Viegas, Ballambattu Vishnu Bhat, Gwendolyn Vliegen, Elizabeth A. Witherden, Umesh C.S. Yadav, Vengala Rao Yenuganti, and Huihui You

Published
2018
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2. Oxidative Signaling in Chronic Obstructive Airway Diseases

Author

Tania A. Thimraj, Swapna Upadhyay, Syed Asrafuzzaman, Koustav Ganguly, and Leema George

Subjects
chemistry.chemical_classification, COPD, Reactive oxygen species, Antioxidant, Chemistry, medicine.medical_treatment, Oxidative phosphorylation, medicine.disease_cause, medicine.disease, Proinflammatory cytokine, Pathogenesis, Immunology, medicine, Genetic predisposition, Oxidative stress
Abstract

Oxidant imbalance is a key feature in the pathogenesis and progression of chronic obstructive airway diseases (COADs) like asthma and chronic obstructive pulmonary disease (COPD). Proinflammatory reaction and oxidative stress complement each other in COAD pathogenesis. Genetic predisposition, like variations and altered regulation of antioxidant genes as well as their transcriptional control mechanisms, may also render susceptibility to COADs. Dietary supplementation particularly of nonenzymatic antioxidants such as vitamin E and C are suggested as plausible preventive measures for COAD development. Thiols, and antioxidant mimetics like spin traps are also being explored as potential therapeutic options for COADs. This chapter discusses the association of disrupted redox homeostasis in asthma and COPD, various exogenous and endogenous sources of reactive oxygen species that contribute to oxidative stress development in COAD, antioxidant defense system of the lung, biochemical mechanisms of oxidative stress mediated damage, and the antioxidant based preventive as well as therapeutic modalities that are currently being explored to treat COADs.

Published
2018
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