1. Minoxidil (Mx) as a prophylaxis of doxorubicin--induced alopecia.
- Author
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Rodriguez R, Machiavelli M, Leone B, Romero A, Cuevas MA, Langhi M, Romero Acuña L, Romero Acuña J, Amato S, and Barbieri M
- Subjects
- Adult, Aged, Alopecia chemically induced, Double-Blind Method, Female, Humans, Middle Aged, Neoplasms drug therapy, Alopecia prevention & control, Doxorubicin adverse effects, Minoxidil therapeutic use
- Abstract
Background: Minoxidil (Mx) is known to induce hair growth in men with male-pattern baldness. Based on this potential, the effectiveness of Mx 2% topical solution was evaluated in cancer patients (pts) to prevent doxorubicin-induced alopecia., Patients and Methods: 48 female pts with different types of solid tumors treated with doxorubicin-based chemotherapy in a dose range of 50-60 mg/m2/cycle were randomly assigned to receive Mx 2% topical solution or placebo., Results: 88% and 92% of pts in both arms showed severe alopecia (p = ns). No adverse effects were observed., Conclusion: In this study Mx 2% topical solution was non-toxic but was not effective in the prevention of chemotherapy-induced alopecia.
- Published
- 1994
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