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Posterior Cortical Atrophy (PCA) is a rare neurodegenerative syndrome characterized by an occipital atrophy resulting in a progressive impairment of upper visual functions. The inconsistency of terminology of this pathology makes its diagnosis difficult and delayed. We present a 76-year-old patient with PCA having difficulties in reading, writing, and daily manipulations. The objective was to evaluate the kinematic writing parameters. Linguistic, cognitive-non-linguistic and non-cognitive-non-linguistic graphical tasks were performed. The kinematic parameters extracted were jerk, velocity and pressure. We found a kinematic profile for all these parameters different from what observed in healthy controls and patients with Alzheimer's Disease. This study, through an analysis of writing features never studied before in PCA, shows the interest of handwriting kinematic analysis in the clinical diagnosis of PCA., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Objective: We tested whether acute cerebellar stroke may determine changes in brain network architecture as defined by cortical sources of EEG rhythms., Methods: Graph parameters of 41 consecutive stroke patients (<5 days from the event) were studied using eLORETA EEG sources. Network rearrangements of stroke patients were investigated in delta, alpha 2, beta 2 and gamma bands in comparison with healthy subjects., Results: The delta network remodeling was similar in cerebellar and middle cerebral artery strokes, with a reduction of small-worldness. Beta 2 and gamma small-worldness, in the right hemisphere of patients with cerebellar stroke, increase respect to healthy subjects, while alpha 2 small-worldness increases only among patients with a middle cerebral artery stroke., Conclusions: The network remodeling characteristics are independent on the size of the ischemic lesion. In the early post-acute stages cerebellar stroke differs from the middle cerebral artery one because it does not cause alpha 2 network remodeling while it determines a high frequency network reorganization in beta 2 and gamma bands with an increase of small-worldness characteristics., Significance: These findings demonstrate changes in the balance of local segregation and global integration induced by cerebellar acute stroke in high EEG frequency bands. They need to be integrated with appropriate follow-up to explore whether further network changes are attained during post-stroke outcome stabilization., (Copyright © 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)

The effect of B cell cross-match (XM) was investigated in 680 first deceased-donor kidney transplants in a single centre from 1990 to 1999: 74 transplants presented a B-positive XM (Group 1) 606 had a B-negative XM (Group 2). The absence in Group 1 of weak/low-titre anti-HLA Class I antibodies was assured blocking anti-Class I reactivity by treating B cells with non-cytotoxic anti-beta2 microglobulin (alphabeta2 M) serum before XM. Graft survivals up to 5 years were not significantly different; some differences were nevertheless observed: HLA-A,B,DR mismatches influenced graft outcome in Group 1: patients with 0-2 mismatches had better survival than patients with 3-4. When analysed according DR mismatch, patients with 1 mismatch had worse graft survival than well matched patients (p<0.05). No significant difference depending on HLA match was observed in Group 2. Early acute rejection rate was similar in the Groups except the rejection episodes after one year: Group 1 had significantly more. 61/74 patients of Group 1 were retrospectively analysed for anti-HLA-DR,DQ reactivity: only 11/61 had anti-HLA-DR or DQ antibodies (3/11 were donor specific); graft survival and rejections were not significantly different in the patients with and without anti-HLA Class II antibodies. Anti-donor B cell reactivity, at XM, once excluded the presence of weak/low-titre anti-HLA Class I antibodies, did not influence first kidney graft survival.

Designs to enrich the environment are crucial in the effort to fully address the biological needs of domestic animals. Although enrichment programs have been shown to improve health and welfare, little is known of their potential for application to commercial broiler breeder environments. We investigated the potential benefits of cover panels for broiler breeder reproductive performance in a commercial setting. This demonstration trial occurred on 5 commercial broiler breeder farms, each with a control and panel treatment room containing approximately 7,000 females and 800 males. Reproductive performance was measured from 25 to 60 wk by the number of eggs laid per female per week as well as weekly fertility and hatchability rates. The location of marked males was recorded weekly to quantify male movement. Access to cover panels improved egg production by 2.1% and maintained better hatchability and fertility throughout the breeding cycle (significant interactions of age and panel treatment) leading to an additional 4.5 chicks/female. Male home ranges, based on minimum convex polygons, were larger in the enriched (259 +/- 24.4 m(2)) vs. control flocks (184 +/- 23.1 m(2)). Providing enrichment in the form of cover panels improved reproductive performance, most likely by increasing males' mating opportunities and reducing female stress. We found a clear economic benefit to providing enrichment, an estimated $3 million if all breeder houses within the participating company were outfitted with the panels. These results demonstrate that environmental enrichment is not only beneficial for broiler breeder welfare, but can also be economically advantageous, resulting in a win-win situation for poultry welfare and production.

The manner in which an animal moves throughout and utilizes the space available to it depends on the dispersal, availability, and level of competition for resources the animal requires for its biological functioning. We tested groups of broilers (Gallus gallus domesticus) in 3 experimental group sizes of 5, 10, and 20 individuals per group under 3 resource distribution patterns. Groups were tested with access to 1 large single feeder, 2 medium-sized feeders, or 4 small feeders. In all arrangements the total amount of food available per bird remained constant. During the first phase groups had free access to all available feeders, and in the second phase access at each feeder was restricted to a single bird. Space use, measured by calculating core areas and interindividual distances between group members, increased as group size grew larger and as feeders became more widely distributed. Not all group sizes responded equally to the resource distribution patterns. Space use patterns for the smaller group sizes were more strongly affected by resource distribution patterns than the larger group sizes. When access to the feeders was restricted, consumption, aggression, and space use increased. Broilers adjusted their space use and aggressive behavior according to the level of competition, dictated not only by group size but also resource distribution and accessibility.

We tested male broiler chickens in 3 experimental group sizes (GS) to examine the mediating effects of GS and feed handling time on patch choice. We tested the experimental GS in a 3-patch discrimination trial with patches that contained identical amounts of feed but differed in the proportion of inedible filler material (wood shavings) added. The patch requiring the least handling time offered the highest profitability and was composed of 25% filler and 75% feed (by volume), whereas the mid and low profitability patches contained 50 and 75% filler, respectively. Food consumption, foraging duration, patch residence time, number of foraging bouts, and number of discrete patch visitors were significantly greater at the more profitable patches, requiring less handling time. We found a greater number of birds exploiting all 3 patches at larger GS, although we did not detect a parallel increase in aggression. On the contrary, aggression increased only as handling time decreased. These results suggest that at large GS resource monopolization did not occur; birds were most likely involved in scramble competition, particularly at the more profitable patches. Our findings show that broilers are able to discern the handling time required to obtain nutritious feed and adjust their foraging behavior according to the number of competitors.

OBJECTIVE: To determine the incidence of Chlamydia pneumoniae respiratory tract infection in HIV-positive or AIDS patients. METHODS: Serum samples from 82 HIV-positive patients with fever and respiratory symptoms were evaluated using microimmunofluorescence assay to detect C. pneumoniae-specific IgG and IgM antibodies. RESULTS: Twenty patients were found to have IgG antibodies to C. pneumoniae at titers ranging between 1:16 and 1:1024. Seven of the patients had evidence of acute C. pneumoniae infection (a fourfold rise in the titer of IgG antibody, or a single IgG titer of greater-than-or-equal1:512, or a single IgM titer greater-than-or-equal1:16). Five were diagnosed as having pneumonia and two bronchitis. No co-infection with other respiratory tract pathogens was found. CONCLUSIONS: Results of this study indicate that C. pneumoniae may play a role in the etiology of respiratory tract infections in HIV-positive patients; this fact should affect empirical antibiotic prescription.

Studies were conducted to investigate the effect of ovine luteinizing hormone (LH) treatment on steroid and LH secretion and ovulation in intact, saline-primed hens and in pregnant mare serum gonadotropin (PMSG)-primed hens. Intact, saline-primed hens, injected 12 hr prior to the first (C1) ovulation of the sequence, responded with fully potentiated preovulatory surges of progesterone (P4) (peak value was 371% above preinjection values), estradiol-17 beta (E2) (117% above baseline), LH (220% above baseline), and premature ovulation. By comparison, those hens injected at the same time prior to the second (C2) ovulation responded with a lesser increase in plasma P4 (peak value was 305% above baseline) and E2 (72% above baseline), and there was no significant increase in plasma LH. Within this group, 4 of 5 hens failed to ovulate prematurely. All groups of PMSG-primed hens had significantly higher preinjection concentrations of P4 and E2, and lower basal concentrations of LH, compared to saline-primed hens. Subsequent to treatment of PMSG-primed hens with 25 or 100 micrograms ovine LH, there was a significant increase in plasma P4 to approximately 200% above preinjection concentrations. By contrast, there was a nonsignificant increase in plasma LH (50% above baseline values) and no significant increase in plasma E2. The ovulatory response following PMSG-priming was greatest in hens injected with 100 micrograms ovine LH (5 of 5 hens ovulated), while 3 of 5 hens injected with 25 micrograms ovine LH and 6 of 6 saline-challenged hens failed to ovulate.(ABSTRACT TRUNCATED AT 250 WORDS)