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Your search keyword '"Kuo-Tai Yang"' showing total 4 results
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4 results on '"Kuo-Tai Yang"'

1. Protective effects of crude chalaza hydrolysates against liver fibrogenesis via antioxidation, anti-inflammation/anti-fibrogenesis, and apoptosis promotion of damaged hepatocytes

Author

Yi-Ling Lin, Ching-Fu Lu, Yi-Hsieng Samuel Wu, Kuo-Tai Yang, Wen-Yuan Yang, Jr-Wei Chen, Jung-Kai Tseng, and Yi-Chen Chen

Subjects
anti-inflammation, antioxidant, apoptosis, crude chalaza hydrolysates, liver fibrosis, Animal culture, SF1-1100
Abstract

ABSTRACT: Four-hundred metric-ton chalazae are produced annually from the liquid-egg processing and always cause a heavy burden due to handling cost in Taiwan. After chalazae were hydrolyzed by protease A, the amounts of hydrophobic, aromatic, and branched-chain amino acids, as well as anserine were dramatically increased. This study was to understand the antifibrogenic effects of protease A-digested crude chalaza hydrolysates (CCH-As) on livers of thioacetamide (TAA) treated rats. CCH-As improved (P< 0.05) growth performance, serum liver damage indices, histopathological liver inflammation, and liver collagen deposition in TAA-treated rats. The antifibrogenic effects of CCH-As were due to decreased (P < 0.05) inflammatory/fibrogenic cytokine contents, α-smooth-muscle-actin (α-SMA) protein expression, and matrix metallopeptidase (MMP)-2 and -9 activities, as well as increased (P < 0.05) the antioxidant capacity in livers. CCH-As also increased (P < 0.05) cleaved caspase-3 and cleaved poly ADP-ribose polymerase protein levels in livers of TAA-treated rats which accelerating cell renewal. Thus, this study does not only reveal a novel nutraceutical ingredient, CCH-As, against liver fibrogenesis, but also offer an alternative way to expand the utilization of poultry byproducts.

Published
2021
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2. L-carnitine ameliorates dyslipidemic and hepatic disorders induced by a high-fat diet via regulating lipid metabolism, self-antioxidant capacity, and inflammatory response

Author

Chang-Chao Su, Chaung-Sung Chang, Chung-Hsi Chou, Yi-Hsieng Samuel Wu, Kuo-Tai Yang, Jung-Kai Tseng, Yuan-Yen Chang, and Yi-Chen Chen

Subjects
Antioxidant effect, High-fat diet, L-carnitine, Lipid homeostasis, Non-alcoholic fatty liver disease, Serum lipid, Nutrition. Foods and food supply, TX341-641
Abstract

The cardiovascular and liver protection of carnitine (CNT) in a high-fat diet was investigated. Male C57BL/6 mice were divided randomly into four groups: 1) CON: Control, 2) HFD: high-fat diet, 3) CNTL: HFD + 500 mg CNT/kg BW, and 4) CNTH: HFD + 1500 mg CNT/kg BW. After a 25-week experimental period, CNT supplementation reduced (p

Published
2015
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4. Kisspeptin expression in mouse Leydig cells correlates with age

Author

Leang-Shin Wu, Jyun-Yuan Wang, Kuo-Tai Yang, Chih-Hsien Chiu, Meng-Chieh Hsu, and Tai-Hsiang Tseng

Subjects
Male, medicine.medical_specialty, puberty, steroidogenesis, 3-Hydroxysteroid Dehydrogenases, Leydig cells, Biology, Receptors, G-Protein-Coupled, kisspeptin, Mice, Kisspeptin, Internal medicine, medicine, KISS1 Gene, Animals, Testosterone, Cholesterol Side-Chain Cleavage Enzyme, Receptor, Cells, Cultured, Medicine(all), Kisspeptins, Mice, Inbred ICR, lcsh:R5-920, KISS1R Gene, Age Factors, Estrogen Receptor alpha, Antagonist, General Medicine, Gonadosomatic Index, Endocrinology, lcsh:Medicine (General), Estrogen receptor alpha, Receptors, Kisspeptin-1
Abstract

Background Kisspeptin, encoded by the Kiss1 gene, has many forms including kisspeptin54, kisspeptin14, kisspeptin13, and kisspeptin10, and all these peptides have the same affinity to their receptor KISS1R encoded by the Kiss1r gene. The KISS1–KISS1R system was discovered in neurons, and many reports stress on their function in the brain. However, recent studies have shown that Kiss1 and Kiss1r are expressed in the testes. The goal of this study was to demonstrate the roles of Kiss1 and Kiss1r in testicular function, especially their steroidogenic activity. Methods Kisspeptin10 and the kisspeptin10 antagonist peptide234 were used to determine their effect on testosterone production. Moreover, expression of steroidogenic genes in mouse testes and their gonadosomatic index (weight of the testes divided by the total body weight) and also serum testosterone level were studied between the ages of 2 weeks and 15 weeks. Results Kisspeptin10 and peptide234 did not affect testosterone production in primary Leydig cells from adult mice. Kiss1 and Esr1 expression also increased during puberty. The peak gonadosomatic index occurred at 4 weeks of age, and serum testosterone levels plateaued after the age of 4 weeks. Conclusion Our results suggest that kisspeptin10 does not affect steroidogenesis in adult Leydig cells, but its pattern of expression follows the stages of testicular development. Future studies should determine if kisspeptin regulates testicular development during puberty.

Published
2015

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