1. Relation between macrophage inflammatory protein-1 and intercellular adhesion molecule-1 and computed tomography findings in critically-ill saudi covid-19 patients
- Author
-
Aljohara Mohmoud Hamza, Warda Demerdash Khalifa Ali, Nagwa Hassanein, Waddah Bader Albassam, Mohammad Barry, Abdullah Mofareh Mousa AlFaifi, Khalid Abdullah Sulaiman Altayyar, Nuha Abdulrahman M. Aboabat, Wafa Khaled Fahad Alshaiddi, Howayda Mohammad Hamed AbuSabbah, Ahmed Hameed Alamri, Sara Abdullah Hamad Albabtain, and Eman Alsayed
- Subjects
Covid-19 ,Computed tomography ,Macrophage inflammatory protein-1 alpha ,MIP 1α ,Intracellular adhesion molecule 1 ,ICAM-1 ,Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Background: Several, clinical and biochemical factors were suggested as risk factors for more severe forms of Covid-19. Macrophage inflammatory protein-1 alpha (MIP-1α, CCL3) is a chemokine mainly involved in cell adhesion and migration. Intracellular adhesion molecule 1 (ICAM-1) is an inducible cell adhesion molecule involved in multiple immune processes. The present study aimed to assess the relationship between baseline serum MIP-1α and ICAM-1 level in critically-ill Covid-19 patients and the severity of computed tomography (CT) findings. Methods: The study included 100 consecutive critically-ill patients with Covid-19 infection. Diagnosis of infection was established on the basis of RT-PCR tests. Serum MIP-1α and ICAM-1 levels were assessed using commercially available ELISA kits. All patients were subjected to a high-resolution computed tomography assessment. Results: According to the computed tomography severity score, patients were classified into those with moderate/severe (n=49) and mild (n = 51) pulmonary involvement. Severe involvement was associated with significantly higher MIP-1α and ICAM-1 level. Correlation analysis identified significant positive correlations between MIP-1α and age, D-dimer, IL6, in contrast, there was an inverse correlation with INF-alpha. Additionally, ICAM-1 showed significant positive correlations with age, D‐Dimer,- TNF—α, IL6,while an inverse correlation with INF-alpha was observed. Conclusions: MIP-1α and ICAM-1 level are related to CT radiological severity in Covid-19 patients. Moreover, these markers are well-correlated with other inflammatory markers suggesting that they can be used as reliable prognostic markers in Covid-19 patients.
- Published
- 2022
- Full Text
- View/download PDF