8 results on '"Keith R Martin"'
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2. List of contributors
- Author
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Hanif Ahmad, Raid G. Alany, Jorge L. Alió, Andrew J. Anderson, Anmol Arora, Augusto Azuara-Blanco, Jorge Alio del Barrio, Christophe Baudouin, Reeda Bou Said, Rupert R.A. Bourne, Fatima Butt, David J. Calkins, Geoffrey Z.P. Chan, Ching-Yu Cheng, Rachel S. Chong, Maria Francesca Cordeiro, Jonathan G. Crowston, Qëndresë Daka, Ramin Daneshvar, Jonathan Denniss, Sundeep Singh Deol, Rebecca Epstein, Monica Ertel, Jonathan M. Fam, Ronald L. Fellman, Ted Garway-Heath, Gus Gazzard, Clare Gilbert, Kevin Gillmann, Ivan Goldberg, Jeffrey L. Goldberg, Sumit Grover, Gregg A. Heatley, Esther Hoffmann M., Alex S. Huang, Zi-Bing Jin, Murray Johnstone, Malik Kahook, L. Jay Katz, Paul L. Kaufman, Pearse A. Keane, Anthony P. Khawaja, Ziad Khoueir, Mitchell Lawlor, Christopher Leung, Boris Malyugin, Steven L. Mansberger, Kaweh Mansouri, Keith R. Martin, Christine E. Martinez, Allison M. McKendrick, André Mermoud, Robert W. Nickells, Kouros Nouri-Mahdavi, Tyler D. Oostra, Joel Palko, Radhika Pooja Patel, Zia S. Pradhan, Ramesh Priyanka, Harsha L. Rao, Reza Razeghinejad, Tony Realini, Robert Ritch, Sylvain Roy, Kerstin Sailer, Facundo G. Sanchez, Ursula Schlötzer-Schrehardt, Joel S. Schuman, Andrew Scott, Leonard Seibold, Anant Sharma, George Spaeth, Clemens A. Strohmaier, Maja Szymanska, Angelo P. Tanna, Dada Tanuj, Ian H. Tapply, Andrew J. Tatham, Carol B. Toris, Konstantinos T. Tsasousis, Ningli Wang, Robert N. Weinreb, Janey L. Wiggs, Yu Jun Wo, Gadi Wollstein, Shen Wu, Zhichao Wu, Chen Xin, Chungkwon Yoo, Cara Capitena Young, and Jingxue Zhang
- Published
- 2023
- Full Text
- View/download PDF
3. Activated retinal glia mediated axon regeneration in experimental glaucoma
- Author
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James W. Fawcett, Keith R Martin, Alessandra Guidi, and Barbara Lorber
- Subjects
Male ,Retinal Ganglion Cells ,genetic structures ,Nerve Crush ,Retinal ganglion ,lcsh:RC321-571 ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,medicine ,Animals ,Retinal ganglion cell ,Axon ,Axon regeneration ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Cells, Cultured ,Intraocular Pressure ,Retina ,Glial fibrillary acidic protein ,biology ,Optic Nerve ,Retinal ,Glaucoma ,Axons ,eye diseases ,Nerve Regeneration ,Rats ,Disease Models, Animal ,medicine.anatomical_structure ,Neurology ,chemistry ,nervous system ,biology.protein ,Optic nerve ,Activated retinal glia ,sense organs ,2-Aminoadipic Acid ,Neuroglia ,Neuroscience ,Neurotrophin - Abstract
Glaucoma, a leading cause of blindness, is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons in the optic nerve and their cell bodies in the retina. Reactive retinal glial changes have been observed in glaucoma but the role of such glial changes in the pathogenesis of the condition remains unclear. In the present study we found that retinal ganglion cells in an experimental animal model of glaucoma have an increased axon regenerative potential. Regeneration of adult rat retinal ganglion cell axons after optic nerve crush was significantly increased in vivo when combined with intraocular pressure-induced experimental glaucoma. This enhanced axon regeneration response was correlated with a significant increase in activation of glial fibrillary acidic protein+retinal glia. Using a dissociated retinal ganglion cell culture model we showed that reducing the number of activated retinal glia with a glial specific toxin, α-Aminoadipic acid, significantly reduced the growth potential of retinal ganglion cells from glaucomatous rat eyes, suggesting that activated retinal glia mediate, at least in part, the growth promoting effect. This was shown to be mediated by both membrane-bound and soluble glial-derived factors. Neurotrophin and ciliary neurotrophic/leukemia inhibitory factor blockers did not affect the regenerative potential, excluding these growth factors as principal mediators of the enhanced growth response occurring in glaucomatous retinal cultures. These observations are the first to reveal that retinal ganglion cells from glaucomatous rat eyes have an enhanced regenerative capacity. Furthermore, our results suggest that activated retinal glia mediate at least part of this response. Further work to understand and enhance the regeneration-promoting effect of activated retinal glia is required to determine if this approach could be useful as part of a therapeutic strategy to encourage optic nerve regeneration in glaucoma.
- Published
- 2012
4. Stem Cells
- Author
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Thomas V. Johnson and Keith R Martin
- Subjects
medicine.medical_specialty ,business.industry ,Ophthalmology ,medicine ,Glaucoma ,Stem cell ,medicine.disease ,business - Published
- 2015
- Full Text
- View/download PDF
5. Stem cell approaches to glaucoma
- Author
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Craig S Pearson and Keith R Martin
- Subjects
Intraocular pressure ,Retina ,genetic structures ,business.industry ,Mesenchymal stem cell ,Glaucoma ,medicine.disease ,Neuroprotection ,Retinal ganglion ,eye diseases ,medicine.anatomical_structure ,Medicine ,sense organs ,Trabecular meshwork ,Stem cell ,business ,Neuroscience - Abstract
Long-term pharmacological management of glaucoma currently relies on self-administered drugs to regulate intraocular pressure (IOP). A number of approaches using stem cells have recently shown promise as potential future treatment strategies complementary to IOP lowering. Several sources of endogenous stem cells have been identified in the eye, some of which may be able to repair the damaged trabecular meshwork and restore functional regulation of aqueous outflow. Neural and mesenchymal stem cells secrete growth factors which provide neuroprotective effects, reducing loss of retinal ganglion cells (RGCs) in animal models. In the future, stem cells may even replace RGCs to reform functional connections between the eye and the brain, although the complexity of such a repair task is formidable. With advances in biomaterial cell scaffolds and concurrent efforts in other neural systems, stem cell therapies are becoming a realistic option for treating multiple eye diseases, and despite ongoing challenges, there are reasons for optimism that stem cells may play a role in the treatment of human glaucoma in the future.
- Published
- 2015
- Full Text
- View/download PDF
6. List of Contributors
- Author
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Leslie Abrams-Tobe, Samer A Abuswider, Jorge Acosta, Pavi Agrawal, Oscar Albis-Donado, Luciana M Alencar, R Rand Allingham, Annahita Amireskandari, Nitin Anand, Florent Aptel, Makoto Araie, Enyr S Arcieri, Ehud I Assia, Tin Aung, George Baerveldt, Nafees Baig, Annie K Baik, Rajendra K Bansal, Mirko Babic, Anita Barikian, Howard Barnebey, Keith Barton, Christophe Baudouin, Allen Beck, Sonya L Bennett, Stanley J Berke, Tui H Bevin, Shibal Bhartiya, Philip A Bloom, Dana M Blumberg, Kathryn Bollinger, Christopher Bowd, John W Boyle, James D Brandt, David C Broadway, Stephen Brocchini, Alain M Bron, Donald L Budenz, Catey Bunce, Claude F Burgoyne, Jennifer Burr, Yvonne M Buys, Louis B Cantor, Joseph Caprioli, Roberto G Carassa, Daniel S Casper, Yara Paula Catoira-Boyle, Piero Ceruti, Debasis Chakrabarti, Raka Chakrabarti, Pratap Challa, Errol Chan, Peter T Chang, Robert T Chang, Balwantray C Chauhan, Aiyin Chen, Jason Cheng, Paul TK Chew, Mark Chiang, Etsuo Chihara, Neil T Choplin, George A Cioffi, Colin I Clement, Anne L Coleman, Nathan G Congdon, Michael A Coote, Vital P Costa, David P Crabb, Alan S Crandall, E Randy Craven, Laura Crawley, Jonathan G Crowston, Emmett T Cunningham, Elie Dahan, Annegret H Dahlmann-Noor, Karim F Damji, Alexander Day, Me'Ja Day, Philippe Denis, Syril Dorairaj, J Crawford Downs, Gordon N Dutton, Hassan Eldaly, Fathi F El Sayyad, Benedetto Falsini, Francisco Fantes, Herbert P Fechter, Robert D Fechtner, Ronald L Fellman, Eva Fenwick, Arosha Fernando, Ann Caroline Fisher, Frederick W Fitzke, Brad Fortune, Paul Foster, Panayiota Founti, Jeffrey Freedman, Stefano A Gandolfi, Julián García-Feijoó, David Garway-Heath, Gus Gazzard, Steven J Gedde, Noa Geffen, Stelios Georgoulas, Annette Giangiacomo, Katie Gill, Zisis Gkatzioufas, Ivan Goldberg, Pieter Gouws, Stuart L Graham, Alana L Grajewski, David S Greenfield, Franz Grehn, Daniel E Grigera, Ronald L Gross, Davinder S Grover, Rafael Grytz, Meenakashi Gupta, Neeru Gupta, Carlos Gustavo de Moraes, Ali S Hafez, Farhad Hafezi, Teruhiko Hamanaka, Alon Harris, Marcelo Hatanaka, Matthew J Hawker, Paul R Healey, The late Catherine J Heatley, Dale K Heuer, Eve J Higginbotham, Cornelia Hirn, Roger A Hitchings, Gábor Holló, Ann M Hoste, Andrew Huck, Cindy ML Hutnik, Camille Hylton, Sabita M Ittoop, Farrah Ja'afar, Henry Jampel, Thomas V Johnson, Jost B Jonas, Malik Y Kahook, Michael A Kass, Andreas Katsanos, L Jay Katz, Jill E Keeffe, Thomas Kersey, Naira Khachatryan, Sir Peng Tee Khaw, Albert S Khouri, Dan Kiage, Lee Kiang, Danny Kim, Yoshiaki Kiuchi, Thomas Klink, Helen Koenigsman, Anastasios GP Konstas, Aachal Kotecha, Avinash Kulkarni, Alexander V Kuroyedov, Antoine Labbé, Alan Lacey, Dennis SC Lam, Ecosse L Lamourex, Graham Lee, Paul Lee, Hans G Lemij, Anthony Leoncavallo, Mark R Lesk, Christopher KS Leung, Dexter YL Leung, Leonard A Levin, Richard A Lewis, K Sheng Lim, Ridia Lim, Ricardo de Lima, Yutao Liu, Alastair Lockwood, Sancy Low, Fumihiko Mabuchi, David A Mackey, Rizwan Malik, Anil K Mandal, Steven L Mansberger, Kaweh Mansouri, Giorgio Marchini, Manjula Marella, Keith R Martin, Robert H McGlynn, Steven H McKinley, Stuart J McKinnon, J Ryan McManus, Felipe A Medeiros, André Mermoud, Clive S Migdal, Don Minckler, Anthony CB Molteno, Paolo Mora, Javier Moreno-Montañés, James E Morgan, Sameh Mosaed, Marilita M Moschos, Kelly W Muir, Gonzalo Muñoz, Francisco J Muñoz-Negrete, Arvind Neelakantan, Anil K Negi, Peter A Netland, Paula Anne Newman-Casey, Marcelo T Nicolela, Nuwan Niyadurupola, Magdy A Nofal, Winnie Nolan, Monisha E Nongpiur, Baha'a N Noureddin, Gary D Novack, Brenda Nuyen, Krishnamurthy Palaniswamy, Camille Palma, Ki Ho Park, Richard K Parrish, Maria Papadopoulos, Rajul S Parikh, Louis R Pasquale, Alice Pébay, Sergey Petrov, Jody Piltz-Seymour, Luís Abegão Pinto, Ian F Pitha, Norbert Pfeiffer, Luciano Quaranta, Pradeep Y Ramulu, Emilie Ravinet, Tony Realini, Gema Rebolleda, Nic J Reus, Adam C Reynolds, Douglas J Rhee, Isabelle Riss, Robert Ritch, Charles E Riva, Gloria Roberti, Cynthia J Roberts, Alan L Robin, Prin Rojanapongpun, Sylvain Roy, John F Salmon, Juan Roberto Sampaolesi, Chiara Sangermani, Usman A Sarodia, Jamie Lea Schaefer, Ursula Schloetzer-Schrehardt, Gregory S Schultz, Joel S Schuman, Leonard K Seibold, Tarek M Shaarawy, Peter Shah, Mark B Sherwood, Lineu Oto Shiroma, Brent Siesky, Sergio Estrela Silva, Annapurna Singh, Arun D Singh, Kuldev Singh, Chelvin CA Sng, Brian J Song, George L Spaeth, Alexander Spratt, Ingeborg Stalmans, Robert L Stamper, Kazuhisa Sugiyama, Remo Susanna, Orathai Suwanpimolkul, William H Swanson, Ernst R Tamm, Tak Yee Tania Tai, Angelo P Tanna, Chaiwat Teekhasaenee, Clement CY Tham, Hagen Thieme, Ravi Thomas, Andrew M Thompson, Ravilla D Thulasiraj, John Thygesen, Karim Tomey, Yokrat Ton, Fotis Topouzis, Carol B Toris, Roberto Tosi, James C Tsai, Sonal S Tuli, Anja Tuulonen, Nicola Ungaro, Luke Vale, Leonieke ME van Koolwijk, Reena S Vaswani, Rengaraj Venkatesh, Cristina Venturini, Stephen A Vernon, Eranga N Vithana, Lingam Vijaya, Ananth C Viswanathan, Gabriele Vizzari, Irini C Voudouragkaki, Michael Waisbourd, Mark J Walland, Robert N Weinreb, Mark Werner, Anthony Wells, Boateng Wiafe, Jacob Wilensky, Tina T Wong, Darrell WuDunn, Jennifer LY Yip, Yeni Yucel, Linda M Zangwill, Virginia E Zanutigh, Joseph R Zelefsky, and Thierry Zeyen
- Published
- 2015
- Full Text
- View/download PDF
7. Stem cells for neuroprotection in glaucoma
- Author
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Natalie D. Bull, Thomas V. Johnson, and Keith R Martin
- Subjects
Transplantation ,Somatic cell ,Neurotrophic factors ,medicine ,Stem cell ,Biology ,medicine.disease ,Fetal Stem Cells ,Neuroprotection ,Spinal cord injury ,Embryonic stem cell ,Neuroscience - Abstract
Stem cell transplantation is currently being explored as a therapy for many neurodegenerative diseases including glaucoma. Cellular therapies have the potential to provide chronic neuroprotection after a single treatment, and early results have been encouraging in models of spinal cord injury and Parkinson's disease. Stem cells may prove ideal for use in such treatments as they can accumulate at sites of injury in the central nervous system (CNS) and may also offer the possibility of targeted treatment delivery. Numerous stem cell sources exist, with embryonic and fetal stem cells liable to be superseded by adult-derived cells as techniques to modify the potency and differentiation of somatic cells improve. Possible neuroprotective mechanisms offered by stem cell transplantation include the supply of neurotrophic factors and the modulation of matrix metalloproteinases and other components of the CNS environment to facilitate endogenous repair. Though formidable challenges remain, stem cell transplantation remains a promising therapeutic approach in glaucoma. In addition, such studies may also provide important insights relevant to other neurodegenerative diseases.
- Published
- 2008
- Full Text
- View/download PDF
8. Activated retinal glia mediated axon regeneration in experimental glaucoma
- Author
-
Barbara Lorber, Alessandra Guidi, James W. Fawcett, and Keith R. Martin
- Subjects
Glaucoma ,Retinal ganglion cell ,Axon regeneration ,Activated retinal glia ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Glaucoma, a leading cause of blindness, is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons in the optic nerve and their cell bodies in the retina. Reactive retinal glial changes have been observed in glaucoma but the role of such glial changes in the pathogenesis of the condition remains unclear.In the present study we found that retinal ganglion cells in an experimental animal model of glaucoma have an increased axon regenerative potential. Regeneration of adult rat retinal ganglion cell axons after optic nerve crush was significantly increased in vivo when combined with intraocular pressure-induced experimental glaucoma. This enhanced axon regeneration response was correlated with a significant increase in activation of glial fibrillary acidic protein+retinal glia. Using a dissociated retinal ganglion cell culture model we showed that reducing the number of activated retinal glia with a glial specific toxin, α-Aminoadipic acid, significantly reduced the growth potential of retinal ganglion cells from glaucomatous rat eyes, suggesting that activated retinal glia mediate, at least in part, the growth promoting effect. This was shown to be mediated by both membrane-bound and soluble glial-derived factors. Neurotrophin and ciliary neurotrophic/leukemia inhibitory factor blockers did not affect the regenerative potential, excluding these growth factors as principal mediators of the enhanced growth response occurring in glaucomatous retinal cultures.These observations are the first to reveal that retinal ganglion cells from glaucomatous rat eyes have an enhanced regenerative capacity. Furthermore, our results suggest that activated retinal glia mediate at least part of this response. Further work to understand and enhance the regeneration-promoting effect of activated retinal glia is required to determine if this approach could be useful as part of a therapeutic strategy to encourage optic nerve regeneration in glaucoma.
- Published
- 2012
- Full Text
- View/download PDF
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