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A generic multi-compartment, multi-zone population balance model (PBE) is developed. The model considers particle properties as well as the geometric coordinates (apparatus length). Further features of the presented model are the possibility to include different transport mechanisms from one process chamber to the next, the possibility of arbitrary positions of particle recycle as well as different operating conditions in each chamber. By parametric studies the influence of important process parameters on the product quality is investigated. It is the aim of this work to link product properties, in particular the particle size distribution, to a multi-zone model that can be readily applied in an industrial environment for process design and optimization.