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8 results on '"Jugnoo S. Rahi"'

1. A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration

Author

Rosie Clark, Samantha Sze-Yee Lee, Ran Du, Yining Wang, Sander C.M. Kneepkens, Jason Charng, Yu Huang, Michael L. Hunter, Chen Jiang, J.Willem L. Tideman, Ronald B. Melles, Caroline C.W. Klaver, David A. Mackey, Cathy Williams, Hélène Choquet, Kyoko Ohno-Matsui, Jeremy A. Guggenheim, Joan E. Bailey-Wilson, Paul N. Baird, Veluchamy A. Barathi, Ginevra Biino, Kathryn P. Burdon, Harry Campbell, Li Jia Chen, Ching-Yu Cheng, Emily Y. Chew, Jamie E. Craig, Margaret M. Deangelis, Cécile Delcourt, Xiaohu Ding, Qiao Fan, Maurizio Fossarello, Paul J. Foster, Puya Gharahkhani, Xiaobo Guo, Annechien E.G. Haarman, Toomas Haller, Christopher J. Hammond, Xikun Han, Caroline Hayward, Mingguang He, Alex W. Hewitt, Quan Hoang, Pirro G. Hysi, Adriana I. Iglesias, Robert P. Igo, Sudha K. Iyengar, Jost B. Jonas, Mika Kähönen, Jaakko Kaprio, Anthony P. Khawaja, Barbara E. Klein, Jonathan H. Lass, Kris Lee, Terho Lehtimäki, Deyana Lewis, Qing Li, Shi-Ming Li, Leo-Pekka Lyytikäinen, Stuart MacGregor, Nicholas G. Martin, Akira Meguro, Andres Metspalu, Candace Middlebrooks, Masahiro Miyake, Nobuhisa Mizuki, Anthony Musolf, Stefan Nickels, Konrad Oexle, Chi Pui Pang, Olavi Pärssinen, Andrew D. Paterson, Norbert Pfeiffer, Ozren Polasek, Jugnoo S. Rahi, Olli Raitakari, Igor Rudan, Srujana Sahebjada, Seang-Mei Saw, Claire L. Simpson, Dwight Stambolian, E-Shyong Tai, Milly S. Tedja, J. Willem L. Tideman, Akitaka Tsujikawa, Cornelia M. van Duijn, Virginie J.M. Verhoeven, Veronique Vitart, Ningli Wang, Ya Xing Wang, Juho Wedenoja, Wen Bin Wei, Katie M. Williams, James F. Wilson, Robert Wojciechowski, Jason C.S. Yam, Kenji Yamashiro, Maurice K.H. Yap, Seyhan Yazar, Shea Ping Yip, Terri L. Young, Xiangtian Zhou, Naomi Allen, Tariq Aslam, Denize Atan, Sarah Barman, Jenny Barrett, Paul Bishop, Graeme Black, Catey Bunce, Roxana Carare, Usha Chakravarthy, Michelle Chan, Sharon Chua, Valentina Cipriani, Alexander Day, Parul Desai, Bal Dhillon, Andrew Dick, Alexander Doney, Cathy Egan, Sarah Ennis, Paul Foster, Marcus Fruttiger, John Gallacher, David Garway-Heath, Jane Gibson, Dan Gore, Jeremy Guggenheim, Chris Hammond, Alison Hardcastle, Simon Harding, Ruth Hogg, Pirro Hysi, Pearse A. Keane, Peng Tee Khaw, Anthony Khawaja, Gerassimos Lascaratos, Thomas Littlejohns, Andrew Lotery, Phil Luthert, Tom MacGillivray, Sarah Mackie, Bernadette McGuinness, Gareth McKay, Martin McKibbin, Danny Mitry, Tony Moore, James Morgan, Zaynah Muthy, Eoin O'Sullivan, Chris Owen, Praveen Patel, Euan Paterson, Tunde Peto, Axel Petzold, Nikolas Pontikos, Jugnoo Rahi, Alicja Rudnicka, Jay Self, Panagiotis Sergouniotis, Sobha Sivaprasad, David Steel, Irene Stratton, Nicholas Strouthidis, Cathie Sudlow, Robyn Tapp, Caroline Thaung, Dhanes Thomas, Emanuele Trucco, Adnan Tufail, Stephen Vernon, Ananth Viswanathan, Katie Williams, Jayne Woodside, Max Yates, Jennifer Yip, Yalin Zheng, Neurology, Ophthalmology, APH - Mental Health, APH - Methodology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Epidemiology, Clinical Genetics, and Erasmus MC other

Subjects
All institutes and research themes of the Radboud University Medical Center, General Medicine, General Biochemistry, Genetics and Molecular Biology, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]
Abstract

Contains fulltext : 292919.pdf (Publisher’s version ) (Open Access) BACKGROUND: High myopia (HM), defined as a spherical equivalent refractive error (SER) ≤ -6.00 diopters (D), is a leading cause of sight impairment, through myopic macular degeneration (MMD). We aimed to derive an improved polygenic score (PGS) for predicting children at risk of HM and to test if a PGS is predictive of MMD after accounting for SER. METHODS: The PGS was derived from genome-wide association studies in participants of UK Biobank, CREAM Consortium, and Genetic Epidemiology Research on Adult Health and Aging. MMD severity was quantified by a deep learning algorithm. Prediction of HM was quantified as the area under the receiver operating curve (AUROC). Prediction of severe MMD was assessed by logistic regression. FINDINGS: In independent samples of European, African, South Asian and East Asian ancestry, the PGS explained 19% (95% confidence interval 17-21%), 2% (1-3%), 8% (7-10%) and 6% (3-9%) of the variation in SER, respectively. The AUROC for HM in these samples was 0.78 (0.75-0.81), 0.58 (0.53-0.64), 0.71 (0.69-0.74) and 0.67 (0.62-0.72), respectively. The PGS was not associated with the risk of MMD after accounting for SER: OR = 1.07 (0.92-1.24). INTERPRETATION: Performance of the PGS approached the level required for clinical utility in Europeans but not in other ancestries. A PGS for refractive error was not predictive of MMD risk once SER was accounted for. FUNDING: Supported by the Welsh Government and Fight for Sight (24WG201).

Published
2023

2. Differences in self-rated versus parent proxy-rated vision-related quality of life and functional vision of visually impaired children

Author

Valerija Tadić, Alexandra O Robertson, Lisanne A Horvat-Gitsels, Jugnoo S Rahi, and Mario Cortina-Borja

Subjects
Parents, 0303 health sciences, Functional vision, Visually impaired, Gold standard, Visual impairment, Logistic regression, Proxy, State Medicine, Odds, 03 medical and health sciences, Ophthalmology, Cross-Sectional Studies, 0302 clinical medicine, Quality of life, Quality of Life, 030221 ophthalmology & optometry, medicine, Humans, medicine.symptom, Child, Psychology, 030304 developmental biology, Clinical psychology, Parent proxy
Abstract

Purpose:\ud To investigate disagreement between children's self-reported vision-related quality of life (VQoL) and functional vision (FV), and their parents’ proxy-reports.\ud \ud Design:\ud Cross-sectional study.\ud \ud Methods:\ud 152 children aged 7-18 years with visual impairment (VI) (defined by the World Health Organization), and their parents, were recruited from 22 National Health Service (NHS) Ophthalmology Departments in the United Kingdom.\ud \ud Age-appropriate versions of 2 vision-specific instruments capturing VQoL and FV, were administered to children alongside modified versions for completion by parents on behalf of their child (i.e. parent proxy-report). Disagreement between self- and parent proxy-report was examined using the Bland-Altman (BA) method, and a threshold of disagreement based on 0.5 standard deviation. Disagreement was analysed according to participants’ age, gender and clinical characteristics, using logistic regression analyses.\ud \ud Results:\ud Children rated themselves as having better outcomes than their parents did, although parents both under- and over-estimated their child's VQoL (mean score difference = 7.7). With each year of increasing age, there was a 1.18 (1.04 – 1.35) higher odds of children self-rating their VQoL better than their parents (p = 0.013). Although parents consistently under-estimated their child's FV (mean score difference = -4.7), no characteristics were significantly associated with differences in disagreement.\ud \ud Conclusions:\ud Disagreement between child self-report on the impact of VI, and their parents’ proxy-reports varies by age. This implies that self-report from children must remain the gold standard. Where self-reporting is not possible, parent proxy-reports may provide useful insights, but must be interpreted with caution.

Published
2021

4. List of Contributors

Author

Luis Amaya, Jane L Ashworth, Robert A Avery, Jack Bartram, Shannon J Beres, Gil Binenbaum, Valérie Biousse, Eileen E Birch, Susmito Biswas, Graeme C M Black, Joanna Black, Richard J C Bowman, John A Bradbury, Michael C Brodsky, Donal Brosnahan, Alejandra de Alba, Jayne E Camuglia, Susan M Carden, Giovanni Castano, Ingele Casteels, Yvonne Chung, Michael P Clarke, David K Coats, Richard Collin, John Crompton, Emmett T Cunningham, Joseph L Demer, Hélène Dollfus, Peter J Dolman, Sean P Donahue, Clive Edelsten, Alistair R Fielder, David R. FitzPatrick, Anne B Fulton, Brenda L Gallie, Megan Geloneck, Clare E Gilbert, Christy Giligson, Glen A Gole, William V Good, John R B Grigg, Hans Grossniklaus, Patrick Hamel, Sheryl M Handler, Ronald M Hansen, Gena Heidary, Richard W Hertle, Göran Darius Hildebrand, Graham E Holder, Creig S Hoyt, G Baker Hubbard, Amy K Hutchinson, Saurabh Jain, Robyn V Jamieson, Hanne Jensen, Nadja Kadom, Ramesh Kekunnaya, Robert C Kersten, Philippe Kestelyn, Jan E E Keunen, Peng Tee Khaw, Chong Ae Kim, Jan Koopman, Stephen P Kraft, Burton J Kushner, Scott R Lambert, G Robert LaRoche, Dorte Ancher Larsen, Andrew G Lee, Barry Lee, Phoebe Lenhart, Alki Liasis, Grant T Liu, Christopher Lloyd, Christopher J Lyons, Carey A Matsuba, Caroline J MacEwen, Alan A McNab, Vaishali Mehta, Michel Michaelides, Daniel Mojon, Hans Ulrik, Anthony T Moore, Andrew A M Morris, Nancy J Newman, Ken K Nischal, Una O'Colmain, Anna R O'Connor, Michael O'Keefe, Scott E Olitsky, Luis H Ospina, Darren T Oystreck, Maria Papadopoulos, Sunju Park, Evelyn A Paysse, Jason H Peragallo, Erika Mota Pereira, Rachel F Pilling, Stacy Pineles, Venkatesh Prajna, Frank Antony Proudlock, Narman Puvanachandra, Anthony G Quinn, Graham E Quinn, Jugnoo S Rahi, Michael X Repka, Joshua Robinson, Buddy Russell, Luis Carlos Ferreira de Sá, Virender Sachdeva, Daniel J Salchow, Richard L Scawn, Nicoline Schalij-Delfos, Mary J van Schooneveld, Jay Self, Panagiotis I Sergouniotis, Carol L Shields, Jerry A Shields, John J Sloper, Martin P Snead, Sameh E Soliman, Timothy John Sullivan, C Gail Summers, Kimberley Tan, David S Taylor, Dorothy A Thompson, Elias I Traboulsi, Stephen J Tuft, Jimmy M Uddin, Perumalsamy Vijayalakshmi, Patrick Watts, David R Weakley, and Jill Razor Wells

Published
2017

6. List of Contributors

Author

Nisha R Acharya, James F Acheson, Gillian G W Adams, John R Ainsworth, Alejandra de Alba Campomanes, Louise E Allen, Jane Louise Ashworth, Pinar Aydin, Valérie Biousse, Susmito Biswas, Graeme C M Black, Joanna Black, Thomas M Bosley, Richard J C Bowman, John A Bradbury, Michael C Brodsky, John L Brookes, Donal Brosnahan, J Raymond Buncic, Jayne E Camuglia, Susan M Carden, Ingele Casteels, Kara Cavuoto, Wilma Y Chang, Michael P Clarke, J Richard O Collin, John Crompton, Emmett T Cunningham, Kenneth K Dahn, Susan H Day, Hélène Dollfus, Gordon N Dutton, Clive Edelsten, James Elder, John S Elston, Alistair R Fielder, David R Fitzpatrick, Anne B Fulton, Peter J Francis, Douglas Frederick, Charlotte L Funnell, Brenda L Gallie, Megan M Geloneck, Clare E Gilbert, Glen A Gole, William V Good, Irene Gottlob, Philip G Griffiths, John R B Grigg, Christopher J Hammond, Nancy N Hanna, Georgina Hall, Ronald M Hansen, Yoshikazu Hatsukawa, Hugo W A Henderson, Richard W Hertle, Göran D Hildebrand, Melanie Hingorani, Peter Hodgkins, David A Hollander, Gerd S Holmström, Graham E Holder, Creig Hoyt, David G Hunter, Robyn V Jamieson, James E Jan, Saurabh Jain, Hanne Jensen, Rohit Jolly, Robert C Kersten, Phillippe Kestelyn, Peng T Khaw, Stephen P Kraft, Burton J Kushner, Robert A Kyle, Scott R Lambert, G Robert LaRoche, David Laws, Andrew G Lee, Alki Liasis, Christopher Lloyd, Christopher J Lyons, Caroline J MacEwen, D Luisa Mayer, Craig A McKeown, Stephen D McLeod, Michel Michaelides, Joel M Miller, Neil R Miller, Nor Fadhilah Mohamad, Hans Ulrik Møller, Anthony T Moore, Andrew Alan Myles Morris, Robert Morris, Anne Moskowitz, Nancy J Newman, Ken K Nischal, Hiroshi Nishikawa, Michael O’Keefe, Maria Papadopoulos, Manoj V Parulekar, Cameron F Parsa, Carlos E Pavesio, Derrick C Pau, Evelyn A Paysse, Erika Mota Pereira, Rachel Fiona Pilling, Venkatesh Prajna, Frank A Proudlock, Anthony Quinn, Graham E Quinn, Jugnoo S Rahi, Muralidhar Rajamani, M Ashwin Reddy, Michael X Repka, Bruce Richard, Jack Rootman, Isabelle M Russell-Eggitt, Tina Rutar, Luis Carlos Ferreira de Sá, Reecha Sachdeva, Mandeep Sagoo, Alison Salt, Alvina Pauline D Santiago, Richard L Scawn, Alan B Scott, Jay Self, Panagiotis Sergouniotis, Ankoor S Shah, Akbar Shakoor, Carol L Shields, Jerry A Shields, Ian Simmons, John J Sloper, Martin P Snead, Carlos R Souza-Dias, Jane C Sowden, Lynne Speedwell, Jay M Stewart, Yoshiko Sugiyama, Aileen Sy, Naomi Tan, David Taylor, Robert H Taylor, Dorothy A Thompson, Chris Timms, Elias I Traboulsi, Stephen John Tuft, Lawrence Tychsen, Jimmy M Uddin, Alain Verloes, Anthony J Vivian, Patrick Watts, David R Weakley, David Webb, James Edmond Wraith, and Patrick Yu-Wai-Man

Published
2013

7. Taylor and Hoyt's Pediatric Ophthalmology and Strabismus, E-Book

Author

Christopher J. Lyons, Scott R. Lambert, Christopher J. Lyons, and Scott R. Lambert

Subjects
Pediatric ophthalmology, Strabismus
Abstract

Providing foundational knowledge and expert guidance on the complete spectrum of childhood eye disorders and strabismus, Taylor and Hoyt's Pediatric Ophthalmology and Strabismus, 6th Edition, remains the #1 reference of choice for practicing and trainee pediatric ophthalmologists. Edited by global leaders in the field, Drs. Christopher J. Lyons and Scott R. Lambert, this newly revised volume offers authoritative coverage of all the pediatric ophthalmic conditions you're likely to encounter in practice, including the latest clinical advances in etiology, diagnosis, and medical and surgical management. Comprehensive updates, as well as new chapters, images, and video clips, make this well-regarded title the most current and complete reference available in this evolving field.Offers state-of-the-art coverage of key areas such as OCT and current imaging techniques for the eye, orbit and visual pathways; anti-VEGF treatment for retinopathy of prematurity; pediatric cataracts; childhood glaucoma; and minimally invasive strabismus surgery.Contains five new chapters covering Imaging the Child's Eye, Aniridia Syndromes, Mitochondrial Disorders, Neurofibromatosis Type 1 and 2, and Myasthenia Gravis.Includes a unique'practical problems'section designed to help you handle difficult patient situations and a'how to'perform strabismus surgery chapter with extensive step-by-step illustrations for complete visual guidance.Features more than 1,800 high-quality images and illustrations, including 600 new to this edition, that provide visual guidance in diagnosis and management.Provides access to more than 50 narrated instructional video clips (nine are new!) depicting multiple diagnostic and surgical techniques, including the insertion of prosthetic eyes, lensectomy, pediatric cataract extraction, complications during strabismus surgery, goniotomy, the removal of conjunctival tumors, and more.Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Published
2023

8. Taylor and Hoyt's Pediatric Ophthalmology and Strabismus E-Book

Author

Scott R. Lambert, Christopher J. Lyons, Scott R. Lambert, and Christopher J. Lyons

Subjects
Pediatric ophthalmology, Strabismus, Ophthalmology
Abstract

New chapters, new editors and contributors make Taylor and Hoyt's Pediatric Ophthalmology and Strabismus, 5th Edition, the most current and complete reference available in this evolving field. Editors Scott R. Lambert and Christopher J. Lyons, both globally recognized leaders, provide authoritative coverage of all the pediatric ophthalmic conditions you're likely to encounter in practice, including the latest clinical advances in etiology, diagnosis, and medical and surgical management. Expert guidance on the complete spectrum of childhood eye disorders and strabismus, including a unique'practical problems'section designed to help you handle difficult patient situations. More than 1,800 high-quality images and artworks provide visual guidance in diagnosis and management. A practical'how to'perform strabismus surgery chapter with extensive step-by-step artworks for complete visual guidance. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Comprehensive updates of all topics, with nine brand-new chapters covering significant advances in the management of refractive errors in children; binocular vision; conjunctival tumors; optimal approaches to patient-family communication, and a unique chapter on the impact of mobile apps for the pediatric ophthalmologist. State-of-the-art coverage of key areas such as OCT and all of the newest imaging techniques for the eye, orbit and visual pathways; anti-VEGF treatment for retinopathy of prematurity; and minimally invasive strabismus surgery. An expanded video collection with more than 60 narrated instructional clips depicting multiple diagnostic and surgical techniques. Expert Consult™ eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Published
2017

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