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4 results on '"John Tsiaoussis"'

1. Data on the putative role of p53 in breast cancer cell adhesion: Technical information for adhesion assay

Author

Kallirroi Voudouri, Dragana Nikitovic, Aikaterini Berdiaki, John Tsiaoussis, Dimitris Kletsas, Nikos K. Karamanos, and George N. Tzanakakis

Subjects
Breast cancer cell adhesion, Fibronectin, Insulin growth factor receptor –I (IGF-IR), p53 tumor suppressor gene, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390
Abstract

In this data article, the potential role of p53 tumor suppressor gene (p53) on the attachment ability of MCF-7 breast cancer cells was investigated. In our main article, “IGF-I/ EGF and E2 signaling crosstalk through IGF-IR conduit point affect breast cancer cell adhesion” (K. Voudouri, D. Nikitovic, A. Berdiaki, D. Kletsas, N.K. Karamanos, G.N. Tzanakakis, 2016) [1], we describe the key role of IGF-IR in breast cancer cell adhesion onto fibronectin (FN). p53 tumor suppressor gene is a principal regulator of cancer cell proliferation. Various data have demonstrated an association between p53 and IGF-IR actions on cell growth through its’ putative regulation of IGF-IR expression. According to our performed experiments, p53 does not modify IGF-IR expression and does not affect basal MCF-7 cells adhesion onto FN. Moreover, technical details about the performance of adhesion assay onto the FN substrate were provided.

Published
2016
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2. An anatomic aberration and a surgical challenge: Mediastinal parathyroid adenoma anterior the pericardium. A case report

Author

Maria Zarokosta, George Noussios, Antonios Patrinos, Theodoros Mariolis-Sapsakos, Theodoros Piperos, and John Tsiaoussis

Subjects
medicine.medical_specialty, Adenoma, endocrine system diseases, business.industry, medicine.medical_treatment, Single parathyroid adenoma, Aberrant location, Mediastinum, Nerve injury, medicine.disease, Article, medicine.anatomical_structure, PHPT, Ectopic parathyroid, Case report, medicine, Hypercalcemia, Pericardium, Surgery, Radiology, Thoracotomy, Presentation (obstetrics), medicine.symptom, business, Parathyroid adenoma
Abstract

Highlights • Ectopic parathyroid adenomas located deeper in the mediastinum remain a surgical challenge. • Their incidence reaches up to 20% of the general population and they tend to constitute a severe cause of failed primary surgery for PHPT. • Such aberrations seem to be more common than described in the literature and there are possible anatomic aberrations that have not been described yet. • Preoperative detection of the mediastinal parathyroid adenoma and detailed exposure of the operative field are essential for a safe mid-sternal thoracotomy., Introduction Ectopic parathyroid glands occur in 6–16% of cases of PHPT and they constitute a potential cause of failed primary surgical therapy. In particular, aberrant adenomas located deeper in the mediastinum, as in the presented case, remain a severe challenge for the surgeons. Presentation of case A 54-year-old Caucasian female proceeded to our institution with signs and symptoms of PHPT. Imaging studies performed identified a large mass localized in the lower anterior mediastinum, on the left of the median line. A mid-sternal thoracotomy was performed and the aberrant adenoma was finally detected anterior to the pericardium and the left pericardiophrenic vessels and the left phrenic nerve. The operation was uneventful. A meticulous review of the literature was conducted as well. Discussion Single parathyroid adenomas are the key culprits of PHPT. Anatomic aberrations of the location of the parathyroid glands and their adenomas are more common than described in the literature and there are possible anatomic aberrations that have not been described yet. All these anatomic variations constitute major risk-factors of thoracic bleeding and of nerve injury. Conclusion Detailed preoperative detection in addition to meticulous exposure of the operative field are fundamental in order to perform a safe adenoma excision without harmful impacts to the patient.

Published
2019

3. Pancreatic and Ovarian Cancer Biomarkers

Author

Aristidis Tsatsakis, Charalampos Mamoulakis, John Tsiaoussis, Wallace A. Hayes, George Georgiadis, and Charalampos Belantis

Subjects
Oncology, medicine.medical_specialty, Diagnostic methods, business.industry, medicine.medical_treatment, Disease, medicine.disease, Targeted therapy, Natural history, Pancreatic cancer, Internal medicine, medicine, Curative surgery, Ovarian cancer, business, Chemoradiotherapy
Abstract

Pancreatic cancer (PC) and ovarian cancer (OC) consist two major causes of mortality associated with abdominal malignancies. Their common characteristic to manifest delayed clinical symptomatology results in ineffective therapeutic strategy at the time of diagnosis. Particularly for PC, overall survival percentages after curative surgery still remain disappointing despite the significant progress achieved in several aspects of disease management, including a better understanding of biological background/natural history; innovative diagnostic methods; and availability of new therapeutic modalities mainly focused on chemoradiotherapy and targeted therapy. On the other hand, patients with OC with early-stage disease (confined exclusively in ovaries) exhibit a quite high curative rate. These data necessitate the development and usage of more sophisticated tools such as biomarkers, aiming to improve diagnosis, prognosis, and prediction of patients with PC and OC. In this chapter, an overview on this challenging issue is presented.

Published
2019
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4. Contributors

Author

Arturo Anadón, Vellareddy Anantharam, Anthony E. Archibong, Irma Ares, Adam D. Aulbach, Nikee Awasthee, Aryamitra Banerjee, Leah D. Banks, Frank A. Barile, Sudheer R. Beedanagari, Charalampos Belantis, Enrico Bergamaschi, Sadikshya Bhandari, Sneha P. Bhatia, Karyn Bischoff, David J. Borts, Emily Brehm, Subash Chandra Gupta, Saurabh Chatterjee, Catheryne Chiang, Anirudh J. Chintalapati, P. Cohn, Robert W. Coppock, Lucio G. Costa, Tirupapuliyur V. Damodaran, Clinton D'Souza, Wolf-D. Dettbarn, Amy A. Devlin, Robin B. Doss, Shiwangi Dwivedi, Margitta M. Dziwenka, Jorge Estévez, Daniel S. Fabricant, A.M. Fan, Vanessa A. Fitsanakis, John Flaskos, Jodi A. Flaws, Swaran J.S. Flora, Sue M. Ford, Jessica S. Fortin, Domniki Fragou, Shayne C. Gad, Bianca Galateanu, Dale R. Gardner, George Georgiadis, Fernando Gil, Saryu Goel, Mary Gulumian, P.K. Gupta, Ramesh C. Gupta, Rekha K. Gupta, Sharon Gwaltney-Brant, Alan J. Hargreaves, Kelly L. Harris, Kenneth J. Harris, Holly E. Hatfield, Wallace A. Hayes, Ioannis Heretis, Antonio F. Hernández, Corey J. Hilmas, Darryl B. Hood, Pasi Huuskonen, Stewart B. Jacobson, Sandra A. James-Yi, Huajun Jin, Jun Kanno, Arthi Kanthasamy, Anumantha G. Kanthasamy, Shilpa N. Kaore, Navinchandra M. Kaore, Bhupendra S. Kaphalia, Vesa Karttunen, Gurjot Kaur, Ravneet Kaur, Prasada Rao S. Kodavanti, Urmila P. Kodavanti, George A. Kontadakis, Gopala Krishna, Priya A. Krishna, Kavya A. Krishna, Maria Kummu, George D. Kymionis, Rajiv Lall, P. Lin, Bommanna G. Loganathan, Jarkko Loikkanen, Marcello Lotti, Michael A. Lynes, Brinda Mahadevan, Jitendra K. Malik, Charalampos Mamoulakis, Jane A. Mantey, María Rosa Martínez-Larrañaga, María Aránzazu Martínez, Charalampos Mavridis, Roger O. McClellan, Vincent P. Meador, Lars Friis Mikkelsen, Dejan Milatovic, Ida R. Miller Mukherjee, Anupama Mukherjee, Pushpinder Kaur Multani, Päivi Myllynen, Kirsi Myöhänen, Rekek Negga, Carolina Negrei, Meliton N. Novilla, Stephanie Padilla, Carlos M. Palmeira, Kip E. Panter, Markku Pasanen, Daniel J. Patrick, Sofia Pavanello, Henrik Duelund Pedersen, Olavi Pelkonen, Michael A. Pellizzon, Jason Pitt, Argyro Plaka, Aramandla Ramesh, Saniya Rattan, Jenni Repo, Matthew R. Ricci, Anabela P. Rolo, Magdalini Sachana, Heidi Sahlman, Nitin Saini, Vandana Saini, Kai Savolainen, Ratanesh Kumar Seth, Abha Sharma, Anurag Sharma, Elina Sieppi, Rui Silva, Anita Sinha, Iordanis Skamagkas, Samantha J. Snow, Miguel A. Sogorb, Ajay Srivastava, Szabina A. Stice, Markus Storvik, David T. Szabo, João S. Teodoro, Aristidis M. Tsatsakis, John Tsiaoussis, Kirsi Vähäkangas, Sumit Singh Verma, Eugenio Vilanova, Suryanarayana V. Vulimiri, Genoa R. Warner, Kevin D. Welch, Christina Wilson-Frank, S.H. You, Snjezana Zaja-Milatovic, Ioannis E. Zisis, and Csaba K. Zoltani

Published
2019
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