1. Noninferiority meta-analysis of autologous vs allogeneic osteochondral transplantation for the treatment of osteochondral defects of the knee confounded by defect size differences
- Author
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Dexter Seow, Jin Hean Koh, Hannah L.X. Cheang, Gin Way Law, Glenys Poon, Li Yi Tammy Chan, Keng Lin Wong, and James Hui
- Subjects
Allograft ,Autograft ,Articular cartilage ,Sport ,Subchondral bone ,Trauma ,Diseases of the musculoskeletal system ,RC925-935 ,Other systems of medicine ,RZ201-999 ,Sports medicine ,RC1200-1245 - Abstract
Background: Autologous and allogeneic osteochondral transplantations are widely employed for knee osteochondral defects (OCDs). However, there has been a lack of consensus on the efficacy of autografts vs allografts. Objectives: To evaluate the complication profile following autologous vs allogeneic osteochondral transplantation for knee OCDs. Data sources: PubMed and Embase. Study eligibility criteria, participants, and interventions: Clinical studies that reported complication rates following autologous or allogeneic osteochondral transplantation for knee OCDs. Study appraisal and synthesis methods: Meta-analysis of proportions using the restricted maximum-likelihood method after the Freeman-Tukey double-arcsine transformation. Results: There were 35 studies with 2647 and 2569 OCDs included before and after lost to follow-up, respectively. Graft failure rates were not significantly lower in autografts vs allografts in all analyses: as reported (6.23% vs 10.81%, respectively; P = .63), best-case (6.00% vs 10.24%, respectively; P = .66) and worst-case analyses (7.46% vs 14.43%, respectively; P = .42). In the subgroup of mean follow-up time
- Published
- 2023
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