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Thirty percent of all patients with cancer develop pulmonary metastases. Chemotherapy is the general management for these patients; however, in a small proportion of patients, where complete resection of pulmonary metastasis can be accomplished, a survival benefit can be expected if there are no local or distant recurrences. The preoperative work-up will assess the primary tumor control and determine the possibility to perform complete resection of pulmonary metastases. Alternative approaches for patients that cannot undergo surgery (radiofrequency and radiotherapy) have been described with interesting outcomes on the control of the pulmonary metastases.