1. Persistent synaptic inhibition of the subthalamic nucleus by high frequency stimulation
- Author
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Leon A. Steiner, Andrea A. Kühn, Jörg RP. Geiger, Henrik Alle, Milos R. Popovic, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, William D. Hutchison, and Luka Milosevic
- Subjects
Deep brain stimulation ,Parkinson's disease ,Synaptic dynamics ,Synaptic depression ,Subthalamic nucleus ,Substantia nigra pars reticulata ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background: Deep brain stimulation (DBS) provides symptomatic relief in a growing number of neurological indications, but local synaptic dynamics in response to electrical stimulation that may relate to its mechanism of action have not been fully characterized. Objective: The objectives of this study were to (1) study local synaptic dynamics during high frequency extracellular stimulation of the subthalamic nucleus (STN), and (2) compare STN synaptic dynamics with those of the neighboring substantia nigra pars reticulata (SNr). Methods: Two microelectrodes were advanced into the STN and SNr of patients undergoing DBS surgery for Parkinson's disease (PD). Neuronal firing and evoked field potentials (fEPs) were recorded with one microelectrode during stimulation from an adjacent microelectrode. Results: Inhibitory fEPs could be discerned within the STN and their amplitudes predicted bidirectional effects on neuronal firing (p = .013). There were no differences between STN and SNr inhibitory fEP dynamics at low stimulation frequencies (p > .999). However, inhibitory neuronal responses were sustained over time in STN during high frequency stimulation but not in SNr (p
- Published
- 2022
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