1. Unexpectedly facile synthesis of symmetrical P1,P2-dinucleoside-5'pyrophosphates.
- Author
-
Kanavarioti A, Lu J, Rosenbach MT, and Hurley TB
- Subjects
- 2,2'-Dipyridyl chemistry, Chromatography, High Pressure Liquid, Dimethyl Sulfoxide, Dinucleoside Phosphates analysis, Dinucleoside Phosphates isolation & purification, Diphosphates chemical synthesis, Imidazoles chemistry, Inosine Monophosphate analogs & derivatives, 2,2'-Dipyridyl analogs & derivatives, Dinucleoside Phosphates chemical synthesis, Disulfides chemistry, Organophosphorus Compounds chemistry
- Abstract
Symmetrical dinucleoside 5'-pyrophosphates have been synthesized from the corresponding nucleoside 5'-phosphate free acid in high yield. The one-pot procedure is carried out in DMF or DMSO using triphenylphosphine and 2,2'-dipyridyldisulfide as the coupling agents, and 1-methylimidazole as the catalyst.
- Published
- 1991
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