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Age-related gastrointestinal decline contributes to whole-organism frailty and mortality. Genistein is known to have beneficial effects on age-related diseases, but its precise role in homeostasis of the aging gut remains to be elucidated. Here, wild-type aging mice and Zmpste24 -/- progeroid mice were used to investigate the role of genistein in lifespan and homeostasis of the aging gut in mammals. A series of longitudinal, clinically relevant measurements were performed to evaluate the effect of genistein on healthspan. It was found that dietary genistein promoted a healthier and longer life and was associated with a decrease in the levels of systemic inflammatory cytokines in aging mice. Furthermore, dietary genistein ameliorated gut dysfunctions, such as intestinal inflammation, leaky gut, and impaired epithelial regeneration. A distinct genistein-mediated alteration in gut microbiota was observed by increasing Lachnospira abundance and short-chain fatty acid (SCFA) production. Further fecal microbiota transplantation and dirty cage sharing experiments indicated that the gut microbiota from genistein-fed mice rejuvenated the aging gut and extended the lifespan of progeroid mice. It was demonstrated that genistein-associated SCFAs alleviated tumor necrosis factor alpha-induced intestinal organoid damage. Moreover, genistein-associated propionate promoted regulatory T cell-derived interleukin 10 production, which alleviated macrophage-derived inflammation. This study provided the first data, to the authors' knowledge, indicating that dietary genistein modulates homeostasis in the aging gut and extends the healthspan and lifespan of aging mammals. Moreover, the existence of a link between genistein and the gut microbiota provides a rationale for dietary interventions against age-associated frailty., Competing Interests: Declarations of interests None., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)

The importance of lighting regimen is increasing with the industrialization of poultry production, as lighting has been intimately associated with not only the establishment of rhythm and synchronous physiology of broiler chickens, but also the secretion of hormones associated with broiler maturation and growth. In recent years, increasing attention has been paid to the effects of lighting management on growth performance, immune status, and welfare of broilers. An appropriate lighting regimen, including proper source of lighting, intensity, duration, and wavelength (color) of light, is crucial to improve the growth performance and welfare of broilers. In this review, we updated the impacts of different light regimens on health and growth performance of broilers., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)