1. Clinical remission of a treatment-refractory individual with severe repetitive rituals and rumination.
- Author
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Sang DE, Shi LJ, Yue KC, He CY, Zhao HZ, Wang CH, and Hu XZ
- Subjects
- Adult, Humans, Male, Obsessive-Compulsive Disorder complications, Obsessive-Compulsive Disorder physiopathology, Remission Induction, Rumination, Cognitive physiology, Adaptation, Psychological, Cognitive Behavioral Therapy methods, Obsessive-Compulsive Disorder therapy
- Abstract
Background: Obsessive-compulsive disorder (OCD) is a severe chronic mental disorder and tends to be refractory to pharmacotherapy or psychotherapy. For treatment-refractory patients, neurosurgical interventions are options. 64 % of OCD patients who undergo neurosurgery still have greater than 16 in the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) after a long-term follow-up. Here, we reported a patient living with long-term OCD (20 years) who was refractory to pharmacotherapy, mindfulness-based psychotherapy, and neurosurgery that injured his bilateral anterior cingulates (AC) and caudate nucleus., Methods: The patient accepted a novel psychotherapy named cognitive-coping therapy (CCT) and completed Y-BOCS, Hamilton depression rating scale, the Hamilton anxiety rating scale, social and occupational function assessment, and resting-state function magnetic resonance imaging scans (rs-fMRI) before and after 4-week CCT., Results: His Y-BOCS score was reduced from 25 to 4. His depression score and anxiety score were reduced from 19 to 3 and from 12 to 3, respectively. The global assessment of functioning score increased from 32 to 88., Conclusions: The remission of the patient suggested that CCT could be an alternative intervention for treatment-refractory OCD and those with severe OCD could be cured in short-term., Competing Interests: Declaration of Competing Interest No authors have conflicts of interest to declare., (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Published
- 2020
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