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Summary: Background & Aims: Despite substantial efforts in promoting prevention and the advancements in surgical and minimally invasive techniques, breast cancer remains a leading cause of mortality among women worldwide. Genetics and risk factors, including diet and lifestyle, play a critical role in determining the susceptibility to this neoplasm. The primary objective of this study is to investigate the pivotal role of adherence to the Mediterranean diet in breast cancer prevention. Additionally, we assessed differences in diet, Body Mass Index (BMI), smoking and alcohol habits, work shifts, exposure to environmental pollutants, and hormonal factors between patients with previously diagnosed breast cancer and healthy subjects. Methods: The validated CREA questionnaire, alongside additional inquiries, was administered to the Italian population. Adherence to the Mediterranean diet was examined, and respondents were categorized into two groups: the general population and patients with a previous cancer diagnosis. Descriptive and inferential statistics were applied to assess all risk factors among these groups. Results: Results revealed low adherence to the Mediterranean diet, particularly among less educated individuals, those engaged in 24-hour shift work, smokers, and those with a high BMI. Furthermore, significant differences in working time distribution, consumption of meat, milk, and alcohol, as well as significant differences in hormonal factors such as age of menarche and menopause, age of first pregnancy, number of children and abortions, breastfeeding time, and contraceptive use were observed between these groups. Conclusions: These findings underscore the importance of targeted interventions and personalized strategies to address specific risk factors and enhance preventive measures for individuals at risk.

Multicellular organisms, such as plants, fungi, and animals, develop organs with specialized functions. Major challenges in developing such structures include establishment of polarity along three axes (apical-basal, medio-lateral, and dorso-ventral/abaxial-adaxial), specification of tissue types and their coordinated growth, and maintenance of communication between the organ and the entire organism. The gynoecium of the model plant Arabidopsis thaliana embodies the female reproductive organ and has proven an excellent model system for studying organ establishment and development, given its division into different regions with distinct symmetries and highly diverse tissue types. Upon pollination, the gynoecium undergoes dramatic changes in morphology and developmental programming to form the seed-containing fruit. In this review, we wish to provide a detailed overview of the molecular and genetic mechanisms that are known to guide gynoecium and fruit development in A. thaliana. We describe networks of key genetic regulators and their interactions with hormonal dynamics in driving these developmental processes. The discoveries made to date clearly demonstrate that conclusions drawn from studying gynoecium and fruit development in flowering plants can be used to further our general understanding of organ formation across the plant kingdom. Importantly, this acquired knowledge is increasingly being used to improve fruit and seed crops, facilitated by the recent profound advances in genomics, cloning, and gene-editing technologies., (© 2019 Elsevier Inc. All rights reserved.)

Various species of fish living in coral reef communities show sequential hermaphroditism, or sex change. In a typical case, an individual first matures as a female, and later, when it becomes dominant in the mating group, it becomes a male (i.e., protogynous sex change). Many species show only unidirectional changes but some of coral reef fishes exhibit bidirectional sex changes, in which even a dominant male may revert to female when a socially more dominant competitor arrives. However, bidirectional sex change has rarely been observed in natural conditions, even among those species exhibiting it under experimental conditions. Here we explain the rarity of bidirectional sex change by studying dynamics of hormones controlling sex expression. We consider social status factor, S F , which is elevated when the individual becomes more dominant in the mating group. When the S F level is high, the dynamics would culminate with low estradiol expression and high testosterone expression, suggesting a male phenotype. In contrast, when S F level is low, the system converges to an equilibrium with high estradiol expression and low testosterone expression, suggesting a female phenotype. There is a parameter region in which the dynamics exhibit bistability. The model demonstrates hysteresis: as S F increases smoothly, the system undergoes a sudden transition in the levels of sex hormones. The model can explain why species show unidirectional sex change, in that an individual's switch to a new sex is irreversible, even if the individual's social situation returns to the original subdominant status., (Copyright © 2018 Elsevier Ltd. All rights reserved.)