1. Alteration of cardiovascular and neuronal function in M1 knockout mice.
- Author
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Hamilton SE, Hardouin SN, Anagnostaras SG, Murphy GG, Richmond KN, Silva AJ, Feigl EO, and Nathanson NM
- Subjects
- Animals, Cells, Cultured, Electrophysiology, GTP-Binding Proteins metabolism, Gene Targeting, Heart drug effects, Hippocampus cytology, Hippocampus physiology, Humans, Learning physiology, Memory physiology, Mice, Mice, Knockout, Muscarinic Agonists pharmacology, Neurons drug effects, Oxotremorine pharmacology, Pilocarpine pharmacology, Rats, Receptor, Muscarinic M1, Receptors, Muscarinic genetics, Seizures chemically induced, Signal Transduction genetics, Telencephalon cytology, Telencephalon physiology, Calcium Channels metabolism, Heart physiology, Neurons physiology, Potassium Channels metabolism, Receptors, Muscarinic metabolism, Signal Transduction physiology
- Abstract
We used gene targeting to generate mice lacking the M1 muscarinic acetylcholine receptor. These mice exhibit a decreased susceptibility to pilocarpine-induced seizures, loss of regulation of M-current potassium channel activity and of a specific calcium channel pathway in sympathetic neurons, a loss of the positive chronotropic and inotropic responses to the novel muscarinic agonist McN-A-343, and impaired learning in a hippocampal-dependent test of spatial memory.
- Published
- 2001
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