8 results on '"Haoran Dong"'
Search Results
2. PM2.5 exposure associated with microbiota gut-brain axis: Multi-omics mechanistic implications from the BAPE study
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Tiantian Li, Jianlong Fang, Song Tang, Hang Du, Liang Zhao, Yanwen Wang, Fuchang Deng, Yuanyuan Liu, Yanjun Du, Liangliang Cui, Wanying Shi, Yan Wang, Jiaonan Wang, Yingjian Zhang, Xiaoyan Dong, Ying Gao, Yu Shen, Li Dong, Huichan Zhou, Qinghua Sun, Haoran Dong, Xiumiao Peng, Yi Zhang, Meng Cao, Hong Zhi, Jingyang Zhou, and Xiaoming Shi
- Subjects
PM2.5 ,gut-brain axis ,multi-omics ,gut microbiota ,tryptophan metabolism ,Science (General) ,Q1-390 - Abstract
Summary: Recent studies have shown that PM2.5 may activate the hypothalamus-pituitary-adrenal (HPA) axis by inducing hormonal changes, potentially explaining the increase in neurological and cardiovascular risks. In addition, an association between PM2.5 and gut microbiota and metabolites was established. The above evidence represents crucial parts of the gut-brain axis (GBA). In view of this evidence, we proposed a hypothesis that PM2.5 exposure may affect the HPA axis through the gastrointestinal tract microbiota pathway (GBA mechanism), leading to an increased risk of neurological and cardiovascular diseases. We conducted a real-world prospective repeated panel study in Jinan, China. At each visit, we measured real-time personal PM2.5 and collected fecal and blood samples. A linear mixed-effects model was used to analyze the association between PM2.5 and serum biomarkers, gut microbiota, and metabolites. We found that PM2.5 was associated with increased serum levels of hormones, especially the adrenocorticotropic hormone (ACTH) and cortisol, which are reliable hormones of the HPA axis. Gut microbiota and tryptophan metabolites and inflammation, which are important components of the GBA, were significantly associated with PM2.5. We also found links between PM2.5 and changes in the nervous and cardiovascular outcomes, e.g., increases of 19.77% (95% CI: −36.44, 125.69) in anxiety, 1.19% (95% CI: 0.65, 1.74) in fasting blood glucose (FBG), 2.09% (95% CI: 1.48, 2.70) in total cholesterol (TCHOL), and 0.93% (95% CI: 0.14, 1.72) in triglycerides (TG), were associated with 10 μg/m3 increase in PM2.5 at the lag 0–72 h, which represent the main effects of GBA. This study indicated the link between PM2.5 and the microbiota GBA for the first time, providing evidence of the potential mechanism for PM2.5 with neurological and cardiovascular system dysfunction.
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- 2022
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3. Exposure to organophosphate esters in elderly people: Relationships of OPE body burdens with indoor air and dust concentrations and food consumption
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Minmin Hou, Jianlong Fang, Yali Shi, Song Tang, Haoran Dong, Yuanyuan Liu, Fuchang Deng, John P. Giesy, Krystal J. Godri Pollitt, Yaqi Cai, and Xiaoming Shi
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Flame retardants ,Exposure pathways ,China BAPE ,Whole blood ,Urine ,Di-OPEs ,Environmental sciences ,GE1-350 - Abstract
Human exposure to OPEs is pervasive and should be of great concern due to associations with adverse health effects, especially in susceptible populations. In this study, body burdens and exposure pathways of OPEs were investigated for 76 healthy elderly people in Jinan, China based on the measured OPE and metabolite concentrations in human bio-samples (whole blood and urine) and paired environmental matrices (air and dust), as well as food frequency questionnaire. Eight of 16 OPEs and 5 of 11 metabolites were detected in > 50% of whole blood and urine samples, respectively. Tri(1-chloro-2-propyl) phosphate (TCIPP), tris(2-chloroethyl) phosphate (TCEP), tri-phenyl phosphate (TPHP), and 2-ethylhexyl di-phenyl phosphate (EHDPP) were frequently detected and abundant in whole blood, while their corresponding metabolites were detected at low frequencies or levels in urine. The reduced metabolic and/or excretory capacity of elderly people may be an important reason, implying a higher health risk to them. Fourteen OPEs had over 50% detection frequencies in indoor air and dust, while 6 di-esters in indoor dust. Tris(2-ethylhexyl) phosphate (TEHP) in indoor dust and tri-n-butyl phosphate (TnBP) in indoor air were positively correlated with paired levels in blood but not with their metabolites (BEHP and DnBP) in urine. Combined with the direct intakes of BEHP and DBP from dust, blood is indicated as more suitable biomarker for TEHP and TnBP exposure. High consumption frequencies of several foods were associated with higher blood concentrations of three OPEs and urinary levels of four di-OPEs, indicating the importance of dietary exposure pathway. Estimated daily total intakes of OPEs via inhalation, dust ingestion, and dermal absorption ranged from 2.78 to 42.0 ng/kg bw/day, which were far less than the reference dosage values. Further studies were warranted to explore the potential health effects of OPE exposure in the elderly populations.
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- 2021
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4. Exploring personal chemical exposures in China with wearable air pollutant monitors: A repeated-measure study in healthy older adults in Jinan, China
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Pengfei Guo, Elizabeth Z. Lin, Jeremy P. Koelmel, Enmin Ding, Ying Gao, Fuchang Deng, Haoran Dong, Yuanyuan Liu, Yu'e Cha, Jianlong Fang, Xiaoming Shi, Song Tang, and Krystal J. Godri Pollitt
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Airborne exposome ,Passive samplers ,Wearable sensors ,Wristband ,Air pollution ,Repeated measures ,Environmental sciences ,GE1-350 - Abstract
The health impact of airborne contaminants has been challenging to assess due to current limitations in measurement technologies. The emergence of wearable passive samplers coupled with high resolution mass spectrometry (HR-MS) chemical analysis has enabled comprehensive characterization of personal exposures. We conducted a repeated-measure study among 84 older adults in Jinan, China, as part of the Biomarkers for Air Pollutants Exposure (China BAPE) study. Study objectives were: 1) to characterize the occurrence, magnitude, and distribution of personal exposure to airborne contaminants; 2) to evaluate the temporal variation of chemical exposures across the study population; and 3) to identify behavioral and environmental factors that influence the observed variance in chemical exposures. The FreshAir wristband was worn by participants for three consecutive days each month from September 2018 to January 2019 and collected with paired time-activity logs. Passive air samplers were also deployed in parallel at a local outdoor air monitoring station. Spearman’s Rho trend test and trajectory cluster analysis were used to identify exposure trends and variation patterns, respectively. Out of the 70 airborne compounds of potential concern screened, 26 compounds from 10 chemical classes were found to be above detection thresholds across >70% of the study population. Personal exposures were predominantly characterized by nine polycyclic aromatic hydrocarbons (PAHs), four phthalates, three nitroaromatics, and two volatile organic compounds (VOCs). Phthalate personal exposures were positively correlated with outdoor temperatures while the inverse relationship was observed for certain PAHs (p
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- 2021
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5. Integration of nanoscale zero-valent iron and functional anaerobic bacteria for groundwater remediation: A review
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Haoran Dong, Long Li, Yue Lu, Yujun Cheng, Yaoyao Wang, Qin Ning, Bin Wang, Lihua Zhang, and Guangming Zeng
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Environmental sciences ,GE1-350 - Abstract
The technology of integrating nanoscale zero-valent iron (nZVI) and functional anaerobic bacteria has broad prospects for groundwater remediation. This review focuses on the interactions between nZVI and three kinds of functional anaerobic bacteria: organohalide-respiring bacteria (OHRB), sulfate reducing bacteria (SRB) and iron reducing bacteria (IRB), which are commonly used in the anaerobic bioremediation. The coupling effects of nZVI and the functional bacteria on the contaminant removal in the integrated system are summarized. Generally, nZVI could create a suitable living condition for the growth and activity of anaerobic bacteria. OHRB and SRB could synergistically degrade organic halides and remove heavy metals with nZVI, and IRB could reactive the passivated nZVI by reducing the iron (hydr)oxides on the surface of nZVI. Moreover, the roles of these anaerobic bacteria in contaminant removal coupling with nZVI and the degradation mechanisms are illustrated. In addition, this review also discusses the main factors influencing the removal efficiency of contaminants in the integrated treatment system, including nZVI species and dosage, inorganic ions, organic matters, pH, type of pollutants, temperature, and carbon/energy sources, etc. Among these factors, the nZVI species and dosage play a fundamental role due to the potential cytotoxicity of nZVI, which might exert a negative impact on the performance of this integrated system. Lastly, the future research needs are proposed to better understand this integrated technology and effectively apply it in groundwater remediation. Keywords: Nanoscale zero-valent iron, Organohalide-respiring bacteria, Sulfate reducing bacteria, Iron reducing bacteria, Groundwater remediation
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- 2019
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6. Personal black carbon exposure and its determinants among elderly adults in urban China
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Huichan Zhou, Jingjing Lin, Yu Shen, Fuchang Deng, Ying Gao, Yuanyuan Liu, Haoran Dong, Yingjian Zhang, Qinghua Sun, Jianlong Fang, Song Tang, Yanwen Wang, Yanjun Du, Liangliang Cui, Shiman Ruan, Fanling Kong, Zhaorong Liu, and Tiantian Li
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Environmental sciences ,GE1-350 - Abstract
Personal exposure to air pollution is affected by its concentration in the microenvironment and individual time-activity patterns. To investigate personal black carbon (BC) exposure levels and identify their potential determinants, we conducted a panel study among 67 elderly residents aged 60–69 years in Jinan, China. Personal BC exposure was measured using portable real-time monitors, while corresponding ambient BC concentrations and meteorological conditions were also collected from the local central site. Time-activity and household characteristics were recorded. A linear mixed-effects model was used to identify potential determinants of personal BC exposure. The daily average personal BC exposure concentration was 4.1 ± 2.0 μg/m3 (±standard deviation, SD), which was significantly lower than the ambient concentration (4.6 ± 2.5 μg/m3) (p
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- 2020
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7. List of Contributors
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Ye Cai, Hui Chen, Zhaoming Chen, Yaocheng Deng, Haoran Dong, Siyuan Fang, Chengyang Feng, Haopeng Feng, Haoyu Liu, Sishi Liu, Yani Liu, Yuanyuan Liu, Beiqing Long, Xilian Ouyang, Ya Pang, Bo Peng, Xiaoya Ren, Jing Tang, Lin Tang, Jiajia Wang, Jingjing Wang, Xue Wei, Guide Yang, Jiangfang Yu, Mingliang Yu, Guangming Zeng, Hao Zhang, Mingjuan Zhang, Yi Zhang, Yaoyu Zhou, Chao Zhu, and Jingjing Zhu
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- 2019
8. Iron-Based Nanohybrids for Aquatic Recalcitrant Pollutant Treatment
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Jing Tang, Haopeng Feng, Sishi Liu, Guide Yang, Lin Tang, Haoran Dong, and Guangming Zeng
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Pollutant ,Future perspective ,Chemistry ,Iron based ,Fabrication methods ,Environmental chemistry ,Heavy metals ,Environmental pollution - Abstract
This chapter mainly describes the fabrication and application of iron-based nanohybrids for aquatic recalcitrant pollutant treatment. First, ZVI-based nanohybrid materials and magnetic nanohybrids are classified. The fabrication methods of iron-based nanohybrids with different chemical and physical properties are detailed. Second, the performances of iron-based nanohybrids toward aquatic recalcitrant organic pollutants and heavy metals are discussed as well as relevant reaction mechanisms including adsorption, reduction, oxidation, and synergetic effects. Third, the environmental risks and the application of iron-based nanohybrids for aquatic recalcitrant pollutant treatment are summarized. Finally, the challenges and future perspective in the application of iron-based nanohybrid nanomaterials for environmental pollution control are provided.
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- 2019
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